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Nano Research 2024年第6期17卷 4720-4728页

作者： Liting Wei Kaini zhang Rui Zhao Lei zhang Yan zhang Suyi Yang Jinzhan Su International Research Center for Renewable Energy&State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Applied Chemistry Yuncheng UniversityYuncheng 044000China

NiFe-based electrocatalysts will experience dynamical surface reconstruction during oxygen evolution reaction(OER)process,and the derived metal(oxy)hydroxide hybrids on the surface have been considered as the actual active species for *** efforts have been dedicated to understanding the surface reconstruction,but there is rare research on recognizing the origin of improved performance derived from anion species of ***,the OER electrocatalytic characteristics were tuned with different anions in NiFe-based catalyst,using NiFe-based oxides/nitride/sulfide/selenides/phosphides(NiFeX,X=O,N,S,Se,and P)as the model *** combination of X-ray photoelectronic spectroscopy,electrochemical tests,operando spectroscopic characterizations,and density functional theory(DFT)calculations,reveals that anion with lower electronegativity in NiFe-based catalyst leads to higher conductivity and delayed valence transition of Ni sites,as well as optimized adsorption behavior towards oxygen intermediates,contributing to enhanced OER ***,NiFeP electrocatalyst demonstrates an ultralow overpotential of 265 mV at 20 mA·cm−2 for OER,as well as long-term *** work not only offers further insights into the effect of anionic electronegativity on the intrinsic OER electrocatalytic properties of NiFe-based electrocatalyst but also provides guide to design efficient non-noble metal-based electrocatalysts for water oxidation.

关键词： oxygen evolution reaction(OER) anion species electronegativity valence transition

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宋代解决人口与土地矛盾思想研究

山西财经大学学报 2009年第2期31卷 13-18页

作者：方宝璋江西财经大学会计学院江西南昌330013

宋代人口增长迅速、分布不均,土地兼并严重,使人口与土地矛盾突出。当时不少人就此提出解决思路:一是调整人口分布;二是实行限田;三是主张土地集约经营。从宋代解决人地矛盾的思想可以看出,对人地冲突的综合治理不仅有助于减轻人口对土... 详细信息

宋代人口增长迅速、分布不均,土地兼并严重,使人口与土地矛盾突出。当时不少人就此提出解决思路:一是调整人口分布;二是实行限田;三是主张土地集约经营。从宋代解决人地矛盾的思想可以看出,对人地冲突的综合治理不仅有助于减轻人口对土地的压力,而且还可以缓和社会矛盾,维护生态平衡。

关键词：宋代人地矛盾人口分布限田土地集约经营

Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection

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Zoological Research 2022年第6期43卷 1041-1062页

作者： Qiang Ma Wenji Ma Tian-zhang Song Zhaobo Wu Zeyuan Liu Zhenxiang Hu Jian-bao Han Ling Xu Bo Zeng Bosong Wang Yinuo Sun Dan-Dan Yu Qian Wu Yong-Gang Yao Yong-Tang Zheng Xiaoqun Wang State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China LivzonBio Inc.ZhuhaiGuangdong 519045China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China Advanced Innovation Center for Human Brain Protection Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100069China

Infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes diverse clinical manifestations and tissue injuries in multiple ***, cellular and molecular understanding of SARS-CoV-2 infection-associated pathology and immune defense features in different organs remains incomplete. Here, we profiled approximately 77 000single-nucleus transcriptomes of the lung, liver,kidney, and cerebral cortex in rhesus macaques(Macaca mulatta) infected with SARS-CoV-2 and healthy controls. Integrated analysis of the multiorgan dataset suggested that the liver harbored the strongest global transcriptional alterations. We observed prominent impairment in lung epithelial cells, especially in AT2 and ciliated cells, and evident signs of fibrosis in fibroblasts. These lung injury characteristics are similar to those reported in patients with coronavirus disease 2019(COVID-19).Furthermore, we found suppressed MHC class I/II molecular activity in the lung, inflammatory response in the liver, and activation of the kynurenine pathway,which induced the development of an immunosuppressive microenvironment. Analysis of the kidney dataset highlighted tropism of tubule cells to SARS-CoV-2, and we found membranous nephropathy(an autoimmune disease) caused by podocyte dysregulation. In addition, we identified the pathological states of astrocytes and oligodendrocytes in the cerebral cortex, providing molecular insights into COVID-19-related neurological implications. Overall, our multi-organ single-nucleus transcriptomic survey of SARS-CoV-2-infected rhesus macaques broadens our understanding of disease features and antiviral immune defects caused by SARS-CoV-2 infection,which may facilitate the development of therapeutic interventions for COVID-19.

