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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Numerical simulations for g-Brownian motion

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Frontiers of Mathematics in China 2016年第6期11卷 1625-1643页

作者： jie YANg Weidong zha. School of Mathematics & Finance Institute Shandong University Jinan 250100 China

This paper is concerned with numerical simulations for the g- Brownian motion （defined by S. Peng in Stochastic Analysis and Applications, 2007, 541-567）. By the definition of the g-normal distribution, we first show that the g-Brownian motions can be simulated by solving a certain kind of Hamilton-Jacobi-Bellman （HJB） equations. Then, some finite difference methods are designed for the corresponding HJB equations. Numerical simulation results of the g-normal distribution, the g-Brownian motion, and the corresponding quadratic variation process are provided, which characterize basic properties of the g-Brownian motion. We believe that the algorithms in this work serve as a fundamental tool for future studies, e.g., for solving stochastic differential equations （SDEs）/stochastic partial differential equations （SPDEs） driven by the g-Brownian motions.

关键词： Nonlinear expectation g-Brownian motion g-normal distribu- tion Hamilton-Jacobi-Bellman (HJB) equation

Structural Stability and Half Metallic Features of Zn_(0.5)Cr_(0.5)S under Pressure

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Journal of Materials Science & Technology 2014年第3期30卷 234-238页

作者： Yuhong Huang Wanqi jie Yan Zhou gangqiang zha State Key Laboratory of Solidification Processing School of Materials Science and Engineering Northwestern Polytechnical University

Spin-polarized first-principle was performed to study the structural stability and the electronic states of Cr doped ZnS with the Cr component of 50% in zincblende （ZB）, wurtzite （W） and rocksalt （RS） structures under pressure. The results show that the zincblende and wurtzite structures become unstable under low pressures of about 4.68 and 9.61 gPa, respectively, but the rocksalt structure can be maintained up to an extremely high pressure of about 32.92 gPa. Both zincblende and wurtzite ***.5S display half metallic features under pressure, while rocksalt *** exhibits metallic feature. The half metallic features can be ascribed to the stronger interactions between S-3p and Cr-3d states and the metallic feature is due to the higher crystal symmetry of rocksalt Zn0.5Cr0.5S. These results can provide helpful guidance for Cr doped ZnS to be used in spintronic devices.

关键词： Structural stability Half metallic features Electronic properties Zn0.5Cr0.5S Pressure

Ranking approach of cross-efficiency based on improved TOPSIS technique

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Journal of Systems Engineering and Electronics 2011年第4期22卷 604-608页

作者： jie Wu Jiasen Sun Yong zha.Liang Liang School of Management University of Science and Technology of China Hefei 230026 R R. China

The cross-efficiency evaluation method is reviewed which is developed as a data envelopment analysis （DEA） extensive tool. The cross-efficiency evaluation method is utilized to identify the decision making unit （DMU） with the best practice and to rank the DMUs by their respective cross-efficiency scores. The main drawbacks of the cross-efficiency evaluation method when the ultimate average cross-efficiency scores are used to evalu- ate and rank the DMUs are also pointed out. With the research gap, an improved technique for order preference by similarity to ideal solution （TOPSIS） is introduced to rank the crossfficiency by eliminating the average assumption. Finally, an empirical example is illustrated to examine the validity of the proposed method.

关键词： data envelopment analysis (DEA) cross-efficiency,improved technique for order preference by similarity to ideal solu-tion (TOPSIS) decision making unit (DMU).

ZnCl_2-assisted Synthesis of ZnSe Polycrystal

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Journal of Materials Science & Technology 2012年第4期28卷 373-378页

作者： Changyou Liu Tao Wang gangqiang zha.Zhi gu Wanqi jie State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

A chemical-assisted element direct-reaction method is developed to synthesize ZnSe compound semiconductor material at a relatively low temperature （-1000 ℃）. ZnSe polycrystal was obtained in the closed-tube systems with Zn-Se, Zn-Se-Zn（NHa）2CI2, ZnoSe-NH4CI and Zn-Se-ZnCI2. The as-synthesized samples were tested by X-ray diffraction （XRD）, thermogravimetric analysis （TgA） and analyzed by thermodynamic numerical method. The results demonstrate that the synthesis efficiency is higher than 99.96% for Zn-Se-ZnCl2 system at around 1000 ℃ for 3 weeks. It also exhibits that not only temperature, but also low apparent ratio of volume and surface area of the source materials and higher ZnCl2 content are required to achieve high synthesis efficiency. A SeCI transporting reaction synthesis process is proposed based on the thermodynamic analysis.

