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Journal of Genetics and Genomics 2019年第5期46卷 247-257页

作者： Wenjing Zhao Jieqiong Tan Tengfei zhu Jianjun Ou Ying Li Lu Shen Huidan Wu Lin Han Yanling Liu Xiangbin Jia Ting Bai Honghui Li Xiaoyan Ke jingping Zhao Xiaobing Zou Zhengmao Hu Hui Guo Kun Xia Center of Medical Genetics & Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha410078China Mental Health Institute of the Second Xiangya Hospital Central South UniversityChangsha410011China Key Laboratory of Developmental Disorders in Children Liuzhou Maternity and Child Healthcare HospitalLiuzhou545001China Child Mental Health Research Center Nanjing Brain Hospital Affiliated of Nanjing Medical UniversityNanjing210029China Children Development Behavior Center of the Third Affiliated Hospital of Sun Yat-sen University Guangzhou510630China School of Life Sciences and Technology Xinjiang UniversityUrumqi830046China CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT) Chinese Academy of SciencesShanghai200030China

Excess de novo likely gene-disruptive and missense variants within dozens of genes have been identified in autism spectrum disorder(ASD)and other neurodevelopmental ***,many rare inherited missense variants of these high-risk genes have not been thoroughly *** this study,we analyzed the rare missense variant burden of POGZ in a large cohort of ASD patients from the Autism Clinical and Genetic Resources in China(ACGC)and further dissected the functional effect of diseaseassociated missense variants on neuronal *** results showed a significant burden of rare missense variants in ASD patients compared to the control population(P=4.6×10-5,OR=3.96),and missense variants in ASD patients showed more severe predicted functional outcomes than those in ***,by leveraging published large-scale sequencing data of neurodevelopmental disorders(NDDs)and sporadic case reports,we identified 8 de novo missense variants of POGZ in NDD *** analysis revealed that two inherited,but not de novo,missense variants influenced the cellular localization of POGZ and failed to rescue the defects in neurite and dendritic spine development caused by Pogz knockdown in cultured mouse primary cortical ***,L1CAM,an autism candidate risk gene,is differentially expressed in POGZ deficient cell *** expression of L1cam was able to partially rescue the neurite length defects caused by Pogz *** study showed the important roles of rare inherited missense variants of POGZ in ASD risk and neuronal development and identified the potential downstream targets of POGZ,which are important for further molecular mechanism studies.

关键词： Autism POGZ Neuronal development Missense variants

Evaluation of Clinical Efficacy of Combined Use of Acupuncture and Medicine in Treating Sleep Disorder in Patients with Anxiety Disorder

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Medicinal Plant 2021年第3期12卷 91-93页

作者： Xiangpu LIU jingping MU Xinhua YU Shun ZENG Nannan LIU Xiaohu zhu Orthopedic Rehabilitation Ward 3 Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China Sleep Disorder Center Shiyan Taihe Hospital (Affiliated Hospital of Hubei University of Medicine) Shiyan 442000 China

[Objectives]To evaluate the clinical efficacy of combined acupuncture and medicine in the treatment of sleep disorders in patients with anxiety disorders.[Methods]A total of 300 anxiety patients with sleep disorders were randomly selected and divided into a research group and a control group,with 150 cases in each *** control group was administered with western medicine,and the research group was treated with acupuncture and medicine to compare their clinical treatment effects.[Results]The total effective rate of treatment in the research group was significantly higher than that in the control group;after treatment,both the PSQI and SAS scores of the two groups were significantly reduced,and the reduction degree of the research group was higher than that of the control group,the difference was statistically significant(P<0.05).[Conclusions]Combined use of acupuncture and medicine to treat sleep disorders in patients with anxiety disorders has better curative effect and fewer adverse reactions,so it has high clinical application value.

关键词： Combined use of acupuncture and medicine Anxiety disorder Sleep disorder

Anaerobic digestion of sludge by different pretreatments:Changes of amino acids and microbial community

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Frontiers of Environmental Science & Engineering 2022年第2期16卷 109-123页

作者： Keke Xiao Zecong Yu Kangyue Pei Mei Sun Yuwei zhu Sha Liang Huijie Hou Bingchuan Liu jingping Hu Jiakuan Yang School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Hubei Provincial Engineering Laboratory of Solid Waste Treatment Disposal and Recycle TechnologyWuhan 430074China State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China

