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Achieving 1.2 fm/Hz^(1/2)Displacement Sensitivity with Laser Interferometry in Two-Dimensional Nanomechanical Resonators:Pathways towards Quantum-Noise-Limited Measurement at Room Temperature

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Chinese Physics Letters 2023年第3期40卷 74-81页

作者： Jiankai Zhu Luming Wang Jiaqi Wu Yachun Liang Fei Xiao Bo Xu zejuan zhang Xiulian Fan Yu Zhou Juan Xia Zenghui Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China School of Physics and Electronics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangsha 410083China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China

Laser interferometry is an important technique for ultrasensitive detection of motion and *** push the limit of laser interferometry through noise optimization and device *** contribution of noises other than shot noise is reduced from 92.6%to 62.4%,demonstrating the possibility towards shotnoise-limited *** noise thermometry,we quantify the laser heating effect and determine the range of laser power values for room-temperature *** detailed analysis and optimization of signal transduction,we achieve 1.2 fm/Hz^(1/2)displacement measurement sensitivity at room temperature in twodimensional(2D)Ca Nb_(2)O_(6)nanomechanical resonators,the best value reported to date among all resonators based on 2D *** work demonstrates a possible pathway towards quantum-noise-limited measurement at room temperature.

关键词： noise interferometry optimization

Broad-range,high-linearity,and fast-response pressure sensing enabled by nanomechanical resonators based on 2D non-layered material:β-In_(2)S_(3)

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InfoMat 2024年第8期6卷 119-127页

作者： Junzhi Zhu Song Wu Luming Wang Jiaqi Wu Jiankai Zhu Luwei Zou Fei Xiao Ziluo Su Chenyin Jiao Shenghai Pei zejuan zhang Jiaze Qin Bo Xu Yu Zhou Juan Xia Zenghui Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengduthe People's Republic of China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghaithe People's Republic of China School of Physics Hunan Key Laboratory of Nanophotonics and DevicesCentral South UniversityChangshathe People's Republic of China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengduthe People's Republic of China

Two-dimensional(2D)non-layered materials,along with their unique surface properties,offer intriguing prospects for sensing *** mechanical degrees of freedom is expected to enrich the sensing performances of 2D non-layered devices,such as high frequency,high tunability,and large dynamic range,which could lead to new types of high performance ***,we demonstrate 2D non-layered nanomechanical resonant sensors based onβ-In_(2)S_(3),where the devices exhibit robust nanomechanical vibrations up to the very high frequency(VHF)*** show that such device can operate as pressure sensor with broad range(from 103 Torr to atmospheric pressure),high linearity(with a nonlinearity factor as low as 0.0071),and fast response(with an intrinsic response time less than 1μs).We further unveil the frequency scaling law in theseβ-In_(2)S_(3) nanomechanical sensors and successfully extract both the Young's modulus and pretension for the *** work paves the way towards future wafer-scale design and integrated sensors based on 2D non-layered materials.

关键词： 2D non-layered materials frequency scaling nanomechanical resonators pressure sensing

心理研究中统计方法应用的元分析——以《心理学报》《心理科学》(1998-2008)统计方法应用为例

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心理科学 2010年第1期33卷 48-54页

作者：焦璨黄泽娟张敏强吴利王宣承深圳大学师范学院心理系深圳518060 华南师范大学心理研究中心广州510631

统计方法在心理研究中得到了广泛的应用。统计方法的应用,除了具备一定的统计方法知识外,还应当了解统计方法应用的必要前提条件。通过调查、分析国内最具代表性的两种杂志《心理学报》、《心理科学》(1998 2008)应用了统计方法的论文(... 详细信息

统计方法在心理研究中得到了广泛的应用。统计方法的应用,除了具备一定的统计方法知识外,还应当了解统计方法应用的必要前提条件。通过调查、分析国内最具代表性的两种杂志《心理学报》、《心理科学》(1998 2008)应用了统计方法的论文(或报告),主要了解哪些统计方法得到最多的应用以及发现应用中存在的一些问题,并对此作了评述。目的是使心理学研究者在心理研究中能更好地应用统计方法分析问题,解决问题。

