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慢性牙周炎与帕金森病之间潜在相关性的初探

华西口腔医学杂志 2024年第4期42卷 521-530页

作者：杨荣霞宗颖睿张晨郑州大学第一附属医院口腔综合科郑州450052

目的探讨慢性牙周炎(CP)和帕金森病(PD)之间潜在的核心基因、相关通路和转录因子。方法从基因表达综合(GEO)数据库下载CP(GSE16134、GSE23586和GSE10334)和PD(GSE20141和GSE49036)的基因表达谱进行差异表达分析、功能聚类分析,并构建蛋... 详细信息

目的探讨慢性牙周炎(CP)和帕金森病(PD)之间潜在的核心基因、相关通路和转录因子。方法从基因表达综合(GEO)数据库下载CP(GSE16134、GSE23586和GSE10334)和PD(GSE20141和GSE49036)的基因表达谱进行差异表达分析、功能聚类分析,并构建蛋白质相互作用(PPI)网络,通过4种拓扑分析算法和模块划分筛选出核心基因,进行转录因子的预测及功能聚类分析。通过CP和PD的外部数据集对核心基因进行验证,并通过双本孟德尔随机化(MR)进一步评估二者的因果关系。结果合并数据后,CP数据集共筛选出1211个差异表达基因(DEG),其中551个上调,660个下调,PD数据集共筛选出2407个DEG,其中1438个上调,969个下调;PPI网络包括145个节点和126条边,最终筛选出4个核心基因,分别为FCGR3B、PRF1、IL18和CD33;预测的转录因子包括HSF1、HSF2和HSF4;相关通路主要为自然杀伤细胞(NK)介导的细胞毒性作用;MR结果表明,CP与PD的发病风险可能呈正向因果关系。结论本研究探索了CP和PD的潜在共同发病机制及可能的因果关系,为进一步的机制研究提供新思路,预测的转录因子为可能的治疗靶点提供新见解。

关键词：慢性牙周炎帕金森病核心基因转录因子孟德尔随机化

Enhancing the Efficiency and Durability of Perovskite Solar Cells by Donor-Acceptor Covalent Organic Framework with Thiazolo[5,4-d]thiazole Unit

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CCS Chemistry 2024年第7期6卷 1721-1730页

作者： Liyi Yao Shuainan Liu Lin Li Bangdi Ge Wenyu Jiao Siyu zong Xiaowei Song Donglei Zhou Zhiqiang Liang State Key Lab of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012 State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012 Electron Microscopy Center Jilin UniversityChangchun 130012

Donor-Acceptor(D-A)alignment is considered a productive strategy to improve the charge separation efficiency of covalent organic frameworks(COFs)and enhance the charge-transfer yield(CTY)of ***,organic molecules containing heteroatoms can produce coordination interaction with PbI2 of perovskite precursor to affect the crystallization process,thereby impeding the decomposition and improving the stability of perovskite ***,a thiazolo[5,4-d]thiazole(TZ)-based D-A type COF_(TPDA-TZDA) was designed and synthesized from N,N,N′,N′-tetrakis(4-aminophenyl)-1,4-benzenediamine(TPDA)and 4,4′-(thiazolo[5,4-d]thiazole-2,5-diyl)dibenzaldehyde(TZDA).Upon incorporation into the FAPbI3 layer,COF_(TPDA-TZDA) not only restrained the perovskite defects and enhanced the grain size of perovskite films through the coordination effect of the N atoms of TZDA but also ameliorated the charge transport within the perovskite film,which was the benefit of the D-A structure of COF_(TPDA-TZDA).As a result,incorporation of COF_(TPDA-TZDA) into the perovskite solar cells(PSCs)led to a remarkable power conversion efficiency(PCE)of up to 23.51%.Furthermore,even after being stored in high relative humidity(RH≈60%)for 480 h,these PSCs maintained over 90.55%of their original *** work sets the foundation for the development of highly efficient and stable PSCs by utilizing TZ-based D-A type COFs.

关键词： thiazolo[5,4-d]thiazole perovskite solar cells donor-acceptor covalent organic frameworks charge-transfer

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抗真菌药物在儿科的临床应用

中华儿科杂志 2005年第9期43卷 714-717页

作者：董宗祈武汉市儿童医院内科 430016

在儿科,深部真菌感染、尤其是免疫功能低下患儿的机会性真菌感染的患病率不断上升,使真菌病的治疗面临严峻挑战.众所周知的念珠菌属是常见院内感染致病菌,曲霉菌属既见于院内感染亦见于社区感染,此外,尚有隐球菌病等.以往的药物治疗都... 详细信息

在儿科,深部真菌感染、尤其是免疫功能低下患儿的机会性真菌感染的患病率不断上升,使真菌病的治疗面临严峻挑战.众所周知的念珠菌属是常见院内感染致病菌,曲霉菌属既见于院内感染亦见于社区感染,此外,尚有隐球菌病等.以往的药物治疗都不够理想.近年来,不少新的抗真菌药物相继问世,给真菌病治疗带来转机,但在儿科的临床应用方面经验不多,远不如其他抗生素使用经验丰富.特别是某些抗真菌药尚缺少儿科用药的规范剂量,对患儿也未全面观察毒副反应.为了进一步规避风险,深入了解抗真菌药物的作用特点,做到及时合理的治疗,恰当客观评价抗真菌药物在儿科的应用和疗效,已成为临床用药的研究热点.

