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Numerical simulation on the impact characteristics between rockfalls of different shapes and gravel cushions

Journal of Mountain Science 2023年第9期20卷 2731-2743页

作者： zhu Chun XU Jia-jun WANG Ya-jun HE Man-chao CUI Sheng-hua ZHANG Xiao-hu TAO Zhi-gang School of Earth Sciences and Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China School of Civil Engineering Guizhou University of Engineering ScienceBijie 551700China

The shape of rockfalls significantly affects the performance of the impact cushion,which is manifested by the difference in the impact force and the penetration depth of the rockfall during the *** this study,we built the collision numerical model between rockfalls and cushions based on the results from previous studies,and simulated the collision process of rockfalls with four different shapes(cylindrical,cuboid,spherical,and cubic)and different *** parameters when rockfalls impact cushions are calculated,including the maximum impact forces on the surface and bottom of the cushions and the maximum penetration depth of the *** results showed that the maximum impact force on the surface and the bottom of the cushions varies with the rockfall *** maximum impact force on the cushion surface caused by cylindrical rockfall is the smallest,followed by the cuboid rockfall,the cube rockfall,and the spherical *** maximum impact force at the cushion bottom also follows this ***,the penetration depth of cuboid rockfall is the smallest,followed by the cylindrical rockfall,the cubic rockfall,and the spherical *** results of this study provide more extensive theoretical support for rockfall disaster prevention using gravel cushions.

关键词： Gravel cushion Impact force Penetration depth Rockfall shape Numerical simulation

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Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali–Acid-Heat and Hydrothermal Treatments

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Acta Metallurgica Sinica(English Letters) 2019年第9期32卷 1075-1088页

作者： Jun-Lei Li Shuai Wang Fang Cao Xiao Lin Xiao-Wei Wei zhen-hua Zhao Xiao-Jie Dou Wei-Ting Yu Ke Yang De-Wei Zhao Department of Orthopaedics Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215006China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Porous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect ***,insufficient osteointegration and osteoinduction still remain to open as one of the major problems to achieve satisfactory therapeutic *** solve this problem,many studies have been carried out to improve the bioactivity of porous titanium scaff old by surface *** this study,porous Ti6Al4V scaff olds were fabricated using additive manufacturing *** architectures were built up based on a diamond pore structure ***–acid-heat(AH)treatment was applied to create a TiO2 layer on the porous Ti6Al4V scaff old(AH-porous Ti6Al4V).Subsequently,a hydrothermal treatment was employed to enable the formation of HA coating with nanopillar-like morphology on the alkali–acid-heat-treated surface(HT/AH-porous Ti6Al4V).The effects of surface modifications on apatite-forming ability,protein adsorption,cell attachment,cell proliferation and osteogenic gene expression were studied using apatite-forming ability test,protein adsorption assay and in vitro cell culture *** was found that the HT/AH-porous Ti6Al4V exhibited the highest apatite formation ability and best affinity to fibronectin and *** vitro studies indicated that the mesenchymal stem cells(MSCs)cultured on the HT/AH-porous Ti6Al4V presented improved adhesion and differentiation compared with the porous Ti6Al4V and AH-porous Ti6Al4V.

关键词： Additive manufacturing Biomaterials Porous titanium scaffold HA coating

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Piperlongumine Inhibits Zika Virus Replication In vitro and Promotes Up-Regulation of HO-1 Expression, Suggesting An Implication of Oxidative Stress

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Virologica Sinica 2021年第3期36卷 510-520页

作者： Weizhi Lu Linjuan Shi Jing Gao Huimin zhu Ying hua Jintai Cai Xianbo Wu Chengsong Wan Wei Zhao Bao Zhang Biosafety Level-3 Lab School of Public HealthSouthern Medical UniversityGuangzhou 510515China Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515China

Owing to the widespread distribution of mosquitoes capable of transmitting Zika virus, lack of clinical vaccines and treatments, and poor immunity of populations to new infectious diseases, Zika virus has become a global public health concern. Recent studies have found that Zika virus can continuously infect human brain microvascular endothelial *** cells are the primary components of the blood–brain barrier of the cerebral cortex, and further infection of brain tissue may cause severe damage such as encephalitis and fetal pituitary disease. The present study found that a biologically active base, piperlongumine(PL), inhibited Zika virus replication in human brain microvascular endothelial cells, Vero cells, and human umbilical vein endothelial cells. PL also significantly increased heme oxygenase-1(HO-1) gene expression, while silencing HO-1 expression and using the reactive oxygen species scavenger, N-acetylcysteine, attenuated the inhibitory effect of PL on Zika virus replication. These results suggest that PL induces oxidative stress in cells by increasing reactive oxygen species. This, in turn, induces an increase in HO-1 expression, thereby inhibiting Zika virus replication. These findings provide novel clues for drug research on the prevention and treatment of Zika virus.

