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Polylactic acid micro/nanoplastic-induced hepatotoxicity: Investigating food and air sources via multi-omics

Environmental Science and Ecotechnology 2024年第5期21卷 294-308页

作者： hua zha Shengyi Han Ruiqi Tang Dan Cao Kevin Chang Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Statistics The University of AucklandAucklandNew Zealand

Micro/nanoplastics(MNPs)are detected in human liver,and pose significant risks to human *** exposure to MNPs derived from non-biodegradable plastics can induce toxicity in mouse ***,nasal exposure to non-biodegradable plastics can cause airway dysbiosis in ***,the hepatotoxicity induced by foodborne and airborne biodegradable MNPs remains poorly *** we show the hepatotoxic effects of biodegradable polylactic acid(PLA)MNPs through multi-omics analysis of various biological samples from mice,including gut,fecal,nasal,lung,liver,and blood *** results show that both foodborne and airborne PLA MNPs compromise liver function,disrupt serum antioxidant activity,and cause liver ***,foodborne MNPs lead to gut microbial dysbiosis,metabolic alterations in the gut and serum,and liver transcriptomic *** MNPs affect nasal and lung microbiota,alter lung and serum metabolites,and disrupt liver *** gut Lachnospiraceae_NK4A136_group is a potential biomarker for foodborne PLA MNP exposure,while nasal unclassified_Muribaculaceae and lung Klebsiella are potential biomarkers for airborne PLA MNP *** relevant results suggest that foodborne PLA MNPs could affect the“gut microbiota-gutliver”axis and induce hepatoxicity,while airborne PLA MNPs could disrupt the“airway microbiota-lungliver”axis and cause *** findings have implications for diagnosing PLA MNPs-induced hepatotoxicity and managing biodegradable materials in the *** current study could be a starting point for biodegradable MNPs-induced *** research is needed to verify and inhibit the pathways that are crucial to MNPs-induced hepatotoxicity.

关键词： Micro/nanoplastics Hepatotoxicity Microbiota dysbiosis Metabolic disruption Transcriptomic dysregulation

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The coupling control of biological precursors and environmental factors onβ-carotane enrichment in alkaline lacustrine source rocks:A case study from the Fengcheng formation in the western Junggar Basin,NW China

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Petroleum Science 2024年第2期21卷 836-854页

作者： Mao-guo Hou Ming zha hua Liu Hai-Lei Liu Jiang-Xiu Qu Ablimit Imin Xiu-Jian Ding Zhong-Fa Jiang School of geosciences China University of PetroleumQingdaoShandong266580China Research Institute of Exploration and Development Xinjiang Petroleum Administration BureauKaramayXinjiang834000China

The organic-rich mudstones and dolostones of the Permian Fengcheng Formation(Fm.)are typically alkaline lacustrine source rocks,which are typified by impressively abundantβ-*** β-carotane has been well acknowledged as an effective indicator of biological sources or depositional ***,the specific biological sources of β-carotane and the coupling control of biological sources and environmental factors on the enrichment of β-carotane in the Fengcheng *** *** on a comprehensive investigation of the bulk,molecular geochemistry,and organic petrology of sedimentary rocks and the biochemistry of phytoplankton in modern alkaline lakes,we proposed a new understanding of the biological precursors of β-carotane and elucidated the enrichment mechanism of β-carotane in the Fengcheng *** results show that the biological precursors crucially control the enrichment of β-carotane in the Fengcheng *** haloalkaliphilic cyanobacteria are the primary biological sources of β-carotane,which is suggested by a good positive correlation between the 2-methylhopane index,7-+8-methyl heptadecanes/C_(max),C_(29%),and β-carotane/C_(max)in sedimentary rocks and the predominance of cyanobacteria with abundantβ-carotene in modern alkaline *** enrichment of β-carotane requires the reducing condition,and the paleoredox state that affects the enrichment of β-carotane appears to have a *** paleoclimate conditions do not considerably impact the enrichment of β-carotane,but they have some influence on the water's paleosalinity by affecting evaporation and *** it does not directly affect the enrichment of β-carotane in the Fengcheng Fm.,paleosalinity does have an impact on the cyanobacterial precursor supply and the preservation conditions.

