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基于组合赋权的企业数字供应链风险行为评价及防范——以志邦家居为例

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物流工程与管理 2024年第4期46卷 49-55页

作者：从雨婷汪传雷王蕾冯泽莹江宁静安徽大学安徽合肥230000

结合当下区块链、边缘计算等迅猛发展的态势,针对企业数字供应链全过程中的风险进行界定、评价和防范,提高企业应对风险的能力。结合SCOR和BSC-SC,从计划、采购、制造、配送、回收、绩效分析和供应链协作7个维度进行指标选取,构建风险... 详细信息

结合当下区块链、边缘计算等迅猛发展的态势,针对企业数字供应链全过程中的风险进行界定、评价和防范,提高企业应对风险的能力。结合SCOR和BSC-SC,从计划、采购、制造、配送、回收、绩效分析和供应链协作7个维度进行指标选取,构建风险行为评价模型,利用AHP和熵权法计算主客观权重并组合赋权,利用专家打分和沃尔评分法进行指标打分,最后以志邦家居数字供应链为案例进行分析。结果显示,志邦家居在计划、制造、回收维度存在较大改进空间,进而提出防范措施,以提高其数字供应链风险识别和风险防范能力。

关键词：风险评价风险防范组合赋权数字供应链

Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3709-3722页

作者： Meng-Zhi Wu Yi-chuan Yuan Bi-Yu Huang Jin-Xi Chen Bin-Kui Li Jian-Hong Fang Shi-Mei zhuang MOE Key Laboratory of Gene Function and Regulation School of Life SciencesCollaborative Innovation Center for Cancer MedicineSun Yat-sen UniversityXin Gang Xi Road 135#Guangzhou 510275P.R.China Department of Hepatobiliary Surgery Sun Yat-sen University Cancer CenterDong Feng Road East 651#Guangzhou 510060P.R.China

Aberrant activation of the TGF-β/SMAD signaling pathway is often observed in hepatocellular carcinoma(HCC).Whether lncRNA regulates the TGF-β/SMAD signaling remains largely ***,we identified an oncogenic lncRNA that was upregulated in HCC and was transcriptionally induced by TGF-β(named lnc-UTGF,lncRNA upregulated by TGF-β).Upon TGF-βstimulation,SMAD2/3 bound to the lnc-UTGF promoter and activated lnc-UTGF *** turn,the TGF-β/SMAD signaling was augmented by overexpressing lnc-UTGF,but was inhibited by silencing *** investigations revealed that lnc-UTGF interacted with the mRNAs of SMAD2 and SMAD4 via complementary base-pairing,resulting in enhanced stability of SMAD2/4 *** data suggest a novel TGF-β/SMAD/lnc-UTGF positive feedback *** gain-and loss-of-function analyses disclosed that lnc-UTGF promoted the migration and invasion of hepatoma cells,and this effect of lnc-UTGF was attenuated by repressing SMAD2/4 expression or by mutating the SMAD2/4-binding sites in *** using mouse models further confirmed that in vivo metastasis of hepatoma xenografts was inhibited by silencing lnc-UTGF,but was enhanced by ectopic expression of *** lnc-UTGF level was positively correlated with the SMAD2/4 levels in ***,we detected an association of lnc-UTGF upregulation with increase of SMAD2,SMAD4,and their metastasis effector SNAIL1 in human *** high lnc-UTGF level was also significantly associated with enhanced metastasis potential,advanced TNM stages,and worse recurrence-free ***:there exists a lnc-UTGF-mediated positive feedback loop of the TGF-βsignaling and its deregulation promotes hepatoma *** findings may provide a new therapeutic target for HCC metastasis.

关键词： metastasis SMAD inhibited

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双组分水性超薄耐磨反光标线研发与应用研究

山东交通科技 2024年第4期 158-161页

作者：刘世亮李辉王川周凯张宁李方倪山东高速交通科技有限公司山东济南250022 山东高速集团有限公司山东济南250098

针对季冻区传统标线较厚、易被铲雪车破坏、造成浪费且灌封开槽施划标线易损坏原路面等问题,在现有水性标线涂料配方基础上,对乳液进行改性,引入分子杂化技术、自交联技术、快干技术等,将基料与颜填料复配,通过对涂层性能、玻璃珠黏附... 详细信息

