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Chinese Journal Of Geochemistry 2008年第1期27卷 53-57页

作者： tang Youjun WEN Zhigang zan Ling Key Laboratory of Exploration Technologies for Oil and Gas Resources Ministry of Education Department of Geochemistry Yangtze University Jingzhou 434023 China Faculty of Resources and Information Technology China University of Petroleum Beijing102249 China

In the future time the exploration of marine oil and gas will be one of the significant domains in China. In this paper the biomarker assemblage characteristics of oilshow in the Nanlinghu Formation of the Majiashan pro- file, which is located in Chaoxian County, south of Anhui Province, are described in the light of gas chromatogra- phy/mass spectrometric (GCMS) analysis on the qualitative and quantitative basis. Based on the investigation of the biomarker assemblage characteristics of possible source rocks developed in the area studied, a conclusion is drawn that the oilshow was generated from the Nanlinghu Formation source rocks (abbreviated as T1n), instead of the Qixia Formation source rocks (abbreviated as P1q). It is pointed out that the T1n is of strong potential for future oil explora- tion, and therefore much attention should be paid to it.

关键词：地理特征岩石油-水系统安徽省

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基于施工全过程老旧厂房加固的抗震性能分析

工程抗震与加固改造 2024年第1期46卷 161-168,147页

作者：吴涛万伟王开君程明龙王潭唐柏赞中铁四局集团市政工程有限公司安徽合肥230022 华东交通大学轨道交通基础设施性能监测与保障国家重点实验室江西南昌330013

某老旧厂房因年久失修和使用功能的变化,需在原结构基础上进行加固改造。为使改造后的老旧厂房满足抗震性能要求,针对施工全过程并采用“永临结合”的施工理念,形成“永临结合”的加固方式。基于有限元软件ABAQUS建立施工过程中及竣工... 详细信息

某老旧厂房因年久失修和使用功能的变化,需在原结构基础上进行加固改造。为使改造后的老旧厂房满足抗震性能要求,针对施工全过程并采用“永临结合”的施工理念,形成“永临结合”的加固方式。基于有限元软件ABAQUS建立施工过程中及竣工后老旧厂房的非线性有限元数值模型,并对其抗震性能及加固效果进行评估。结果表明:在当地设防烈度的多遇和罕遇地震作用下,改造加固后的老旧厂房抗震性能得到大幅度提高,且施工时和竣工后的老旧厂房均满足抗震设防目标,老旧厂房施工全过程的加固措施可行有效。

关键词：工业厂房加固改造施工全过程抗震性能数值分析

Intrathecal administration of resiniferatoxin produces analgesia against prostatodynia in rats

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Chinese Medical Journal 2007年第18期120卷 1616-1621页

作者： tang Wei SONG Bo ZHOU zan-song LU Gen-sheng Urological Research Institute of PLA Southwest Hospital ThirdMilitary Medical University Chongqing 400038 China

Background Prostatodynia remains a difficult clinical problem. Resiniferatoxin （RTX）, an ultrapotent vanilloid, can produce a selective and long-lasting desensitization of nociception via C-fiber sensory neurons. Substance P （SP） and calcitonin gene-related peptide （CGRP） released from C-fibers are key neurotransmitters in visceral pain. In this study, we evaluated the analgesic effect of intrathecal RTX on rat prostatodynia. Methods Male Sprague-Dawley rats were divided into 3 groups for different treatment. In group A, sham operation was preformed. In group B, 100 μl complete Freund＇s adjuvant （CFA） was injected into the rat＇s bilateral ventral prostate to induce chronic inflammation. In group C, after prostatitis formed, 50 μl 10 nmol/L RTX was injected into the rat＇s lumbosacral （L5-S2） vertebral canal. SP and CGRP contents in the spinal cord were investigated by immunohistochemistry and radioimmunoassay （RIA）. Their transcriptional levels in dorsal root ganglion （DRG） were determined by reverse transcriptase polymerase chain reaction （RT-PCR）. In addition, pelvic nerve afferent discharge was recorded to explore the neuro-electrophysiological mechanisms underlying RTX-induced effect. Results SP and CGRP released in the spinal cord and their synthesis in DRG were increased significantly in response to CFA-induced chronic prostatitis, whereas this increase was effectively inhibited by intrathecal RTX. Meanwhile, pelvic nerve afferent electrical activity was enhanced significantly in rats with chronic prostatitis, but it was attenuated markedly in RTX-treated rats paralleled by the change of neuropeptides. Conclusions Intrathecal RTX administration could produce an analgesic effect on rat prostatodynia. Suppression of pelvic nerve afferent electrical activity may be a crucial mechanism underlying RTX-induced analgesia. RTX intrathecal application may present a novel analgesic strategy of prostatodynia.

