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SDS-PAGE study on photooxidation damage of lysozyme induced by riboflavin

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Science china Chemistry 2007年第1期50卷 84-90页

作者： zhang {1. {2. {3. zhu hongping GE Min wang wenfeng yao side LI WenXin shanghai {1. of {2. {3. Chinese Academy of SciencesShanghai 201800China Graduate University of chinese Academy of Sciences Beijing 100049China

The photooxidation damage of lysozyme under 3.0}-3.5 nm irradiation in the presence of riboflavin was studied by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).Indica- tions showed that the mechanisms and products of oxidative damage were relative to the concentra- tion of riboflavin,the time of irradiation and the *** type I process was examined in a nitrogen saturated solution,whereas both type I and type II were observed in an aerobic atmosphere and type II was the dominant *** study also suggested that antioxidants,such as melatonin, can reduce the damage of lysozyme effectively.

关键词： lysozyme riboflavin photooxidation SDS-PAGE antioxidant

Recombinant Bivalent Vaccine against Foot-and-Mouth Disease Virus Serotype O/A Infection in Guinea Pig

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Acta Biochimica et Biophysica Sinica 2004年第9期36卷 589-596页

作者： Jian-Zhong YI1, Ming-Qiu LIU1, Cai-zhu zhu2. Qiang {2.1, Zu-Tian SHENG3. Qing-Yun DU3. Wei-yao YAN1, and zhao-Xin ZHENG1* State Key Laboratory of Genetics Engineering, Life Science School, Fudan University, shanghai 2.043., china 1The Veterinary institute of chinese Academy of Agricultural Sciences, Lanzhou 73.046, china 2.he Virus Research institute of Zhejiang Academy of Agricultural Sciences, Hangzhou 3.002., china State Key Laboratory of Genetics Engineering Life Science School Fudan University The Veterinary institute of {1. Academy of Agricultural Sciences

In this study, two DNA fragments encoding amino acid (1.1.1.0)-({3.–40)-(1.1.1.0) of the VP1.of FMDV (foot-and-mouth disease virus) serotype O and (1.8–1.0)-({3.–40)-(1.8–1.0) of the serotype A FMDV were chemically synthesized. These two tandem-repeat fragments were ligated and transfected into prokaryotic expression vector pTrcHis A to construct pTH-O-A. The other vector called pTH-O-scIgG-A was constructed similarly only that the two tandem-repeat DNA fragments were linked by the bovine- IgG heavy chain coding sequence. Guinea pigs immunized with the two bivalent vaccines pTH-O-A and pTH-O-scIgG-A showed both specific antibody activity and T cell proliferation responses. FMDV challenge tests showed that 85% and 70% of guinea pigs vaccinated twice with {3.0 μg of the fusion protein of pTH-O-A were protected from FMDV serotype O and serotype A infection respectively. 70% and 57% of the guinea pigs immunized with the fusion protein of pTH-O-scIgG-A were protected from FMDV serotype O and serotype A infection respectively.

关键词： foot-and-mouth disease FMDV serotype O FMDV serotype A VP1.protein bivalent vaccine guinea pig

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jinyi zhao Sulin {1. Lu Liu Yumin {1. Wei Xu Maolin Shao Jingjing Peng Shuai Xia Yan {3. Keke {1. Xianglei {1. Ruxue {1. jian Li Wenhao Dai Zhen Ge Shulei Hu Changyue Yu Jiang wang Dakota Ma Mingyue Zheng Haitao Yang Gengfu Xiao Zihe Rao Lu Lu Leike {1. Fang Bai yao zhao Shibo Jiang Hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China shanghai {1. for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2.specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2.variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1.CAPN1.are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,1.a and 1.b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1.in complex with 1.a and 1.b revealed the covalent binding of a-ketoamide groups of 1.a and 1.b to C2. of CTSL and C1.5 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2.and its variants of concern(VOCs)with ECso values ranging from 0.80 to 1.1.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,1.a and 1.b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 1.a and 1.b treatments demonstrated potent antiviral potency against SARS-CoV-2.XBB 1.1. variant infection in a K1.-hACE2.transgenic mouse *** 1.b also showed effective antiviral activity against HCoV-OC43.infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 1.a and 1.b exhibited excellent antiinflammatory effects in Raw 2.4.7 mouse macrophages and in mice with acute *** together,these results suggested that 1.a and 1.b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

An air-stable single-crystal layered oxide cathode based on multifunctional structural modulation for high-energy-density sodium-ion batteries

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Science china Chemistry 2024年

