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Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi Qing LIU Li Qun HUANG De Qin WANG Yu Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan Ling ZHANG Ya Di SHAO Jia Kang zhu yi min CHEN yi Meng LIU Mei ZHAO Wei Hong Medical School of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(P<0.001).The rate of HER2-low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,P<0.001,Pearson’s R=0.159,P<0.001).Survival analysis revealed a significantly longer overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

Relationship between let-7a and gastric mucosa cancerization and its significance

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World Journal of Gastroenterology 2010年第26期16卷 3325-3329页

作者： zhu, yi-min Zhong, Zheng-Xiang Liu, Zhi-ming Second Hosp Jiaxing Dept Gen Surg Jiaxing 314000 Zhejiang Peoples R China Guangxi Med Univ Affiliated Hosp 1 Dept Gen Surg Nanning 530021 Guangxi Zhuang Peoples R China

AIM: To investigate let-7a expression and analyze the correlation between let-7a and progression of gastric mucosa cancerization. METHODS: The tissue microarray was constructed previously in 52 cases of human gastric carcinoma, 17 cases of chronic atrophic gastritis (atypical hyperplasia) and 11 cases of normal gastric tissue, and tissue microarrays combined with in situ hybridization were used to detect the expression of let-7a. RESULTS: The positive rates of let-7a in normal gastric tissue, chronic atrophic gastritis and gastric carcinoma were 90.9%, 88.2% and 86.5%, respectively, without significant differences among the groups (P > 0.05). However, an intense signal of let-7a was observed in gastric epithelial cells, whereas a less intense signal was found in gastric atypical hyperplasia epithelial cells anda weak signal in gastric carcinoma epithelial cells. The expression of let-7a decreased along with the progression of gastric mucosa cancerization (P < 0.05). In the group of gastric carcinoma, the expression of let-7a was even significantly lower in gastric carcinomas with lymph node metastasis than in those without metastasis (P < 0.05). CONCLUSION: Gastric carcinoma has relatively lower expression of let-7a. Reduced let-7a may be a fundamental factor in the formation and lymph node metastasis of gastric carcinoma.

关键词： Tissue microarray In situ hybridization MicroRNA Gastric carcinoma Precancerous lesions

On the Difference Between the Skew-rank of an Oriented Graph and the Rank of Its Underlying Graph

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 129-136页

作者： Jia-min zhu Bo-jun Yuan yi Wang School of Mathematical Sciences Anhui UniversityHefei230601China School of Science Zhejiang University of Science and TechnologyHangzhou310023China

Let G be a simple graph and G~σ be the oriented graph with G as its underlying graph and orientation σ.The rank of the adjacency matrix of G is called the rank of G and is denoted by r(G).The rank of the skew-adjacency matrix of G~σ is called the skew-rank of G~σ and is denoted by sr(G~σ).Let V(G)be the vertex set and E(G) be the edge set of *** cyclomatic number of G,denoted by c(G),is equal to |E(G)|-|V(G)|+ω(G),where ω(G) is the number of the components of *** is proved for any oriented graph G~σ that-2c(G)≤sr(G~σ)-r(G)≤2c(G).In this paper,we prove that there is no oriented graph G~σwith sr(G~σ)-r(G)=2c(G)-1,and in addition,there are infinitely many oriented graphs G~σ with connected underlying graphs such that c(G)=k and sr(G~σ)-r(G)=2c(G)-l for every integers k,l satisfying 0 ≤l≤4k and l≠1.

