Pharmacological activity,phytochemical analysis and toxicity of methanol extract of Etlingera elatior(torch ginger) flowers

作     者：Subramanion Jo Thy Lachumy Sreenivasan Sasidharan Velio Sumathy Zakaria Zuraini 

作者机构：School of Distance EducationUniversiti Sains MalaysiaMinden 11800Pulau PinangMalaysia Institute for Research in Molecular Medicine(INFORMM)Universiti Sains MalaysiaMinden 11800Pulau PinangMalaysia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2010年第3卷第10期

页      面：769-774页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Universiti Sains Malaysia fellowship from Institute for Postgraduate Studies Universiti Sains Malaysia 

主　　题：Etlingera elatior Pharmacological activity Phytochemical analysis Artemia salina 

摘      要：Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior（***）.Methods:Phytochemical screening of the flower extract was done to determine the phytochemical in the *** pharmacological study included the determination of antimicrobial activity and minimum inhibitory concentration（MIC） of metabolic flower *** antimicrobial activity of the extract was tested against medically important bacterial,yeast and fungal *** from that,the methanolic extract of *** flower was further tested in vivo toxicity using the brine shrimp lethality ***,the flower extract was qualitatively screened for their free radical scavenging activity by 2,2-diphenyl-1- picrylhydrazyl radical（DPPH） ***:The extract was effective on tested microorganisms and MIC values were in the range of 1.563-50.000 mg/*** brine shrimp lethality test exhibited no significant toxicity(LC50= 2.52 mg/mL) against Artemia *** *** flower extract with high LC50 value signified that this plant is not toxic to *** the phytochemical screening of the flower extract revealed the presence of the following compounds: flavonoids,terpenoids,saponin,tannins and carbohydrates whereas,alkaloids,anthraquinone and reducing sugars were *** concentration of the flower extract required for 50% inhibition of DPPH radical scavenging effect(IC50) were 9.14 mg/mL and 8.08 mg/mL for butylated hydroxytoluene 8.08 mg/***:These findings indicate that the extract of *** flower possesses pharmacological properties and potential to develop natural products based pharmaceuticals products.