作者： Yi-Feng Liu Hai-Yan Hu Jia-Yang Li Hongrui wang Yi {1. Jingqiang wang Yuan-Bo Wu Yan-Jiang Li Guang-Yu {3. Qing-Qun Sun Yan-Fang zhu Rui-Ren Tang Xiong-Wei Wu Jia-{1. wang Shi-Xue Dou Shu-Lei Chou yao Xiao Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University School of Chemistry and Materials Science Hunan Agricultural University institute of Energy Materials Science University of Shanghai for Science and Technology Wenzhou Key Laboratory of Sodium-Ion Batteries Wenzhou University Technology Innovation Institute for Carbon Neutralization institute for Carbon Neutralization College of Chemistry and Materials Engineering Wenzhou University College of Chemistry and Chemical Engineering Central South University

P2.type layered oxide, Na2.3.i1.3.n2.3.2. has drawn particular interest as a promising cathode material for sodium-ion batteries(SIBs) due to its fast sodium-ion transport channels with low migration potential. However, some catastrophic flaws, such as air instability, complicated multiphase evolution, and irreversible anionic redox, limit its electrochemical performance and hinder its application. Here, an air-stable single-crystal P2.type Na2.3.i1.3.n1.3.i1.3.2.s proposed based on the multifunctional structural modulation of Ti substitution that could alleviate the issues for practical SIBs. As a result, the cathode with high energy density shows excellent air stability and highly reversible phase transitions(P2.OP4), and delivers faster kinetics and stable anion redox chemistry. Meanwhile, a thorough investigation of the relationship between structure, function, and properties is demonstrated,emphasizing formation processes, electrochemical behavior, structural evolution, and air stability. Overall, this study provides the direction of multifunctional structural modulation for the development of high-performance sodium-based layered cathode materials for practical applications.

关键词：

1.B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao wang Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan {1. Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong {2. Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑{3. He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑yao Jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan {1.‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng wang Peng‑Cheng wang {1.‑Hui wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui {2. Hang‑Chang {2. Lin‑Hao {2. Qi‑Wei {2. Xian‑Peng {2. Yu‑Liang {2. Yue {2. Zhi‑Yong {2. Zhi‑Hao Zhou Ke‑Jun {3. Chong Zou institute of High Energy {1. Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research institute Co.Ltd Nanjing 211106China Department of Modern physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear physics and Technology School of PhysicsPeking UniversityBeijing 100871China institute of Modern {1. Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China china Academy of Engineering {1. Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest institute of Nuclear Technology Xi’an 710024China University of chinese Academy of Sciences Beijing 100049China china Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1.80s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the{1. Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 1.B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1.1.0 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1.1.0 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 1.B doped MCP detector White neutron source Sample nuclide identification

主链含萘酰亚胺的聚芳醚型聚合物的合成及其光电性能

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发光学报 2012年第3期33卷 243-246页

作者：陈杰贺英潘照东张瑶斐朱棣顾莹王均安上海大学材料科学与工程学院高分子材料系上海200072 上海大学材料科学与工程学院材料研究所上海200072

萘酰亚胺衍生物是一类发光效率优良的电子传输型电致发光材料。本文采用亲核取代反应将其作为聚合物主链的一部分构成主链含1.8-萘酰亚胺的聚芳醚型发光聚合物(PENI),聚合物的重均分子量为4 3.0。通过FT-IR和NMR对单体及聚合物的结构进... 详细信息

萘酰亚胺衍生物是一类发光效率优良的电子传输型电致发光材料。本文采用亲核取代反应将其作为聚合物主链的一部分构成主链含1.8-萘酰亚胺的聚芳醚型发光聚合物(PENI),聚合物的重均分子量为4 3.0。通过FT-IR和NMR对单体及聚合物的结构进行了鉴定,并研究了其光致发光性能和电化学性能。在分子量较小时,PENI薄膜的PL发射峰位于407,456,53. nm;当聚合物分子量提高后,发射峰红移1. nm左右。采用循环伏安法测得聚合物的HOMO和LUMO分别为-5.64 eV和-2.93.eV,Eg为2.71.eV。

关键词： 1.8-萘酰亚胺光电聚合物亲核取代

Association of a complete breast cancer pathologic response with axillary lymph node metastasis via neoadjuvant chemotherapy:Results from the CSBrS-01.0}study

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chinese Medical Journal 2024年第11期137卷 1369-1371页

