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Diversified Application of Barcoded PLATO(PLATO-BC) Platform for Identification of Protein Interactions

Genomics, Proteomics & Bioinformatics 2019年第3期17卷 319-331页

作者： Weili Kong Tsuyoshi Hayashi Guillaume Fiches Qikai xu Mamie ZLi Jianwen Que Shuai Liu Wei Zhang jun Qi Netty Santoso Stephen JElledge Jian Zhu Department of Microbiology and Immunology Department of Biochemistry and BiophysicsUniversity of Rochester Medical Center Division of Genetics Brigham and Women’s HospitalHoward Hughes Medical InstituteDepartment of GeneticsHarvard Medical School Department of Medicine Columbia University Medical Center Department of Chemistry College of Science and MathematicsUniversity of Massachusetts Boston Dana-Farber Cancer Institute Harvard Medical School Department of Pathology Ohio State University Wexner Medical Center

Proteins usually associate with other molecules physically to execute their *** these interactions is important for the functional analysis of ***,we reported the parallel analysis of translated ORFs(PLATO)to couple ribosome display of full-length ORFs with affinity enrichment of mRNA/protein/ribosome complexes for the “bait”molecules,followed by the deep sequencing analysis of ***,the sample processing,from extraction of precipitated mRNA to generation of DNA libraries,includes numerous steps,which is tedious and may cause the loss of *** PLATO(PLATO-BC),an improved platform was further developed to test its application for protein interaction *** this report,we tested the antisera-antigen interaction using serum samples from patients with inclusion body myositis(IBM).Tripartite motif containing 21(TRIM21)was identified as a potentially new IBM *** also expanded the application of PLATO-BC to identify protein interactions for JQ1,single ubiquitin peptide,and NS5 protein of Zika *** PLATO-BC analyses,we identified new protein interactions for these “bait”*** demonstrate that Ewing sarcoma breakpoint region 1(EWSR1)binds to JQ1 and their interactions may interrupt the EWSR1 association with acetylated histone *** kinase 3(RIOK3),a newly identified ubiquitin-binding protein,is preferentially associated with K63-ubiquitin *** also find that Zika NS5 protein interacts with two previously unreported host proteins,par-3 family cell polarity regulator(PARD3)and chromosome 19 open reading frame 53(C19orf53),whose attenuated expression benefits the replication of Zika *** results further demonstrate that PLATO-BC is capable of identifying novel protein interactions for various types of “bait”molecules.

关键词： Barcoded PLATO Protein interaction Ubiquitin-binding protein Bromodomain inhibitor JQ1 Zika virus

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The spatial distribution characteristics of shallow fissures of a landslide in the Wenchuan earthquake area

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Journal of Mountain Science 2016年第9期13卷 1544-1557页

作者： xu Xing-qian Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Shallow fissures, being the main infiltration paths of fluid on the surface of a slope, played an important role in the whole process of a landslide. However, the spatial distribution characteristics of fissures in the slope are difficult to be determined. In this study, we attempted to characterize the variation pattern of slope fissures along depth in the Wenchuan earthquake area in Sichuan Province by combining engineering geological investigation, geomorphologic analysis and geophysical investigation. The geophysical methods that were used in this study include Multichannel Analysis of Surface Wave(MASW), Ground Penetrating Radar(GPR) and Electrical Resistivity Tomography(ERT). The results suggested that geophysical parameters(shear wave velocity, electromagnetic signals attenuation and resistivity) could provide valuable information for the spatial network of shallow fissures. Through the verification by engineering geological survey and geophysical sensitivity analysis, this work highlighted that MASW was the most appropriate technique to delineate the propagation of shallow fissures in a gravel soil slope.

关键词： Shallow fissures Landslide Wenchuanearthquake Geophysical prospecting

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Partial Differential Equation Approach to E_7

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Acta Mathematica Sinica,English Series 2015年第2期31卷 177-200页

作者： Xiao Ping xu Hua Loo-Keng Mathematical Laboratory Institute of Mathematics Academy of Mathematics & System Sciences Chinese Academy of Sciences

By solving certain partial differential equations, we find the explicit decomposition of the polynomial algebra over the 56-dimensional basic irreducible module of the simple Lie algebra E7 into a sum of irreducible submodules. This essentially gives a partial differential equation proof of a combinatorial identity on the dimensions of certain irreducible modules of E7. We also determine two three-parameter families of irreducible submodules in the solution space of Cartan＇s well-known fourth-order Ez-invariant partial differential equation.

