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Pharmacological activity,phytochemical analysis and toxicity of methanol extract of Etlingera elatior(torch ginger) flowers

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 769-774页

作者： Subramanion Jo Thy Lachumy Sreenivasan Sasidharan Velio Sumathy zakaria zuraini School of Distance Education Universiti Sains MalaysiaMinden 11800Pulau PinangMalaysia Institute for Research in Molecular Medicine(INFORMM) Universiti Sains MalaysiaMinden 11800Pulau PinangMalaysia

Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior（***）.Methods:Phytochemical screening of the flower extract was done to determine the phytochemical in the *** pharmacological study included the determination of antimicrobial activity and minimum inhibitory concentration（MIC） of metabolic flower *** antimicrobial activity of the extract was tested against medically important bacterial,yeast and fungal *** from that,the methanolic extract of *** flower was further tested in vivo toxicity using the brine shrimp lethality ***,the flower extract was qualitatively screened for their free radical scavenging activity by 2,2-diphenyl-1- picrylhydrazyl radical（DPPH） ***:The extract was effective on tested microorganisms and MIC values were in the range of 1.563-50.000 mg/*** brine shrimp lethality test exhibited no significant toxicity(LC50= 2.52 mg/mL) against Artemia *** *** flower extract with high LC50 value signified that this plant is not toxic to *** the phytochemical screening of the flower extract revealed the presence of the following compounds: flavonoids,terpenoids,saponin,tannins and carbohydrates whereas,alkaloids,anthraquinone and reducing sugars were *** concentration of the flower extract required for 50% inhibition of DPPH radical scavenging effect(IC50) were 9.14 mg/mL and 8.08 mg/mL for butylated hydroxytoluene 8.08 mg/***:These findings indicate that the extract of *** flower possesses pharmacological properties and potential to develop natural products based pharmaceuticals products.

关键词： Etlingera elatior Pharmacological activity Phytochemical analysis Artemia salina

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Antioxidant activity and phytochemical screening of the methanol extracts of Euphorbia hirta L

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 386-390页

作者： Abu Arra Basma zuraini zakaria Lacimanan Yoga Latha Sreenivasan Sasidharan Biology Division School of Distance EducationUniversiti Sains MalaysiaUSM 11800Pulau PinangMalaysia Institutes for Research in Molecular Medicine(INFORMM) Universiti Sains MalaysiaUSM 11800Pulau PinangMalaysia

Objective:To assess antioxidant activities of different parts of Euphorbia hirta（***）,and to search for new sources of safe and inexpensive ***:Samples of leaves,stems, flowers and roots from *** were tested for total phenolic content,and flavonoids content and in vitro antioxidant activity by diphenyl-1-picrylhydrazyl（DPPH） assay and reducing power was measured using cyanoferrate ***:The leaves extract exhibited a maximum DPPH scavenging activity of（72.96±0.78）%followed by the flowers,roots and stems whose scavenging activities were（52.45±0.66）%,（48.59±0.97）%,and（44.42±0.94）%,*** standard butylated hydroxytoluene（BHT） was（75.13±0.75）%.The IC50,for leaves,flowers,roots,stems and BHT were 0.803,0.972,0.989,1.358 and 0.794 mg/mL,*** reducing power of the leaves extract was comparable with that of ascorbic acid and found to be dose dependent. Leaves extract had the highest total phenolic content[（206.17±1.95） mg GAE/g],followed by flowers,roots and stems extracts which were（117.08±3.10） mg GAE/g,（83.15±1.19） mg GAE/g,and （65.70±1.72） mg GAE/g,*** the other hand,total flavonoids content also from leave had the highest value[（37.970±0.003） mg CEQ/g],followed by flowers,roots and stems extracts which were（35.200±0.002） mg CEQ/g,（24.350±0.006） mg CEQ/g,and（24.120±0.004） mg CEQ/ g,*** bioautography analysis of phenolic and antioxidant substance revealed phenolic *** screening of *** leaf extract revealed the presence of reducing sugars,terpenoids,alkaloids,steroids,tannins,flavanoids and phenolic compounds. Conclusions:These results suggeste that *** have strong antioxidant *** study is necessary for isolation and characterization of the active antioxidant agents,which can be used to treat various oxidative stress-related diseases.

关键词： Antioxidant Euphorbia hirta L DPPH scavenging Reducing power Total phenolics content Total flavonoids content Phytochemical screening

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A transmission electron microscopy study of the diversity of Candida albicans cells induced by Euphorbia hirta *** extract in vitro

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 20-22页

作者： Abu Arra Basma zakaria zuraini Sreenivasan Sasidharan Biology Division School of Distance EducationUniversiti Sains Malaysia Institutes for Research in Molecular Medicine(INFORMM) Universiti Sains Malaysia

Objective:To determine the major changes in the microstructure of Candida albicans(C. albicans) after treatment with Euphorbia hirta(***) *** ***:Transmission electron microscopy was used to study the ultrastructural changes caused by *** extract on C. albicans cells al various exposure ***:It was found that the main abnormalities were the alterations in morphology,lysis and complete collapse of the yeast cells after 36 h of exposure to the *** the control cultures showed a typical morphology of Candida with a uniform central density,typically structured nucleus,and a cytoplasm with several elements of endomembrane system and enveloped by a regular,intact cell ***:The significant antifungal activity shown by this methanol extract of *** *** its potential against infections caused by *** extract may be developed as an anticandidal agent.

关键词： Candida albicans Euphorbia hirta L. Transmission electron microscopy Anticandidal agent

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