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A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting

International Journal of Extreme Manufacturing 2023年第4期5卷 486-499页

作者： Yuanrong Li Mingjun Xie Shang Lv Yuan Sun Zhuang Li zeming gu Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002People’s Republic of China Plastic and Reconstructive Surgery Center Department of Plastic and Reconstructive SurgeryZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouZhejiang 310014People’s Republic of China

Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism.

关键词： biomimetic air-blood barrier,composite material design,controllable mechanical stimulus structure

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Development of 3D bioprinting:From printing methods to biomedical applications

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Asian Journal of Pharmaceutical Sciences 2020年第5期15卷 529-557页

作者： zeming gu Jianzhong Fu Hui Lin Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China

Biomanufacturing of tissues/organs in vitro is our big dream,driven by two needs:organ transplantation and accurate tissue models.Over the last decades,3D bioprinting has been widely applied in the construction of many tissues/organs such as skins,vessels,hearts,etc.,which can not only lay a foundation for the grand goal of organ replacement,but also be served as in vitro models committed to pharmacokinetics,drug screening and so on.As organs are so complicated,many bioprinting methods are exploited to figure out the challenges of different applications.So the question is how to choose the suitable bioprinting method?Herein,we systematically review the evolution,process and classification of 3D bioprinting with an emphasis on the fundamental printing principles and commercialized bioprinters.We summarize and classify extrusion-based,dropletbased,and photocuring-based bioprinting methods and give some advices for applications.Among them,coaxial and multi-material bioprinting are highlighted and basic principles of designing bioinks are also discussed.

关键词： 3D bioprinting Extrusion-based bioprinting Droplet-based bioprinting Photocuring-based bioprinting Bioink

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Aurivillius compound Bi_(5)Ti_(3)CrO_(15) as a visible-light-active photocatalyst for hydrogen production from water

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Journal of Energy Chemistry 2021年第11期30卷 572-580,I0013页

作者： zeming gu Jun Qian Ran Wang Meilin Lv Xiaoxiang Xu Chun Luo Clinical and Central Lab Shanghai Putuo District People’s HospitalTongji UniversityShanghai 200060China Department of Neurosurgery Tongji HospitalTongji University School of MedicineShanghai 200065China Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina

Layered Aurivillius compound Bi_(5)Ti_(3)CrO_(15) has been synthesized by a hydrothermal method for the application as a photocatalyst to liberate hydrogen from water. Bi_(5)Ti_(3)CrO_(15) owns a narrow band gap (Eg ~2.46 eV) and shows stable photocatalytic activity under both full range (λ ≥250 nm) and visible light illumination (λ ≥420 nm). A short hydrothermal reaction time is critical to achieve high photocatalytic activity as defects such as Cr^(6+) and Bi^(5+) can be avoided. An AQE as high as 3.66% at 420 nm ± 20 nm has been recorded, warranting promising application in the field of solar energy conversions. DFT calculation reveals the important role of Cr^(3+) cations for visible light sensitivity of Bi_(5)Ti_(3)CrO_(15).

关键词： Bi_(5)Ti_(3)CrO_(15) Aurivillius phase Photocatalyst Water splitting Visible light DFT

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Why choose 3D bioprinting?Part II:methods and bioprinters

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Bio-Design and Manufacturing 2020年第1期3卷 1-4页

作者： Yong He zeming gu Mingjun Xie Jianzhong Fu Hui Lin State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China

Classification of 3D bioprinting As we mentioned in the last editorial,3D printing,also known as additive manufacturing,could be considered as the reverse process of potato cutting,automatically assembling sliced potato,shredded potato,diced potato to integrity[1].Generally speaking,cell-laden 3D bioprinting can be classified into three types:extrusion-based,droplet-based and photocuring-based bioprinting according to different printing principles.Extrusion-based bioprinting squeezes out continuous hydrogel fibers to set up structures;dropletbased bioprinting generates droplets as the basic unit for biofabrication;and photocuring-based bioprinting utilizes the characteristics of light-sensitive materials,to stack 3D models layer-by-layer.Different bioprinting approaches own diverse characteristics facing various scenarios and have specific requirements for bioinks.

关键词： printing utilize printer

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SrTiO_(3)-CaCr_(0.5)Nb_(0.5)O_(3) solid solutions as p-type photocatalysts for Z-scheme water splitting under visible light illumination

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Journal of Materials Science & Technology 2021年第28期87卷 46-53页

作者： zeming gu Qi Wang Xiaoqin Sun Lingwei Lu Yuwei Zhang Ran Wang Shu Jin Yinlin Shao Jun Qian Xiaoxiang Xu Clinical and Central Lab Putuo People’s HospitalDepartment of NeurosurgeryTongji HospitalTongji University School of MedicineShanghai Key Lab of Chemical Assessment and SustainabilitySchool of Chemical Science and EngineeringTongji UniversityShanghaiChina State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou310027China