关键词： cyclomatic number rank skew-rank

Electrochemical Probe of Hydroxylation of 4-Nitro-phenol by Cytochrome C with Hydrogen Peroxide

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Chemical Research in Chinese Universities 1998年第2期14卷 45-51页

作者： zhu yi-min WANG Jin-cheng LI Jing-hong DONG Shao-jun BU Feng-quan Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022 Norma n Bethune Univer sity of Medica l Science Cha ngchun130023

BU Fengquan(Norman Bethune University of Medical Science, Changchun, 130023)(Received Dec. 2, 1996) The reaction of hydrogen peroxide with cytochrome c makes them coupled to lead to the hydroxylation of 4-nitrophenol. In situ electrochemical probe was used to detect the hydroxylation of 4-nitrophenol, which can avoid the tedious extraction procedure, the loss of the active species and the interference of some colored substances in the detection of 4-nitrocatechol by spectroscopic method. The hydroxyl radical scavengers mannitol and sodium benzoate did not eliminate hydroxylation, but the inhibitory effect of uric acid on the hydroxylation lead to the formation of the ferryl species of the protein during the reaction. These studies suggest that the electrochemical probe might efficiently detect the trace 4-nitrocatechol from the onset of the hydroxylation reaction and thus provides a more sensitive tool.

关键词： Hydrogen peroxide Hydroxylation of 4-nitrophenol Cytochrome c

FEASIBILITY OF DIAGNOSING AND STAGING LIVER FIBROSIS WITH DIFFUSION WEIGHTED IMAGING

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Chinese Medical Sciences Journal 2008年第3期23卷 183-186页

作者： Nai-yi zhu Ke-min Chen Wei-min Chai Wei-xia Li Lian-jun Du Department of Radiology Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai 200025

Objective To assess the clinical feasibility of diagnosing and staging liver fibrosis by apparent diffusion coefficient (ADC). Methods Totally, 43 patients (mean age 29.3 years) with chronic hepatitis by liver biopsy and 7 healthy controls (mean age 39.9 years) underwent liver diffusion weighted imaging (DWI) with four b values: 0, 200, 500, and 1000 s/mm2 respectively. The liver fibrosis was staged according to Ishak fibrosis stage. The ADC value of liver fibrosis patients and healthy controls was compared. The correlation of ADC value and liver fibrosis staging was analyzed. Result The histological staging showed 8 stage 1 patients, 10 stage 2 patients, 6 stage 3 patients, 9 stage 4 patients, 8 stage 5 patients and 2 stage 6 patients. The mean ADC value of liver fibrosis patients was significantly lower than that of healthy controls except for stage 1 group (P < 0.05). There was a negative correlation between liver fibrosis staging and ADC value (r = -0.697 with b=500 s/mm2, P < 0.01). Receiver operating characteristic (ROC) curve of ADC value of advanced liver fibrosis (Ishak stage F3 and higher) showed that area under curve = 0.913, 0.825, and 0.794 with b = 500, 1000, and 200 s/mm2, respectively (95% confidence interval: 83.6%-99.0%, 70.7%-94.3%, 66.5%- 92.4%; P < 0.05). When b value was 500 s/mm2, the sensitivity (84%) and specificity (80%) of DWI for diagnosis of advanced liver fibrosis were the highest. Conclusion DWI is proved to be a useful clinical tool in the quantitative evaluation of liver fibrosis and in the prediction of the process of liver fibrosis with the recommendable b value (500 s/mm2).

关键词： diffusion weighted imaging apparent diffusion coefficient liver fibrosis

Preimplantation genetic diagnosis for Down syndrome pregnancy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第7期8卷 515-521页

作者： ZHANG Yu XU Chen-ming zhu yi-min DONG min-yue QIAN Yu-li JIN Fan HUANG He-feng Department of Reproductive Endocrinology Women＇s Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Objective: To evaluate the effect of preimplantation genetic diagnosis (PGD) conducted for women who had Down syndrome pregnancy previously. Methods: Trisomy 21 was diagnosed by using fluorescence in site hybridization (FISH) before embryo transfer in two women who had Down syndrome pregnancies. Each received one or two PGD cycles respectively. Results: Case 1: one PGD cycle was conducted, two oocytes were fertilized and biopsied. One embryo is of trisomy 21 and the other of monosomy 21. No embryo was transferred. Case 2: two PGD cycles were conducted, in total, sixteen oocytes were fertilized and biopsied. Four embryos were tested to be normal, six of trisomy 21, and one of monosomy 21. Five had no signal. Four normal embryos were transferred but no pregnancy resulted. Conclusion: For couples who had pregnancies with Down syndrome pre-viously, PGD can be considered, and has been shown to be an effective strategy.