关键词： prostatitis analgesia resiniferatoxin neuropeptides electrophysiology

溱潼凹陷阜二段页岩岩相组合特征及其对含油性的影响

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中国海上油气 2024年第2期36卷 37-49页

作者：李思佳唐玄昝灵花彩霞冯赫青陈学武郑逢赞陈宗铭中国地质大学(北京)能源学院北京100083 自然资源部页岩气资源战略评价重点实验室北京100083 中国石化华东油气分石油勘探开发研究院江苏南京210019 中国石油华北油田公司勘探开发研究院河北任丘062552

苏北盆地溱潼凹陷阜宁组二段(阜二段)页岩油勘探取得了一系列突破。溱潼凹陷阜二段页岩矿物组成占比接近,且岩相单层厚度薄、垂向上变化十分频繁,依靠传统矿物组成的岩相划分方法在本地区应用受到很大局限。以溱页1井湖相泥页岩层段岩... 详细信息

苏北盆地溱潼凹陷阜宁组二段(阜二段)页岩油勘探取得了一系列突破。溱潼凹陷阜二段页岩矿物组成占比接近,且岩相单层厚度薄、垂向上变化十分频繁,依靠传统矿物组成的岩相划分方法在本地区应用受到很大局限。以溱页1井湖相泥页岩层段岩心为研究对象,通过岩心、薄片观察、全岩X射线衍射、有机地球化学等实验分析,开展岩相划分及其组合特征研究,并分析其对含油性的影响。研究认为:在页岩矿物组成近似条件下,基于沉积构造,溱潼凹陷阜二段页岩可分为块状黏土质泥岩(MCM)、块状混合质泥岩(MMM)、纹层状混合质页岩(LMS)、层状混合质页岩(BMS)和纹层状长英质页岩(LSS)共5种岩相类型,根据岩相在垂向上分布的规律又划分出8种岩相组合;阜二段页岩岩相组合与层段划分具有一定对应性,以S1=1.5 mg/g、OSI=100 mg/g为主要界限指标,可以将不同岩相组合含油性及可动性进行很好的区分,符合S1>1.5 mg/g、OSI>100 mg/g标准的MCM-LMS-BMS和LMS-BMS-LMS岩相组合确定为该区有利岩相组合,其所属层段为页岩油勘探有利层段。本研究认识为陆相页岩岩相及其对油气聚集控制理论的完善提供了有益补充。

关键词：苏北盆地溱潼凹陷阜宁组页岩岩相岩相组合页岩油含油性可动性

MYOM2基因在临床医学和畜牧生产中的作用研究进展

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中国畜牧杂志 2024年第1期60卷 117-123页

作者：杨皓杰卢洁汤嘉玉毛晓宇陈旭昝林森王洪宝西北农林科技大学动物科技学院陕西杨凌712100 国家肉牛改良中心陕西杨凌712100

肌间蛋白(Myomesin)基因家族分布于骨骼肌和心肌的M线中,是M线的重要连接器,主要参与肌原纤维的组装和机械力量传导,在哺乳动物中有3种亚型。肌间蛋白2(Myomesin-2,MYOM2)是Myomesin基因家族中的一员,其与骨骼肌和心肌发育有密切关系,... 详细信息

肌间蛋白(Myomesin)基因家族分布于骨骼肌和心肌的M线中,是M线的重要连接器,主要参与肌原纤维的组装和机械力量传导,在哺乳动物中有3种亚型。肌间蛋白2(Myomesin-2,MYOM2)是Myomesin基因家族中的一员,其与骨骼肌和心肌发育有密切关系,在肌肉收缩和关节发育的过程中发挥重要作用,并与很多人类疾病的发生息息相关。MYOM2同时对畜禽肉品质改善起重要调控作用,可作为候选基因改善畜禽的肉嫩度。本文综述了MYOM2的发现过程、基因信息及其在临床医学和畜牧生产中的研究进展,为相关研究工作提供思路。

关键词： MYOM2 肌肉发育肉质临床医学畜禽畜牧生产

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非生物胁迫下青花菜内参基因的筛选

西南农业学报 2024年第3期37卷 513-523页

作者：焦鹏刘院梅裴徐梨冯鹏宇唐征荆赞革李金林徐谦昆明学院农学与生命科学学院昆明650214 温州科技职业学院农业与生物技术学院浙江温州325006

【目的】检测非生物胁迫下常见内参基因的表达稳定性,筛选出青花菜的适宜内参基因。【方法】以青花菜高代自交系“KU19-3”为试验材料,利用已有的转录组数据和文献,筛选出31个候选内参基因,对其在不同非生物胁迫下(盐、干旱、渍水、弱... 详细信息

