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Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing LIU Wei zhu Di LI xing HU Liang SONG Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution

“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu zhu Huanyu Liang Ping Li Chenglong Qiu Jingyi Wu Jingwei Chen Weiqian Tian yue zhu Zhi Li Huanlei Wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms

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应用免疫算法求解博弈问题

系统工程学报 2006年第4期21卷 398-404页

作者：邱中华高洁朱跃星南京邮电大学数理学院江苏南京210003 中国农业银行深圳龙翔支行广东深圳518000

设计了用于求解博弈问题的免疫算法的结构,讨论了二进制编码情况下的多样性控制,探讨了利用免疫算法求解博弈问题的方法和优势,分析了博弈问题的适应度评估方案,证实了设计的免疫算法具有稳定的收敛性.并通过对几个完全信息静态博弈实... 详细信息

设计了用于求解博弈问题的免疫算法的结构,讨论了二进制编码情况下的多样性控制,探讨了利用免疫算法求解博弈问题的方法和优势,分析了博弈问题的适应度评估方案,证实了设计的免疫算法具有稳定的收敛性.并通过对几个完全信息静态博弈实例的计算,验证了免疫算法求解博弈问题的有效性.

关键词：免疫算法 Nash均衡适应度评估

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen zhu Tingting Guo Yiran Zhang Tingting xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

森林资源—环境—经济复合大系统可持续发展优化模型及其应用

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中国人口·资源与环境 2006年第6期16卷 85-89页

作者：张智光竺杏月南京林业大学经济管理学院江苏南京210037

运用系统工程方法和大系统理论,分析区域性森林资源—环境—经济复合大系统(FREES)的结构与原理。在可持续发展的总体要求下,将森林资源、森林环境和林业经济三个子系统作为一个有机整体,构建基于ε-约束法的多目标优化模型,以及包含各... 详细信息

运用系统工程方法和大系统理论,分析区域性森林资源—环境—经济复合大系统(FREES)的结构与原理。在可持续发展的总体要求下,将森林资源、森林环境和林业经济三个子系统作为一个有机整体,构建基于ε-约束法的多目标优化模型,以及包含各子系统的目标函数模型、约束条件模型和关联模型在内的FREES大系统分解-协调优化模型。然后,将该模型用于江苏省FREES可持续发展优化问题,得出了具有实际指导意义的最优方案。

关键词：林业资源-环境-经济系统大系统模型可持续发展多目标优化

百菌清残留检测及其与中药相互作用荧光光谱研究(英文)

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光谱学与光谱分析 2015年第2期35卷 415-419页

作者：季仁东赵志敏陈梦岚王乐新朱星玥南京航空航天大学江苏南京210016 淮阴工学院江苏淮安223003

固定激发波长320nm,对不同浓度百菌清药液进行荧光光谱实验,发现在352和366nm处有明显特征峰,随着药液浓度降低,366nm肩峰逐渐消失,而352nm特征峰保持稳定;对百菌清浓度和所得发射光谱荧光强度（352nm）进行指数函数回归分析,相关系数为... 详细信息

固定激发波长320nm,对不同浓度百菌清药液进行荧光光谱实验,发现在352和366nm处有明显特征峰,随着药液浓度降低,366nm肩峰逐渐消失,而352nm特征峰保持稳定;对百菌清浓度和所得发射光谱荧光强度（352nm）进行指数函数回归分析,相关系数为0.999,实验结果与荧光强度-浓度理论计算公式相符合;对低浓度药液浓度和荧光强度进行线性拟合,其百菌清残留预测模型函数相关系数为0.995,最低检出限为0.018 8μg·mL-1,定量极限值为0.062 7μg·mL-1,线性范围为0.062 7~28.45μg·mL-1。通过对中药材黄芪和枸杞与百菌清混合体系的荧光光谱进行研究,发现两种中药材对百菌清荧光强度都有较强的衰减,表明它们都和百菌清发生了相互作用。经过分析计算,黄芪和枸杞的衰减率分别为88.5%和99.7%,对其建立强度衰减模型函数,相关系数分别为0.994和0.997。研究结果为利用荧光光谱检测百菌清残留提供了实验依据,表明可以采用荧光光谱方法直接对百菌清农药残留进行检测,相关参数值满足检测要求标准,这为进一步利用荧光光谱检测该农药在果蔬中的残留具有重要的参考价值。同时发现药食同源类中药材枸杞和黄芪都能对百菌清荧光特征峰强度产生显著衰减,这为研究利用药食同源类中药材降解农药残留提供了新的研究思路。

