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Real-life experience of ranibizumab therapy for neovascular age-related macular degeneration from Turkey

International Journal of Ophthalmology(English edition) 2018年第2期11卷 267-273页

作者： zafer cebeci Yusuf Cem Yilmaz Nur Kir Department of Ophthalmology Istanbul Faculty of Medicine Istanbul University

AIM： To report the real-life experience and clinical results of intravitreal ranibizumab injections to neovascular agerelated macular degeneration（nAMD） in a single institution in ***： A total of 101 eyes of 89 patients with nAMD treated with intravitreal ranibizumab injection, followed up for at least 24 mo between 2009 and June 2014, which were evaluated retrospectively. A pro re nata（PRN） treatment protocol was performed after the patients had received three, monthly loading injections. Best corrected visual acuity（BCVA） and central macular thickness measurements were evaluated at baseline and 3, 6, 12, 18, and 24 mo. Number of injections and visits were also ***： Of the 89 patients, 34（38.2%） were male and 55（61.8%） were female and the mean age was 74.0±9.5（52-91）y. The mean follow-up period was 24.82±4.4（24-29）mo. Mean number of visits was 8.4±1.12（7-12） in the first year and 6.6±1.33（4-12） in the second year. The mean number of injections was 5.8±1.6（3-10） and 4.2±2.2（0-9） in the first and second year, respectively. The mean BCVA was 59±15.8 letters at baseline by the Early Treatment Diabetic Retinopathy Study（ETDRS） chart. The mean BCVA at 3, 12, and 24 mo was 70.3±15.9, 67.9±14.3 and 67.3±16.9 letters, respectively. Improvement in visual acuity for each of the visits from baseline was found to be statistically significant（P〈0.01）. Visual acuity in 9 eyes at month 3, 7 eyes at month 12, and 13 eyes at month 24 did not change. The mean central macular thickness（CMT） was 437.99±164.78 μm at baseline. The mean CMT was 348.05±138.47 μm, 349.27±139.79 μm, and 344.13±146.30 μm at months 3, 12, and 24, respectively. The decrease in CMT for each of the visits from baseline was found to be statistically significant（P〈0.01）.CONCLUSION： Anatomical and functional achievement are obtained in our study, but the mean number of injections and visits are found to be lower than the findings reported in randomized controlled clinical trials in the litera

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Injector of the Turkish light source facility TURKAY

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Nuclear Science and Techniques 2017年第11期28卷 210-216页

作者： zafer Nergiz Avni Aksoy Department of Physics Faculty of Arts and Sciences Omer Halisdemir University 51200 Nigde Turkey Institute of Accelerator Technologies Ankara University06830 Golbasi Ankara Turkey

A synchrotron radiation source called TURKAY is proposed as a sub-project of the Turkish Accelerator Center Project. The storage ring of TURKAY is a low emittance synchrotron and the radiation ranges between 0.01 and 60 keV can be generated from the insertion devices and bending magnets placed on it. The injector system of the facility will mainly consist of a 150 MeV linac and full energy booster. In this study, we present design considerations and beam dynamics studies of the pre-injector linac and booster ring for TURKAY.

关键词： Booster ring Pre-injector linac Beam dynamics

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NONLINEAR DYNAMIC ANALYSIS OF A LAMINATED HYBRID COMPOSITE PLATE SUBJECTED TO TIME-DEPENDENT EXTERNAL PULSES

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Acta Mechanica Solida Sinica 2012年第6期25卷 586-597页

作者： Mehmet Senyer zafer Kazanci Turkish Air Force Academy Aeronautics and Space Technologies Institute34149 Ye silyurt Istanbul Turkey Turkish Air Force Academy Aerospace Engineering Department34149 Ye silyurt Istanbul Turkey

Nonlinear dynamic responses of a laminated hybrid composite plate subjected to time-dependent pulses are investigated. Dynamic equations of the plate are derived by the use of the virtual work principle. The geometric nonlinearity effects are taken into account with the yon Karman large deflection theory of thin plates. Approximate solutions for a clamped plate are assumed for the space domain. The single term approximation functions are selected by considering the nonlinear static deformation of plate obtained using the finite element method. The Galerkin Method is used to obtain the nonlinear differential equations in the time domain and a MATLAB software code is written to solve nonlinear coupled equations by using the Newmark Method. The results of approximate-numerical analysis are obtained and compared with the finite element results. Transient loading conditions considered include blast, sine, rectangular, and triangular pulses. A parametric study is conducted considering the effects of peak pressure, aspect ratio, fiber orientation and thicknesses.