关键词： Down syndrome Fluorescence in site hybridization (FISH) Preimplantation genetic diagnosis (PGD)

Binding SnO2 Nanoparticles with MoS2 Nanosheets Toward Highly Reversible and Cycle-Stable Lithium/Sodium Storage

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Energy & Environmental Materials 2024年第4期7卷 135-142页

作者： Deliang Cheng Wenbiao Zhang yi Tang Qingsheng Gao Renzong Hu Lichun Yang min zhu Institute of Advanced Materials Jiangxi Normal University School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan University Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Laboratory of Advanced Materials and Collaborative Innovation Center of Chemistry for Energy Materials Fudan University

SnO2,with its high theoretical capacity,abundant resources,and environmental friendliness,is widely regarded as a potential anode material for lithium-ion batteries （LIBs）.Nevertheless,the coarsening of the Sn nanop... 详细信息

关键词： 1 T-MoS2 heterostructure lithium-ion batteries Sn coarsening SnO2

Research on social endowment insurance of lost-land peasant --A case study of Hefei city in Anhui province

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International English Education Research 2015年第5期 87-89页

作者： zhu yi Wang min min School of Management Shanghai University of Engineering and Science Shanghai 201620 China

With the accelerating process of urbanization and industrialization, the peasants for loss of land use fights has become a universal social phenomenon, the problem of landless peasants old-age security community has aroused much attention. However, the presence of Hefei landless peasants pension current pension system is not perfect, the shortcomings of the current government policy, peasants lack insurance awareness and so on. This paper argucs that the land should bc constructed by the pension insurance system, improvc the land compensation policy, increase financial input and improve peasants＇ pension fund supervision and management mechanism to ensure the standardization of the system, thereby providing an important guarantee for building a socialist new urbanization.

关键词： lost-land peasant endowment insurance Hefei

Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis

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Chinese Medical Journal 2016年第14期129卷 1744-1751页

作者： yi-Ping Tian yi-min zhu Xiao-Hui Sun Mao-De Lai Department of Pathology Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China Key Laboratory of Disease Proteomics of Zhejiang Province School of Basic Medical Sciences Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China Department of Epidemiology and Biostatistics Zhejiang University School of Public Health Hangzhou Zhejiang 310058 China

Objective： Aberrant expression of ten-eleven translocation 1 （TET1） plays a critical role in tumor development and progression. We systematically summarized the latest research progress on the role and mechanisms of TET1 in cancer biology. Data Sources： Relevant articles published in English from 1980 to April 2016 were selected from the PubMed database. Tile terms ＂＇ten-eleven translocation 1,＂＂＇SmC,＂＇5hmC,＂＇microRNA,＇＂＂hypoxia,＂ and ＂＇embryonic stem cell＇＂ were used tbr the search. Study Selection： Articles focusing on the role and mechanism ofTETI in tumor were reviewed, including clinical and basic research articles. Results： TET proteins, the key enzymes converting 5-methylcytosine to 5-hydroxymethylcytosine, play vital roles in DNA demethylation regulation. Recent studies have shown that loss of TETI is associated with tumorigenesis and can be used as a potential biomarker for cancer therapy, which indicates that TETI serves as tumor suppressor gene. Moreover, besides its dioxygenase activity, TET1 could induce epithelial-mesenchymal transition and act as a coactivator to regulate gene transcription, such as developmental regulator in embryonic stem cells （ESCs） and hypoxia-responsive gene in cancer. The regulation of TETl is also correlated with microRNA in a posttranscriptional modification process. Hence, it is complex but critical to coaprehend the mechanisms of TETI in the biology of ESCs and cancer. Conclusions： TET I not only serves as a demethylation enzyme but also plays multiple roles during tumorigenesis and progression. More studies should be carried out to elucidate the exact mechanisms of TETI and its associations with cancer betbre considering it as a therapeutic tool.

关键词： 5-hydroxymethylcytosine 5-methylcytosine Embryonic Stem Cells Hypoxia MicroRNA Ten-eleven TranslocationProteins