关键词： Simple Lie algebra E7 partial differential equation irreducible module decomposition,combinatorial identity

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Synthesis and Reactivity of Trifluoromethylthiophosphonium Salts

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Chinese Journal of Chemistry 2023年第21期41卷 2779-2787页

作者： Wen-Qi xu Xiu-Hua xu Feng-Ling Qing Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academyof Sciences345 LinglingLuShanghai 200032China

This article described an unprecedented synthesis of trifluoromethylthiophosphonium salts from allyl trifluoromethyl sulfoxide and phosphines in the presence of trimethylsilyl trifluoromethanesulfonate(TMSOTf)through Mislow-Evans-type *** resulting trifluoromethylthiophosphonium salts were firstly isolated and fully *** fluoroalkylphosphonium salts,as exemplified by trifluoromethylthio triphenylphosphonium salt(6a),exhibited unique and versatile reaction with nucleophiles and deoxygenative trifluoromethylthiolation reaction of carboxylic ***,the photoredox catalytic tunable radical hydrotrifluoromethylation and hydrotrifluoromethythiolation of unactivated alkenes with 6a was successfully.

关键词： Phosphonium salts Fluorine Rearrangement Trifluoromethylthiolation Synthetic methods

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Fault deformation anomaly and intermedi-ate and short-term prediction of the Jingtai Ms=5.9 earthquake

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Acta Seismologica Sinica(English Edition) 2001年第2期14卷 156-165页

作者： WANG Shuang-xu The Second Crustal Deformation Monitoring Center China Seismological Bureau Xi’an China

The time-space distribution characteristics of fault deformation anomaly in the near-source region and its outlying zone in the seismogenic process of the Jingtai Ms=5.9 earthquake occurred on june 6, 2000 in Gansu Province is studied preliminary. The distribution scope of fault deformation anomaly before the earthquake is wide, the anomaly shape is complicated and the pattern anomalous zone of fault deformation (strain) information index is obvious. The shape and amplitude of fault deformation anomaly in different regions differ significantly, which is closely related with the tectonic location of anomaly. The fault deformation anomaly of α β, and γ phases along the western segment of Haiyuan fault zone shows the process from the quasi-linearity to non-linearity of fault movement in the near-source region, matches the high-value anomalous area of fault deformation (strain) information index, and reflects the high strain accumulation in the seismogenic region. However, the anomaly of abrupt jump and cusp with a large amplitude occurred in the areas far from the earthquake, such as Liupanshan fault zone which is the tectonic convergent section does not reflect the strain accumulation of its location, maybe it is a sign that the regional tectonic stress field is strengthened in the seismogenic process. Based on the above-mentioned facts and combined with the preliminary summary of experiences and lessons in the intermediate and short-term prediction of the Jingtai Ms=5.9 earthquake, we study and explore the application of fault deformation anomaly to earthquake judgment.

关键词： Anomaly characteristics Fault deformation Intermediate and short-term earthquake prediction Jingtai Ms=5.9 earthquake

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A Mean Value of Cochrane Sum

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Acta Mathematica Sinica,English Series 2009年第2期25卷 223-234页

作者： Zhe Feng xu College of Science Xi'an Jiaotong University Xi'an 710049 P. R. China Department of Mathematics Northwest University Xi'an 710069 P. R. China

Let q 〉 4 be an integer. The main purpose of this paper is to study the mean value of Cochrane sum C（a, q） in quarter intervals, and obtain a sharp asymptotic formula for it.

关键词： Dedekind sum Cochrane sums mean value asymptotic formula

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Budget-Aware Dynamic Incentive Mechanism in SpatialCrowdsourcing

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Journal of Computer Science & Technology 2017年第5期32卷 890-904页

作者： Jia-xu Liu Yu-Dian Ji Wei-Feng Lv Ke xu State Key Laboratory of Software Development Environment Beihang University Beijing 100191 China School of Software Liaoning Technical University Huludao 125105 China Department of Computer Science and Engineering Hong Kong University of Science and Technology Hong Kong China State Key Laboratory of Software Development Environment Beihang University Beijing 100191 China

The ubiquitous deployment of GPS-equipped devices and mobile networks has spurred the popularity of spatial crowdsourcing. Many spatial crowdsourcing tasks require crowd workers to collect data from different locations. Since workers tend to select locations nearby or align to their routines, data collected by workers are usually unevenly distributed across the region. To encourage workers to choose remote locations so as to avoid imbalanced data collection, we investigate the incentive mechanisms in spatial crowdsourcing. We propose a price adjustment function and two algorithms, namely DFBA (Dynamic Fixed Budget Allocation) and DABA (Dynamic Adjusted Budget Allocation), which utilize price leverage to mitigate the imbalanced data collection problem. Extensive evaluations on both synthetic and real-world datasets demonstrate that the proposed incentive mechanisms are able to effectively balance the popularity of different locations.