P-type semiconductivity has been observed in solid solution series(SrTiO_(3))_(1-x)(CaCr_(0.5)Nb_(0.5)O_(3))x(0.0≤x≤0.15),which all adopt cubic symmetry and own intense absorption in the visible light region.These solid solutions are superior H2 evolution photocatalysts under visible light illumination(λ≥400 nm).An AQE as high as 1.02%at 420±20 nm has been achieved at optimal composition(SrTiO_(3))_(0.85)(CaCr_(0.5)Nb_(0.5)O_(3))0.15 which significantly surpasses the parent compounds.Stoichiometric H_(2)/O_(2) production under visible light illumination has been successfully realized using Z-scheme system containing(SrTiO_(3))_(0.85)(CaCr_(0.5) Nb_(0.5) O_(3))_(0.15),WO_(3) and I^(-)/IO_(3)^(-)redox couple.

关键词： p-Type semiconductor Photocatalyst Z-scheme Water splitting Solid solution

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THEORETICAL PREDICTION OF TOOL-CHIP CONTACT LENGTH IN ORTHOGONAL METAL MACHINING BY COMPUTER SIMULATION

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Chinese Journal of Mechanical Engineering 2002年第3期15卷 233-237页

作者： gu Lizhi Long zeming Cao LiwenCollege of Mechanical Engineering, Jiamusi University, Jiamusi 154007, ChinaYuan Zhejun Harbin Institute of Technology College of Mechanical Engineering Jiamusi University Jiamusi 154007 Harbin Institute of Technology

A method for determination of tool-chip contact length is theoreticallypresented in orthogonal metal machining. By using computer simulation and based on the analyses ofthe elastro-plastic deformation with lagrangian finite element method in the deformation zone, theaccumulated representative length of the low layer, the tool-chip contact length of the chipcontacting the tool rake are calculated, experimental studies are also carried out with 0.2 percentcarbon steel. It is shown that the tool-chip contact lengths obtained from computer simulation havea good agreement with those of measured values.

关键词： Tool-chip contact length Computer simulation Finite element method Elastro-plastic deformation Representative length of an element

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Research and Analysis of Regional Ecological Positioning in Planning Environmental Impact Assessment

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Meteorological and Environmental Research 2022年第5期13卷 19-24页

作者： Jianqiao QIN Donghang JIANG Fuxing gu Meng HU Rongjin YANG Yingli JIE zeming ZHENG Haojia XU Xiaoxiao LIAO College of Environmental and Chemical Engineering Zhaoqing UniversityZhaoqing 526061China guangdong Provincial Key Laboratory of Environmental Health and Land Resource Zhaoqing UniversityZhaoqing 526061China guangdong Zhonghao Survey and Design Consulting Co. Ltd.Zhaoqing 526061China Chinese Research Academy of Environmental Sciences Beijing 100012China

The regional ecological positioning of one area is based on the region’s ecological orientation by the country or a larger region.Combined with the region’s natural geographical features,ecological background,main ecological problems,regional ecological structure,pattern,process,function and service,etc.,the position of a certain area in ecological space,structure,process,function and service,etc.is determined through the analysis and research.Regional ecological positioning is an important prerequisite and core basis for regional ecological impact assessment.However,in the current regional ecological impact assessment,most of them have not analyzed and studied the regional ecological positioning.Due to the lack of research on regional ecological positioning,it is rare to apply the research results of regional ecological positioning to the establishment of regional ecological objectives and the construction of index system.Regional ecological positioning does not guide the direction of regional ecological protection and construction well,and there is a general tendency of regional ecological positioning being one-sided and slogan-based.This paper analyzes the necessity and importance of research of regional ecological positioning,puts forward the technology framework of study on regional ecological positioning.With regional ecological positioning research in planning ecological impact assessment of the Chengdu-Chongqing Economic Zone as an example,how to carry out the study on the regional ecological positioning and how to apply the results of the study on the regional ecological positioning in regional ecological impact assessment are explained and illustrated.

关键词： Regional planning Ecological impact assessment Ecological positioning Chengdu-Chongqing Economic Zone

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同一笼养生境下金头狮面狨猴、赤掌柽柳猴和棉顶狨猴肠道菌群比较

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兽类学报 2023年第5期43卷 580-592页

作者：张泽明姚红玉吴楠赵玲玲顾逸如王宇吴弘赵大鹏天津师范大学生命科学学院天津300387 南京市红山森林动物园南京210028

动物的肠道菌群组成与宿主种类及其生存环境直接相关,研究同一生境下不同物种的肠道菌群组成对于物种多样性保护具有积极意义。本研究采用非损伤取样和16S rDNA高通量测序等方法,以南京市红山森林动物园笼养的金头狮面狨猴(Leontopithec... 详细信息

