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Journal of Sport and Health Science 2022年第6期11卷 716-724页

作者： zachary yukio kerr Avinash Chandran Aliza K.Nedimyer Allison E.Rothschild Melissa C.Kay Paula Gildner K.Hunter Byrd Juliet K Haarbauer-Krupa Johna K.Register-Mihalik Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNC 27599-8700USA Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center University of North CarolinaChapel HillNC 27599-8700USA Injury Prevention Research Center University of North CarolinaChapel HillNC 27510USA Human Movement Science Curriculum University of North CarolinaChapel HillNC 27599-8700USA Department of Health Behavior Gillings School of Public HealthUniversity of North CarolinaChapel HillNC 27599-7400USA School of Health Professions University of Southern MississippiHattiesburgMS 39406USA National Center for Injury Prevention and Control Centers for Disease Control and PreventionAtlantaGA 30341USA

Objective:Parents may use various information sources to obtain information about sport-related concussions(SRC).This study examined SRCrelated information sources used by parents of United States middle school children(age:10-15 years).Methods:A panel of 1083 randomly selected ***,aged≥18 years and identifying as parents of middle school children,completed an online questionnaire capturing parental and child characteristics,and utilization and perceived trustworthiness of various sources of SRC-related *** logistic regression models identified factors associated with utilizing each *** odds ratios(OR)with 95%confidence intervals(95%CIs)excluding 1.00 were deemed ***:Doctors/healthcare providers(49.9%)and other healthcare-related resources(e.g.,Centers for Disease Control and Prevention,WebMD)(37.8%)were common SRC-related information sources;64.0%of parents utilized≥1 of these *** sources were considered“very”or“extremely”trustworthy for SRC-related information among parents using these sources(doctors/healthcare providers:89.8%;other healthcare-related resources:70.9%).A 10-year increase in parental age was associated with higher odds of utilizing doctors/healthcare providers(adjusted odd ratio(OR_(adjusted))=1.09,95%CI:1.02-1.16)and other healthcare-related resources(OR_(adjusted)=1.11,95%CI:1.03-1.19).The odds of utilizing doctors/healthcare providers(OR_(adjusted)=0.58,95%CI:0.40-0.84)and other healthcare-related resources(OR_(adjusted)=0.64,95%CI:0.44-0.93)were lower among parents whose middle school children had concussion histories versus the parents of children who did not have concussion ***:One-third of parents did not report using doctors/healthcare providers or other healthcare-related resources for SRC-related *** associated with underutilization of these sources may be targets for future *** education for healthcare providers and e

关键词： Information seeking Media use Traumatic brain injury

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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Xiamen after 20 Years of Ecological Transformation

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China Today 2025年第1期74卷 66-68页

作者： zachary G.LUNDQUIST 不详

The efforts Xiamen has made in ecological protection over the last 20 years have helped it become a beautiful and clean *** years ago,I had the opportunity to travel to the city of Xiamen in southeastern China’s Fujian ***,due to the fact that I was in a rush,I did not have the chance to see the whole *** memory of Xiamen was its pleasant climate and unforgettable beauty-I knew if I ever got the opportunity,I would revisit this *** years went by until I was able to return to this city *** emerging from the airport,I realized that I had grown older,while Xiamen was becoming increasingly youthful and *** exactly had given this city such vitality?

关键词： Ecological Xiamen Transformation

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What strategies are implied by STRATEGY?

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Science China(Life Sciences) 2017年第3期60卷 319-320页

作者： zachary Bloomgarden Department of Medicine Icahn School of Medicine at Mount SinaiNew York NY 10029USA

Weng and coauthors enrolled 5,535 type 2 diabetic patients in a study of the combined effect of metformin with sitagliptin,nearly half achieving HbAlc〈7.0%,with an average 0.85%fall from a baseline of 8.03%.This supp... 详细信息

关键词：隐含二甲双胍 2型糖尿病联合效应抑制剂

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Exertional heat illness risk factors and physiological responses of youth football players

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Journal of Sport and Health Science 2021年第1期10卷 91-98页