关键词： Crystallites growth from vapor Zinc compounds Semiconducting II-VI materials

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Rangeland grasshoppers in Relation to Soils in the Qinghai Lake Region, China

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Pedosphere 2007年第1期17卷 84-89页

作者： NI Shao-Xiang WANg jie-Chen JIANg Jian-Jun zha.Yong College of geographical Science Nanjing Normal University Nanjing 210097 （China） Department of Urban and Resources Science Nanjing UniversityNanjing 910093 （China）

The relationship between rangeland grasshopper density and soil type as well as topsoil moisture content was analyzed with in situ soil data collected in the Qinghai Lake region of China. grasshoppers were confined mainly to the areas with light chestnut soil or chestnut soil, and very few were found in areas with subalpine meadow soil. grasshoppers were almost absent from other types of soil, such as aeolian soil. In addition, analysis of 14 soil samples collected in the study area revealed that a soil moisture content between 18 and 32 g kg-1 coincided spatially with a higher density of grasshoppers, with the grasshopper density averaging 15 head m-2. In areas with a soil moisture content above 42 g kg-1 or below 10 g kg-1, grasshopper density dropped to less than 5 head m-2. These indicated that for the study area, soils with very high or very low moisture contents were not conducive to the survival of grasshoppers.

关键词： Qinghai Lake rangeland grasshopper soil type soil moisture

Production of anthocyanins in metabolically engineered microorganisms:Current status and perspectives

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Synthetic and Systems Biotechnology 2017年第4期2卷 259-266页

作者： Jian zha.Mattheos A.g.Koffas Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA Department of Biological Sciences Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNYUSA

Microbial production of plant-derived natural products by engineered microorganisms has achieved great success thanks to large extend to metabolic engineering and synthetic ***,the water-soluble colored pigments found in terrestrial plants that are responsible for the red,blue and purple coloration of many flowers and fruits,are extensively used in food and cosmetics industry;however,their current supply heavily relies on complex extraction from plant-based materials.A promising alternative is their sustainable production in metabolically engineered ***,we review the recent progress on anthocyanin biosynthesis in engineered bacteria,with a special focus on the systematic engineering modifications such as selection and engineering of biosynthetic enzymes,engineering of transportation,regulation of UDP-glucose supply,as well as process *** promising engineering strategies will facilitate successful microbial production of anthocyanins in industry in the near future.

关键词： Anthocyanin Enzyme engineering Metabolic engineering Microbial production

大跨径预应力混凝土连续梁桥施工监控技术研究

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价值工程 2025年第1期44卷 62-64页

作者：查李剑上海同济检测技术有限公司上海201900

桥梁结构理想的几何线形与合理的内力状态不仅与设计有关,而且还依赖于科学合理的施工方法。如何通过施工时的浇筑过程的控制以及结构标高调整来获得预先设计的应力状态和几何线形,是大跨桥梁施工中非常关键的问题。因此,在对大跨度预... 详细信息

桥梁结构理想的几何线形与合理的内力状态不仅与设计有关,而且还依赖于科学合理的施工方法。如何通过施工时的浇筑过程的控制以及结构标高调整来获得预先设计的应力状态和几何线形,是大跨桥梁施工中非常关键的问题。因此,在对大跨度预应力混凝土桥梁施工过程中,为了保障其施工质量及安全性,应采取必要的监控技术对其进行检测。本文以实际工程为例,对监控技术进行总结,为类似大跨度预应力混凝土桥梁施工监控提供借鉴作用。

关键词：预应力混凝土悬臂桥梁施工监控