动物的肠道菌群组成与宿主种类及其生存环境直接相关,研究同一生境下不同物种的肠道菌群组成对于物种多样性保护具有积极意义。本研究采用非损伤取样和16S rDNA高通量测序等方法,以南京市红山森林动物园笼养的金头狮面狨猴(Leontopithecus chrysomelas)、赤掌柽柳猴(Saguinus midas)和棉顶狨猴(Saguinus oedipus)三种新大陆猴为研究对象,比较分析其肠道菌群结构组成差异,并进行功能预测。结果发现:3个物种的肠道菌群合计14门20纲50目101科231属356种。优势菌门均为厚壁菌门(Firmicutes)、放线菌门(Actinobacteria)、变形菌门(Proteobacteria)和拟杆菌门(Bacteroidetes),共有优势菌属为链球菌属(Streptococcus)和双歧杆菌属(Bifidobacterium)。3个物种间肠道菌群在门水平和属水平均存在显著差异,其中金头狮面狨猴的肠道菌群丰富度显著高于另外两个物种。本研究结果为灵长类肠道菌群多样性与生存适应研究提供基础数据,同时为相关物种的易地保护管理提供参考依据。

关键词：新大陆猴肠道菌群高通量测序技术 16S rDNA

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不同放牧强度下蒙古栎天然林土壤物理性质及土壤质量综合评价

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中南林业科技大学学报 2023年第12期43卷 137-144页

作者：王冰鹤姚辰昊张立蓉曹国红刘子剑米泽明李校王兴董阳谷建才河北农业大学林学院河北保定071000 河北省木兰围场国有林场河北承德068450 河北省林业和草原技术推广总站河北石家庄050081

【目的】为定量分析不同放牧强度对冀北山地蒙古栎天然林林下土壤物理性质的影响,以及探究放牧干扰作用下的森林土壤物理性质的评价体系。【方法】采集放牧强度重度(HG)、中度(MG)、轻度(LG)下蒙古栎天然林0~20 cm土壤为研究对象,以及... 详细信息

【目的】为定量分析不同放牧强度对冀北山地蒙古栎天然林林下土壤物理性质的影响,以及探究放牧干扰作用下的森林土壤物理性质的评价体系。【方法】采集放牧强度重度(HG)、中度(MG)、轻度(LG)下蒙古栎天然林0~20 cm土壤为研究对象,以及立地条件相同且长期封禁处理的作为对照组(CK)。对各放牧强度的土壤物理因子进行单因素方差分析(ANOVA)、灰色关联度分析来揭示不同放牧强度对蒙古栎天然林土壤物理性质的影响。应用主成分分析法、多维空间坐标综合评定值累加法、熵权-TOPSIS法对放牧干扰下的土壤物理质量进行综合评价。【结果】1)土壤中粗粉粒、沙粒、黏粒含量随放牧强度的增加而增加,中粉粒、细粉粒含量随放牧强度的增加而减少,放牧强度对土壤分形维数的影响并不显著。2)土壤容重随放牧强度的增加而增加,其余物理因子均随放牧强度的增加而减小,重度放牧组与其他各放牧组各土壤物理因子间均存在显著差异。3)所选用的3种评价方法均表现出一致的排序结果:CK>LG>MG>HG。【结论】针对于放牧后对林下土壤物理性质产生的影响,综合考虑后得出:轻度放牧会促进林下凋落物的分解并有利于改善林下土壤物理质量,过度放牧会对林下土壤造成不良影响。放牧对林下土壤的影响是多层次的,仍需加强长期监测与深入研究。

关键词：放牧强度土壤物理性质分形维数综合评价熵权-TOPSIS法

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冀北地区不同林分枯落物层的持水能力分析

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防护林科技 2023年第3期 19-22,26页

作者：李娟万超米泽明谷建才卢金平河北省木兰围场国有林场河北承德068450 河北农业大学林学院河北保定071000

采用样地调查和室内浸泡法,对河北省木兰围场国有林场孟滦分场3种不同林分枯落物的持水能力进行了研究。结果表明:枯落物的蓄积量为针阔混交林>油松林>蒙古栎林;枯落物的吸水速率在未分解层和半分解层中均表现为针阔混交林>蒙古栎林>油... 详细信息

采用样地调查和室内浸泡法,对河北省木兰围场国有林场孟滦分场3种不同林分枯落物的持水能力进行了研究。结果表明:枯落物的蓄积量为针阔混交林>油松林>蒙古栎林;枯落物的吸水速率在未分解层和半分解层中均表现为针阔混交林>蒙古栎林>油松林。在未分解层中最大持水量为蒙古栎林(2931.7)>针阔混交林(2477.6)>油松林(1504.8);而在半分解层中最大持水量为针阔混交林(2801.2)>蒙古栎林(2718.3)>油松林(1128.4)。枯落物的有效拦蓄量未分解层和半分解层均表现为油松林>蒙古栎林>针阔混交林。蒙古栎林的持水能力优于其他2种林分类型。

关键词：枯落物层蓄积量吸水速率最大持水量

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