关键词： nonlinear vibration hybrid composite plate Newmark method dynamic loads

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Additive manufacturing of biodegradable magnesium implants and scaffolds: Review of the recent advances and research trends

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Journal of Magnesium and Alloys 2021年第2期9卷 392-415页

作者： Nurettin Sezer zafer Evis Muammer Koç Division of Sustainable Development College of Science and EngineeringHamad Bin Khalifa UniversityQatar FoundationEducation CityDohaQatar Engineering Sciences Middle East Technical UniversityPO Box 06800AnkaraTurkey University of Karabük Turkey

Synthetic grafting needs improvements to eliminate secondary surgeries for the removal of implants after healing of the defected *** scaffolds are engineered to serve as temporary templates,which support the affected tissue and gradually degrade through the healing *** mechanical function to withstand the anatomic loading conditions,scaffolds should also provide a decent biological function for the diffusion of nutrients and oxygen to the cells,and excretion of the wastes from the cells to promote the new tissue growth and ***,the degradation byproducts of the scaffolds should be safe to the human *** of such multifunctional scaffolds requires selection of the right material,design,and manufacturing *** has been recognized as the prominent biodegradable metal with regards to its mechanical properties matching to that of human bone,degradability in the body fluid,and its ability to stimulate new tissue *** with intricate porous structures can be designed according to the patient-specific anatomic data using computer aided *** manufacturing(AM)is the right method to materialize these models rapidly with reasonably acceptable range of dimensional ***,the recent research trend is to develop ideal scaffolds using biodegradable Mg through AM *** review compiles and discusses the available literature on the AM of biodegradable Mg parts from the viewpoints of material compositions,process conditions,formation quality,dimensional accuracy,microstructure,biodegradation,and mechanical *** current achievements are summarized together,and future research directions are identified to promote clinical applications of biodegradable Mg through the advancement of AM.

关键词： Magnesium Alloy Implant Tissue scaffold Additive manufacturing Biodegradation

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Optimizing Cr^(3+) concentration and evaluating energy transfer from Cr^(3+) to Nd^(3+) in Cr,Nd:GGG nanocrystals prepared by sol-gel method

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Journal of Rare Earths 2016年第11期34卷 1077-1082页

作者： Yassin Alshikh Mohamad Yomen Atassi zafer Moussa Department of Applied Physics Higher Institute for Applied Science and Technology

Nanopowder of Cr：GGG and nanopowder of Cr,Nd：GGG with different concentrations of Cr3＋ ranging from 0.1 at.% to 1.5 at.% were synthesized by the sol-gel method using acetic acid and ethylene glycol. Thermal gravimetric analysis and differential scanning calorimetry （TGA-DSC）, X-ray diffraction （XRD） and photoluminescence spectroscopy were used to characterize the powder. The crystallite size was about 58 nm when treated at 1000 oC for 2 h. Cr3＋ photoluminescence spectrum in GGG showed a broad band emission around 730 nm. The intensity of this band decreased when co-doped with Nd, indicating an efficient energy transfer from Cr3＋ to Nd3＋. Photoluminescence intensity of Nd in Cr,Nd：GGG at 1.06μm showed that the optimum concentration of Cr3＋ was about 1 at.% （more or less） for 1 at.% Nd3＋. This result was also confirmed by chromium fluorescence decay rate analysis. Energy transfer efficiency was found to be about 84% for 1 at.% concentration of each chromium and neodymium.

关键词： nanopowder Cr,Nd:GGG sol-gel fluorescence lifetime energy transfer efficiency rare earths

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Assessment of commonly used tests in experimental depression studies according to behavioral patterns of rodents

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Medical Review 2023年第6期3卷 526-531页

作者： zafer Sahin Department of Physiology Faculty of MedicineKaradeniz Technical UniversityTrabzon 61080Turkey

Considering the main factor that causes or triggers depression in humans is *** stress factors are applied to form depression-like symptoms in *** tests are used to analyze the nature and patterns of ***-founded modeling and versatile evaluation of tests are necessary to investigate a hypothesis that is related to *** is impossible to model or test all aspects of depression in humans by using experimental *** a result,the aims of the study should be determined specifically in depression *** correct interpretation of the tests that are suitable for these aims is indispensable for the reliability of the *** achieve this goal,the biological basis of the depression-related behaviors of animals should be well *** this review,model and test concepts related to depression are discussed and behavioral patterns of rodents are explained with several examples.

