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Prevalence of white matter hyperintensities increases with age

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Neural Regeneration Research 2018年第12期13卷 2141-2146页

作者： Feng-juan zhuang Yan Chen Wen-Bo He Zhi-You Cai Department of Neurology Renmin Hospital Hubei University of Medicine Department of Neurology Chongqing General Hospital University of Chinese Academy of Sciences

White matter hyperintensities（WMHs） that arise with age and/or atherosclerosis constitute a heterogeneous disorder in the white matter of the brain. However, the relationship between age-related risk factors and the prevalence of WMHs is still obscure. More clinical data is needed to confirm the relationship between age and the prevalence of WMHs. We collected 836 patients, who were treated in the Renmin Hospital, Hubei University of Medicine, China from January 2015 to February 2016, for a case-controlled retrospective analysis. According to T2-weighted magnetic resonance imaging results, all patients were divided into a WMHs group（n = 333） and a non-WMHs group（n = 503）. The WMHs group contained 159 males and 174 females. The prevalence of WMHs increased with age and was associated with age-related risk factors, such as cardiovascular diseases, smoking, drinking, diabetes, hypertension and history of cerebral infarction. There was no significant difference in sex, education level, hyperlipidemia and hyperhomocysteinemia among the different age ranges. These findings confirm that age is an independent risk factor for the prevalence and severity of WMHs. The age-related risk factors enhance the occurrence of WMHs.

关键词： nerve regeneration white matter prevalence severity age risk factor retrospective analysis cerebrovascular neural regeneration

Peripapillary retinal nerve fiber layer thickness distribution in Chinese with myopia measured by 3D-optical coherence tomography

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 626-631页

作者： Jing-Jing Zhao Wen-juan zhuang Xue-Qiu Yang Shan-Shan Li Wei Xiang Weifang Eye Hospital Department of Ophthalmology General Hospital of Ningxia Medical University Shandong Eye Hospital Shandong Eye Institute Shangdong Acadeny of Medical Sciences Yinchuan Health Inspection Bureau

AIMTo assess the effect of myopia on the thickness of retinal nerve fiber layer (RNFL) measured by 3D optical coherence tomography (3D-OCT) in a group of nonglaucomatous Chinese subjects.

关键词： optical coherence tomography myopia retinal nerve fiber layer

Improved and excellent ethanol sensing properties of SnO_2/multiwalled carbon nanotubes

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Chinese Science Bulletin 2010年第4期55卷 382-385页

作者： LIU Li zhuang juan LIU KuiXue WANG LianYuan LI ShouChun LI Wei LI XiaoLong National Laboratory of Superhard Materials College of Physics Jilin University Changchun 130012 China School of Physics and Optoelectronic Engineering Dalian University of Technology Dalian 116024 China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012 China College of lnstrumentation and Electrical Engineering Jilin University Changchun 130026 China

SnO2/multiwalled carbon nanotubes (MWNTs) have been studied as gas sensing materials. Compared with pure SnO2, SnO2/MWNTs exhibit improved ethanol sensing properties such as higher sensitivity and quicker response/recovery at 300°C. The sensitivity is 35, 65, 166 and 243 to 500, 1000, 2000 and 3000 ppm ethanol, respectively. The response time is about 1 s, and the recovery time is about 5 s. The sensing improvement is explained in terms of the appropriate basal resistance and enhanced signal transfer brought by MWNTs.

关键词：多壁碳纳米管气敏性能乙醇斯诺 MWNTs 气敏材料响应时间信号传输

Numerical Simulation of Particle Densities Distributions in Atmospheric Pressure Ar/SiH4/H2 Mixed Plasma Under Very High Frequency Excitation

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高电压技术 2013年第9期39卷 2228-2234页

作者： zhuang juan SANG Chaofeng WU Mengxue WANG Dezhen School of Physics and Optoelectronic Technology Dalian University of Technology Dalian 116030 China

To improve the microcrystalline silicon thin film deposition in quality and to increase its microcrystalline silicon content,we numerically investigated the characteristics of homogeneous discharges in hydrogen diluted silane and argon mixed gases at atmospheric pressure using a two-dimensional fluid *** model takes into account the primary processes of excitation and ionization,sixteen reactions of radicals with radicals in silane/hydrogen/argon discharges,so this model can adequately describe the discharge *** effects of very high frequency(VHF)excitation on the electron density in such discharges are *** simulation results show that the electron density does not linearly vary with the excitation frequency within from 90150 *** maximum value occurs at an appropriate excitation frequency *** transition *** the excitation frequency would effectively increase the electron density before the transition frequency,but decreases the density ***,the densities of involved particle species,including H2+,H,Ar*,Ar+,SiH3+,SiH3,SiH3,SiH2are closely interrelated.

