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Hypolipidemic activity of Tamarix articulata Vahl. in diabetic rats

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Journal of Integrative Medicine 2017年第6期15卷 476-482页

作者： morad hebi mohamed eddouks faculty of sciences and techniques errachidia moulay ismail universityBoutalamine52000 Errachidia Morocco

OBJECTIVE： Tamarix articulata Vahl. （Tamaricaceae） is a medicinal plant commonly used in Morocco for the treatment of diabetes mellitus and cardiovascular diseases. The objective of this study was to evaluate the hypolipidemic activity of aqueous extract of T. articulata in normal and streptozotocin （STZ）-induced diabetic rats. Phytochemical analysis as well as determination of polyphenol and flavonoid contents in the aqueous extract of T. articulata was performed. METHODS： The effects of oral administration of aqueous extract of T. articulata （5 mg/kg） on the plasma total cholesterol, triglyceride and high-density lipoprotein cholesterol （HDL-c） concentrations were measured in both normal and STZ-induced diabetic rats. Total phenolic content of the aqueous extract was determined by Folin-Ciocalteu method. In addition, determination of flavonoid content was performed using colorimetric AICI3 method. RESULTS： A single oral administration in diabetic rats induced a significant increase in the HDL-c concentration after 6 h of treatment with T. articulata （5 mg/kg）. The results also demonstrated that the aqueous extract of T. articulata produced a significant decrease of serum total cholesterol after repeated oral administration in diabetic rats （P 〈 0.01）. The total polyphenol and flavonoid contents of T. articulata aqueous extract were equal to 102.50 mg of gallic acid equivalent per gram of extract and 54.83 mg of quercetin equivalent per gram of extract, respectively. CONCLUSION： According to preliminary phytochemical screening of the aerial part of T. articulata, severa classes of chemicals have been found, such as polyphenols, flavonoids, tannins, cyanidins （flavones, catechols）, mucilage, sesquiterpenes, terpenoids and carbohydrates. In conclusion, T. articulata exhibits a hypolipidemic effect in diabetic rats and its beneficial role as hypolipidemic agent should be evaluated in clinical studies.

关键词： hypolipidemic streptozotocin total cholesterol triglycerides flavonoids

Enhanced Chimp Optimization Algorithm Using Attack Defense Strategy and Golden Update Mechanism for Robust COVID-19 Medical Image Segmentation

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Journal of Bionic Engineering 2024年第4期21卷 2086-2109页

作者： Amir Hamza morad Grimes Abdelkrim Boukabou Samira Dib Non Testing Destructive Laboratory Faculty of TechnologyUniversity of Jijel18000JijelAlgeria Laboratory of Renewable Energy Faculty of TechnologyUniversity of Jijel18000JijelAlgeria

Medical image segmentation is a powerful and evolving technology in medical *** fact,it has been identified as a very effective tool to support and accompany doctors in their fight against the spread of the coronavirus(COVID-19).Various techniques have been utilized for COVID-19 image segmentation,including Multilevel Thresholding(MLT)-based meta-heuristics,which are considered crucial in addressing this ***,despite their importance,meta-heuristics have significant ***,the imbalance between exploration and exploitation,as well as premature convergence,can cause the optimization process to become stuck in local optima,resulting in unsatisfactory segmentation *** this paper,an enhanced War Strategy Chimp Optimization Algorithm(WSChOA)is proposed to address MLT *** strategies are incorporated into the traditional Chimp Optimization *** update mechanism that provides diversity in the ***,the attack and defense strategies are incorporated to improve the search space leading to avoiding local *** experimental results were conducted by comparing WSChoA with recent and well-known algorithms using various evaluation metrics such as Feature Similarity Index(FSIM),Structural Similarity Index(SSIM),Peak signal-to-Noise Ratio(PSNR),Standard deviation(STD),Freidman Test(FT),and Wilcoxon Sign Rank Test(WSRT).The results obtained by WSChoA surpassed those of other optimization techniques in terms of robustness and accuracy,indicating that it is a powerful tool for image segmentation.

关键词： Image processing Segmentation Optimization Chimp Golden update mechanism Attack-defense strategy COVID-19

Application of reliability-centered maintenance for productivity improvement of open pit mining equipment:Case study of Sungun Copper Mine

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Journal of Central South University 2014年第6期21卷 2372-2382页

作者： Amin Moniri morad Mohammad Pourgol-Mohammad Javad Sattarvand Department of Mining Engineering Sahand University of Technology Department of Mechanical Engineering Sahand University of Technology

Equipment plays an important role in open pit mining industry and its cost competence at efficient operation and maintenance techniques centered on reliability can lead to significant cost *** application of optimal maintenance process was investigated for minimizing the equipment breakdowns and downtimes in Sungun Copper *** results in the improved efficiency and productivity of the equipment and lowered expenses as well as the increased profit *** field operating data of 10 trucks are used to estimate the failure and maintenance profile for each component,and modeling and simulation are accomplished by using reliability block diagram *** analysis was then conducted to select proper probabilistic model for maintenance *** reliability of the system was evaluated and importance of each component was computed by weighted importance measure *** analysis led to identify the items with critical impact on availability of overall equipment in order to prioritize improvement ***,the availability of trucks was evaluated using Monte Carlo simulation and it is revealed that the uptime of the trucks is around 11000 h at 12000 operation ***,uncertainty analysis was performed to account for the uncertainty sources in data and models.