关键词： depression forced swimming test tail suspension test sucrose preference test

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An experimental investigation of properties of polyethylene reinforced with Al powders

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第8期12卷 583-592页

作者： Victoria CHIFOR zafer TEKINER Mehmet TURKER Radu ORBAN Department of Materials Science and Technology Faculty of Materials Science and EngineeringTechnical University of Cluj-Napoca Mechanical/Metallurgy Education Department Faculty of Technical EducationGazi University

Mechanical and physical properties, such as tensile strength, elongation at break, modulus of elasticity, Shore D hardness, melt flow rate (MFR), and electrical and thermal conductivities of composites with high density polyethylene matrix reinforced with Al powders were investigated experimentally. Measurements of the mechanical and physical properties were performed up to a reinforcing component concentration of 30% volume Al powder and compared with mathematical models from the literature. The obtained results have shown that experimental data were in good agreement with theoretical data. The ultimate tensile strength (UTS) and elongation at break decreased with increasing Al powder content, which was attributed to the intro-duction of discontinuities in the polymer structure, and modulus of elasticity increased with increasing Al content. The composite preparation conditions allowed the formation of a random distribution of metallic particles in the polymer matrix volume for system high density polyethylene-Al (HDPE-Al). There was a cluster formation of Al particles at higher Al contents in the polymer matrix. Electrical and thermal conductivity values of HDPE-Al composites were higher than pure HDPE values.

关键词： Polymer composite Mechanical properties Melt flow rate(MFR) Thermal conductivity Electrical conductivity

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Effects of thinning on stand structure and tree stability in an afforested oriental beech(Fagus orientalis Lipsky) stand in northeast Turkey

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Journal of Forestry Research 2015年第1期26卷 123-129页

作者： zafer Yücesan Sevilay ?z?elik Ercan Oktan Faculty of Forestry Karadeniz Technical University General Directorate of Combating to Desertification and Erosion Control

We studied relationships between stand structure and stand stability according to thinning intensity in an afforested oriental beech stand. Various thinning intensities were applied in sample stands. We sampled eight plots in stands that were lightly thinned, eight plots in heavily thinned stands and eight plots in unthinned stands as a control. Height and diameter distributions of the stands were measured to assess stand structure. We quantified individual tree stability and collective stability. Heavy thinning during the first thinning operation damaged the storied structure of the stand in thicket stage and affected collective structuring ability. While most control plots had multi-storied stands, after light and heavy thinning two-storied structure became more *** gaps occurred in the canopy after heavy thinning. On average, nine tree collectives were formed per sampling plot in the untreated stand, seven collectives after thinning in 2008 and four collectives after thinning in 2009. Stable trees accounted for 17 % of trees in control plots, 24 % in lightly thinned plots, and 15 % in heavily thinned plots. Collective stability values were 83 % in control plots, 82 % in lightly thinned plots and 36 % in heavily thinned plots. We conclude that it is necessary to retain collective structuring capacity during thinning operations for sustaining stand stability.

关键词： Oriental beech Thinning Stand structure Tree stability

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Synthesis and characterization of salt-impregnated anodic aluminum oxide composites for low-grade heat storage

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 112-118页

作者： Bengisu Yilmaz Behiye Yüksel Gökhan Orhan Devrim Aydin zafer Utlu stanbul University-Cerrahpasa Faculty of EngineeringDepartment of Metallurgy and Materials EngineeringIstanbul 34320Turkey Istanbul Gedik University Department of Mechanical EngineeringIstanbul 34876Turkey Eastern Mediterranean University Faculty of EngineeringDepartment of Mechanical EngineeringMersin 10Turkey

Thermochemical heat storage(THS)systems have recently attracted a lot of attention in research and *** this study,an anodic aluminum oxide(AAO)template,fabricated by a two-step anodization method,was used for the first time as the matrix material for a THS *** salts were studied as thermochemical materials for their suitability in low-grade heat storage application driven by solar energy for an open *** were prepared by absorbing CaCl2,MgCl2,LiCl,LiNO3 and mixtures of these salts under a vacuum in an AAO *** Emission Scanning Electron Microscopy was used to examine the morphology of the produced AAO *** energy storage capacities of the composites were characterized using a differential scanning *** analysis showed that anodized Al plates were suitable matrix materials for THS systems,and composite sorbent prepared with a 1:1 ratio LiCl/LiNO3 salt mixture had the highest energy value among all composites,with an energy density of 468.1 k J·kg-1.

关键词： thermal energy storage salt impregnation thermochemical heat storage anodizing salt in matrix

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Mattress sutures for the modification of end-to-end dunking pancreaticojejunostomy

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 556-558页

作者： Nurkan Torer Ali Ezer Tarlk zafer Nursal Department of General Surgery Baskent University Faculty of Medicine

Despite the improvement of surgical techniques,the rate of anastomotic failure of pancreaticojejunostomy remains high(30%-50%).Here we describe the use of vertical mattress sutures in the modification of dunking pancreaticojejunal *** 7 patients who used this technique,neither anastomotic failure nor any major postsurgical complication *** technique is an easy,safe,and promising for the performance of pancreaticojejunostomy.

关键词： pancreaticoduodenectomy pancreaticojejunostomy technique

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