Prevalence of white matter hyperintensities increases with age

作     者：Feng-Juan Zhuang Yan Chen Wen-Bo He Zhi-You Cai 

作者机构：Department of Neurology Renmin Hospital Hubei University of Medicine Department of Neurology Chongqing General Hospital University of Chinese Academy of Sciences 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2018年第13卷第12期

页      面：2141-2146页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Natural Science Foundation of Hubei Province of China,No.2015CFB260 the Health and Family Planning Scientific Research Project of Hubei Province of China,No.WJ2015MB219(to WBH and ZYC) 

主　　题：nerve regeneration white matter prevalence severity age risk factor retrospective analysis cerebrovascular neural regeneration 

摘      要：White matter hyperintensities（WMHs） that arise with age and/or atherosclerosis constitute a heterogeneous disorder in the white matter of the brain. However, the relationship between age-related risk factors and the prevalence of WMHs is still obscure. More clinical data is needed to confirm the relationship between age and the prevalence of WMHs. We collected 836 patients, who were treated in the Renmin Hospital, Hubei University of Medicine, China from January 2015 to February 2016, for a case-controlled retrospective analysis. According to T2-weighted magnetic resonance imaging results, all patients were divided into a WMHs group（n = 333） and a non-WMHs group（n = 503）. The WMHs group contained 159 males and 174 females. The prevalence of WMHs increased with age and was associated with age-related risk factors, such as cardiovascular diseases, smoking, drinking, diabetes, hypertension and history of cerebral infarction. There was no significant difference in sex, education level, hyperlipidemia and hyperhomocysteinemia among the different age ranges. These findings confirm that age is an independent risk factor for the prevalence and severity of WMHs. The age-related risk factors enhance the occurrence of WMHs.