【目的】检测非生物胁迫下常见内参基因的表达稳定性,筛选出青花菜的适宜内参基因。【方法】以青花菜高代自交系“KU19-3”为试验材料,利用已有的转录组数据和文献,筛选出31个候选内参基因,对其在不同非生物胁迫下(盐、干旱、渍水、弱光、高温和低温)的表达水平进行荧光定量PCR检测,采用geNorm、Normfinder和BestKeeper软件分析其表达稳定性,从而筛选出适宜的内参基因。【结果】31个候选内参基因的扩增特异性良好,且表达水平差异明显。其中BOL029171的Ct值最小,表达量最大;而BOL001470的Ct值最大,表达量最小。其他基因的Ct值介于20~40。3种软件综合分析结果表明:BOL034565和BOL008820在高温胁迫下最稳定,BOL043724和BOL005937在弱光胁迫下表达稳定性最好,BOL043724和BOL001470、BOL005937和BOL006136分别在低温和盐胁迫下表达最稳定,BOL024326和BOL025875、BOL008820和BOL001788分别在渍水和干旱胁迫处理下表达最稳定。综合上述得出BOL006136和BOL008820可作为非生物胁迫下青花菜的通用内参基因。【结论】本研究筛选出青花菜在非生物胁迫下通用内参基因是BOL006136和BOL008820,结果可为以后开展青花菜逆境胁迫下相关基因的表达特征研究和青花菜抗逆种质创建提供一定的科学基础。

关键词：青花菜内参基因实时荧光定量PCR 非生物胁迫

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地形起伏超临界CO_(2)管道两端阀室放空动态模拟

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油气储运 2024年第5期43卷 561-569页

作者：闫冰史博会陈俊文汤晓勇昝林峰王妍静李玉培宫敬中国石油大学(北京)碳中和示范性能源学院·油气管道输送安全国家工程研究中心·石油工程教育部重点实验室·天然气水合物国家重点实验室·城市油气输配技术北京市重点实验室中国石油工程建设有限公司西南分公司

[目的]碳捕集,利用与封存(Carbon Capture, Utilization and Storage, CCUS)技术作为实现碳中和的重要手段,其中CO_(2)的安全高效输送是关键环节。超临界相CO_(2)管道输送已在国际上得到广泛应用,国内现已基本掌握了超临界CO_(2)管道稳... 详细信息

[目的]碳捕集,利用与封存(Carbon Capture, Utilization and Storage, CCUS)技术作为实现碳中和的重要手段,其中CO_(2)的安全高效输送是关键环节。超临界相CO_(2)管道输送已在国际上得到广泛应用,国内现已基本掌握了超临界CO_(2)管道稳态输送的工艺规律,但对于具有起伏地形的超临界CO_(2)管道放空作业的动态规律和安全风险认识尚不够深入。[方法]借助OLGA软件,建立具有起伏地形的超临界CO_(2)管道两端阀室放空物理模型,开展管道放空的动态模拟分析,揭示了放空过程中主管道内低温现象的物理本征,探讨了地形起伏超临界CO_(2)管道放空过程中的关键问题,特别关注了地形起伏对相态变化、低温风险及干冰生成的影响,提出了控制背压的安全放空方案。[结果]具有地形起伏超临界CO_(2)管道放空应尽量避免在高压、低温下进行;需设计适宜的放空管径和开度,以规避低温脆断、干冰生成等风险;所提出的放空方案在具体地形条件下表现良好,能有效解决主管道放空过程中低洼地段的极致低温问题,并对放空出口的危害较小。[结论]研究成果为地形起伏地区超临界CO_(2)管道的安全放空工艺设计与工程建设提供了理论支持,对工程实际应用具有参考价值,有助于保障CO_(2)管道的安全高效输送。

关键词：超临界CO_(2) 放空低温风险相态变化

Hot Deformation Behavior of ATI 718Plus Alloy with Different Microstructures

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Acta Metallurgica Sinica(English Letters) 2022年第8期35卷 1383-1396页

作者： Chang Liu Jianbo Zhang Yikai Yang Xingchuan Xia Tian He Jian Ding Ying tang zan Zhang Xueguang Chen Yongchang Liu School of Material Science and Engineering Hebei University of TechnologyTianjin 300130China College of Physics and Electronic Engineering Xingtai UniversityXingtai 054001China School of Science Hebei University of TechnologyTianjin 300130.China School of Material Science and Engineering Tianjin UniversityTianjin 300130China

In this work, the eff ect of microstructure on hot deformation behavior of ATI 718Plus(hereinafter refers to 718Plus) alloy was studied by isothermal compression test. The results showed that when the strain rate was 0.01–0.1s^(-1) with deformation temperature of 980 and 1030℃, hot deformation behavior was mainly aff ected by dislocation density. Dislocation density of the air-cooling alloy was larger than that of the furnace-cooling alloy, which makes its critical strain smaller and peak stress higher than that of the furnace-cooling alloy. When the strain rate was 1 s^(-1), hot deformation behavior of the alloy was mainly aff ected by twins and γ ′ phase, and high-density deformation twins in air-cooling alloys resulted in higher critical strain. γ ′ phase exists in furnace-cooling alloy, which makes its peak stress higher than that of air-cooling alloy. 718Plus alloy is sensitive to cooling rate;dislocation and γ ′ phase have obvious eff ects on its hot deformation behavior.

