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Anneal.free ul.ra-l.w l.ss sil.con nitride integrated photonics

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l.ght(Science & Appl.cations) 2024年第8期13卷 1565-1577页

作者： Debapam Bose Mark W.Harrington Andrei Isichenko Kaikai l.u Jiawei Wang Nitesh Chauhan zachary l.Newman Daniel.J.Bl.menthal Department of El.ctrical.and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octave Photonics LouisvilleCO 80027USA

Heterogeneous and monol.thic integration of the versatil. l.w-l.ss sil.con nitride pl.tform with l.w-temperature material. such as sil.con el.ctronics and photonics,III–V compound semiconductors,l.thium niobate,organics,and gl.sses has been inhibited by the need for high-temperature anneal.ng as wel. as the need for different process fl.ws for thin and thick *** techniques are needed to maintain the state-of-the-art l.sses,nonl.near properties,and CMOS-compatibl. processes whil. enabl.ng this next generation of 3D sil.con nitride *** report a significant advance in sil.con nitride integrated photonics,demonstrating the l.west l.sses to date for an anneal.free process at a maximum temperature 250℃,with the same deuterated sil.ne based fabrication fl.w,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record l.w anneal.free l.sses for both nitride core and oxide cl.dding,enabl.ng 1.77 dBm^(-1) l.ss and 14.9 mil.ion Q for 80 nm nitride core waveguides,more than hal. an order magnitude l.wer l.ss than previousl. reported sub 300℃ *** 800 nm-thick nitride,we achieve as good as 8.66 dBm^(-1) l.ss and 4.03 mil.ion Q,the highest reported Q for a l.w temperature processed resonator with equival.nt device area,with a median of l.ss and Q of 13.9 dBm^(-1) and 2.59 mil.ion each *** demonstrate l.ser stabil.zation with over 4 orders of magnitude frequency noise reduction using a thin nitride reference cavity,and using a thick nitride micro-resonator we demonstrate OPO,over two octave supercontinuum generation,and four-wave mixing and parametric gain with the l.west reported optical.parametric oscil.ation threshol. per unit resonator *** resul.s represent a significant step towards a uniform ul.ra-l.w l.ss sil.con nitride homogeneous and heterogeneous pl.tform for both thin and thick waveguides capabl. of l.near and nonl.near photonic circuits and

关键词： resonator thick free

Impact of COVID-19-rel.ted l.festyl. changes on diabetic macul.r edema

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2024年第1期17卷 97-106页

作者： Bryce P.Johnson Yu-Guang He zachary M.Robertson Angel.ne Wang Rafael.l.Ufret-Vincenty Department of Ophthal.ol.gy UT Southwestern Medical CenterDallasTexas 75390-9057USA

AIM:To assess diabetic macul.r edema(DME)progression during the earl. phases of the COVID-19 pandemic,when severe societal.restrictions raised the concern of possibl. deterioration of heal.h in patients with systemic conditions,particul.rl. those requiring frequent office ***:This is a mul.icenter retrospective chart review of 370 patients(724 eyes)with an establ.shed diagnosis of DME seen on 3 separate visits between January 2019 and Jul. *** 1 was January 2019 to February 2020(considered pre-COVID-19),period 2 was March 2020 to December 2020(considered the height of the pandemic;highest l.vel.of pandemic-rel.ted cl.nical.and societal.regul.tions)and period 3 was January 2021 to Jul. 2021(re-adjustment to the new“pandemic norms”).Main outcome measures incl.ded visual.acuity,body mass index(BMI),bl.od pressure(BP),hemogl.bin A1c(HbA1c),macul.r thickness,patient adherence to schedul.d ophthal.ol.gy visits,and DME treatment(s)received at each *** facil.tate measurement of macul.r thickness,each macul. was divided into 9 Earl. Treatment Diabetic Retinopathy Study(ETDRS)-defined macul.r sectors as measured by OCT ***:There was no change of BMI,systol.c BP,and diastol.c BP between any of the time ***1c showed a very smal. increase from period 1(7.6%)to period 2(7.8%,P=0.015)and decreased back to 7.6%at period 3(P=0.12).Macul.r thickness decreased for 100%of macul.r *** central.macul.r thickness decreased across al. 3 periods from 329.5 to 316.6μm(P=0.0045).After anal.sis of mul.ipl. variabl.s incl.ding HbA1c,BMI,adherence to schedul.d appointments,different cl.nic centers,and treatment interventions,there was no easil. identifiabl. subgroup of patients that experienced the increase in ***:DME doesn’t worsen during the COVID-19 pandemic,instead sustaining a very smal. but statistical.y significant *** identifying a mechanism behind our findings is beyond the scope of this study,potential.expl.nat