关键词： incentive mechanism crowdsensing spatial crowdsourcing

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单分散镍碳复合纳米球和碳微球的制备

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功能材料 2009年第9期40卷 1567-1569页

作者：郁军许并社太原理工大学材料科学与工程学院山西太原030024 太原理工大学新材料界面科学与工程省部共建教育部重点实验室山西太原030024

以脱油沥青(deoiled asphalt)为碳源,采用化学气相沉积法(CVD)制备碳微球,其裂解后的残渣经真空热处理制得单分散镍碳复合纳米球。用场发射扫描电镜(FESEM)、高分辨透射电镜(HRTEM)和X射线衍射仪(XRD)对产物进行表征。结果表明,碳微球高... 详细信息

以脱油沥青(deoiled asphalt)为碳源,采用化学气相沉积法(CVD)制备碳微球,其裂解后的残渣经真空热处理制得单分散镍碳复合纳米球。用场发射扫描电镜(FESEM)、高分辨透射电镜(HRTEM)和X射线衍射仪(XRD)对产物进行表征。结果表明,碳微球高纯,属无定型碳结构,大小分布在1～2μm范围内;镍碳复合纳米球为准球形核壳结构,核为镍,壳为碳,尺寸在10～30nm范围,晶化程度较高,结构较完善。

关键词：镍碳纳米球碳微球热处理脱油沥青

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基于建筑空间布置规则性的结构优化分析

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建筑结构学报 2018年第S1期39卷 379-386页

作者：赵旭董军奥雅纳工程咨询( 上海) 有限公司北京分公司北京100020 北京建筑大学结构工程与新材料北京市高等学校工程研究中心北京100044

结构体系中的大空间或者核心筒的布置不规则,会给建筑抗震设计带来诸多困扰。提出优化设计的方法用于对结构刚度进行调整,以降低建筑空间布置不规则的影响。优化方法是基于进化结构优化法,建立新的灵敏度定义,以修正建筑空间布置规则性... 详细信息

结构体系中的大空间或者核心筒的布置不规则,会给建筑抗震设计带来诸多困扰。提出优化设计的方法用于对结构刚度进行调整,以降低建筑空间布置不规则的影响。优化方法是基于进化结构优化法,建立新的灵敏度定义,以修正建筑空间布置规则性为设计目标,优化结构体系中抗侧体系的刚度分布。从建立结构模型开始,直接从建筑设计模型中,提取必要的设计参数,导入优化设计程序中进行建模,提高了建模的效率和准确度。在有限元分析过程中全部采用壳单元,并且在考虑解析准确度的基础上对壳单元进行分割,应用泰森多边形理论对荷载进行计算。在优化计算中,主要从结构整体等效应力分布的均匀性,重心与刚心的相对位置关系以及结构的两向抗侧刚度比三个方面对结构体系的应力、水平以及竖向构件刚度分布进行优化设计,调整建筑空间布局以满足布置的规则性,对进一步深化设计提供可参考的分析结果。

关键词：结构优化设计进化结构优化法规则性

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Spreadable Magnetic Soft Robots with On-Demand Hardening

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Research 2024年第3期2023卷 487-498页

作者： Zichen xu Yuanhe Chen Qingsong xu Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina.

Magnetically actuated mobile robots demonstrate attractive advantages in various medical applications due to their wireless and programmable executions with tiny sizes. Confronted with complex application scenarios, however, it requires more flexible and adaptive deployment and utilization methods to fully exploit the functionalities brought by magnetic robots. Herein, we report a design and utilization strategy of magnetic soft robots using a mixture of magnetic particles and non-Newtonian fluidic soft materials to produce programmable, hardened, adhesive, reconfigurable soft robots. For deployment, their ultrasoft structure and adhesion enable them to be spread on various surfaces, achieving magnetic actuation empowerment. The reported technology can potentially improve the functionality of robotic end-effectors and functional surfaces. Experimental results demonstrate that the proposed robots could help to grasp and actuate objects 300 times heavier than their weight. Furthermore, it is the first time we have enhanced the stiffness of mechanical structures for these soft materials by on-demand programmable hardening, enabling the robots to maximize force outputs. These findings offer a promising path to understanding, designing, and leveraging magnetic robots for more powerful applications.

关键词： execution attractive enable

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