关键词：抗真菌药物儿科用药临床应用深部真菌感染免疫功能低下药物治疗院内感染抗生素使用念珠菌属

A Novel Line Segments Extraction Algorithm Based on DBSCAN Method

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A Novel Line Segments Extraction Algorithm Based on DBSCAN M...

基于广义卡尔曼滤波的飞机防滑刹车变结构控制

第19届中国系统仿真技术及其应用学术年会

作者：王纪凯 Chen zong-hai Department of Automation University of Science and Technology of China

Line-segment extraction from a single observation is an important issue for mobile robot implementing SLAM in structured *** paper proposes a novel line-segment extraction algorithm which is carried out in three steps:First,detect breakpoints and segment the laser ***,calculate the orientation angle of two adjacent points in each segmentation according to sample order and cluster the orientation angle set using DBSCAN ***,establish the correspondence between points and line-segments and extract *** clustering procedure enables our method to extract breakpoints and corners *** experimental results have shown that our method can handle the uncertainty of observation and extract line-segments with high accuracy and robustness.

关键词： Line-Segment Orientation Angle DBSCAN Method

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系统仿真学报 2007年第3期19卷 585-588,592页

作者：李波焦宗夏北京航空航天大学自动化科学与电气工程学院北京100083

飞机防滑刹车控制的关键是控制机轮的滑移率,为了使机轮工作在最佳滑移率,得到最大结合系数,提出了一种基于滑移率控制的防滑刹车变结构控制律。由于飞机滑跑时的真实速度很难测量,为此采用广义卡尔曼滤波器得到飞机刹车系统非线性模型... 详细信息

飞机防滑刹车控制的关键是控制机轮的滑移率,为了使机轮工作在最佳滑移率,得到最大结合系数,提出了一种基于滑移率控制的防滑刹车变结构控制律。由于飞机滑跑时的真实速度很难测量,为此采用广义卡尔曼滤波器得到飞机刹车系统非线性模型的状态估计,状态估计值作为防滑刹车控制器的输入。计算机仿真结果显示该控制律改善了飞机的防滑刹车性能,具有较强的鲁棒性。

关键词：防滑刹车滑移率结合系数变结构控制广义卡尔曼滤波器

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杏鲍菇多糖抗运动性疲劳机制

中国食用菌 2020年第3期39卷 37-40页

作者：向超宗杨小庆重庆大学城市科技学院重庆402167 重庆工商职业学院智能制造与汽车学院重庆401520

以昆明鼠为试验动物,将小鼠分为4组,对照组灌胃生理盐水,低剂量组、中剂量组、高剂量组分别灌胃50 mg·kg^-1d^-1、100 mg·kg^-1d^-1、200 mg·kg^-1d^-1的杏鲍菇(Pleurotus eryngii)多糖溶液,进行爬杆试验和负重游泳试验,并测定相关... 详细信息

以昆明鼠为试验动物,将小鼠分为4组,对照组灌胃生理盐水,低剂量组、中剂量组、高剂量组分别灌胃50 mg·kg^-1d^-1、100 mg·kg^-1d^-1、200 mg·kg^-1d^-1的杏鲍菇(Pleurotus eryngii)多糖溶液,进行爬杆试验和负重游泳试验,并测定相关生化指标。结果显示低剂量组、中剂量组、高剂量组的爬杆和游泳时间均比对照组有延长,差异显著(P<0.05),超氧化物歧化酶活性及肝糖原含量高于对照组,血乳酸含量低于对照组,均有显著性差异(P<0.05),表明杏鲍菇多糖能够增强运动耐力,有抗运动性疲劳作用。

关键词：食用菌多糖杏鲍菇多糖抗运动性疲劳疲劳机制

Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus:An observational study

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World Journal of Gastroenterology 2021年第19期27卷 2394-2414页

作者： Xia Liu Yi-Wen Cheng Li Shao Shu-Hong Sun Jian Wu Qing-Hai Song Hong-Sheng Zou zong-Xin Ling Department of Intensive Care Unit Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Institute of Hepatology and Metabolic Diseases Hangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina Institute of Translational Medicine The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310000Zhejiang ProvinceChina Department of Laboratory Medicine Linyi People’s HospitalLinyi 276000Shandong ProvinceChina Department of Geriatrics Lishui Second People's HospitalLishui 323000Zhejiang ProvinceChina Department of Intensive Care Unit People’s Hospital of RongchengRongcheng 264300Shandong ProvinceChina

