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Structural and molecular features of intestinal strictures in rats with Crohn's-like disease

World Journal of Gastroenterology 2016年第22期22卷 5154-5164页

作者： Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi Department of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged H-6726 Szeged Hungary Avidin Ltd. H-6726 Szeged Hungary

AIm: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn’s disease (CD).mETHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9 (mmP9) and TImP1 mRNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding ***: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells (SmCs). Enhanced caspase 9 expression on day 90 in the SmCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The mRNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of mmP9 and down-regulation of TImP1 were demonstrated. The progressive increase in the amount

关键词： Crohn’ s disease Rat model TGF-beta Intestinal strictures mmP9 TImP1

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Performance test and process parameter optimization of 9FF type square bale straw crusher

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International Journal of Agricultural and Biological Engineering 2021年第3期14卷 232-240页

作者： Jie Zhang Bin Feng Lei Guo Lingzhuo Kong Chao Zhao Xiuzhen yu Wenjie Luo za Kan School of mechanical and Electrical Engineering Shihezi UniversityShihezi 832000XinjiangChina Research Institute of Agricultural mechanization Xinjiang Academy of Agricultural SciencesUrumqi 830091China

In order to solve the problem of low productivity,unqualified segment length and high energy consumption during the process of crushing square bale straw caused by improper operation parameters,a 9FF square bale straw crusher was *** this study,by taking maize straw as the test material,the feeding speed,spindle speed of the crushing device and the state of the crushing device were taken as influence factors,and standard straw length rate,productivity per net working hour(hereinafter referred to as NWH)and energy consumption per ton of product as test indicators,the influence of the factors on the indicators were studied,and tests were carried out on the process of square bale straw *** adopting the single factor test on the effect of the feeding speed,the spindle speed of the crushing device and the state of the crushing device on the test indicators,the suitable range of each factor was determined,*** the orthogonal test method,range method,variance method and comprehensive balance method,the experiment analyzed the significance of the influence of the three factors on various indicators and the order of *** test results showed that:the feeding speed was 5 m/min,spindle speed was 3000 r/min,and the state of the crushing device was a mixing cutter hammer,which was the best parameter combination(A1B1C1)for the processing technology of the square bale forage *** standard straw length rate was 93.7%,and the productivity per NWH was 2.80 t/h,with energy consumption per ton of 4.72 kW·h/t,in which the standard straw length rate and productivity per NWH reached optimal values,and the energy consumption per ton of product was slightly higher than the optimal value in the *** research results can provide a reference for the optimal design of the special crusher for square bale straw.

关键词： square bale straw crusher crushing working parameter optimization performance test

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Alleviated mucosal and neuronal damage in a rat model of Crohn's disease

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World Journal of Gastroenterology 2014年第44期20卷 16690-16697页

作者： Petra Talapka Lajos István Nagy Alexandra Pál marietta Zita Poles Anikó Berkó mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi Department of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged Avidin Ltd.

AIm:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s ***:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of *** samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal *** means of the ulcerated area were measured to evaluate the macroscopic mu-cosal *** density of myenteric neurons was determined on whole mounts by Hu C/Hu D *** oxygenase-1(HO-1)expression was evaluated by molecular biological ***:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental *** widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS *** repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed ***-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints ***,the HO-1protein up-regulation after the second TNBS treatment proved to be *** the third treatment HO-1 protein expression could not be ***:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal *** persistent up-regulation of HO-1 m RNA expression may correlate with this.

关键词： Crohn's disease Experimental rat model Heme oxygenase-1 myenteric neurons Repetitive re-lapsing inflammation

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A Phenomenological Constitutive Law for the Description of Nonlinear Post-yield Behaviour of Glassy Polymers under Different Strain Rate

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宁波大学学报(理工版) 2003年第4期16卷 382-387页

作者： F.za■RI K.WOZNICA m.NA■T ABDELAZIZ Universite des Sciences et Technologies de Lille Ecole Polytechnique Universitaire de Lille Laboratoire de Mecanique de Lille(UMR CNRS 8107)59655 Villeneuve d’Ascq cedex France

In this study, a modelization of the viscoplastic behaviour of amorphous polymers is proposed, from an approach originally developed for metals behaviour at high temperature, in which state variable constitutive equations have been modified. The model includes the effect of strain rate sensitivity, strain softening and strain hardening. A procedure for the identification of model parameters is developed through the use of experimental data from uniaxial tests extracted from the literature, across a variety of strain rates and below the glass transition temperature ( Tg). The numerical algorithm shows that the predictions of this model well describe the intrinsic softening upon yield threshold and the subsequent progressive orientational hardening typical for amorphous glassy polymers.

