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Development of NK cell-based cancer immunotherapies through receptor engineering

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Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey page Nicolas Chuvin Jenny Valladeau-Guilemond Stéphane Depil Centre de Recherche en Cancérologie de Lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance Centre Léon Bérard LyonFrance UniversitéClaude Bernard Lyon 1 LyonFrance

Natural killer(NK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in NK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of NK-mediated recognition and elimination of cancer *** addition,engineering NK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by NK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered NK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of NK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained NK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in NK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： NK cells Cell therapy Receptor engineering CAR

非凡与平凡现代科技可救人一命,也可料理餐食

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空中英语教室（高级版．彭蒙惠英语） 2024年第7期 14-16,40-42页

作者： page DESIGN BY VICKY TSUNG 不详

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可... 详细信息

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可以开创心脏外科手术的新领域,使年轻患者在日后的人生当中免于接受多次高风险的手术。

关键词：心脏移植手术心脏外科手术捐赠者年轻患者新生儿外科医生现代科技

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乐高如何培养客户忠诚度

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 32-33,48页

作者： Jason Aten VICKY TSUNG(page DESIGN) 不详

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱... 详细信息

乐高出现在我们身边已经91年了,而其中的大部分时间,它都是全世界最热门的玩具之一。它也是目前营收额最高的玩具制造商,并且建立了堪称全世界忠诚度最高的粉丝群。顺带一提,那些粉丝可不只有儿童,数以百万计充满热情的成年人仍旧喜爱用乐高积木建造作品。在你可能接触到的所有品牌当中,乐高也许拥有最忠诚的粉丝。

关键词：客户忠诚度粉丝玩具制造商成年人

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从空中发现疾病

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 14-15,41,42页

作者： Grace Toohey OLIVE CHU(page DESIGN) 不详

美国宇航局的植物早期疾病检测技术具有重大潜在效益,新研究发现,美国宇航局的尖端影像技术能够检测-种植物病毒的早期迹象。这种病毒如果没有及时处理,往往会为酿酒厂与葡萄种植者带来严重损失。这项突破对于葡萄酒与葡萄产业而言是好... 详细信息

美国宇航局的植物早期疾病检测技术具有重大潜在效益,新研究发现,美国宇航局的尖端影像技术能够检测-种植物病毒的早期迹象。这种病毒如果没有及时处理,往往会为酿酒厂与葡萄种植者带来严重损失。这项突破对于葡萄酒与葡萄产业而言是好消息一此产业每年因为这种摧毁作物的疾病而损失数十亿美元一一同时,它也有助于全球农业的整体发展。

关键词：植物病毒葡萄种植疾病检测美国宇航局葡萄产业影像技术潜在效益葡萄酒

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你就是专家

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 36-37,50页

作者： Emma Fox OLIVE CHU(page DESIGN) 不详

许多类型的专业人士选择在社交媒体上聚焦他们的职业,有的是为了引起人们对其职业的兴趣、更正错误观念、吸引客户、赚取额外收入,有的只是为了好玩。观众也乐于关注他们。你是否想要迈出那一步来成为线上专家?你想不想和自己领域里的... 详细信息

许多类型的专业人士选择在社交媒体上聚焦他们的职业,有的是为了引起人们对其职业的兴趣、更正错误观念、吸引客户、赚取额外收入,有的只是为了好玩。观众也乐于关注他们。你是否想要迈出那一步来成为线上专家?你想不想和自己领域里的其他专业人士产生联结,并和群众分享资源?下面是一些决窍,告诉你如何利用自己在工作上已经建立的专长来打造个人品牌。

关键词：社交媒体个人品牌专业人士额外收入兴趣更正错误专家职业

Synthesis of phosphonated graphene oxide by electrochemical exfoliation to enhance the performance and durability of high-temperature proton exchange membrane fuel cells

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Journal of Energy Chemistry 2023年第1期76卷 448-458,I0011页

作者： Jianuo Chen Zunmin Guo Maria Perez-page Yifeng Jia Ziyu Zhao Stuart M.Holmes Department of Chemical Engineering and Analytical Science University of ManchesterOxford RoadManchester M139PLUnited Kingdom Chemistry Research Laboratory Department of ChemistryUniversity of Oxford12 Mansfield RoadOxford OX13TAUnited Kingdom

The doping of functionalized graphene oxide(GO)in the membranes becomes a promising method for improving the performance of high-temperature proton exchange membrane fuel cells(HT-PEMFC).Phosphonated graphene oxide(PGO)with a P/O ratio of 8.5%was quickly synthesised by one-step electrochemical exfoliation based on a three-dimensiaonal(3D)printed reactor and natural graphite *** with the GO prepared by the two-step electrochemical exfoliation method,the PGO synthesized by the one-step electrochemical exfoliation can better improve the performance of the membrane-electrode-assembly(MEA)based on the polybenzimidazole(PBI)membrane in the *** doping of 1.5 wt%GO synthesised by electrochemical exfoliation with the 2-step method or reactor method in PBI increased the peak power density by 17.4%or 35.4%compared to MEA based on pure PBI membrane at 150℃,*** addition,the doping of PGO in PBI improves its durability under accelerated stress test(AST).

