Development of 3D bioprinting:From printing methods to biomedical applications

作     者：Zeming Gu Jianzhong Fu Hui Lin Yong He Zeming Gu;Jianzhong Fu;Hui Lin;Yong He

作者机构：State Key Laboratory of Fluid Power and Mechatronic SystemsSchool of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang ProvinceSchool of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of General SurgerySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2020年第15卷第5期

页      面：529-557页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0802[工学-机械工程] 0836[工学-生物工程] 080201[工学-机械制造及其自动化] 

基　　金：sponsored by the National Natural Science Foundation of China(No.U1609207) 

主　　题：3D bioprinting Extrusion-based bioprinting Droplet-based bioprinting Photocuring-based bioprinting Bioink 

摘      要：Biomanufacturing of tissues/organs in vitro is our big dream,driven by two needs:organ transplantation and accurate tissue *** the last decades,3D bioprinting has been widely applied in the construction of many tissues/organs such as skins,vessels,hearts,etc.,which can not only lay a foundation for the grand goal of organ replacement,but also be served as in vitro models committed to pharmacokinetics,drug screening and so *** organs are so complicated,many bioprinting methods are exploited to figure out the challenges of different *** the question is how to choose the suitable bioprinting method?Herein,we systematically review the evolution,process and classification of 3D bioprinting with an emphasis on the fundamental printing principles and commercialized *** summarize and classify extrusion-based,dropletbased,and photocuring-based bioprinting methods and give some advices for *** them,coaxial and multi-material bioprinting are highlighted and basic principles of designing bioinks are also discussed.