关键词： viscoplasticity parameters identification glassy polymers behaviour

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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家禽肉品质评估方法研究进展

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中国家禽 2011年第17期33卷 37-42页

作者： m.Petracci E.Baéza 黄正洋(译) 意大利博洛尼亚大学法国农业科学研究院不详

目前,基于不同的原理和设备发展起来的许多方法可用于检测家禽肉品质。当采用这些方法进行检测时,特别要注意分析前的样品准备和分析时的操作标准化。鉴于屠宰后禽肉加工的复杂性以及质量特性,不同的研究和实验室获得的结果并不总是一... 详细信息

目前,基于不同的原理和设备发展起来的许多方法可用于检测家禽肉品质。当采用这些方法进行检测时,特别要注意分析前的样品准备和分析时的操作标准化。鉴于屠宰后禽肉加工的复杂性以及质量特性,不同的研究和实验室获得的结果并不总是一致。因此,为了便于比较,所有研究者都需严格遵从相同的测量程序(标准),文章对家禽肉品质化学和物理物性的检测方法进行综述。

关键词：家禽肉品质评估

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Evaluation and Prediction of Groundwater Quality in the municipality of za-Kpota (South Benin) Using machine Learning and Remote Sensing

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Journal of Water Resource and Protection 2024年第7期16卷 502-522页

作者： Jennifer A. Ahlonsou Firmin m. Adandedji Abdoukarim Alassane Consolas Adihou mama Daouda Laboratoire dHydrologie Applique (Lha) Institut National de lEau (INE) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Centre dExcellence dAfrique pour lEau et lAssainissement (C2EA) University of Abomey-Calavi (UAC) Abomey-Calavi Benin Department of Water Directorate of Zou Water Service Bohicon Benin

Accessing drinking water is a global issue. This study aims to contribute to the assessment of groundwater quality in the municipality of za-Kpota (southern Benin) using remote sensing and machine Learning. The methodological approach used consisted in linking groundwater physico-chemical parameter data collected in the field and in the laboratory using AFNOR 1994 standardized methods to satellite data (Landsat) in order to sketch out a groundwater quality prediction model. The data was processed using QGis (Semi-Automatic Plugin: SCP) and Python (Jupyter Netebook: Prediction) softwares. The results of water analysis from the sampled wells and boreholes indicated that most of the water is acidic (pH varying between 5.59 and 7.83). The water was moderately mineralized, with conductivity values of less than 1500 μs/cm overall (59 µS/cm to 1344 µS/cm), with high concentrations of nitrates and phosphates in places. The dynamics of groundwater quality in the municipality of za-Kpota between 2008 and 2022 are also marked by a regression in land use units (a regression in vegetation and marshland formation in favor of built-up areas, bare soil, crops and fallow land) revealed by the diachronic analysis of satellite images from 2008, 2013, 2018 and 2022. Surveys of local residents revealed the use of herbicides and pesticides in agricultural fields, which are the main drivers contributing to the groundwater quality deterioration observed in the study area. Field surveys revealed the use of herbicides and pesticides in agricultural fields, which are factors contributing to the deterioration in groundwater quality observed in the study area. The results of the groundwater quality prediction models (ANN, RF and LR) developed led to the conclusion that the model based on Artificial Neural Networks (ANN: R2 = 0.97 and RmSE = 0) is the best for groundwater quality changes modelling in the za-Kpota municipality.