Many studies have investigated the effects of different pretreatments on the performance of anaerobic digestion of ***,the detailed changes of dissolved organic nitrogen,particularly the release behavior of proteins and the byproducts of protein hydrolysis-amino acids,are rarely known during anaerobic digestion of sludge by different *** we quantified the changes of three types of proteins and 17 types of amino acids in sludge samples solubilized by ultrasonic,thermal,and acid/alkaline pretreatments and their transformation during anaerobic digestion of *** protein,aromatic protein I,aromatic protein II,and cysteine were identified as the key dissolved organic nitrogen responsible for methane production during anaerobic digestion of sludge,regardless of the different pretreatment *** from the depletion of other amino acids,cysteine was resistant to degradation after an incubation period of 30 days in all sludge ***,the“cysteine and methionine metabolism(K00270)”was absent in all sludge samples by identifying 6755 Kyoto Encyclopedia of Genes and Genomes assignments of genes *** contributed to the generation of methane and the degradation of acetic,propionic,and n-butyric acids through decreasing oxidation-reduction potential and enhancing biomass *** study provided an alternative strategy to enhance anaerobic digestion of sludge through in situ production of cysteine.

关键词： Sludge pretreatments Dissolved organic nitrogen Proteins Amino acids Structural equation model Metagenomic sequencing analysis

MicroRNA-29b inhibits supernatants from silica treated macrophages from inducing extracellular matrix synthesis in lung fibroblasts

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MicroRNA-29b inhibits supernatants from silica treated macro...

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Zhonghui zhu Ximeng Lian Xiaowei Chen jingping Sun Yan Wang Lin Tian School of Public Health Capital Medical University

Objectives Silicosis is pathologically characterized by diffused pulmonary fibrosis and abundant deposition of extracellular matrix(ECM) *** ECM is mainly secreted by myofibroblasts which are the activated state of ***-29 b(miR-29 b) is one of the well-known microRNAs involved in fibrosis,but its roles in silicosis have not been *** In this study,we hypothesized that miR-29 b might play a protective role in the progression of *** assay,qRT-PCR,immunofluorescence and western blotting were *** The results demonstrated that the supernatants from silica-treated macrophages not only caused the proliferation of fibroblasts(NIH-3 T3 and MRC-5)but were also involved in the downregulation of miR-29 *** they could induce fibroblast activation,increasing the expression of ECM components such as collagen 1 and collagen3,in a silica dose-dependent ***,overexpression of miR-29 b by transfecting mimics markedly reduced the expression of ECM components and inhibited ECM *** These findings indicate that miR-29 b inhibits the supematants from silica treated macrophages from inducing extracellular matrix synthesis,thus miR-29 b might have a strong anti-fibrotic capacity in silicosis and serve as a potential therapeutic agent for the treatment.

关键词： miR-29b silica fibroblast

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两原子腔QED系统中的双光子吸收现象

光学学报 2022年第21期42卷 40-44页

作者：敖云娜许静平朱成杰同济大学物理科学与工程学院上海200092 苏州大学物理科学与技术学院江苏苏州215006

详细研究了两原子腔量子电动力学系统中的双光子吸收现象。在自由空间中,由于存在量子干涉效应,两个不同频率的原子无法被同时激发。但是,在强耦合的腔量子电动力学系统中,原子与腔场间的耦合导致系统中出现新的跃迁通道,从而使双原子... 详细信息

详细研究了两原子腔量子电动力学系统中的双光子吸收现象。在自由空间中,由于存在量子干涉效应,两个不同频率的原子无法被同时激发。但是,在强耦合的腔量子电动力学系统中,原子与腔场间的耦合导致系统中出现新的跃迁通道,从而使双原子激发成为可能。通过数值模拟主方程,详细研究了两原子腔量子电动力学系统的光子激发谱,并与双光子激发谱进行比较,证明了双光子激发的可能性。通过进一步分析光子的二阶关联函数、双原子激发概率,揭示了腔内光子的统计性质和实现双原子激发的物理机制。

关键词：物理光学强耦合两原子腔腔量子电动力学双光子过程

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基于多关系网络的社区检测算法

系统仿真学报 2015年第1期27卷 147-154页

作者：喻金平郑杰朱桂祥江西理工大学工程研究院赣州341000 江西理工大学信息工程学院赣州341000

针对传统的社区检测算法主要适用于单关系网络,忽略了多关系网络中各关系间的相互影响,不能区分出各关系对于社区检测的重要性等问题,提出一种基于节点和关系联合排名模型,能够将多关系合并为单关系的Interact Rank算法。该算法在多关... 详细信息

针对传统的社区检测算法主要适用于单关系网络,忽略了多关系网络中各关系间的相互影响,不能区分出各关系对于社区检测的重要性等问题,提出一种基于节点和关系联合排名模型,能够将多关系合并为单关系的Interact Rank算法。该算法在多关系网络中结合Page Rank算法以及随机游走模型的思想,考虑了多关系网络中各关系内和关系间个体的联系。同时,利用谱聚类对Interact Rank算法得到的单关系网络进行聚类,用于社区检测。通过UCI标准数据集上的仿真实验表明:Interact Rank算法能够在多关系网络进行有效的社区检测。