关键词：心理研究统计方法心理学报心理科学

基于TCGA、GEO数据库联合挖掘结肠癌诊断和预后生物标志物

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西北民族大学学报（自然科学版） 2024年第2期45卷 37-45页

作者：黄睿安随虎张泽娟高亚珍麻江涛李鹏达刘金英西北民族大学西北民族地区环境生态与人群健康国家民委重点实验室甘肃兰州730030

目的:应用GEO和TCGA数据库中的结肠癌基因表达数据,通过生物信息学手段挖掘影响结肠癌诊断和预后的关键基因,以期找到结肠癌早期诊断及预后相关的生物标志物,为结肠癌的临床诊断及结肠癌药物研发提供分子基础.方法:检索GEO基因表达数据... 详细信息

目的:应用GEO和TCGA数据库中的结肠癌基因表达数据,通过生物信息学手段挖掘影响结肠癌诊断和预后的关键基因,以期找到结肠癌早期诊断及预后相关的生物标志物,为结肠癌的临床诊断及结肠癌药物研发提供分子基础.方法:检索GEO基因表达数据库,下载符合条件的结肠癌患者基因芯片数据集,同时下载TCGA中结肠癌的转录组测序数据.应用R语言及相应的R包进行数据处理及统计学分析.首先通过R语言将下载的GEO基因芯片数据集和TCGA转录组数据集整理为基因表达矩阵,应用“limma”包进行基因表达差异分析,找出每个数据集的差异表达基因;再利用RRA包对这些差异表达基因进行优先级排序,找出在这些数据集中共同上调和共同下调的基因以及根据其变化倍数进行的优先级排序表.同时对这些共同上调和下调基因进行GO和KEGG信号通路富集分析,根据TCGA中的病人临床信息对上调和下调中排名前20的基因进行生存相关分析及蛋白质-蛋白质相互作用分析.结果:从TCGA结肠癌数据集、GSE44861数据集、GSE33113数据集、GSE39582数据集中分别筛选出差异基因4002,349,8917,1697个,接着使用RRA算法得到85个共同显著性上调基因和141个共同显著性下调基因,这些共同上调基因和共同下调基因参与多种信号通路,在肿瘤中的变化倍数高达1000倍,其中有多种下调基因参与金属离子的代谢.还发现GUCA2A,CA4,GCG,CXCL1,CXCL8,CLCA1六个基因的表达水平与生存时间之间存在显著性正相关性.结论:CLCA1,GUCA2A,GCG,CXCL1和CXCL8与结肠癌的发展和预后可能相关.

关键词：结肠癌 GEO数据库 TCGA数据库生物信息学

Sequential dual-locking strategy using photoactivated Pt(Ⅳ)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3251-3265页

作者： Jun Li Qiang zhang Hao Yang Wenli Lu Yulong Fu Yingcai Xiong Xuan Wang Tianming Lu Yanlin Xin zejuan Xie Weichao Chen Guoqiang Wang Yuanyuan Guo Ruogu Qi School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Mesoscopic Chemistry of Ministry of Education Institute of Theoretical and Computational ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Laboratory for Manufacturing Low Carbon and Functionalized Textiles College of Textiles&ClothingQingdao UniversityQingdao 266071China

Selective activation of Pt(Ⅳ)prodrugs within tumors has emerged as a promising strategy in tumor *** progress has been made with photo-and ultrasound-activated Pt(Ⅳ)prodrugs,concerns remain over the non-specific activation of photosensitizers(PS)and the potential for phototoxicity and chemical *** this study,a sequential dual-locked Pt(Ⅳ)nano-prodrug that can be activated by both the acidic tumor microenvironment and light was *** Pt(Ⅳ)prodrug was prepared by conjugating PS-locked Pt(Ⅳ)to a polymeric core,which was then chelated with metallo iron to lock its photoactivity and form a metallo-nano *** acidic tumor microenvironment conditions,the metallo-nano prodrug undergoes dissociation of iron,triggering a reduction process in oxaliplatin under light irradiation,resulting in the activation of both chemotherapy and photodynamic therapy(PDT).Additionally,the prodrug could induce metallo-triggered ferroptosis and polarization of tumorassociated macrophages(TAM),thereby enhancing tumor *** dual-lock strategy employed in a nanoparticle delivery system represents an expansion in the application of platinum-based anticancer drugs,making it a promising new direction in cancer treatment.