关键词： operating costs maintenance mining dump truck reliability availability uncertainty

The Odd Log-Logistic Weibull-G Family of Distributions with Regression and Financial Risk Models

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Journal of the Operations Research Society of China 2022年第1期10卷 133-158页

作者： Mahdi Rasekhi Emrah Altun morad Alizadeh Haitham M.Yousof Department of Statistics Malayer UniversityMalayerIran Department of Mathematics Bartin UniversityBartinTurkey Department of Statistics Persian Gulf UniversityBushehrIran Department of Statistics Mathematics and InsuranceBenha UniversityBenhaEgypt

A new generalization of the Weibull-G family is proposed with two extra shape param*** mathematical properties are derived in great *** the Weibull and normal distributions as baseline distributions,two models are *** first model is a location-scale regression model based on a new extension of the Weibull *** second model is a new two-step financial risk model to forecast the daily value at *** flexibility and applicability of the proposed models are investigated by means of five real data sets on the lifetime and financial *** findings of the study show that proposed models work well and produce better results than other well-known models for financial risk modeling and censored lifetime data analysis.

关键词： Odd log-logistic-G family Weibull-G family Regression model Value at risk Simulation Maximum likelihood Financial risk modeling

Generation of Different Classes of Multipartite Entanglement Using Cavity-QED

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Communications in Theoretical Physics 2018年第2期69卷 131-136页

作者： Mustapha Ziane Rachid El Guerbouz Fatima-Zahra Siyouri morad El Baz Equipe Sciences de la Matière et du Rayonnement Département de Physique Faculté des sciences Université Mohammed V Av.Ibn Battouta

Using a system of cavity quantum electrodynamics （QED） we present two schemes for multipartite entan- glement generation. In the first scheme, a three-level atom is interacting with three cavities successively. In the second one, two three-level atoms are interacted with a coherent optical cavity. These protocols allow us to generate the six c/asses of tripartite entanglement （GHZ, W, A-B-C, AB-C, C-AB, and B-AC class states） by controling the interaction time between atoms and cavities. Moreover, they allow us to generate entanglement between the cavity fields degrees of freedom （from the first scheme）, and a mixed entanglement between the cavity field degrees of freedom and the atomic degrees of freedom.

关键词： entanglement coherent states cavity QE-D GHZ states W states

Flexible Global Aggregation and Dynamic Client Selection for Federated Learning in Internet of Vehicles

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Computers, Materials & Continua 2023年第11期77卷 1739-1757页

作者： Tariq Qayyum zouheir Trabelsi Asadullah Tariq Muhammad Ali Kadhim Hayawi Irfan Ud Din College of Information Technology United Arab Emirates UniversityAl Ain17551UAE Department of Computing School of EECSNational University of Sciences and TechnologyIslamabad44000Pakistan College of Technological Innovation Zayed UniversityAbu Dhabi144534UAE Department of Computer Science The Superior UniversityLahore54000Pakistan

Federated Learning(FL)enables collaborative and privacy-preserving training of machine learning models within the Internet of Vehicles(IoV)*** FL effectively tackles privacy concerns,it also imposes significant resource *** traditional FL,trained models are transmitted to a central server for global aggregation,typically in the *** approach often leads to network congestion and bandwidth limitations when numerous devices communicate with the same *** need for Flexible Global Aggregation and Dynamic Client Selection in FL for the IoV arises from the inherent characteristics of IoV *** include diverse and distributed data sources,varying data quality,and limited communication *** employing dynamic client selection,we can prioritize relevant and high-quality data sources,enhancing model *** address this issue,we propose an FL framework that selects global aggregation nodes dynamically rather than a single fixed *** global aggregation ensures efficient utilization of limited network resources while accommodating the dynamic nature of IoV data *** approach optimizes both model performance and resource allocation,making FL in IoV more effective and *** selection of the global aggregation node is based on workload and communication speed ***,our framework overcomes the constraints associated with network,computational,and energy resources in the IoV environment by implementing a client selection algorithm that dynamically adjusts participants according to predefined *** approach surpasses Federated Averaging(FedAvg)and Hierarchical FL(HFL)regarding energy consumption,delay,and accuracy,yielding superior results.

