Hypolipidemic activity of Tamarix articulata Vahl. in diabetic rats

作     者：morad hebi mohamed eddouks Morad Hebi;Mohamed Eddouks

作者机构：faculty of sciences and techniques errachidiamoulay ismail universityBoutalamine52000 Errachidia Morocco 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2017年第15卷第6期

页      面：476-482页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the CNRST under grant N PPR/2015/35 

主　　题：hypolipidemic streptozotocin total cholesterol triglycerides flavonoids 

摘      要：OBJECTIVE： Tamarix articulata Vahl. （Tamaricaceae） is a medicinal plant commonly used in Morocco for the treatment of diabetes mellitus and cardiovascular diseases. The objective of this study was to evaluate the hypolipidemic activity of aqueous extract of T. articulata in normal and streptozotocin （STZ）-induced diabetic rats. Phytochemical analysis as well as determination of polyphenol and flavonoid contents in the aqueous extract of T. articulata was performed. METHODS： The effects of oral administration of aqueous extract of T. articulata （5 mg/kg） on the plasma total cholesterol, triglyceride and high-density lipoprotein cholesterol （HDL-c） concentrations were measured in both normal and STZ-induced diabetic rats. Total phenolic content of the aqueous extract was determined by Folin-Ciocalteu method. In addition, determination of flavonoid content was performed using colorimetric AICI3 method. RESULTS： A single oral administration in diabetic rats induced a significant increase in the HDL-c concentration after 6 h of treatment with T. articulata （5 mg/kg）. The results also demonstrated that the aqueous extract of T. articulata produced a significant decrease of serum total cholesterol after repeated oral administration in diabetic rats （P 〈 0.01）. The total polyphenol and flavonoid contents of T. articulata aqueous extract were equal to 102.50 mg of gallic acid equivalent per gram of extract and 54.83 mg of quercetin equivalent per gram of extract, respectively. CONCLUSION： According to preliminary phytochemical screening of the aerial part of T. articulata, severa classes of chemicals have been found, such as polyphenols, flavonoids, tannins, cyanidins （flavones, catechols）, mucilage, sesquiterpenes, terpenoids and carbohydrates. In conclusion, T. articulata exhibits a hypolipidemic effect in diabetic rats and its beneficial role as hypolipidemic agent should be evaluated in clinical studies.