关键词： Dual-locking Pt(Ⅳ)reduction Chemotherapy Photodynamic therapy Ferroptosis Macrophage polarization Medicinal inorganic chemistry Metals in medicine

Unmanned Aerial Vehicle Control of Major Sugarcane Diseases and Pests in Low Latitude Plateau

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Agricultural Biotechnology 2019年第4期8卷 48-51页

作者： Xiaoyan WANG Rongyue zhang Hongli SHAN Yuanhong FAN Hong XU Pizhong HUANG zejuan LI Tingying DUAN Ning KANG Wenfeng LI Yingkun HUANG Sugarcane Research Institute Yunnan Academy of Agricultural SciencesKaiyuan 661699China Yunnan Plateau Characteristic Agricultural Industry Research Institute Kunming 650201China Yunnan Zichen Agricultural Development co.LTD Xiangyun 672100China Lincang Nanhua Sugar Industry co.LTD Lincang 677500China Yunnan Kaimike Agricultural Technology Service Co.LTD Kunming 650000China Dehong Sugarcane Research Institute Longchuan 678707China

This research was aimed at the defects in traditional artificial spraying control method and the problems such as the difficulty in pesticides applying,labor shortage and low operating efficiency in the middle and late stage of sugarcane high stalk *** aerial pesticide application technology for sugarcane main diseases and pests was systematically developed and demonstrated from the aspects of aircraft type choice,selection of special pesticides and auxiliaries,integration of pesticides and equipment,field operation,technical specifications,and large-scale application organization *** UAV model and flight technical parameters suitable for the sugarcane planting area in low-latitude plateau were analyzed,and the optimal agent formulation combination and application technology of the UAV flight control were screened out,and the UAV flight control was applied to the major sugarcane pests and diseases control in the low-latitude plateau in large scale(UAV flight control was popularized and applied to 15 527 hm 2 in 2018).The research results provided mature whole-process technical support for the normalization of the application of the UVA flight control of major sugarcane pests and *** UAV control technology for major sugarcane pests and diseases had the advantages of ultra-low pesticides applying dosage and high operating efficiency,and could effectively solve the problems such as the difficulty in pesticides applying,labor shortage and low operating efficiency in the middle late growth stage of high stalk *** technology successfully opened up a simple,efficient and new way for the effective control of major sugarcane pests and diseases,and practically accelerated the process of integrated control and prevention of sugarcane pests and *** addition,this technology had an extremely significant effect on reducing the loss of sugarcane farmers and enterprises caused by the epidemic and outbreak of sugarcane pests and diseases,increasing

关键词： Low latitude plateau Sugarcane diseases and pests Unmanned aerial vehicle Prevention and control technology

UTE序列肺部成像技术优势及在儿童肺部疾病中的应用进展

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现代医用影像学 2023年第10期32卷 1952-1956页

作者：林泽娟张琳厦门市儿童医院(复旦大学附属儿科医院厦门医院)放射医学科福建厦门361006

近些年来,随着MRI设备和技术的改进,特别是超短回波时间序列(ultrashort echo-time,UTE)的使用,肺部MRI在儿童中的应用越来越广泛。UTE序列可以有效减少信号衰减,显著增强肺部信号,降低敏感性伪影,提高对比度、噪声比,改善肺的结构成像... 详细信息

近些年来,随着MRI设备和技术的改进,特别是超短回波时间序列(ultrashort echo-time,UTE)的使用,肺部MRI在儿童中的应用越来越广泛。UTE序列可以有效减少信号衰减,显著增强肺部信号,降低敏感性伪影,提高对比度、噪声比,改善肺的结构成像;并可以采用UTE序列进行超极化129Xe MRI、动态增强灌注成像技术和氧增强MRI等功能成像。本文总结了UTE序列的技术优势,UTE在肺部结构相和肺功能成像中的应用以及在儿童肺部疾病中的应用现况。

关键词：儿童肺部磁共振成像(MRI) 超短回波时间序列(UTE)