针对季冻区传统标线较厚、易被铲雪车破坏、造成浪费且灌封开槽施划标线易损坏原路面等问题,在现有水性标线涂料配方基础上,对乳液进行改性,引入分子杂化技术、自交联技术、快干技术等,将基料与颜填料复配,通过对涂层性能、玻璃珠黏附性及施工性能等进行测试,确定涂料性能最佳的配方,研发出一种耐高低温变换、黏结力强、耐雪铲的双组分水性超薄耐磨反光标线涂料。工程实际应用证明,与传统热熔标线材料相比,具有显著的耐雪铲能力,经过2 a的服役时间依然可以保持较好的完整性及视认性,应用效果显著。

关键词：道路标线双组分水性涂料涂料性能工程应用

Continuous Preparation of Chitosan‑Based Self‑Powered Sensing Fibers Recycled from Wasted Materials for Smart Home Applications

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Advanced Fiber Materials 2022年第6期4卷 1584-1594页

作者： Yingying Li chuanhui Wei Yang Jiang Renwei Cheng Yihan Zhang chuan ning Kai Dong Zhong Lin Wang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‑Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400People’s Republic of China Center On Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Material Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332‑0245USA

Currently,the gradual depletion of fossil resources and the large amount of plastic waste are causing serious harm to the land and marine *** rapid development of wearable smart fibers is accompanied by rapid growth in the material demand for fibers,and the development of green and high-performance biomass-based fibers has become an important research topic to reduce the dependence on synthetic fiber materials and the harm to the ***,chitosan is first prepared from the waste material by chemical *** the chitosan-based self-powered induction fibers are prepared by electrospinning core wire ***-based self-powered sensing fiber is ultra-light and flexible,which can achieve about 2500 collisions without damaging the ***-based self-powered sensing fiber can also be used in smart home sensing applications to control home appliance switches with a light touch,which has a great application prospect in smart home and wearable fields.

关键词： Recycled wasted materials Chitosan nanofibers Electrospinning Self-powered sensing Smart home

Estimation of photon counting statistics with imperfect detectors

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Chinese Physics B 2018年第7期27卷 351-356页

作者： Xiao-chuan Han Dong-Wei zhuang Yu-Xuan Li Jun-Feng Song Yong-Sheng Zhang State Key Laboratory on Integrated Opto-electronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China

The study on photon counting statistics is of fundamental importance in quantum optics. We theoretically analyzed the imperfect detection of an arbitrary quantum state. We derived photon counting formulae for six typical quantum states （i.e., Fock, coherent, squeeze-vacuum, thermal, odd and even coherent states） with finite quantum efficiencies and dark counts based on multiple on/off detector arrays. We applied the formulae to the simulation of multiphoton number detections and obtained both the simulated and ideal photon number distributions of each state. A comparison between the results by using the fidelity and relative entropy was carried out to evaluate the detection scheme and help select detectors for different quantum states.

关键词： fidelity on/off detector photon number detection relative entropy

A novel large animal model of recurrent migraine established by repeated administration of inflammatory soup into the dura mater of the rhesus monkey

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Neural Regeneration Research 2019年第1期14卷 100-106页

作者： ning Chen Wei Su Shu-Hui Cui Jian Guo Jia-chuan Duan Hong-Xia Li Li He Department of Neurology West China Hospital Sichuan University Department of Science & Technology West China Hospital Sichuan University National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine West China Hospital Sichuan University

Several animal models of migraine have been established, and those based on trigeminovascular system activation are widely accepted. How- ever, most of these models have been established on lower animals, such as rodents, and involve only a single administration of a noxious stimulus. In this study, an inflammatory soup （10 μL）, consisting of prostaglandin E2 （0.2 mM）, serotonin （2 mM）, bradykinin （2 raM） and histamine （2 raM）, was injected into the dura mater of conscious rhesus monkeys through an indwelling catheter. The infusion started on day 8 and was repeated every 3 days, for a total of six administrations, to induce neurogenic inflammation. We performed behavioral assessments and measured the expression of the oncogene c-fos, neuronal nitric oxide synthase （nNOS） and calcitonin gene related peptide （CGRP） ill the trigeminal system and in multiple brain regions involved in pain processing by immunohistochemical staining. Compared with monkeys in the control group, three of the four animals in the inflammatory soup group displayed decreased motor behaviors, and two showed increased ipsilateral nose and mouth secretions during the stimulus period. Higher expression levels of c-fos, nNOS and CGRP were found in various brain areas of experimental animals compared with controls, including the trigeminal nucleus caudalis, thalamus, hypothalamus, midbrain, pons and other areas involved in pain perception. These results suggest that repeated inflammatory soup stimulation of the dura activates the trigeminovascular system and produces migraine-like pathological changes and abnormal behaviors in conscious rhesus monkeys.