关键词：放电等离子体激励频率数值模拟大气压力密度分布混合气体激发粒子

Metal complexes of bipyridine-functionalized covalent organic frameworks as efficient electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 3096-3106页

作者： zhuang-zhuang Wu Tian Xia Ying Liang Yong-Peng Li Zhu-Yin Sui Li-juan Feng Dao-Xiong Wu Xin-Long Tian Qi Chen State Key Laboratory of Marine Resource Utilization in South China Sea School of Marine Science and EngineeringHainan UniversityHaikou 570228China School of Chemistry and Chemical Engineering Yantai UniversityZhuhai519041China School of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhai519041China

Electrocatalytic water splitting is considered a clean and practic al method for producing *** this study,COF-Bpy,a bipyridine-functionalized covalent organic framework(COF),was prepared via post-synthetic modification,after which electrocatalysts for the oxygen evolution reactions(OER)were formed through coordination to single-or double-transition metals(Fe,Co,Ni,FeCo,FeNi or CoNi).COF-Bpy@FeNi delivered the best OER performance among the studied electrocatalysts,with an overpotential of 399 mV at 10 mA·cm^(-2)in an alkaline electrolyte(1.0 mol·L^(-1)KOH aqueous).Notably,the electrocatalytic performance of COF-Bpy@FeNi showed slight degradation during durability testing,which is ascribable to its irreversible benzoquinoline structure and strong metal *** expected,COF-Bpy@FeNi exhibited a low overpotential of 347 mV at a turnover frequency(TOF)of 0.1 s^(-1),which suggests that COF-Bpy@FeNi possesses excellent intrinsic electroc atalytic OER ***,density functional theory(DFT)calculations reveal that the Ni site plays a major role,while the Fe site adjusts the electronic structure of the Ni ions,which rationalizes the excellent OER properties of COF-Bpy@*** study not only provides a simple and efficient method for complexing COFs with transition metals,but also offers a novel strategy for designing porous organic polymer electrocatalysts.

关键词： Covalent organic framework Oxygen evolution reactions(OER)electrocatalyst Nickel-iron synergy Water splitting

Evaluating correlation between the ocular biometry and genetic variants of MYOC and ABCA1 with primary angleclosure glaucoma in a cohort from northern China

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1317-1322页

作者： Shao-Lin Wang Shun-Yu Piao Man-Yun Xu Wen Zhang Jian-Qing Ma juan Hao Hao Chi Zhong-Qi Xue Shao-Ping Ha Wen-juan zhuang Clinical Medical College of Ningxia Medical University Yinchuan750001Ningxia Hui Autonomous RegionChina Ningxia Eye Hospital People’s Hospital of Ningxia HuiAutonomous Region(First Affiliated Hospital of NorthwestUniversity For Nationalities)Yinchuan750011Ningxia HuiAutonomous RegionChina Department of Ophthalmology Wuzhong People’sHospitalWuzhong751100Ningxia Hui AutonomousRegionChina Department of Ophthalmology Taiyuan Central HospitalTaiyuan030000Shanxi ProvinceChina Shandong Academy of Medical Sciences Jinan UniversityJinan250000Shandong ProvinceChina

AIM: To investigate whether the gene variants in MYOC and ABCA1 are associated with primary angle-closure glaucoma(PACG) and anterior chamber depth(ACD) and axial length(AL) in samples from northern China. METHODS: The present case-control association study consisted of 500 PACG patients and 720 unrelated controls. Each participant was genotyped for eleven single nucleotide polymorphisms(SNPs) in MYOC and ABCA1 genes(rs12076134, rs183532, rs235875 and rs235913 in MYOC, rs2422493, rs2487042, rs2472496, rs2472493, rs2487032, rs2472459 and rs2472519 near ABCA1) using an improved multiplex ligation detection reaction(iMLDR) technique. The genetic association analyses were performed by PLINK using a logistic regression model. The association between genotypes and ocular biometric parameters was performed by SPSS using generalized estimation equation. Bonferroni corrections wereimplemented and the statistical power was calculated by the Power and Sample Size Calculation. RESULTS: Two SNPs rs183532 and rs235875 as well as a haplotype TTC in MYOC were nominally associated with PACG despite the significance was lost after Bonferroni correction. No association was observed between ABCA1 and PACG, neither did the association between these variants and ACD as well as AL. CONCLUSION: The present study suggests MYOC and ABCA1 do not play a part in the pathogenesis of PACG as well as the regulation of ocular biometric parameters in a northern Chinese population. Further investigations with large sample size are needed to verify this consequence.

