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Chinese Chemical Letters 2017年第7期28卷 1566-1570页

作者： Liang-Run Dong De-Yu Hu zeng-xue wu Ji-Xiang Chen Bao-An Song State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationResearch and Development Center for Fine ChemicalsGuizhou UniversityGuiyang 550025China

A series of novel chalcone derivatives that contain the 1,1-dichloropropene moiety was designed and synthesized. Bioactivity assays showed that most of the target compounds exhibited moderate to good antiviral activity against tobacco mosaic virus（TMV） at 500 mg/m L. Among the target compounds,compound 7h showed the highest in vivo inactivation activity against TMV with the EC50 and EC90value of 45.6 and 327.5 mg/m L, respectively, which was similar to that of Ningnanmycin（46.9 and 329.4 mg/m L）and superior to that of Ribavirin（145.1 and 793.1 mg/m L）. Meanwhile, the microscale thermophoresis and fluorescence spectroscopy experiments showed that the compound 7h had a strong interaction with the tobacco mosaic virus coat protein.

关键词： Chalcone derivatives 1 1-Dichloropropene moiety Synthesis Antiviral activity Interaction mechanisms

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-Lin Li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Grounded-source short offset transient electromagnetic method:Theory and applications in deep mineral exploration

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Science China Earth Sciences 2025年

作者： Guoqiang xue Xin wu Weiying CHEN Nannan ZHOU Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

Abstract The Transient Electromagnetic (TEM) method is a critical geophysical technique for subsurface exploration of metal ore bodies, primarily utilizing either loop or grounded transmitters. The Long Offset Transient Electromagnetic(LOTEM) method employs a grounded-source transmitter, relying on a far-source observation mode and plane wave approximation for detection. However, LOTEM’s far-source configuration weakens signal strength, and the plane wave approximation reduces precision, limiting effective detection depth to approximately 1000 m with a comprehensive error of about 15%. Recently, we have developed the grounded-source Short Offset Transient Electromagnetic (SOTEM) method,achieving greater detection depth and accuracy within the 500–2000 m depth range, a crucial interval for mineral resource exploration. This study explores the theoretical framework, instrumentation, data processing, and field applications of SOTEM. Based on a point charge element model, SOTEM accurately computes surface wave effects in EM field calculations,optimized for near-source observation. High-power, high-resolution, wide-bandwidth exploration equipment and an advanced three-dimensional hybrid inversion technique were also developed to enhance the method’s effectiveness. Application of SOTEM to the deep exploration of the Zhou’an Ni-Cu-PGE deposit in Henan Province yielded high-resolution imaging of conductivity structures to about 2.5 km depth. These results, consistent with existing drill data, delineated mineralized ore bodies from surrounding formations, identified zones of mineralization potential, and suggested extensive resource prospects in the region.

关键词：

盐胁迫下匍匐翦股颖高光谱分析与电解质渗透率反演

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光谱学与光谱分析 2016年第11期36卷 3630-3636页

作者：肖国增吴雪莲滕珂晁跃辉李伟涛韩烈保北京林业大学草坪研究所北京100083 长江大学园艺园林学院湖北荆州434025 华中农业大学经济管理学院湖北武汉430070 滁州学院地理信息与旅游学院安徽滁州239000

叶片电解质渗透率是反映植物细胞渗透性的一个重要指标,对草坪草遭受盐胁迫的研究有重要意义。针对叶片电解质渗透率传统检测方法,耗时长,损伤叶片,无法大面积监测等弊端,探讨了用高光谱快速无损检测叶片电解质渗透率的方法。以匍匐翦股... 详细信息