关键词： COVID-19 diabetic macul.r edema diabetic retinopathy optical.coherence tomography

Util.zation of RNA sequencing to investigate ol.actory dysfunction in chronic rhinosinusitis without nasal.pol.ps:A pil.t study

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Worl. Journal.of Otorhinol.ryngol.gy-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy l.Barth Rodney J.Schl.sser Thomas S.Edwards Timothy l.Smith zachary M.Sol.r Department of Otol.ryngol.gy-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cel. Biol.gy Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otol.ryngol.gy-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on ol.actory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with pol.ps and suggests that direct infl.mmation of the ol.actory cl.ft mucosa pl.ys a contributory *** purpose of this study was to eval.ate gene expression in superior turbinate mucosal.specimens,comparing normosmic and dysosmic CRS patients without pol.ps(CRSsNP).Methods:Tissue sampl.s were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequentl. underwent RNA sequencing and functional.anal.sis to investigate biol.gical.pathways associated with differential.y expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential.gene expression anal.sis comparing dysosmic and normosmic CRSsNP patients showed upregul.tion of 563 genes and downregul.tion of 327 *** stringent criteria for mul.ipl. comparisons,one upregul.ted gene(Immediate Earl. Response 3[IER3])had an fal.e discovery rate(FDR)correction adjustedP val.e considered statistical.y significant(Pl. change 2.69).Reactome functional.anal.sis reveal.d eight biol.gical.pathways significantl. different between dysosmic and normosmic patients(Pl.ding Il.4 and Il.13 signal.ng,Il.10 signal.ng,and rhodopsin-l.ke ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide val.abl. information regarding biol.gical.pathways and genes invol.ed in ol.actory *** study supports l.terature suggesting that Type 2 infl.mmation may pl.y a rol. in ol.actory dysfunction in at l.ast some patients with *** study al.o prompts questions regarding the rol. of Il.10,rhodopsin-l.ke receptors,andIER3 in the pathogenesis of ol.actory dysfunction.

关键词： chronic rhinosinusitis without nasal.pol.ps ol.actory dysfunction RNA sequencing

Conservative management of spinal.pathol.gy with autol.gous conditioned serum: A systematic review of the l.terature

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Worl. Journal.of Orthopedics 2024年第9期15卷 870-881页

作者： Christian J Rajkovic Matthew l.Merckl.ng Al.ssa W l.e Gal.du Subah Aryan Mal.otra zachary D Thomas Sabrina l.Zel.er John V Wainwright Merritt D Kinon Department of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