关键词：多关系网络社区检测 PageRank 随机游走模型谱聚类

气调包装与1-MCP结合抑制苹果蜡质成分降低

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农业工程学报 2013年第16期29卷 269-277页

作者：董晓庆饶景萍朱守亮杨青珍西北农林科技大学园艺学院杨凌712100

为了探讨红富士苹果在贮藏过程中主要蜡质成分特别是与油腻相关的蜡质成分变化,以及贮藏过程中果实主要品质指标的变化规律,研究了聚氯乙烯袋(PVC)自发气调包装(MAP)与1-甲基环丙烯(1-MCP)结合处理(MAP+1-MCP)对(0±1)℃冷藏过程中红富... 详细信息

为了探讨红富士苹果在贮藏过程中主要蜡质成分特别是与油腻相关的蜡质成分变化,以及贮藏过程中果实主要品质指标的变化规律,研究了聚氯乙烯袋(PVC)自发气调包装(MAP)与1-甲基环丙烯(1-MCP)结合处理(MAP+1-MCP)对(0±1)℃冷藏过程中红富士苹果蜡质成分和果实贮藏品质的影响。结果表明:在贮藏过程中,对照(不做任何处理)的蜡质总量一直降低,MAP和MAP+1-MCP处理的在贮藏一个月后升高,随后贮藏的过程中降低。所有处理和对照中,二十九烷和二十七烷含量降低,十六烷酸和9,12-十八碳二烯酸含量升高,二十九-10-醇和二十九-10-酮含量先降低再升高。MAP和MAP+1-MCP能够抑制蜡质总量和其他成分相应的变化。MAP和MAP+1-MCP均能延缓果实硬度的下降、可溶性固形物和可滴定酸的降解速度,降低固酸比率和失重率,抑制呼吸速率和乙烯释放速率,且可以抑制苹果贮藏后期油腻的发生。无论从对蜡质成分的影响,还是对果实贮藏品质的影响来看,MAP+1-MCP的效果优于MAP。PVC气调包装结合1μL/L1-MCP是较为理想的长时间保鲜红富士苹果的处理方式。研究结果可为生产上科学有效的长期贮藏红富士苹果、解决贮藏后期果实油腻问题提供参考。

关键词：贮藏包装果实苹果 1-甲基环丙烯蜡质成分

小胶质细胞显像原理及其在精神分裂症中的应用

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中华精神科杂志 2018年第6期51卷 402-404页

作者：朱芙蓉赵靖平中南大学湘雅二医院精神卫生研究所长沙410011

近年来,随着精神分裂症小胶质细胞(microglia,MI)假说的提出,人们越来越关注该细胞在精神分裂症中的作用[1-2]。大量研究显示小胶质细胞激活后能够大量表达一种转位蛋白(translocator protein,TSPO),利用该蛋白的放射性配体对小胶质细... 详细信息

近年来,随着精神分裂症小胶质细胞(microglia,MI)假说的提出,人们越来越关注该细胞在精神分裂症中的作用[1-2]。大量研究显示小胶质细胞激活后能够大量表达一种转位蛋白(translocator protein,TSPO),利用该蛋白的放射性配体对小胶质细胞进行标记,通过PET可以在体显示激活的小胶质细胞,从而了解疾病的严重程度。

关键词：小胶质细胞精神分裂症显像原理 protein 细胞激活放射性配体 PET 蛋白

面向用户的数字档案资源整合:国外研究及借鉴

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档案学研究 2017年第2期 98-101页

作者：肖静萍朱一丽河北大学管理学院保定071002 中国人民大学信息资源管理学院北京100872

文章主要以综合档案馆的馆藏资源为研究对象对国外的数字档案资源整合进行研究,运用典型案例研究方法,选取英国国家档案馆和收藏在线项目为国外数字档案资源整合的典型案例,对英国以提高研究档案的意识为目标的数字档案资源整合进行分... 详细信息

文章主要以综合档案馆的馆藏资源为研究对象对国外的数字档案资源整合进行研究,运用典型案例研究方法,选取英国国家档案馆和收藏在线项目为国外数字档案资源整合的典型案例,对英国以提高研究档案的意识为目标的数字档案资源整合进行分析总结,指出其对于我国数字档案资源开发的可借鉴之处。同时结合文献调查研究方法对国外档案资源整合的研究现状进行梳理概括并指出面向用户的开放数据是档案资源整合和服务的趋势,以期给我国数字档案服务及模式的研究和实践提供借鉴。

关键词：数字档案资源整合国外研究面向用户