作者： Le Ma Pin Gao Zhenzhen Liu Dechuang Jiao Rui Ling Jingjing Xiao Yi zhao Yitong {1. Hongjian Yang Yunjiang Liu Ke Liu Jianguo {2. Guangyan Li Dahua Mao Yinglei Deng Jianjun He Maimaitiaili Amina Zhigang Yu {1. Fei Yinhua Liu Peifen Fu Minya yao Jiandong {1. Li zhu Hongchuan Jiang Zuowei zhao Xingsong Tian Zhongwei Cao Xinyu Ma Kejin Wu Shaomei Fu Ailin Song Yanwei {1. Jin Feng Zhimin Fan Department of Breast Surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchunJilin 130021China Department of Breast Disease Henan Breast Cancer CenterAffiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China Department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Surgical Oncology Department Shengjing Hospital of China Medical UniversityShenyangLiaoning 110022China Department of Breast Surgery The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310022China Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 052360China Fourth Department of Breast Surgery Jilin Cancer HospitalChangchunJilin 130012China Department of Breast Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Breast Surgery Affiliated Wudang Hospital of Guizhou Medical UniversityGuiyangGuizhou 550009China Department of Breast Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Breast Surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Breast Disease Center Peking University First HospitalBeijing 100034China Department of Breast Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100852China Department of Breast Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Breast Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Breast and Thyroid Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinan

To the Editor:In the last decade,neoadjuvant chemotherapy(NAC)has become a well-accepted treatment option for breast cancer,although few detailed description of NAC in china has yet been reported.[1.A previous study found that among patients with clinically node-negative(cN0)breast cancer,97.7%(43.1.44{1.with breast pathologic complete response(bpCR)had ypN0(absence of metastases in the axillary lymph nodes);and 71.6%(88{1.1.1.{1.without bpCR achieved ypN0(P1..As for human epidermal growth factor receptor {1.HER{1.positive or triple-negative breast cancer(TNBC)that achieved bpCR.

关键词： breast pathologic chemotherapy

基于表面肌电图的手法治疗对老年人膝骨关节炎效果的随机对照试验

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中国康复理论与实践 2024年第9期30卷 1099-1106页

作者：朱博文赵素红李苗秀张帅攀姚重界朱清广房敏上海中医药大学附属曙光医院推拿科上海市201203 上海中医药大学针灸推拿学院上海市201203 上海市中医药研究院中医推拿研究所上海市200437 上海中医药大学附属岳阳中西医结合医院推拿科上海市200437

目的观察基于表面肌电图的手法治疗对老年人膝骨关节炎(KOA)的临床疗效。方法选取2.2.年8月至2.2.年6月上海中医药大学附属曙光医院单侧KOA患者1.6例,随机分为对照组和试验组,各53.。对照组采用常规手法治疗,试验组采用基于平均肌电(AE... 详细信息

目的观察基于表面肌电图的手法治疗对老年人膝骨关节炎(KOA)的临床疗效。方法选取2.2.年8月至2.2.年6月上海中医药大学附属曙光医院单侧KOA患者1.6例,随机分为对照组和试验组,各53.。对照组采用常规手法治疗,试验组采用基于平均肌电(AEMG)制定的手法,共4周。治疗前后采用西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、疼痛视觉模拟量表(VAS)、Tinetti平衡与步态评分和6分钟步行试验(6-MWT)距离进行评定。结果两组各脱落1.。治疗前,试验组患侧股直肌、股内侧肌、腓肠肌内侧头AEMG显著低于健侧(|Z|>8.647,P1.,患侧股外侧肌、半腱肌、股二头肌AEMG值显著高于健侧(|Z|>4.808,P1.。治疗后两组WOMAC、VAS、Tinetti平衡与步态评分和6-MWT距离均较前显著改善(|t|>3.987,P1.,除VAS评分外,试验组各项指标均优于对照组(|t|>2.2.3.P<0.05)。结论基于表面肌电图结果,将激活股直肌、股内侧肌、腓肠肌内侧头,抑制股外侧肌、半腱肌、股二头肌和释放内、外侧副韧带张力作为手法操作重点,可缓解老年人KOA疼痛,改善膝关节活动能力。

关键词：膝骨关节炎老年表面肌电图手法治疗随机对照试验

STCF conceptual design report (Volume 1.: physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker institute of Nuclear {1. Novosibirsk 630090Russia CAS Key Laboratory of Theoretical physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china Normal University Wuhan 430079China Central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 1. Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China institute of Advanced Science Facilities Shenzhen 518107China institute of High Energy {1. Chinese Academy of SciencesBeijing 100049China institute of Modern {1. Chinese Academy of SciencesLanzhou 730000China institute of {1. Academia SinicaTaipeiTaiwan 11529China institute of Theoretical {1. Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the chinese particle {1. *** is designed to operate in a center-of-mass energy range from 2.to 7 GeV with a peak luminosity of 0.5×1.^(3.) cm^(–2.·s^(–1. or *** STCF will produce a data sample about a factor of 1.0 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and {1. beyond the Standard *** STCF project in china is under development with an extensive R&D *** document presents the {1. opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and {1. case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design