关键词： SARS-CoV-2 Rhesus macaque Animal model Single-nucleus RNA sequencing Antiviral immune defects Multiple organs

Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment

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Nano Research 2022年第1期15卷 728-737页

作者： Shiqi Huang Lang Deng Hanming zhang Luyao Wang Yicong zhang Qing Lin Tao Gong Xun Sun Zhirong zhang Ling zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China

Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung,leading to sharply reduced patients'survival *** treating these tumors thus could improve late stage melanoma with lung *** this study,we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA)decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and paclitaxel(PTX)to lung melanoma tumor sites(TRAIL-[ND-PTX]^(CR(NMe)EKA)).These nanodisks displayed better tumor-targeting and penetration capability than spherical nanoparticles,while the fibronectin-targeting CR(NMe)EKA motif also increased the tumor accumulation of loaded *** combined usage of TRAIL and PTX both killed tumor cells and reduced local nutrition supply,leading to stronger overall anti-tumor *** TRAIL-[ND-PTX]^(CR(NMe)EKA)system performed remarkably better than free paclitaxel and also significantly elongated survival rate of melanoma lung metastasis bearing mice,without displaying significant ***,this designing strategy and the fabricated nanoplatform possess potential for further development.

关键词： nanodisks Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA) tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) lung melanoma metastasis tumor-targeting

Quantifying the dissolution of nanomaterials at the nano-bio interface

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Science China Chemistry 2015年第5期58卷 761-767页

作者： Junzhe zhang Xiao He Peng zhang Yuhui Ma Yayun Ding Zhenyu Wang Zhiyong zhang College of Environmental Science and Engineering Ocean University of China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy Physics Chinese Academy of Sciences

With the rapid development of nanoscience and nanotechnology, more engineered nanomaterials(NMs) are being released into the environment. Such releases might lead to unwanted exposure. The dissolution of NMs at nano-bio interfaces is one of the most noteworthy causes of the toxicity of dissolvable NMs. A growing number of studies are focusing assessing NMs dissolution during exposure tests. This mini review considers recent developments in the quantitative tools for the assessment of NMs dissolution, and highlights the critical points in the evaluation of the toxicity of dissolvable NMs.

关键词： nanomaterials nano-bio interface dissolution ions toxicology

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时效处理对AZ80镁合金冲击韧度的影响

金属热处理 2007年第10期32卷 69-70页

作者：张星张治民李保成中北大学材料科学与工程学院山西太原030051 山西省精密成形工程中心山西太原030051

采用冲击试验和断口形貌分析对经不同温度时效处理后的AZ80镁合金冲击性能进行了分析。结果表明,AZ80镁合金的冲击韧性随时效温度的上升呈下降趋势,当温度超过140℃时,合金冲击韧度迅速下降。网状组织是AZ80镁合金力学性能降低的主要原因。

关键词：镁合金冲击韧度时效

Modulation of terminal alkyl chain length enables over 15% efficiency in small-molecule organic solar cells

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Science China Chemistry 2021年第7期64卷 1200-1207页

作者： Qianglong Lv Cunbin An Tao zhang Jianqi zhang Shaoqing zhang Pengxin Zhou Chang He Jianhui Hou Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190China College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070China Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In small-molecule organic solar cells(SM-OSCs),it remains a big challenge to obtain favorable bulk heterojunction morphology by donor material ***,we design and synthesize three small-molecule donors BPF3T-C4,BPF3T-C6 and BPF3T-C8,with different terminal alkyl *** they possess similar absorption profiles and molecular energy levels,their crystallinity gradually decreases with the chain length of the terminal alkyl *** blending with an electron acceptor of BO-4Cl,the crystallinity is suppressed and the packing orientations of these donors changed from edge-on to ***,the crystallinity of BO-4Cl is gradually weakened with the chain length of the terminal alkyl chain of donor ***,The BPF3T-C6 with moderate crystallinity exhibits the best phase-separation morphology among these blend *** a result,the BPF3T-C6:BO-4Cl-based SM-OSC shows an impressive power conversion efficiency of 15.1%.