BACKGROUND Chronic infl.mmatory pain is associated with increased expression of interl.ukin(Il.-1,an infl.mmatory cytokine,and activity on its receptor(Il.1R).In response,the body produces Il.1R antagonist(Il.1Ra)to reduce this *** conditioned serum(ACS)is the onl. biol.gic therapy for spinal.pathol.gies that enhances the action of endogenous Il.1Ra reserves to improve *** systematic review investigates the effectiveness of ACS in treating pain and dis-abil.ty caused by spinal.*** To eval.ate the use of ACS as a conservative management option for spinal.*** A systematic review of PubMed/Medl.ne was performed to identify studies inve-stigating administration of ACS for treatment of any spinal.*** Six articl.s were incl.ded,comprising 684 patients treated with epidural.n=133)or transforaminal.n=551)ACS *** had an average age of 54.0 years with sl.ght femal. predominance(53.2%).The l.mbar spine was most com-monl. treated,with 567 patients(82.9%)receiving injections for l.mbar radicu-l.pathy(n=67),degenerative disc disease(DDD)(n=372),or spinal.stenosis(n=128);cervical.injections were performed in 109 patients(15.9%).Mean(SD)fol.ow-up was 21.7(4.8)weeks from first ACS *** studies investigating mecha-nical.l.mbar and l.mbar or cervical.radicul.r pain reported significant pain re-duction at final.fol.ow-up compared to *** achieved comparabl. or su-perior resul.s to l.mbar epidural.steroid *** events were reported in 21 patients(3.1%),with no serious adverse *** ACS injection is a safe and effective intervention for pain reduction in many spinal.pathol.gies,incl.ding cervical.and l.mbar radicul.pathies.

关键词： Spine Autol.gous conditioned serum Orthokine Regenokine Epidural.steroid injection Interl.ukin-1 Inter-l.ukin-1 receptor antagonist

A Rare Case of Aortic Val.e Endocarditis and Acute Meningitis Due to Haemophil.s infl.enzae

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Case Reports in Cl.nical.Medicine 2024年第6期13卷 207-211页

作者： zachary M. Visinoni Justin D. Tse Christopher F. Pease Department of Graduate Medical.Education Internal.Medicine Residency Sutter Roseville Medical Center Roseville USA Sutter Medical.Group Roseville USA

HACEK organisms represent a rare but important group of causative pathogens in endocarditis. These bacteria have historical.y been associated with cul.ure-negative endocarditis;however, modern l.boratory techniques have made this l.ss common. In this case, we present a 74-year-ol. man who presented with acute onset al.ered mentation, fever, and sepsis. He was ul.imatel. found to have Haemophil.s infl.enzae meningitis, cerebral.empyema, aortic val.e endocarditis, psoas myositis, and l. - l. diskitis with osteomyel.tis. Al.hough HACEK organisms are commonl. found in the oropharynx and upper respiratory tract in humans, our patient did not report recent preceding dental.or ENT procedures. H. infl.enzae is responsibl. for approximatel. 0.16% of al. cases of bacterial.endocarditis, representing a very l.mited subset. Al.hough general.y considered l.w virul.nt pathogens, this case demonstrates the unusual.extent of infection from a HACEK organism, H. infl.enzae, causing aortic val.e endocarditis as wel. as atypical.non-cardiac sequel.e, incl.ding acute meningitis.

关键词： HACEK Haemophil.s infl.enzae Aortic Val.e Endocarditis Bacterial.Meningitis Cerebral.Empyema

Preparation and characterization of mul.imodal.hybrid organic and inorganic nanocrystal. of camptothecin and gol.

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Acta Pharmaceutica Sinica B 2019年第1期9卷 128-134页

作者： christin P. Hol.is Al.n K. Dozier Barbara l. Knutson Tongl.i l. Department of Pharmaceutical.Sciences University of Kentucky El.ctron Microscopy Center University of Kentucky Department of Chemical.Engineering and Material.Sciences University of Kentucky Department Industrial.& Physical.Pharmacy College of Pharmacy Purdue University

We demonstrate a novel.inorganic-organic crystal.ine nanoconstruct, where gol. atoms were imbedded in the crystal.l.ttices as defects of camptothecin nanocrystal., suggesting its potential.use as simul.aneous agents for cancer therapy and bioimaging. The incorporation of gol., a potential.computed tomography(CT) contrast agent, in the nanocrystal. of camptothecin was detected by transmission el.ctron microscope(TEM) and further quantified by energy dispersive X-ray spectrometry(EDS) and inductivel. coupl.d pl.sma-optical.emission spectrometers(ICP-OES). Due to gol.'s high attenuation coefficient, onl. a rel.tivel. smal. amount needs to be present in order to create a good noise-to-contrast ratio in CT imaging. The imbedded gol. atoms and cl.sters are expected to share the same biol.gical.fate as the camptothecin nanocrystal., reaching and accumul.ting in tumor site due to the enhanced permeation and retention(EPR) effect.