关键词： IoT Federated Learning sensors IoV OMNeT++ edge computing

The Odd Log-Logistic Generalized Gompertz Distribution:Properties,Applications and Different Methods of Estimation

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Communications in Mathematics and Statistics 2020年第3期8卷 295-317页

作者： morad Alizadeh Lazhar Benkhelifa Mahdi Rasekhi Bistoon Hosseini Department of Statistics Persian Gulf UniversityBushehrIran Department of Mathematics and Informatics Larbi Ben M’Hidi UniversityOum El BouaghiAlgeria Department of Statistics Faculty of Mathematical Sciences and StatisticsMalayer UniversityMalayerIran Kermanshah Province Electricity Distribution Company KermanshahIran

We introduce a four-parameter lifetime distribution called the odd log-logistic generalized Gompertz model to generalize the exponential,generalized exponential and generalized Gompertz distributions,among *** obtain explicit expressions for themoments,moment-generating function,asymptotic distribution,quantile function,mean deviations and distribution of order *** method of maximum likelihood estimation of parameters is compared by six different methods of estimations with simulation *** applicability of the new model is illustrated by means of a real data set.

关键词： Odd log-logistic family of distribution Maximum likelihood estimators Least squares estimators Weighted least squares estimators Method of maximum product spacing Percentile estimators

Existence of Solution for a General Class of Strongly Nonlinear Elliptic Problems Having Natural Growth Terms and L^(1)-Data

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Analysis in Theory and Applications 2023年第1期39卷 53-68页

作者： Youssef Akdim morad Ouboufettal LAMA Laboratory Department of MathematicsFaculty of Sciences Dhar El MahrazUniversity Sidi Mohamed Ben AbdellahP.O.Box 1796 Atlas FezMorocco

This paper is concerned with the existence of solution for a general class of strongly nonlinear elliptic problems associated with the differential inclusionβ(u)+A(u)+g(x,u,Du)■f,where A is a Leray-Lions operator from W^(1,p)_(0)(Ω)into its dual,βmaximal monotone mapping such that 0∈β(0),while g(x,s,ξ)is a nonlinear term which has a growth condition with respect toξand no growth with respect to s but it satisfies a signcondition on *** right hand side f is assumed to belong to L^(1)(Ω).

关键词： Sobolev spaces Leray-Lions operator trunctions maximal monotone graphe

Ficus carica hairy roots:In vitro anti-leishmanial activity against Leishmania major promastigotes and amastigotes

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Asian Pacific Journal of Tropical Medicine 2022年第5期15卷 220-229页

作者： Shahla Amani Shahram Khademvatan Mehdi Mohebodini morad Jafari Vinod Kumar Department of Horticulture Sciences University of Mohaghegh ArdabiliArdabilIran Cellular and Molecular Research Center Urmia University of Medical SciencesUrmiaIran Department of Medical Parasitology and Mycology Urmia University of Medical SciencesUrmiaIran Department of Plant Production and Genetics Urmia UniversityUrmiaIran Centre for Climate and Environmental Protection School of WaterEnergy and EnvironmentCranfield UniversityCranfield MK430ALUK

Objective:To investigate the biochemical capacity,and in vitro inhibitory effects of hairy roots from two cultivars of Ficus carica L.(Sabz and Siah)on Leishmania major promastigotes and ***:In the hairy roots,the activity of antioxidant enzymes compared to normal leaves and roots,and the presence of some phenolic compounds in comparison with fruits were *** IC_(50) values of hairy roots in promastigotes was determined by tetrazolium-dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and trypan blue *** calculating the infectivity index of peripheral blood mononuclear cells(PBMCs),the leishmanicidal activity(IC_(50) values)of hairy roots for amastigotes was *** effects of hairy roots(IC_(50) values)treatment on the levels of IFN-γ and iNOS expression,intracellular reactive oxygen species,and iNOS protein expression in infected-PBMCs were ***:Based on antioxidant enzyme assays and high performance liquid chromatography analysis,hairy roots exhibited high antioxidant capacity and contained high levels of phenolic *** to the results of tetrazolium-dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and trypan blue assays,the hairy root extracts of both cultivars showed considerable dose-dependent inhibitory effects against Leishmania major *** on the concentration and exposure time,treatment of infected-PBMCs with hairy root extracts caused the generation of a significant reactive oxygen species,up-regulation of IFN-γ and iNOS genes expression,and high value of iNOS protein compared to ***:The findings of this study suggest that the hairy roots of Ficus carica can be considered as a promising natural source of antileishmanial agents.

关键词： Antileishmanial agents Hairy roots,IFN-γ Inducible nitric oxide synthase Parasite Reactive oxygen species