关键词： small-molecule donor non-fullerene acceptor intermolecular interaction terminal alkyl chain small-molecule organic solar cells

Acoustic mode waves and individual arrivals excited by a dipole source in fluid-filled boreholes

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Science China(Physics,Mechanics & Astronomy) 2009年第6期52卷 822-831页

作者： zhang XiuMei zhang HaiLan WANG XiuMing State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China

An approach of separating individual wave arrivals for a dipole logging is presented. The branch points are treated as a type of logarithm and the Riemann surface structure of the multivalued function is studied, that is, the displacement potential within the borehole. Based on the theoretical analysis, the complex poles contributing to the wave field on various Riemann sheets are investigated in detail for the case of a fast formation. It is shown that poles on Riemann sheet (0,0) are real and form branches of modes with dispersion. Mathematically, it is demonstrated that the flexural mode has no cutoff frequency, which is different from the traditional point of view. Poles on other relevant Riemann sheets are complex and form many branches on the complex frequency-wavenumber plane. Further investigation on the pole and branch cut contributions indicates that the vertical branch cut integration method has limitations in separating wave arrivals. By properly taking into account the complex poles on various Riemann sheets together with branch cut integrations, wave arrivals are separated from the full wave-forms effectively for both the fast and slow formation models. Specially, there are complex poles on Riemann sheet (0,-1) in the vicinity of the compressional branch cut for a slow formation with a large Poisson's ratio, which have small imaginary parts and contribute a lot to the p-wave arrival.

关键词： dipole sources Riemann sheet cutoff frequency individual arrivals

Algorithms to Calculate the Most Reliable Maximum Flow in Content Delivery Network

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Computer Systems Science & Engineering 2022年第5期41卷 699-715页

作者： Baili zhang Keke Ling Pei zhang Zhao zhang Mingjun Zhong School of Computer Science and Engineering Southeast UniversityNanjing211189China State Key Laboratory of Smart Grid Protection and Control Nanjing211106China Nari Group Corporation Nanjing211106China Department of Computing Science University of AberdeenAberdeenAB243UEUK

Calculating the most reliable maximum flow(MRMF)from the edge cache node to the requesting node can provide an important reference for selecting the best edge cache node in a content delivery network(CDN).However,SDBA,as the current state-of-the-art MRMF algorithm,is too complex to meet real-time computing *** paper proposes a set of MRMF algorithms:NWCD(Negative Weight Community Deletion),SCPDAT(Single-Cycle Preference Deletion Approximation algorithm with Time constraint)and SCPDAP(Single-Cycle Preference Deletion Approximation algorithm with Probability constraint).NWCD draws on the“flow-shifting”algorithm of minimum cost and maximum flow,and further defines the concept of negative weight *** algorithm continuously deletes the negative weight communities,which can increase reliability while keeping the flow constant in the residual *** is proven that when all negative weight communities are deleted,the corresponding maximum flow is the *** tries to approach the optimal solution to the greatest extent possible within the limited time,while SCPDAP tries to reach the probability threshold in the shortest amount of *** of these adopt the strategy of first deleting single-cycle communities(which contribute more to the reliability with lower time cost).Experiments show that,compared with SDBA,NWCD combined with the probabilistic pruning achieves an order of magnitude improvement in time cost,while SCPDAT and SCPDAP demonstrate better time performance and increased applicability.

关键词： Content delivery network uncertain graph maximum flow flow reliability

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基于复数矩的形状轮廓描述与匹配方法

四川大学学报（工程科学版） 2011年第2期43卷 109-115页

作者：赵东保贺添张卡华北水利水电学院资源与环境学院河南郑州450011 郑州大学水利与环境学院河南郑州450001 南京师范大学虚拟地理环境教育部重点实验室江苏南京210046

建立合适的轮廓描述函数是各种形状轮廓匹配算法的前提所在。基于复数矩理论构造了轮廓顶点与形状旋转、缩放和平移无关的局部复数矩不变量,推导了局部复数矩与原始轮廓顶点坐标的正反算公式,将轮廓特征顶点处的局部复数矩和曲率合在一... 详细信息

建立合适的轮廓描述函数是各种形状轮廓匹配算法的前提所在。基于复数矩理论构造了轮廓顶点与形状旋转、缩放和平移无关的局部复数矩不变量,推导了局部复数矩与原始轮廓顶点坐标的正反算公式,将轮廓特征顶点处的局部复数矩和曲率合在一起,从而建立了一种新的轮廓描述函数。该轮廓描述函数较为充分地考虑到了轮廓的全局与局部特征,除了具有不变性和唯一性等性质外,也具有较高的计算效率,仅需花费线性时间即可完成轮廓描述函数的构造,由于仅涉及到低阶几何矩,其局部复数矩也具有较强的抗噪能力。基于该轮廓描述函数,利用串匹配算法实现了形状的轮廓匹配,与现有基于各种轮廓描述函数的匹配方法的实验对比表明,本文轮廓描述函数及其匹配方法具有更为优秀的匹配性能。

关键词：形状匹配轮廓描述函数复数矩