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Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： Ya-Ling Zhu Lei-Lei Meng jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang yun-Shu Tang Min Xue Mei-Zi Zhu jin Peng Xue-jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng Qing-Qing Dai Fan Huang Hao-Shu Fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain ***,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP ***,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory *** total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD *** on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating *** study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac Integrative analysis Enhancer

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Flow instability of supercritical hydrocarbon fuel in a multi-channel cooling system

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Chinese Journal of Aeronautics 2024年第2期37卷 283-295页

作者： Yichao jin Kun WU Xuejun FAN Institute of Applied Physics and Computational Mathematics Beijing 100094China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Thermally-induced flow instabilities are a critical issue in multi-channel regenerative cooling *** particular,the interactions between Density-Wave Oscillations(DWO)and Flow Maldistribution(FMD)can result in complex and disastrous instability *** study investigates the instability behaviors of hydrocarbon fluid in a four-channel system with a constant heat flux ratio using both frequency-and time-domain *** the heat flux increases,the in-tube flow sequentially destabilizes in each channel and converges to new equilibrium states,leading to the emergence of FMD *** also causes the system eigenvalue to change repeatedly from negative to positive rather than increasing ***,the system eigenvalues are between those of the two most unstable channels,indicating that the stability behavior of the entire system is dictated by the most unstable *** FMD occurs,flow oscillations are activated in channels with weak stability,and the in-tube flow is observed to evolve into various flow patterns,including stable flow,self-sustained oscillation,oscillation divergence,quasiperiodic oscillation,and oscillation *** novel instability mode of oscillation excursion involves a spontaneous transition of operating *** oscillates from an equilibrium state and then stabilizes at a new operational state after oscillation-induced ***,the newfound stable state may also be only temporary,with the in-tube flow regressing to the initial state,resulting in quasi-periodic oscillation.

关键词： Cooling Supercritical fluids Hydrocarbons Flow instability Flow maldistribution Density-wave oscillations

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Simultaneous purification of minor components in natural products using twin-column recycling chromatography with a step solvent gradient

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Chinese Journal of Chemical Engineering 2024年第5期69卷 212-219页

作者： Guangxia jin Yuxue Wu Feng Wei School of Biological and Chemical Engineering NingboTech UniversityNingbo 315100China

The isolation of minor components from complex natural product matrices presents a significant challenge in the field of purification science due to their low concentrations and the presence of structurally similar *** study introduces an optimized twin-column recycling chromatography method for the efficient and simultaneous purification of these elusive *** introducing water at a small flowing rate between the twin columns,a step solvent gradient is created,by which the leading edge of concentration band would migrate at a slower rate than the trailing edge as it flowing from the upstream to downstream ***,the band broadening is counterbalanced,resulting in an enrichment effect for those minor components in separation ***,two target substances,which showed similar peak position in high performance liquid chromatography(HPLC)and did not exceed 1.8%in crude paclitaxel were selected as target compounds for *** using the twin-column recycling chromatography with a step solvent gradient,a successful purification was achieved in getting the two with the purity almost 100%.We suggest this method is suitable for the separation of most components in natural produces,which shows higher precision and recovery rate compared with the common lab-operated separation ways for natural products(thin-layer chromatography and prep-HPLC).

关键词： Solvent gradient Twin-column recycling chromatography Purification Minor component Natural products

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The twisted conical Kahler-Ricci solitons on Fano manifolds

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Science China Mathematics 2024年第5期67卷 1085-1102页

作者： Xishen jin Jiawei Liu School of Mathematics Renmin University of ChinaBeijing 100872China School of Mathematics and Statistics Nanjing University of Science&TechnologyNanjing 210094China

In this paper,we show the relation between the existence of twisted conical K?hler-Ricci solitons and the greatest log Bakry-Emery-Ricci lower bound on Fano *** is based on our proofs of some openness theorems on the existence of twisted conical Kahler-Ricci solitons,which generalize Donaldson’s existence conjecture and the openness theorem of the conical K?hler-Einstein metrics to the conical soliton case.

关键词： greatest log Bakry-Emery-Ricci lower bound twisted conical Kahler-Ricci soliton twisted Kahler-Ricci soliton

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Improved lower bound for the complexity of unique shortest vector problem

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Cybersecurity 2024年第3期7卷 102-110页

作者： Baolong jin Rui Xue State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China

Unique shortest vector problem(uSVP)plays an important role in lattice based *** cryptographic schemes based their security on *** the cofidence of those applications,it is essential to clarify the complex-ity of uSVP with different ***,proving the NP-hardness of usVP appears quite *** the state of the art,we are even not able to prove the NP-hardness of usVP with constant *** this work,we gave a lower bound for the hardness of usVP with constant parameters,*** proved that uSVP is at least as hard as gap shortest vector problem(GapSVP)with gap of O(√n/log(n)),which is in NP n *** previous works,our reduction works for paramters in a bigger range,especially when the constant hidden by the big-O in GapsVP is smallerthan1.