关键词： nerve regeneration migraine rhesus monkey neurogenic inflammation cellular oncogene fos neuronal nitric oxide synthase calcitonin gene related peptide trigeminal system behavior immunohistochemistry neural regeneration

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非煤采矿专业背景下的“采煤概论”教学实践

教育教学论坛 2024年第34期 17-20页

作者：刘建庄刘鑫明王盛川孙光华华北理工大学矿业工程学院河北唐山063210 华北理工大学应急管理与安全工程学院河北唐山063210

围绕采矿工程(非煤)专业培养目标中的工程能力、道德责任、沟通合作、终身学习四项要求,通过研判学生在矿山地质、井巷工程和采矿学等方面的知识储备,以采煤背景知识架构、煤矿开采基本概念理解、矿井开拓及工作面回采等重点基础知识掌... 详细信息

围绕采矿工程(非煤)专业培养目标中的工程能力、道德责任、沟通合作、终身学习四项要求,通过研判学生在矿山地质、井巷工程和采矿学等方面的知识储备,以采煤背景知识架构、煤矿开采基本概念理解、矿井开拓及工作面回采等重点基础知识掌握为目标,通过对教师科研项目中金属矿山开采案例的要点剖析,对比分析煤矿开采的特点,总结提炼已有课程资源,融合流程动画演示、物理模型声光电演示系统、案例视频等现代教学手段,强化学生工程能力,拓宽学生的采矿视野,树立安全保障、绿色与科学高效开采的理念,以大采矿的思维应对专业学习、工程设计和管理、科研等方面的问题。通过三轮的小班教学实践,学生课堂参与度逐步提高,理论教学和实验教学的效果良好。

关键词：采矿非煤专业案例剖析教学实践

Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma

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Genes & Diseases 2023年第6期10卷 2226-2228页

作者： Meng Sha chuan Shen Seogsong Jeong ning Xu Chen Chen Hua-lian Hang Ying Tong Jie Cao Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Biomedical Informatics CHA University School of MedicineCHA UniversitySeongnam 13488Republic of Korea Institute of Basic Medical Sciences School of MedicineCHA UniversitySeongnam 13488Republic of Korea Institute for Biomedical Informatics School of MedicineCHA UniversitySeongnam 13488Republic of Korea

Tumor-associated lymphangiogenesis is thought to be an importantmetastaticstepin intrahepaticccholangiocarcinoma(ICC),while the origin of tumor-associated lymphatic vessels within tumors is little *** fibroblasts(CAFs)enhance tumor progression through many aspects.2 CAFs have been discovered exhibiting cellular plasticity of phenotypic transition-such as epithelial-mesenchymal transition(EMT)which promotes increased migratory and invasive capabilities of cells.3However,mesenchymal-to-endothelial,(MEndT)transition is yet to be identified in tumor entities.

关键词： CAFs lymphatic mesenchymal

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生态混凝土材料配合比优化试验研究

山西建筑 2024年第17期50卷 118-122页

作者：马川义扈萍张亚宁张宁庄培芝张圣涛山东高速集团有限公司山东济南250101 济南大学土木建筑学院山东济南250022 山东大学齐鲁交通学院山东济南250100

针对生态混凝土设计中高孔隙率和高强度之间相互矛盾、低碱度难以兼顾的难题,考虑目标孔隙率、水灰比、有机质掺量、灰骨比等四个影响因素,采用正交试验法对生态混凝土的材料配合比进行了优化设计。通过对试验结果进行分析,探讨了不同... 详细信息

针对生态混凝土设计中高孔隙率和高强度之间相互矛盾、低碱度难以兼顾的难题,考虑目标孔隙率、水灰比、有机质掺量、灰骨比等四个影响因素,采用正交试验法对生态混凝土的材料配合比进行了优化设计。通过对试验结果进行分析,探讨了不同因素对生态混凝土强度和pH值的影响程度,并得到一组四种因素组合情况下的生态混凝土最优配合比。

关键词：生态混凝土抗压强度孔隙率 pH值配合比