H3K27变异型弥漫性中线胶质瘤临床病理分析及NTRK作为治疗靶点的初步探讨

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中华病理学杂志 2022年第11期51卷 1115-1122页

作者：段泽君冯景姚坤胡泽娟马忠向磊张绪妃齐雪岭首都医科大学三博脑科医院病理科北京100093 首都医科大学三博脑科医院影像科北京100093

目的分析H3K27变异型弥漫性中线胶质瘤(diffuse midline glioma,H3K27-altered,DMG)的临床病理学特征及预后相关因素,并探讨神经营养原肌球蛋白受体激酶(neurotrophic tropomyosin receptor kinase,NTRK)作为DMG的治疗靶点的可行性。方法收集2016年7月至2021年3月首都医科大学三博脑科医院诊断为DMG的病例样本232例,分析其临床、影像、病理、O6-甲基鸟嘌呤DNA甲基转移酶(MGMT)启动子甲基化比率、NTRK免疫表达、NTRK基因融合的特点,并对肿瘤发生年龄、部位、组织学分级、NTRK蛋白及基因改变、术后辅助治疗方式在预后方面的意义进行研究。结果232例病例(包含原发/复发病例8例,即共有224例患者,男性118例,女性106例),儿童组(≤18岁)98例,成人组(>18岁)126例。儿童组和成人组发病部位分别以脑干(59/98,60.2%)和丘脑(41/126,32.5%)最为多见。影像学上病变多呈现为T1低或等信号,T2高信号,增强信号变化较大,但多数肿瘤无明显增强信号。组织学分级包含2级(9/224,4.0%)、3级(41/224,18.3%)、4级(174/224,77.7%)。肿瘤细胞均弥漫表达H3K27M,而H3K27me3均表达丢失。MGMT启动子甲基化比率较低(1/45,2.2%)。Pan-TRK蛋白阳性率为79.0%(177/224),NTRK1融合阳性率10.0%(5/50)。儿童组和成人组的组织学分级、NTRK蛋白表达、NTRK基因融合比率差异均无统计学意义(P>0.05)。随访患者159例,其中109例死亡(68.6%),总体生存时间1~55个月,中位生存期12个月。患者预后与年龄、部位、手术方式及术后辅助治疗相关(P<0.05)。结论DMG患者临床预后凶险,成人组和儿童组DMG肿瘤的发病部位、预后存在差异。NTRK1基因融合在DMG中占比达10.0%,提示TRK抑制剂可以作为DMG治疗的一个新选择。

关键词：神经胶质瘤 DNA突变分析基因融合预后 H3K27M突变 NTRK融合

基于护理信息系统的接近失误事件及护理不良事件发生现状的纵向研究

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护理研究 2021年第13期35卷 2295-2298页

作者：徐冬梅顾则娟张新月宋燕波王荣江苏省人民医院(南京医科大学第一附属医院) 江苏210029

目的:对南京市某三级甲等医院护士上报接近失误事件及护理不良事件的发生现状进行纵向研究,为临床护理决策提供参考意见。方法:基于“拦截接近失误事件系统”及“不良事件上报系统”,收集2016年1月―2019年8月南京市某三级甲等医院护理... 详细信息

目的:对南京市某三级甲等医院护士上报接近失误事件及护理不良事件的发生现状进行纵向研究,为临床护理决策提供参考意见。方法:基于“拦截接近失误事件系统”及“不良事件上报系统”,收集2016年1月―2019年8月南京市某三级甲等医院护理人员主动上报接近失误事件及不良事件的数据,并分析两类事件的发展趋势及相关性。结果:研究期间接近失误事件呈先慢后快、增长趋势,护理不良事件呈先增长、后略微降低趋势。各科室护士上报接近失误事件与不良事件发生例数呈正相关(r=0.380,P0.05)。结论:接近失误事件及不良事件的发展趋势具有时间差异性,呈现异相关联;同时,每个科室的两类事件发生例数也具有关联性。建议护理管理者加强对接近失误事件的监测与分析,以期降低护理不良事件发生率。

关键词：护理信息系统接近失误事件护理不良事件护理管理纵向研究