关键词： β-carotane enrichment Cyanobacterial input Environmental impact Alkaline lacustrine source rocks The Fengcheng formation

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Simultaneous control of ferromagnetism and ferroelasticity by oxygen octahedral backbone stretching

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Chinese Physics B 2024年第9期33卷 186-192页

作者： genhao Liang Hui Cao Long Cheng Junkun zha Mingrui Bao Fei Ye hua Zhou Aidi zhao Xiaofang zhai Department of Physics University of Science and Technology of ChinaHefei 230026China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Materials Science Division Argonne National LaboratoryLemontIL 60439USA X-ray Science Division Advanced Photon SourceArgonne National LaboratoryLemontIL 60439USA

Coexistence of ferromagnetism and ferroelasticity in a single material is an intriguing phenomenon,but has been rarely *** we studied both the ferromagnetism and ferroelasticity in a group of LaCoO3 films with systematically tuned atomic *** found that all films exhibit ferroelastic domains with four-fold symmetry and the larger domain size(higher elasticity)is always accompanied by stronger *** performed synchrotron x-ray diffraction studies to investigate the backbone structure of the CoO6 octahedra,and found that both the ferromagnetism and the elasticity are simultaneously enhanced when the in-plane Co–O–Co bond angles are *** the study demonstrates the inextricable correlation between the ferromagnetism and ferroelasticity mediated through the octahedral backbone structure,which may open up new possibilities to develop multifunctional materials.

关键词： perovskite oxide film ferromagnetism ferroelasticity twin domain

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The interventional effect of Polygonatum cyrtonema hua polysaccharide on atherosclerosis in mice of different sexes

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Food Science and Human Wellness 2024年第1期13卷 370-380页

作者： Anjun guo Xueying Li Lihua Pan Qiangming Li Jianping Luo Xueqiang zha Engineering Research Centre of Bioprocess of Ministry of Education Hefei University of TechnologyHefei 230009China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes Hefei University of TechnologyHefei 230009China

In the present study,we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide(PCP)on high-fat diet(HFD)-induced atherosclerosis in male and female LDLr-/-*** showed that HFD caused severe dyslipidemia,atherosclerotic lesions,oxidative damages and inflammation in male and female mice,and these effects seemed to be more pronounced in males than in ***,the above variations could be dose-dependently reversed by PCP treatment,and the intervention effects on males were greater than those on *** factor kappa-B(NF-κB),mitogen-activated protein kinase(MAPKs)and protein kinase B(Akt)are 3 pivotal signaling pathways mediating the development of ***,PCP was also found to significantly decrease the phosphorylation of p65,p38,extracellular-regulated kinase 1/2(ERK1/2)and Akt,and increase the protein expression of inhibitor of NF-κB(IκB)in the aortas of male and female mice induced by *** together,these findings indicated that PCP could be effective for the prevention of atherosclerosis,and the intervention effect of PCP on male mice was more obvious than that of female mice.

关键词： Polygonatum cyrtonema polysaccharide Anti-atherosclerosis Sex

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温压耦合作用下锚固界面变形失效机理

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工程科学与技术 2024年第4期56卷 108-119页

作者：刘小虎姚直书程桦查文华安徽理工大学土木建筑学院安徽淮南232000 安徽理工大学矿山地下工程教育部工程研究中心安徽淮南232001 东华理工大学土木与建筑工程学院江西南昌330013

深部地层高地温、高地应力环境使巷道围岩树脂锚固支护结构稳定性降低,围岩变形有效控制问题亟待解决。因此,研究温度与压力耦合作用下锚杆杆体-树脂锚固剂界面变形破坏机理十分必要。首先,根据两淮矿区深部支护工程现状并结合室内不同... 详细信息