作者： Susan W.Yeargin John J.Dickinson Dawn M.Emerson Jessica Koller Toni M.Torres-McGehee zachary Y.kerr Department of Exercise Science University of South CarolinaColumbiaSC 29208USA Palmetto Health/USC Orthopedic Center Keenan High SchoolColumbiaSC 29203USA Department of Health Sportand Exercise SciencesUniversity of KansasLawrenceKS 66045USA Surgi-Care Inc. BostonMA 02115USA Department of Exercise and Sport Science University of North CarolinaChapel HillNC 27599-8700USA

Objective:To determine which intrinsic and extrinsic exertional heat illness(EHI)risk factors exist in youth American football players and observe perceptual and physiological responses of players during events(games and practices).Methods:Cross-sectional cohort study observing 63 youth football players,varying in *** variables were league(weightrestricted(WR,n=27)and age-restricted(AR,n=36))and event *** variables were anthropometrics,work-to-rest ratio,and wet bulb globe *** variables included preparticipation examination and uniform configuration.A subset of 16 players participated in physiological variables(heart rate and gastrointestinal temperature).Data collection occurred on 7 AR and 8 WR nonconsecutive practices and the first 3 games of the ***:Mean values for anthropometric variables were higher(p<0.05)in the AR league than the WR *** time(χ^2(1,111)=4.232;p=0.039)and rest time(χ^2(1,111)=43.41;p<0.001)were significantly greater for games,but ratios were significantly higher for practices(χ^2(1,111)=40.62;p<0.001).The majority of events(77%)observed were in black and red flag wet bulb globe temperature risk categories.A total of 57%of the players had a preparticipation examination,and up to 82%of events observed were in full *** gastrointestinal temperature and heart rate responses ranged widely and no players reached critical ***:Extrinsic(disproportionate work ratios,environmental conditions)and intrinsic(higher body mass index)EHI risk factors exist in youth *** risk factors may be influenced by event and league *** youth football organizations need to create thorough guidelines that address EHI risk factors for local leagues to adopt.

关键词： Adolescents Anthropometrics Core temperature Heat exchange Pediatric Wet bulb globe temperature

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A Multi-Point Distance-Bounding Protocol for Securing Automatic Dependent Surveillance-Broadcast in Unmanned Aerial Vehicle Applications

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Journal of Computer Science & Technology 2020年第4期35卷 825-842页

作者： zachary P.Languell Qijun Gu Department of Computer Science Texas State UniversitySan MarcosTX 78666USA

The Automatic Dependent Surveillance-Broadcast(ADS-B)protocol is being adopted for use in unmanned aerial vehicles(UAVs)as the primary source of information for emerging multi-UAV collision avoidance *** lack of security features in ADS-B leaves any processes dependent upon the information vulnerable to a variety of threats from compromised and dishonest *** could result in substantial losses or damage to *** research proposes a new distance-bounding scheme for verifying the distance and flight trajectory in the ADS-B broadcast data from surrounding *** proposed scheme enables UAVs or ground stations to identify fraudulent UAVs and avoid *** scheme was implemented and tested in the ArduPilot SITL(Software In The Loop)simulator to verify its ability to detect fraudulent *** experiments showed that the scheme achieved the desired accuracy in both flight trajectory measurement and attack detection.

关键词： automatic dependent surveillance-broadcast (ADS-B) unmanned aerial vehicle (UAV) distance bounding collision airspace safety

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Transcription factors promote neural regeneration after spinal cord injury

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Neural Regeneration Research 2022年第11期17卷 2439-2440页

作者： zachary Finkel Li Cai Department of Biomedical Engineering Rutgers University

Human spinal cord injury (SCI) results in locomotor and sensory disabilities,which severely affect the quality of *** restore function after SCI,it is necessary to repair and reconstruct the damaged local *** hurdles in neural regeneration include a limited level of neurogenesis in the adult spinal cord and an inflammatory microenvironment that inhibits neurogenesis and axon regeneration.