关键词： Groundwater Land Use Electrical Conductivity machine Learning za-Kpota

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APPLICATION OF LEAD AS WATER SEALING mATERIAL IN UNDERGROUD mINE

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Acta metallurgica Sinica(English Letters) 1999年第5期12卷 1202-1205页

作者： J. y. Xu1) and T. A. Diany2)1) Central Engineering & Research Institute for Non - Ferrous metallurgical Industries , Beijing 100088 , China2) Chambishi Copper mine , za mbia

The application of lead as tem porary w ater - sealing m aterial for the stan dpipes in under ground mine is reported . It is considered that lead is a good w ater - sealing m aterial in un derground mine , especially for irregular opening with high - pressure rushing w ater . Leadseal is cheap , easy to use and less har m ful to w orkers an d environ m ent and m ay have widerapplication .

关键词： w ater sealing m aterial standpipe lead

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Experimental Analysis and Evaluation of Thermostat Effects on Engine Cooling System

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Journal of Thermal Science 2021年第2期30卷 540-550页

作者： GhaSEmI zaVARAGH hadi KALELI Alirlza SOLmUS Ismail AFShaRI Faraz Department of mechanical Engineering Faculty of Al-ghadirZanjan BranchTechnical and Vocational University(TVU)Tehran 14357Iran Department of Electrical and Electronic Engineering Engineering FacultySamsun UniversitySamsun 55080Turkey Department of mechanical Engineering Ataturk UniversityErzurum 25240Turkey Department of mechanical Engineering Erzurum Technical UniversityErzurum 25240Turkey

Thermostat as a part of engine cooling system has a significant role in the shortening warm-up time and regulating the engine in proper temperature to approach optimal ***,there is not adequate research on this part of the cooling system and its *** this gap and also being used in large scale,this study is intended to evaluate performance and reflex of the wax type thermostat in different engine working *** this regard,performance of engine cooling system was investigated in various engine speeds and loads to reveal positive and negative influences of thermostat on engine cooling efficiency and engine *** to observed results,warm-up period and fuel consumption decrease by using a *** the other hand,however,the temperature oscillation of coolant fluid passing through engine increases sharply,which causes a disruption in the regulating engine temperature and also a possibility of the fluid boiling rises in some regions of the engine that increases the risk of damage in the engine *** temperature,fuel consumption,warm-up duration and emissions were provided and compared in two operation modes,with and without thermostat.

关键词： engine cooling system wax type thermostat warm-up radiator emissions fuel consumption

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膜杂捆料多级破碎机设计与试验

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农业工程学报 2024年第2期40卷 187-195页

作者：严义其坎杂王吉亮陈绍杰杨崇科李佳莉张炳成严伟哲冯震李亚萍石河子大学机械电气工程学院石河子832000 新疆农垦科学院机械装备研究所石河子832003 石河子开发区锐益达机械装备有限公司石河子832003 绿洲特色经济作物生产机械化教育部工程研究中心石河子832000

针对棉田机收膜杂捆料中膜-土-秆分布不均、相互裹绕且体积过大,无法直接进行有效破碎的问题,通过分析膜杂捆料的破碎过程,确定了一种先破捆、再破碎的破碎方案,并设计了一种包含均匀喂料装置、直刀破捆装置、y型甩刀破碎装置的膜杂捆... 详细信息

针对棉田机收膜杂捆料中膜-土-秆分布不均、相互裹绕且体积过大,无法直接进行有效破碎的问题,通过分析膜杂捆料的破碎过程,确定了一种先破捆、再破碎的破碎方案,并设计了一种包含均匀喂料装置、直刀破捆装置、y型甩刀破碎装置的膜杂捆料多级破碎机。以破碎刀辊转速、喂入速度、定刀数量作为主要影响因素,以残膜破碎合格率作为评价指标,进行三因素三水平试验,确定优化参数指标为试验在破碎刀辊转速1 125 r/min;喂入速度为0.012 m/s;定刀数量1个的因素水平下,此时膜杂捆料破碎合格率达到75.15%,满足后续加工工艺要求。该装置的研究对残膜资源化利用关键技术问题具有重要意义和应用价值。

关键词：农业机械试验残膜资源化利用膜杂捆料破碎机器

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