关键词： Piperlongumine Heme oxygenase-1(HO-1) Reactive oxygen species Zika virus(ZIKV) Human brain microvascular endothelial cells

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Transcriptomic profiling of watermelon(Citrullus lanatus) provides insights into male flowers development

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Journal of Integrative Agriculture 2022年第2期21卷 407-421页

作者： zhu Ying-chun YUAN Gao-peng JIA Sheng-feng AN Guo-lin LI Wei-hua SUN De-xi LIU Jun-pu zhengzhou Fruit Research Institute Chinese Academy of Agricultural SciencesZhengzhou 450000P.R.China

Watermelon(Citrullus lanatus(Thunb.) Matsum. & Nakai) is an important cucurbit crop grown worldwide. Watermelon fruit quality, fertility, and seed-setting rate are closely related to male flower development. In this study, the different developmental stages of flower buds of the watermelon cultivar ’Xinteda zhengkang 9’ were distinguished by cytological observation, and transcriptome sequencing analysis was performed subsequently. Acetocarmine staining of anthers was performed and the longitudinal and transverse diameters of the unopened male flower buds were measured. Cytological observations of anthers at different developmental stages showed that the anther grew from the tetrad to the mature stage, and the longitudinal and transverse diameters of the flower buds increased. The length of the male flower buds also changed significantly during development. Transcriptome sequencing analysis at four periods, the tetrad(A group), mononuclear(B group), dikaryophase(C group), and mature stages(D group). A total of 16 288 differentially expressed genes(DEGs) were detected in the four stages, with the prolongation of developmental stages, the number of DEGs increased gradually in the comparison groups, there was 2 014, 3 259, 4 628, 1 490, 3 495 and 1 132 DEGs revealed in six comparison groups(A-vs.-B, A-vs.-C, A-vs.-D, B-vs.-C, B-vs.-D, and C-vs.-D), respectively. Gene Ontology(GO) and KEGG enrichment analysis showed that the DEGs were mainly enriched in cellular component and starch and sucrose metabolism, phenylpropanoid biosynthesis and pentose sugar, etc. Finally, we completely screened 59 DEGs in the six comparison groups, interestingly, we found one pollen-specific protein(Cla001608) that was significantly down-regulated(the value of log2 Fold Change up to 17.32), which indicated that it may play an important role in the development of male flowers. This work provides insight into the molecular basis of the developmental stages of male flowers in watermelon and may

关键词： watermelon male flowers development cytological observation transcriptome sequencing

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Rubus chingii Hu: an overview of botany, traditional uses,phytochemistry, and pharmacology

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Chinese Journal of Natural Medicines 2020年第6期18卷 401-416页

作者： SHENG Jia-Yun WANG Si-Qi LIU Kao-hua zhu Bo ZHANG Qiao-Yan QIN Lu-Ping WU Jian-Jun School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou 310053China

Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits(Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity,and quality control of R. chingii. Possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use.

关键词： Rubus chingii Hu Botany Traditional uses Phytochemistry Pharmacology Review

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企业电子商务战略实施关键成功因素的实证研究

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清华大学学报（自然科学版） 2006年第Z1期46卷 914-922页

作者：赵晶朱镇中国地质大学(武汉)管理学院电子商务国际合作中心武汉430074

为了从电子商务流程的角度分析和论证影响电子商务战略实施的关键成功因素,运用已提出的电子商务流程分析模型,针对中国企业电子商务3类典型应用:电子采购、电子订购和客户关系管理,基于34个成功实施电子商务企业的调查数据,采用因子加... 详细信息

为了从电子商务流程的角度分析和论证影响电子商务战略实施的关键成功因素,运用已提出的电子商务流程分析模型,针对中国企业电子商务3类典型应用:电子采购、电子订购和客户关系管理,基于34个成功实施电子商务企业的调查数据,采用因子加权方法以及模糊综合评判两种方法,分析研究了7个模型变量在3类流程中的影响效果和作用,确定各个流程关键成功因素、影响层次和差异。在此基础上建立关键成功因素图,归纳其主要特征。研究结果表明,电子商务战略规划和信息系统是企业电子商务战略实施的必备关键成功因素,合作流程能力和共享信息能力分别是实现电子采购流程和电子订购流程的关键成功因素,这两个能力也是成功实施客户关系管理的保证。

关键词：电子商务流程关键成功因素共享信息能力合作流程能力

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基于AlSi8系高强韧免热处理压铸铝合金开发及应用

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特种铸造及有色合金 2024年第8期44卷 1032-1037页

作者：周泓江黄华朱宇邓杏坚钟宇毅梁毅烽林韵闫锋林宇飞万里广东鸿图科技股份有限公司肇庆526108 广东鸿图汽车零部件有限公司广州510700

随着新能源汽车市场的快速扩张,一体化压铸技术逐渐成为车身结构件制造的重要发展方向。本研究成功开发出了一种基于AlSi8系的高强韧免热处理压铸铝合金,通过精细化成分调控实现铸态下的高抗拉强度与伸长率。通过断裂拉伸试验和疲劳耐... 详细信息