关键词： MYOC ABCA1 primary angle-closure glaucoma anterior chamber depth axial length single nucleotide polymorphisms

基于改进成本收入比法的DRG成本核算模式探索与实践

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医院管理论坛 2024年第3期41卷 79-86页

作者：张运奎刘国华庄娟崔宗晴李云霞济南市儿童医院

成本收入比法以病案首页的费用分类划分服务单元,进行成本收入归集,存在一定缺陷,通过对成本收入比法进行优化,将服务单元细化为作业中心,引入作业成本费率作为分摊参数,构建DRG成本核算模型,为DRG成本核算方法的应用提供参考。结果显示... 详细信息

成本收入比法以病案首页的费用分类划分服务单元,进行成本收入归集,存在一定缺陷,通过对成本收入比法进行优化,将服务单元细化为作业中心,引入作业成本费率作为分摊参数,构建DRG成本核算模型,为DRG成本核算方法的应用提供参考。结果显示,改进的成本收入比法可以快速、有效地核算DRG成本,核算结果更为精细,对帮助医院实现多维度精细化管理具有重要作用。

关键词：医院按疾病诊断相关分组成本核算成本收入比法

Silicon-erbium ytterbium silicate nanowire waveguides with optimized optical gain

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Frontiers of physics 2017年第1期12卷 57-63页

作者： Xiao-Xia Wang Wei-Hao Zheng Qing-Lin Zhang Xiao-Li Zhu Hong Zhou Xiu-juan zhuang An-Lian Pan Xiang-Feng Duan Key Laboratory for Micro-Nano Physics and Technology of Hunan Province School of Physics and Electronic Science and State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University Changsha 410082 China Department of Chemistry and Biochemistry University of California Los Angeles CA 90095 USA

Single-crystal erbium silicate nanowires have attracted considerable attention because of their high optical gain. In this work, we report the controlled synthesis of silicon-erbium ytterbium silicate core- shell nanowires and fine-tuning the erbium mole fraction in the shell from x = 0.3 to x = 1.0, which corresponds to changing the erbium concentration from 4.8 ×10^21 to 1.6 ×10^22 cm^-3. By controlling and properly optimizing the composition of erbium and ytterbium in the nanowires, we can effectively suppress upeonversion photoluminescence while simultaneously enhancing near-infrared emission. The composition-optimized nanowires have very long photoluminescence lifetimes and large emission cross- sections, which contribute to the high optical gain that we observed. We suspended these concentration- optimized nanowires in the air to measure and analyze their propagation loss and optical gain in the near-infrared communication band. Through systematic measurements using wires with different core sizes, we obtained a maximum net gain of 20 ± 8 dB·mm^-1, which occurs at a wavelength of 1534 nm, for a nanowire with a diameter of 600 nm and a silicon core diameter of 300 nm.

关键词： erbium ytterbium silicate nanowire erbium concentration gain

卵巢癌类器官模型的建立及在药物敏感性测试中的应用

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中国处方药 2024年第8期22卷 14-19页

作者：尹秀英欧阳小芬庄婷娟陈丽萍柯玉秀袁贤琳武警广东省总队医院妇产科广州510507 广州市番禺区中医院广州511408 广州开发区医院广州510730 广东轻工职业技术学院生命健康技术学院广州510300

目的使用临床样本成功构建卵巢癌类器官模型,选用卵巢癌临床常用一线化疗药物卡铂,探究不同处理因素对卵巢癌类器官药物敏感性测试结果的影响,为肿瘤患者个体化用药和精准治疗方案的选择提供依据。方法采用不同细胞密度、不同药物剂量... 详细信息

目的使用临床样本成功构建卵巢癌类器官模型,选用卵巢癌临床常用一线化疗药物卡铂,探究不同处理因素对卵巢癌类器官药物敏感性测试结果的影响,为肿瘤患者个体化用药和精准治疗方案的选择提供依据。方法采用不同细胞密度、不同药物剂量、不同药物作用时间对2例卵巢癌类器官OC-1、OC-2进行处理,设置对照组和处理组,比较分析2例卵巢癌类器官对卡铂的敏感性。药物剂量上设计6组不同浓度(100、50、10、1、0.1、0.01μmol/L)卡铂作用于2例卵巢癌类器官。药物作用时间上,以相同剂量100μmol/L卡铂分别作用于2例卵巢癌类器官3~9 d。细胞药物敏感性测试上通过CCK-8法检测细胞增殖活力,根据肿瘤细胞相对抑制率(T/C)比较分析不同处理因素对卵巢癌类器官药物敏感性测试结果的影响。结果(1)在细胞密度的选择上,每孔接种8000个和4000个细胞时,50~100μmol/L卡铂均对卵巢癌类器官OC-1、OC-2的生长抑制作用显著(P0.05)。(2)在不同药物剂量的选择上,50~100μmol/L卡铂均对卵巢癌类器官OC-1、OC-2体外有效(T/C≤50%),而其余4个剂量组体外无效。(3)在药物作用时间的选择上,100μmol/L的卡铂对类器官OC-1、OC-2在3~9 d观测期中,与对照组相比,随时间延长具有更显著的生长抑制作用(P<0.01或P<0.001)。结论通过卵巢癌类器官模拟体内真实的肿瘤环境下,化疗药物卡铂在不同剂量、不同作用时间下均影响卵巢癌药物敏感性检测结果。利用卵巢癌类器官为卵巢癌患者设计个体化用药方案具有十分积极的意义。

关键词：卵巢癌类器官卡铂药物敏感性