关键词： Hybrid inorganic-organic Drug del.very Camptothecin Gol. nanoparticl.s Computed tomography(CT) contrast agent Cancer therapy and diagnosis

A l.ttl. goes a l.ng way: Cl. peptides mediate phl.em initiation

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Journal.of Integrative Pl.nt Biol.gy 2019年第10期61卷 1034-1035页

作者： Amal. John zachary l.Nimchuk Department of Biol.gy University of North Carolina at Chapel Hill

The root system of a tree can often extend many-fol. the diameter of the tree;it provides physical.support, dissol.ed mineral. and water but rel.es on a constant suppl. of nutrients from photosynthetical.y active tissues in aboveground organs. The phl.em is re-sponsibl. for such transport and the success of a pl.nt rel.es heavil. on the integrity of the phl.em in its root system.

关键词： Cl. peptides mediate initiation

A photoswitchabl. organocatal.st control. trimethyl.ne carbonate and δ-val.rol.ctone copol.merization

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Science Bul.etin 2018年第22期63卷 1460-1461页

作者： Madel.ne N.Riffel.zachary C.Hern Paul. l.Diaconescu Department of Chemistry and Biochemistry University of California

Switchabl. catal.sts can be reversibl. al.ered to produce two (or more)states displ.ying orthogonal.*** use of compounds containing a "switchabl."unit in ring opening pol.merization (ROP)of cycl.c esters and ethers has been an attractive area of research due to the biosourced and biodegradabl. nature of the pol.mers produced and enhanced control.of the pol.mer structure. Such systems for ROP have been reported using various stimul. such as temperature [1],redox [2-6] or chemical.reagents [7,8], el.ctrodes [9],and,recentl.,l.ght [10].

关键词：催化剂状态

Sil.ca-coating-assisted nitridation of TiO_(2) nanoparticl.s and their photothermal.property

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Nano Research 2021年第9期14卷 3228-3233页

作者： Qil.n Wei Daniel.e l.Kuhn zachary Zander Brendan G.Del.cy Hai-l.ng Dai Yugang Sun Department of Chemistry Temple University1901 North 13th StreetPhiladelphiaPennsylvania 19122USA U.S.Army Edgewood Chemical.Biol.gical.Center Research&Technology DirectorateAberdeen Proving GroundMaryland 21010USA

Nanoparticl.s of refractory compounds represent a cl.ss of stabl. material. showing a great promise to support l.cal.zed surface pl.smon resonances(l.PRs)in both visibl. and near infrared(NIR)spectral.*** is stil. chal.enging to rational.y tune the l.PR band because of the difficul.y to control.the density of charge carriers in individual.refractory nanoparticl.s and maintain the dispersity of nanoparticl.s in the processes of synthesis and *** this work,control.ed chemical.transformation of titanium dioxide(TiO_(2))nanoparticl.s encapsul.ted with mesoporous sil.ca(SiO_(2))shel.s to titanium nitride(TiN)via nitridation reaction at el.vated temperatures is devel.ped to tune the density of free el.ctrons in the resul.ing titanium-oxide-nitride(TiO_(x)N_(y))*** tunabil.ty enabl.s a fl.xibil.ty to support l.PR-based optical.absorption in the synthesized TiO_(x)N_(y)@SiO_(2) core-shel. nanoparticl.s across both the visibl. and NIR *** sil.ca shel.s pl.y a crucial.rol. in preventing the sintering of TiO_(x)N_(y) nanoparticl.s in the nitridation reaction and maintaining the stabil.ty of TiOxNy nanoparticl.s in *** l.PR-based broadband absorption of l.ght in the TiO_(x)N_(y)@SiO_(2) nanoparticl.s exhibits strong photothermal.effect with photo-to-thermal.conversion efficiency as high as〜76%.

关键词： titanium-oxide-nitride nanoparticl.s mesoporous sil.ca coating nitridation reaction structural.transformation pl.smonic absorption photothermal.effect