关键词： neural injury SCI

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First integrals of the axisymmetric shape equation of lipid membranes

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Chinese Physics B 2018年第3期27卷 551-559页

作者： Yi-Heng Zhang zachary McDargh Zhan-Chun Tu Department of Physics Beijing Normal UniversityBeijing 100875China Department of Physics Carnegie Mellon University5000 Forbes AvenuePittsburgh PA 15213USA

The shape equation of lipid membranes is a fourth-order partial differential *** the axisymmetric condi-tion,this equation was transformed into a second-order ordinary differential equation(ODE)by Zheng and Liu(***.E 482856(1993)).Here we try to further reduce this second-order ODE to a first-order ***,we invert the usual process of variational calculus,that is,we construct a Lagrangian for which the ODE is the corresponding Euler-Lagrange ***,we seek symmetries of this Lagrangian according to the Noether *** a certain restriction on Lie groups of the shape equation,we find that the first integral only exists when the shape equation is identical to the Will-more equation,in which case the symmetry leading to the first integral is scale *** also obtain the mechanical interpretation of the first integral by using the membrane stress tensor.

关键词： lipid membrane shape equation first integral Noether theorem

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From landrace to modern hybrid broccoli:the genomic and morphological domestication syndrome within a diverse *** collection

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Horticulture Research 2020年第1期7卷 574-590页

作者： zachary Stansell Thomas Björkman Cornell University School of Integrative Plant ScienceCornell UniversityIthacaNY 14850USA Cornell AgriTech Cornell UniversityGenevaNY 14456USA

Worldwide,broccoli(Brassica oleracea ***)is among the most economically important,nutritionally rich,and widely-grown vegetable *** explore the genomic basis of the dramatic changes in broccoli morphology in the last century,we evaluated 109 broccoli or broccoli/cauliflower intermediates for 24 horticultural ***-bysequencing markers were used to determine four subpopulations within italica:Calabrese broccoli landraces and hybrids,sprouting broccoli,and violet cauliflower,and to evaluate between and within group relatedness and *** overall horticultural quality and harvest index of improved hybrid broccoli germplasm has increased by year of cultivar release,this improvement has been accompanied by a considerable reduction in allelic diversity when compared to the larger pool of *** landraces are the most likely founding source of modern broccoli hybrids,and within these modern hybrids,we identified 13 reduction-in-diversity genomic regions,53 selective sweeps,and 30(>1 Mbp)runs of *** accessions collected in southern Italy contained 4.8-fold greater unique alleles per accessions compared to modern hybrids and provide a valuable resource in subsequent improvement *** work broadens the understanding of broccoli germplasm,informs conservation efforts,and enables breeding for complex quality traits and regionally adapted cultivars.

关键词： cultivar germplasm breeding

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Bipolar depression:a review of treatment options

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General Psychiatry 2022年第4期35卷 230-239页

作者： Kate Levenberg zachary A Cordner Psychiatry and Behavioral Sciences Johns Hopkins School of MedicineBaltimoreMarylandUSA

Bipolar depression(BD-D)is both common and incredibly challenging to *** treated individuals with BD-D experience depression approximately 19%of the time,and subsyndromal depression an additional 18%.This stands in clear contrast to the approximately 10%of time spent in hypomania and 1%of time spent in *** this high illness burden,there remain relatively few treatment options approved by the US Food and Drug Administration for *** the approved medications,four are second-generation antipsychotics(SGAs)and one is an SGA combined with an ***,particularly when used long-term,antipsychotics can pose a significant risk of adverse effects,raising the clinical conundrum of weighing the risks associated with longterm antipsychotic use versus the risk of relapse when patients are off ***,we review commonly used treatments for BD-D,including antipsychotics,classic mood stabilisers,electroconvulsive therapy and *** then address the somewhat controversial topic of antidepressant use in ***,we summarise emerging treatment options and highlight ongoing clinical *** hope this review will help compare the risks and benefits of several common and novel options for the treatment of patients with *** doing so,we also hope this review will aid the individualised selection of treatments based on each patient’s history and treatment goals.

关键词： treatment spite approved

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