关键词： Electrochemical exfoliation Phosphonated graphene oxide High-temperature fuel cells

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Turbulence modelling of the aerodynamic interaction ofOGV wakes and diffuser flow

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航空动力学报 2011年第10期26卷 2302-2312页

作者： page Gary McGuirk Jim Department of Aeronautical and Automotive Engineering Loughborough University

Different turbulence closures were used to predict the flow interaction between the wakes created by compressor outlet guide vanes(OGVs) and a downstream annular *** statistical turbulence models were tested based on the classical Reynolds-averaged Navier-Stokes(RANS) *** high-Re and low-Re(Launder-Sharma) versions of the k-ε model were applied to a selected test problem for OGV wake/diffuser *** test problem was specifically chosen because experimentally determined inlet conditions and both profile and performance data were available to validate predictions.A preliminary study was also reported of the more advanced large eddy simulation(LES) *** LES sub-grid-scale(SGS) model was the basic Smagorinsky eddy viscosity assumption,with a Van-Driest damping function for improved capture of near-wall viscous *** between the two RANS models showed little difference in terms of velocity contours at OGV trailing edge and diffuser *** terms of overall diffuser performance(static pressure recovery and total pressure loss coefficients),the high-Re model was shown to agree well with experimental *** preliminary LES study indicates the highly unsteady character of the OGV wake flow,but requires improved treatment of inlet conditions.

关键词： outlet guide vane(OGV) wakes diffuser flow interaction Reynolds-averaged Navier-Stokes(RANS) modelling large eddy simulation(LES) modelling

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近海场址地震活动性及地震动的评定

世界地震工程 1983年第6期 107-113页

作者： Robert a.page 陈达生

序言为了致力于满足国家对能源的需要,正考虑于八十年代在美国边界的许多新的大陆架地区开发石油和天然气。在所考虑的区域中,有一些处于地震活动性强烈的太平洋沿岸。在这些地区实现开发石油和其他矿产资源,需要仔细地评定近海环境的... 详细信息

序言为了致力于满足国家对能源的需要,正考虑于八十年代在美国边界的许多新的大陆架地区开发石油和天然气。在所考虑的区域中,有一些处于地震活动性强烈的太平洋沿岸。在这些地区实现开发石油和其他矿产资源,需要仔细地评定近海环境的地震危险

关键词：地震动地震地震活动性地震定位场址

High-performance polymer electrolyte membranes incorporated with 2D silica nanosheets in high-temperature proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第1期31卷 323-334,I0009页

作者： Zunmin Guo Jianuo Chen Jae Jong Byun Rongsheng Cai Maria Perez-page Madhumita Sahoo Zhaoqi Ji Sarah J.Haigh Stuart M.Holmes Department of Chemical Engineering and Analytical Science The University of ManchesterM139PLUnited Kingdom Department of Materials The University of ManchesterM139PLUnited Kingdom

Silica nanosheets(SN)derived from natural vermiculite(Verm)were successfully incorporated into polyethersulfone-polyvinylpyrrolidone(PES-PVP)polymer to fabricate high-temperature proton exchange membranes(HT-PEMs).The content of SN filler was varied(0.1-0.75 wt%)to study its influence on proton conductivity,power density and *** from the hydroxyl groups of SN that enable the formation of additional proton-transferring pathways,the inorganic-organic membrane displayed enhanced proton conductivity of 48.2 mS/cm and power density of 495 mW/cm^(2) at 150℃ without humidification when the content of SN is 0.25 wt%.Furthermore,exfoliated SN(E-SN)and sulfonated SN(S-SN),which were fabricated by a liquid-phase exfoliation method and silane condensation,respectively,were embedded in PES-PVP polymer matrix by a simple blending *** to the significant contribution from sulfonic groups in S-SN,the membrane with 0.25 wt%S-SN reached the highest proton conductivity of51.5 mS/cm and peak power density of 546 mW/cm^(2) at150℃,48%higher than the pristine PES-PVP *** to unaltered PES-PVP membrane,SN added hybrid composite membrane demonstrated excellent durability for the fuel cell at 150℃.Using a facile method to prepare 2D SN from natural clay minerals,the strategy of exfoliation and functionalization of SN can be potentially used in the production of HT-PEMs.

关键词： Silica nanosheets Vermiculite High-temperature proton exchange membrane Proton conductivity

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