关键词： Computational complexity Unique shortest vector problem Bounded distance decoding Complexity reduction

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Construction and performance test of charged particle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao Zhang Bing‑Feng Lv Ning‑Tao Zhang jin‑Long Zhang Chen‑Gui Lu Bing‑Shui Gao Jun‑Bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu Yan‑yun Yang Hooi‑jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

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Early gastric composite tumor comprising signet-ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma:A case report

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World Journal of Gastroenterology 2024年第38期30卷 4232-4238页

作者： Yi-Fan Jia Fei-Fan Chen Li Yang yun-Xia Ye Yi-Zhu Gao Wen-Yan Zhang jin-Lin Yang Department of Gastroenterology and Hepatology University of Oxford Huaxi Joint Centre for Gastrointestinal CancerFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Emergency West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Composite tumors are neoplasms comprising two distinct,yet intermingling,cell *** paper reports a rare phenomenon where early gastric signet-ring cell carcinoma(SRCC)and gastric mucosa-associated lymphoid tissue(MALT)lymphoma coexist within the same *** SUMMARY A 40-year-old woman presented to the West China Hospital for examination,which revealed a whitish,shallow,and uneven mucosal lesion in the *** lesion was diagnosed as a poorly differentiated adenocarcinoma,including SRCC with atypical lymphoid hyperplasia associated with Helicobacter pylori infection,based on histopathological examination of the biopsy *** lesion was excised using segmental ***,histological exami-nation of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT *** two entities were stage I and coexisted in the same *** It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct *** resection is effective for these lesions.

关键词： Gastric cancer Composite tumors Early stage Signet-ring cell carcinoma Mucosa-associated lymphoid tissue lymphoma Case report

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An Improved Bounded Conflict-Based Search for Multi-AGV Pathfinding in Automated Container Terminals

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2705-2727页

作者： Xinci Zhou jin Zhu Shanghai Maritime University Logistics Science and Engineering Research InstituteShanghai200000China

As the number of automated guided vehicles(AGVs)within automated container terminals(ACT)continues to rise,conflicts have becomemore *** point and edge conflicts ofAGVs,amulti-AGVconflict-free path planning model has been formulated to minimize the total path length of AGVs between shore bridges and *** larger terminalmaps and complex environments,the grid method is employed to model AGVs’road *** improved bounded conflict-based search(IBCBS)algorithmtailored to ACT is proposed,leveraging the binary tree principle to resolve conflicts and employing focal search to expand the search *** experiments involving 60 AGVs indicate a reduction in computing time by 37.397%to 64.06%while maintaining the over cost within 1.019%.Numerical experiments validate the proposed algorithm’s efficacy in enhancing efficiency and ensuring solution quality.

关键词： Automated terminals multi-AGV multi-agent path finding(MAPF) conflict based search(CBS) AGV path planning

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MD Simulation of Diffusion Behaviors in Collision Welding Processes of Al-Cu, Al-Al, Cu-Cu

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Computers, Materials & Continua 2024年第6期79卷 3455-3468页

作者： Dingyi jin Guo Wei School of Intelligent Manufacturing Hunan First Normal UniversityChangsha410082China School of Physics and Technology Center for Ion Beam ApplicationHubei Nuclear Solid Physics Key LaboratoryWuhan UniversityWuhan430072China

To investigate the effects of material combinations and velocity conditions on atomic diffusion behavior near collision interfaces,this study simulates the atomic diffusion behavior near collision interfaces in Cu-Al,Al-Al and Cu-Cu combinations fabricated through collision welding using molecular dynamic(MD)*** atomic diffusion behaviors are compared between similar metal combinations(Al-Al,Cu-Cu)and dissimilar metal combinations(Al-Cu).By combining the simulation results and classical diffusion theory,the diffusion coefficients for similar and dissimilar metal material combinations under different velocity conditions are *** effects of material combinations and collision velocity on diffusion behaviors are also *** diffusion behaviors of dissimilar material combinations strongly depend on the transverse velocity,whereas those of the similar material combinations are more dependent on the longitudinal *** findings can provide guidance for optimizing welding parameters.

关键词： Atomic diffusion behavior molecular dynamics collision welding

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Oxidation behavior of low-grade vanadiferous titanomagnetite concentrate with high titanium

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Journal of Iron and Steel Research International 2024年第2期31卷 329-341页

作者： jin-sheng Liu Zhen-xing Xing Gong-jin Cheng Xue-yong Ding Xiang-xin Xue School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Liaoning Key Laboratory of Recycling Science for Metallurgical Resources Shenyang110819LiaoningChina Innovation Research Institute of Vanadium and Titanium Resource Industry Technology Northeastern UniversityShenyang110819LiaoningChina

In order to clarify the oxidation mechanisms and make better use of the low-grade vanadiferous titanomagnetite concentrate with high titanium(LVTC),the oxidation behavior of LVTC was *** results showed that oxidation degree was achieved within 90 min when temperature was not lower than 700°C,and the main phases of the oxidized LVTC consisted of Fe9TiO15,Fe2O3,CaSiTiO5 and a small amount of *** temperature is favorable to the formation of *** surface of LVTC gradually becomes rough,with fine particles of needle-like and granular shape appearing on the surface,which finally turn from laminar to creamy,spread out,and are interspersed with many tiny *** phase oxidation paths in LVTC were as follows:(1)Fe2.75Ti0.25O4→Fe9TiO15+Fe2O3;(2)Fe2.75Ti0.25O4→Fe2O3+FeTiO3→Fe2TiO5;(3)FeTiO3→Fe2O3+Fe2Ti3O9→*** is predominantly mesoporous whether oxidized or not,with the pores mainly distributed in the range of 2–40 nm,and the specific surface area of LVTC decreases significantly with increasing temperature.

关键词： Low-grade vanadiferous titanomagnetite concentrate Oxidation degree Phase transformation Micromorphology Oxidation path Pore structure

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