叶片电解质渗透率是反映植物细胞渗透性的一个重要指标,对草坪草遭受盐胁迫的研究有重要意义。针对叶片电解质渗透率传统检测方法,耗时长,损伤叶片,无法大面积监测等弊端,探讨了用高光谱快速无损检测叶片电解质渗透率的方法。以匍匐翦股颖(Agrostis stolonifera)为对象,在温室中水培两周后进行浓度分别为0(对照),100和200mmol·L-1的盐处理,7d后按间隔7d取样3次,共72个样。每次取样时先测量样品的光谱值,然后采用电导率法测定叶片电解质渗透率。分析匍匐翦股颖三种盐处理与光谱反射率之间的关系和差异,对三种盐处理的光谱反射率计算归一化植被指数和差值植被指数,采用差分法计算光谱反射率的一阶微分,同时计算出蓝、绿和红光的三边参数,分析叶片电解质渗透率与光谱反射率、归一化植被指数、差值植被指数和三边参数的相关性。利用叶片电解质渗透率和各光谱数据相关程度高的数据,对校正集采用一元线性回归、多元线性回归和偏最小二乘回归法构建叶片电解质渗透率反演模型,用预测集检验反演模型。结果表明:盐胁迫与叶片高光谱在450~700nm波段呈正相关;叶片电解质渗透率与450~732nm波段反射率在0.01水平上显著相关;三边参数中绿边幅值和绿边面积与叶片电解质渗透率显著相关;采用偏最小二乘回归法建立的反演模型精度最好,建模和反演预测的决定系数分别达到了0.681和0.758,均方根误差分别为7.124和7.079。偏最小二乘法构建的反演模型实现了盐胁迫下匍匐翦股颖叶片电解质渗透率的快速无损检测,也为采用高光谱实时监测盐胁迫对匍匐翦股颖及其同类植物的伤害提供了依据和理论参考。

关键词：高光谱盐胁迫草坪草匍匐翦股颖电解质渗透率反演模型

Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan Jiang Yunfei Du Zhichen wu Liang Xu Xinjie Wang Xiaoguang Liu Wanhua Yu Wendong xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing Xuyun Hua Yuwen Zhang Xin xue Jiajia wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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混凝土灌注桩施工质量控制与缺陷处理

筑路机械与施工机械化 2012年第12期29卷 101-103页

作者：曾学武胡雪钦湖南省天行健职业有限公司湖南长沙410000 湖南省第六工程公司设计分公司湖南长沙410004

对混凝土灌注桩在施工过程中常见质量缺陷产生的原因进行归纳与分析,介绍了混凝土灌注桩在施工过程中的质量保证措施;同时结合生产实际,有针对性地提出了断桩、缩颈、钢筋笼上浮、桩身强度不足等一些施工关键质量的控制措施及缺陷处理... 详细信息

对混凝土灌注桩在施工过程中常见质量缺陷产生的原因进行归纳与分析,介绍了混凝土灌注桩在施工过程中的质量保证措施;同时结合生产实际,有针对性地提出了断桩、缩颈、钢筋笼上浮、桩身强度不足等一些施工关键质量的控制措施及缺陷处理方法。

关键词：灌注桩缺陷质量控制处理措施

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稀土镧对薄膜中银纳米粒子的细化作用

物理学报 2002年第5期51卷 1103-1107页

作者：许北雪吴锦雷邵庆益张兆祥刘惟敏薛增泉吴全德北京大学电子学系北京100871

通过更换基底材料 ,证实了稀土镧对Ag BaO薄膜中银纳米粒子的细化作用 .用Lewis Campbell的薄膜理论分析表明 ,稀土镧对银纳米粒子的细化作用机理是 ,基底吸附稀土镧增强了基底对银原子的等效吸附能和基底表面徙动激活能 ,使镧和银结合... 详细信息

通过更换基底材料 ,证实了稀土镧对Ag BaO薄膜中银纳米粒子的细化作用 .用Lewis Campbell的薄膜理论分析表明 ,稀土镧对银纳米粒子的细化作用机理是 ,基底吸附稀土镧增强了基底对银原子的等效吸附能和基底表面徙动激活能 ,使镧和银结合形成的复合小银粒子在基底表面的徙动扩散运动受到削弱 ,进而减少了相互团聚所致 .基底表面徙动激活能增量在 0 .0 4— 0 .0 7eV之间 ,相应的基底对银原子的等效吸附能增量在 0 .0 8— 0 .

关键词：稀土粒度镧薄膜银纳米粒子细化作用