深部地层高地温、高地应力环境使巷道围岩树脂锚固支护结构稳定性降低,围岩变形有效控制问题亟待解决。因此,研究温度与压力耦合作用下锚杆杆体-树脂锚固剂界面变形破坏机理十分必要。首先,根据两淮矿区深部支护工程现状并结合室内不同温度环境下拉拔试验结果,发现高地温环境下树脂锚固体变形破坏加剧;进一步分析锚固体受拉拔荷载作用轴向、径向破坏模式,将第一锚固界面破坏分为弹性围岩-剪切-滑移型、未贯穿-剪胀滑移破坏及贯穿-剪胀滑移破坏等3种模式。其次,基于弹塑力学分析受围岩应力作用锚固界面不同破坏类型的界面受力状态,考虑高温环境下树脂锚固剂层力学强度弱化,建立温度-围岩应力耦合作用的第一界面失效破坏力学计算模型;分析围岩应力、环境温度及弹性模量比等因素变化对第一界面锚固性能影响的规律,发现第一界面极限轴向荷载随温度升高而降低,围岩处于裂隙发育或裂隙贯穿状态时,围岩应力对第一锚固界面剪切破坏影响程度较未产生裂隙时大幅度增高。最后,结合室内拉拔试验数据对比验证所推导计算方程式的合理性。研究可为深部巷道围岩稳定性控制及锚固支护参数设计提供理论依据。

关键词：温度-压力耦合树脂锚固体锚固界面失效机理因素分析

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替加环素和多黏菌素B治疗重症患者耐碳青霉烯类肠杆菌科细菌肺炎的疗效和安全性分析

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中国临床药理学与治疗学 2024年第2期29卷 154-163页

作者：查娴陈大宇邵华东南大学附属中大医院药学部江苏南京210009 南京大学医学院附属鼓楼医院药学部江苏南京210009

目的:比较替加环素和多黏菌素B治疗重症患者耐碳青霉烯类肠杆菌科细菌(CRE)肺炎的疗效和安全性。方法:回顾性分析2018年1月1日至2023年6月30日于我院重症医学科(ICU)接受替加环素或多黏菌素B治疗的CRE肺炎患者的临床资料。主要结局包括2... 详细信息

目的:比较替加环素和多黏菌素B治疗重症患者耐碳青霉烯类肠杆菌科细菌(CRE)肺炎的疗效和安全性。方法:回顾性分析2018年1月1日至2023年6月30日于我院重症医学科(ICU)接受替加环素或多黏菌素B治疗的CRE肺炎患者的临床资料。主要结局包括28 d全因病死率和28 d临床治愈率。次要结局包括ICU病死率、住院病死率、住院时间、ICU住院时间、微生物清除率、机械通气时间。采用Cox回归分析检验影响28 d临床治愈率的独立预测因素。结果:倾向性评分匹配后纳入83名患者,其中替加环素组54例,多黏菌素B组29例。替加环素组28 d全因病死率为31.5%(17/54),多黏菌素B组为37.9%(11/29),差异无统计学意义(P=0.554);替加环素组28 d临床治愈率为63%(34/54),显著高于多黏菌素B组的34.5%(10/29)(P=0.013)。两组的次要结局指标均无统计学差异。多因素回归分析发现,使用替加环素是28 d临床治疗有效的独立预测因素(HR:2.083,95%CI 1.018-4.263,P=0.045)。但替加环素组用药后活化部分凝血活酶时间、凝血酶原时间较多黏菌素B组显著延长(P=0.047;P=0.027),纤维蛋白原显著下降(P<0.001)。结论:替加环素组和多黏菌素组28 d全因病死率无显著差异;与多黏菌素B相比,替加环素可能与更高的28 d临床治愈率相关。同时需注意,替加环素可能增加凝血功能异常的风险。

关键词：替加环素多黏菌素B 肺炎耐碳青霉烯类肠杆菌科细菌

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Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou Ying Hu hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu guisen Li gang Xu Chunbo Chen huafeng Liu Yongjun Shi Yan zha Yaozhong Kong guobin Su Ying Tang Mengchun gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

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环境湿度影响人工催化消减雨效果的数值模拟研究

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大气科学 2024年第2期48卷 572-584页

作者：花少烽查思佳陈宝君中国气象局云降水物理与人工影响天气重点开放实验室北京100081 中国气象局人工影响天气中心北京100081 上海市金山区气象局上海201508

利用耦合了碘化银催化过程的WRF(Weather Research and Forecast)模式,对2014年8月16日南京青奥会开幕式当天实施的人工催化作业开展数值模拟,评估催化效果并通过敏感性数值试验调查低空环境干层对催化效果的影响。结果表明,催化作业产... 详细信息