关键词：百菌清农药检测荧光光谱中药材强度衰减

New insight into the origin and evolution of the flora and fauna of Hainan Island, China

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Science China Earth Sciences 2025年第1期68卷 52-61页

作者： Hua zhu Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants

The origin of the biota of Hainan Island, China, remains a fundamental scientific problem. Comparative studies on the biota, geological tectonics, and paleomagnetism proposed that during the Eocene, Hainan Island connected Vietnam and Guangxi, and then moved to the southeast to reach its present location. This review mainly discusses its biota origin from molecular phylogeny and palaeobotanical research. The formation and evolution of the biological groups of Hainan Island were identified via research on their genomes, phylogeny, and molecular biogeography. This research showed that the genera and species that appeared and diverged early in their evolution(i.e., before the Miocene) can be explained by the land connection between Hainan Island, Vietnam, and Guangxi during the Eocene-Oligocene. According to Southeast Asian tectonic theory, in the Middle Miocene(at about 15 million years ago), Hainan Island had moved to its present position. The population and genetic divergence of species with late divergence times(after 15 Ma) can be reasonably explained by the close proximity(or land connection) between Hainan Island and the Leizhou Peninsula, enabling genetic communication between Hainan Island and the Chinese mainland, but have exceptional cases. Conclusions have been obtained through palaeobotanical studies, showing that in the Eocene-Oligocene period, southwest China and Hainan Island had subtropical vegetation and flora. However, the fossil group in southeast China(in Maoming, near present-day Hainan Island) in the Late Eocene indicated a tropical rainforest vegetation and flora. This suggests that in the Paleogene, Hainan Island may have been located near or on the southwest border of Guangxi and northern Vietnam, rather than in its present location. The floristic division of the flora of Hainan Island basically presents a northeast-southwest inclined distribution pattern. This pattern can be explained by the counterclockwise rotation of Hainan Island during i

关键词： Molecular phylogeny Biogeography Paleobotany Origin of flora and fauna Hainan Island of China

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基于牛血清白蛋白荧光探针的盐酸特拉唑嗪含量测定

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发光学报 2014年第8期35卷 1014-1017页

作者：季仁东赵志敏张吉华陈梦岚朱星玥南京航空航天大学理学院江苏南京210016 淮阴工学院电子与电气工程学院江苏淮安223003

对牛血清白蛋白(BSA)与盐酸特拉唑嗪(THD)混合体系进行了荧光发射光谱和同步光谱实验研究。BSA溶液在340 nm处有明显荧光特征峰,当加入THD后导致牛血清白蛋白发生内源荧光猝灭。据此建立了以BSA为探针的THD含量测定方法,通过该方法所得... 详细信息

对牛血清白蛋白(BSA)与盐酸特拉唑嗪(THD)混合体系进行了荧光发射光谱和同步光谱实验研究。BSA溶液在340 nm处有明显荧光特征峰,当加入THD后导致牛血清白蛋白发生内源荧光猝灭。据此建立了以BSA为探针的THD含量测定方法,通过该方法所得的模型函数相关系数都高于0.99。对所得模型函数进行了实验验证,其中发射光谱模型函数回收率为96.04%~103.16%,同步光谱模型函数回收率为100.41%~105.58%,相对标准偏差分别为3.70%和2.42%。荧光发射光谱和同步光谱方法的检出限分别为0.64×10-8mol/L和0.66×10-8mol/L,定量限分别为0.21×10-7mol/L和0.22×10-7mol/L。

关键词：牛血清白蛋白盐酸特拉唑嗪荧光光谱含量检测