BACKGROUND Gut microbiota dysbiosis is reportedly actively involved in autoimmune diseases such as type 1 diabetes mellitus(T1DM).However,the alterations in the gut microbiota and their correlation with fasting blood glucose(FBG)in Chinese children with T1DM remain *** To investigate alterations in the gut microbiota in Chinese children with T1DM and their associations with clinical *** Samples from 51 children with T1DM and 47 age-matched and gender-matched healthy controls were obtained,to explore the structural and functional alterations in the fecal *** V3-V4 regions of the 16S rRNA gene were sequenced on a MiSeq instrument,and the association with FBG were *** We found that the bacterial diversity was significantly increased in the T1DMassociated fecal microbiota,and changes in the microbial composition were observed at different taxonomic *** T1DM-reduced differential taxa,such as Bacteroides vulgatus ATCC8482,Bacteroides ovatus,Bacteroides xylanisolvens,and Flavonifractor plautii,were negatively correlated with FBG,while the T1DMenriched taxa,such as Blautia,Eubacterium hallii group,Anaerostipes hadrus,and Dorea longicatena,were positively correlated with *** vulgatus ATCC8482,Bacteroides ovatus,the Eubacterium hallii group,and Anaerostipes hadrus,either alone or in combination,could be used as noninvasive diagnostic biomarkers to discriminate children with T1DM from healthy *** addition,the functional changes in the T1DM-associated fecal microbiota also suggest that these fecal microbes were associated with altered functions and metabolic activities,such as glycan biosynthesis and metabolism and lipid metabolism,which might play vital roles in the pathogenesis and development of *** Our present comprehensive investigation of the T1DM-associated fecal microbiota provides novel insights into the pathogenesis of the disease and sheds light on the diagnosis and treatment of T1D

关键词： Dysbiosis Fasting blood glucose Sequencing Metabolism Type 1 diabetes mellitus

Digital subtraction angiographic characteristics of progression of moyamoya disease 6 months prior to surgical revascularisation

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Stroke & Vascular Neurology 2020年第1期5卷 97-102页

作者： Peicong Ge Qian Zhang Xun Ye Xingju Liu Xiaofeng Deng Jia Wang Rong Wang Yan Zhang Dong Zhang Ji zong Zhao Department of Neurosurgery Beijing Tiantan HospitalBeijingChina

background Evidence on the natural angiographic course of moyamoya disease(MMD)is *** takes about 6 months for waiting for revascularisation *** issue of when to perform subtraction angiography(DSA)for follow-up remains *** investigated the natural course of MMD by DSA and attempted to determine the best interval to perform the follow-up *** This is a single-centre cohort study of Chinese MMD inpatients treated from 1 January 2015 to 31 August *** angiographic findings were evaluated on Suzuki stage and collateral circulation between two follow-ups of the same *** A total of 110 patients who met the criteria were enrolled in this *** a median 6 months follow-up,five patients(4.5%)had progression,four females and one *** interval of progression ranged from 4 to 137 months with a mean of 61.4 *** five patients with progression,four had unilateral lesion(two ipsilateral and two contralateral)and one had bilateral *** circulation was changed in three of five *** The angiographic evidence of progression in MMD was rare in the short-term follow-up,and most patients with progression had initial unilateral *** re-examination may be not needed in patients with bilateral MMD,but needed in unilateral MMD.

关键词： involvement progression characteristics

Advances and perspectives in discovery and functional analysis of small secreted proteins in plants

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Horticulture Research 2021年第1期8卷 1618-1631页

作者： Xiao-Li Hu Haiwei Lu Md Mahmudul Hassan Jin Zhang Guoliang Yuan Paul E.Abraham Him K.Shrestha Manuel I.Villalobos Solis Jin-Gui Chen Timothy J.Tschaplinski Mitchel J.Doktycz Gerald A.Tuskan zong-Ming(Max)Cheng Xiaohan yang Department of Plant Sciences University of TennesseeKnoxvilleTNUSA Biosciences Division Oak Ridge National LaboratoryOak RidgeTNUSA State Key Laboratory of Subtropical Silviculture School of Forestry and BiotechnologyZhejiang A&F UniversityHangzhouZhejiangChina The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTNUSA Department of Genome Science and Technology University of TennesseeKnoxvilleTNUSA College of Horticulture Nanjing Agricultural UniversityNanjingJiangsuChina

Small secreted proteins(SSPs)are less than 250 amino acids in length and are actively transported out of cells through conventional protein secretion pathways or unconventional protein secretion *** plants,SSPs have been found to play important roles in various processes,including plant growth and development,plant response to abiotic and biotic stresses,and beneficial plant–microbe *** the past 10 years,substantial progress has been made in the identification and functional characterization of SSPs in several plant species relevant to agriculture,bioenergy,and ***,there are potentially a lot of SSPs that have not been discovered in plant genomes,which is largely due to limitations of existing computational *** advances in genomics,transcriptomics,and proteomics research,as well as the development of new computational algorithms based on machine learning,provide unprecedented capabilities for genome-wide discovery of novel SSPs in *** this review,we summarize known SSPs and their functions in various plant *** we provide an update on the computational and experimental approaches that can be used to discover new ***,we discuss strategies for elucidating the biological functions of SSPs in plants.

关键词： species functional dating