关键词： 718Plus alloy Hot deformation Peak stress Dynamic recrystallization Critical strain

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中药左金丸逆转胃癌顺铂耐药的作用机制

现代肿瘤医学 2024年第3期32卷 398-404页

作者：李赞吴秋雪卫真真阎旻宇隋华汤庆丰上海市第一人民医院嘉定医院上海201803 南京中医药大学无锡附属医院江苏无锡214072 上海中医大学上海201203 上海交通大学医学院附属瑞金医院南翔分院上海201802

目的:探讨左金丸逆转胃癌顺铂耐药的作用机制。方法:体外实验采用人胃癌细胞株SGC-7901及人胃癌顺铂耐药细胞株SGC-7901/DDP,CCK-8法检测细胞增殖率;免疫蛋白印迹法和实时荧光定量PCR法(qRT-PCR)检测左金丸干预后各组基因蛋白表达量;同... 详细信息

目的:探讨左金丸逆转胃癌顺铂耐药的作用机制。方法:体外实验采用人胃癌细胞株SGC-7901及人胃癌顺铂耐药细胞株SGC-7901/DDP,CCK-8法检测细胞增殖率;免疫蛋白印迹法和实时荧光定量PCR法(qRT-PCR)检测左金丸干预后各组基因蛋白表达量;同时构建RTKN基因慢病毒载体转染的胃癌细胞系并验证,结合CCK-8法、qRT-PCR和Western blot法检测RTKN基因干扰对胃癌细胞顺铂耐药性的影响。裸鼠体内实验将RTKN干扰的SGC-7901/DDP细胞移植到裸鼠皮下,分别给予左金丸干预4周后,记录移植瘤大小,绘制肿瘤生长曲线,Western blot检测RTKN、p53、Ace-p53、HDAC1蛋白的表达量。结果:SGC-7901/DDP细胞中的RTKN表达量显著高于SGC-7901细胞,沉默RTKN显著降低SGC-7901/DDP细胞的耐药性;左金丸可显著降低SGC-7901/DDP细胞的耐药性,但沉默RTKN后其对SGC-7901/DDP细胞的耐药性及对裸鼠皮下移植瘤体积无明显影响,提示降低RTKN表达后,左金丸的抗肿瘤作用被抑制。结论:RTKN通过p53脱乙酰化途径增加SGC-7901/DDP细胞对顺铂的耐受性;左金丸能有效增加化疗药物对胃癌细胞增殖的抑制作用,通过抑制RTKN介导p53组蛋白脱乙酰化逆转胃癌顺铂耐药。

关键词：左金丸胃癌肿瘤耐药组蛋白乙酰化

Feasibility of replacing the 3-coach with a 1.5-coach grouping trainmodel in wind tunnel experiment at different yaw angles

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Journal of Central South University 2022年第6期29卷 2062-2073页

作者： YANG Bo XIONG Xiao-hui HE Zhao LI Xiao-bai XIE Peng-hui tang Ming-zan Key Laboratory of Traffic Safety on Track of Ministry of Education Central South UniversityChangsha 410075China Joint International Research Laboratory of Key Technology for Rail Traffic Safety Changsha 410075China National&Local Joint Engineering Research Center of Safety Technology for Rail Vehicle Changsha 410075China

The effects of different yaw angles on the aerodynamic performance of city electric multiple units(EMUs)were investigated in a wind tunnel using a 1:16.8 scaled *** scanning valve and six-component box-type aerodynamic balance were used to test the pressure distribution and aerodynamic force of the head car respectively from the 1.5-and 3-coach grouping city EMU ***,the effects of the yaw angles on the pressure distribution of the streamlined head as well as the aerodynamic forces of the train were *** experimental results showed that the pressure coefficient was the smallest at the maximum slope of the main *** side force coefficient and pressure coefficient along the head car cross-section were most affected by crosswind when the yaw angle was 55°,and replacing a 3-coach grouping with a 1.5-coach grouping had obvious advantages for wind tunnel testing when the yaw angle was within 24.2°.In addition,the relative errors of lift coefficient C_(L),roll moment coefficient C_(Mx),side force coefficient C_(S),and drag coefficient C_(D) between the 1.5-and 3-coach cases were below 5.95%,which all met the requirements of the experimental accuracy.

关键词： wind tunnel electric multiple unit pressure coefficient yaw angle scanning valve 1.5-coach grouping