随着新能源汽车市场的快速扩张,一体化压铸技术逐渐成为车身结构件制造的重要发展方向。本研究成功开发出了一种基于AlSi8系的高强韧免热处理压铸铝合金,通过精细化成分调控实现铸态下的高抗拉强度与伸长率。通过断裂拉伸试验和疲劳耐久试验开发了材料仿真卡片,并在某款新能源车一体化前舱铸件上成功应用,验证了其力学性能和铆接性能。

关键词：免热处理铝合金一体化压铸前舱铸件

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固体稳定态二氧化氯对食源性致病菌的杀灭效果观察

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中国消毒学杂志 2024年第6期41卷 419-421,425页

作者：张珂张震刘春艳夏琳琳袁娟吕晓华四川大学华西公共卫生学院/四川大学华西第四医院四川成都610041 四川省精科生化制品有限责任公司

目的观察某固体稳定态二氧化氯剂对食源性致病菌的杀菌效果。方法以氨基磺酸钠和促活化剂活化该消毒片剂,稀释至溶液中二氧化氯浓度为3~48 mg/L。采用悬液定量杀菌试验方法,在pH值为2~7环境下作用不同时间,检测其对金黄色葡萄球菌、大... 详细信息

目的观察某固体稳定态二氧化氯剂对食源性致病菌的杀菌效果。方法以氨基磺酸钠和促活化剂活化该消毒片剂,稀释至溶液中二氧化氯浓度为3~48 mg/L。采用悬液定量杀菌试验方法,在pH值为2~7环境下作用不同时间,检测其对金黄色葡萄球菌、大肠埃希菌和沙门菌的杀菌效果。通过正交试验筛选杀灭大肠埃希菌的最优作用条件。结果以二氧化氯浓度为24 mg/L的活化后溶液作用5 min,可完全杀灭沙门菌、大肠埃希菌和金黄色葡萄球菌。随着二氧化氯消毒液浓度增加,或作用时间延长和溶液pH值降低,杀菌效果均可增强。结论该固体稳定态二氧化氯消毒剂能快速杀灭食源性致病菌,其杀菌作用受浓度、作用时间和pH值等因素影响。

关键词：固体二氧化氯食源性致病菌杀灭效果影响因素

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密室逃脱教学法在化工分离技术课程中的实践

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贵州师范学院学报 2024年第7期40卷 43-49页

作者：林静王方阔董华泽董雄辎朱金苗合肥师范学院化学与制药工程学院安徽合肥230601

以教育逃生室辅助化工分离技术课程教学,基于游戏闯关与团队协作的学习方式,利用故事情节和神秘线索解决化工传质分离问题。以多组分精馏传质分离章节为例,详述密室逃脱教学法在精馏教学中的应用实践。学生自愿参与度逐年上升,大部分学... 详细信息

以教育逃生室辅助化工分离技术课程教学,基于游戏闯关与团队协作的学习方式,利用故事情节和神秘线索解决化工传质分离问题。以多组分精馏传质分离章节为例,详述密室逃脱教学法在精馏教学中的应用实践。学生自愿参与度逐年上升,大部分学生认为密室逃脱教学法可以深化理解多组分精馏过程。通过章节测验初步验证了该游戏的可行性,卷面平均分数提高,低分段学生占比降低。密室逃脱教学设计为学生提供体验式学习机会,补充概念教学,提炼知识短板,优化团队协作水平,为化工类相关专业课程的实践教学提供参考。

关键词：密室逃脱教学游戏化学工程化工分离技术精馏

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综合物探方法在矿产资源勘查中的应用研究

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世界有色金属 2024年第7期 163-165页

作者：李建平郭元华刘振兵涂登骏李承杰四川会东大梁矿业有限公司四川凉山615000

随着矿产资源勘查的深入发展,对于提高勘探效率、减少勘探成本、提高勘探精度的需求日益增加。因此,研究如何有效地应用新的综合物探方法来解决传统物探技术的局限性,具有重要的理论和实践意义。本论文旨在探讨综合物探方法在矿产资源... 详细信息

随着矿产资源勘查的深入发展,对于提高勘探效率、减少勘探成本、提高勘探精度的需求日益增加。因此,研究如何有效地应用新的综合物探方法来解决传统物探技术的局限性,具有重要的理论和实践意义。本论文旨在探讨综合物探方法在矿产资源勘查中的应用,通过分析传统物探技术的局限性,介绍新的综合物探法的原理和优势,并提出综合物探方法使用过程中的注意事项,为矿产勘探提供新的思路和方法。

关键词：综合物探方法矿产资源勘查

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