利用耦合了碘化银催化过程的WRF(Weather Research and Forecast)模式,对2014年8月16日南京青奥会开幕式当天实施的人工催化作业开展数值模拟,评估催化效果并通过敏感性数值试验调查低空环境干层对催化效果的影响。结果表明,催化作业产生了减雨效果,低空干区的存在是影响催化效果的关键。当低空存在深厚的相对湿度很小的干层时,催化导致减雨效果;当增加低层的相对湿度即弱化低空干层,催化减雨效果减弱甚至出现增雨效果。催化增强了雪的形成过程但减弱了雪的增长过程尤其是凝华增长,导致雪粒子浓度增加但粒径减小,融化产生更多的小雨滴增强了蒸发过程,最终导致地面降水减少。

关键词：人工消减雨碘化银催化环境干层雪融化雨蒸发

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多三相分布式绕组和集中式绕组永磁磁阻电机对比研究

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电工技术学报 2024年第10期39卷 2984-2994页

作者：汪波徐文翰查陈诚刘朝辉程明花为东南大学电气工程学院南京210096 国家新能源汽车技术创新中心北京100176

利用磁阻转矩替代永磁转矩,永磁磁阻电机可减少永磁用量,以较低的成本实现相同的性能,该电机在相关行业应用正愈发得到重视。得益于较低的永磁磁链,该类电机短路电流小,非常适合容错设计。电机运行性能和容错能力与绕组紧密相关,因此该... 详细信息

利用磁阻转矩替代永磁转矩,永磁磁阻电机可减少永磁用量,以较低的成本实现相同的性能,该电机在相关行业应用正愈发得到重视。得益于较低的永磁磁链,该类电机短路电流小,非常适合容错设计。电机运行性能和容错能力与绕组紧密相关,因此该文研究了两台分别采用分布式绕组和集中式绕组的多三相永磁磁阻电机,两台电机基于相同性能指标进行设计加工。通过深入的有限元仿真和实验测试,比较了两台电机的反电动势、最大转矩电流比(MTPA)曲线、输出转矩以及不同故障模式下的故障行为和容错能力。结果表明,对于中低速应用场合,采用集中式绕组永磁磁阻电机较之分布式绕组结构具有更好的容错表现。

关键词：多三相容错电机故障运行匝间短路有限元仿真

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Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

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Science China(Life Sciences) 2024年第8期67卷 1697-1714页

作者： huan Wu Yanman zha.g Yuqian Li Shuya Sun Jintao zha.g Qingsong Xie Yue Dong Shushu Zhou Xuan Sha Kuokuo Li Jinyi Chen Xin zha.g Yang gao Qunshan Shen guanxiong Wang Xiaomin zha Zongliu Duan Dongdong Tang Chuan Xu Hao geng Mingrong Lv Yuping Xu Ping Zhou zhaolian Wei Rong hua Yunxia Cao Mingxi Liu Xiaojin He Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Reproductive Medicine and Offspring Health Clinical Center of Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China NHC Key Laboratory of Study on Abnormal gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China Anhui Province Key Laboratory of Reproductive Health and genetics Hefei 230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei 230032China

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across *** shuttles,particularly adenylate kinase(AK)and creatine kinase(CK),are pivotal in the efficient transfer of intracellular ATP,showing distinct tissue-and ***,the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups,of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across *** AK8 and AK9 were found to be indispensable to male reproduction after analysis of an infertile male *** mouse models showed that AK8 and AK9 were central to promoting sperm *** combined with mass spectrometry revealed that AK8 and AK9 interact with the radial spoke(RS)of the *** of various human and mouse sperm samples with substructural damage,including the presence of multiple RS subunits,showed that the head of radial spoke 3 acts as an adapter for AK9 in the flagellar *** an ATP probe together with metabolomic analysis,it was found that AK8 and AK9 cooperatively regulated ATP transfer in the axoneme,and were concentrated at sites associated with energy consumption in the *** findings indicate a novel function for RS beyond its structural role,namely,the regulation of ATP *** conclusion,the results expand the functional spectrum of AK proteins and suggest a fresh model regarding ATP transfer within mammalian flagella.

关键词： adenylate kinase Subgroup III AKs AK8 AK9 male infertility ATP transfer radial spoke

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