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Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing

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Bioactive Materials 2022年第3期7卷 461-474页

作者： Yang Li Rongzhan Fu Zhiguang Duan chenhui zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Biotech.&Biomed.Research Institute Northwest UniversityXi’an710069ShaanxiChina

Bacterial infection,tissue hypoxia and inflammatory response can hinder the infected wound repair *** mitigate the above issues,tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets(MoS2@TA/Fe NSs)with dual enzyme activities were developed and anchored to a multifunctional *** hydrogel exhibited excellent antibacterial ability owing to the combined effects of photothermal therapy(PTT),glutathione(GSH)loss,and the peroxidase(POD)-like activity(catalyse H2O_(2)into⋅OH under acid condition)of MoS2@TA/Fe *** from the catalase(CAT)-like activity,the hydrogel could decompose H2O_(2)into O_(2)at neutral pH to relieve hypoxia and supply adequate O_(2).POD-like activity was mainly attributed to MoS2 NSs,while CAT-like activity was primarily due to TA/Fe ***,MoS2@TA/Fe NSs endowed the hydrogel with outstanding anti-oxidant ability to scavenge redundant reactive oxygen species(ROS)and reactive nitrogen species(RNS)under neutral environment to maintain the balance of antioxidant systems and prevent *** addition,the hydrogel could inhibit the release of inflammatory factors for the anti-inflammatory property of *** retained partial phenolic hydroxyl groups,which cross-linked the nanosheets to the network structure of the hydrogel and promoted the adhesion of *** to the dynamic boron ester bonds between polyvinyl alcohol(PVA),dextran(Dex),MoS2@TA/Fe,and borax,the hydrogel demonstrated fast self-healing and rapid shape *** shape-adaptable adhesive hydrogel could fill the whole wound and closely contact the wound,ensuring that it achieved its functions with maximum *** MoS2@TA/Fe nanozyme-anchored multifunctional hydrogel showed high potential for bacteria-infected wound healing.

关键词： MoS2@TA/Fe nanozyme Multifunctional hydrogel POD-Like CAT-Like Anti-inflammation

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Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

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Bioactive Materials 2022年第11期7卷 1-17页

作者： Wanyi Zhou Zhiguang Duan Jing Zhao Rongzhan Fu chenhui zhu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi’an710069ShaanxiChina Biotech.&Biomed.Research Institute Northwest UniversityXi’an710069ShaanxiChina

Chronic diabetic wounds are an important healthcare challenge. High concentration glucose, high level of matrix metalloproteinase-9 (MMP-9), and long-term inflammation constitute the special wound environment of diabetic wounds. Tissue necrosis aggravates the formation of irregular wounds. All the above factors hinder the healing of chronic diabetic wounds. To solve these issues, a glucose and MMP-9 dual-response temperature-sensitive shape self-adaptive hydrogel (CBP/GMs@Cel&INS) was designed and constructed with polyvinyl alcohol (PVA) and chitosan grafted with phenylboric acid (CS-BA) by encapsulating insulin (INS) and gelatin microspheres con-taining celecoxib (GMs@Cel). Temperature-sensitive self-adaptive CBP/GMs@Cel&INS provides a new way to balance the fluid-like mobility (self-adapt to deep wounds quickly, approximately 37 ◦C) and solid-like elasticity (protect wounds against external forces, approximately 25 ◦C) of self-adaptive hydrogels, while simultaneously releasing insulin and celecoxib on-demand in the environment of high-level glucose and MMP-9. Moreover, CBP/ GMs@Cel&INS exhibits remodeling and self-healing properties, enhanced adhesion strength (39.65 ± 6.58 kPa), down-regulates MMP-9, and promotes cell proliferation, migration, and glucose consumption. In diabetic full-thickness skin defect models, CBP/GMs@Cel&INS significantly alleviates inflammation and regulates the local high-level glucose and MMP-9 in the wounds, and promotes wound healing effectively through the synergistic effect of temperature-sensitive shape-adaptive character and the dual-responsive system.

关键词： Dual-responsive Temperature-sensitive Shape self-adaptive hydrogels Diabetic wound healing

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High efficiency production of ginsenoside compound K by catalyzing ginsenoside Rb1 using snailase

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Chinese Journal of Chemical Engineering 2018年第7期26卷 1591-1597页

作者： Zhiguang Duan chenhui zhu Jingjing Shi Daidi Fan Jianjun Deng Rongzhan Fu Rong Huang Cuiying Fan Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi'an 710069China Shanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical Engineering Northwest University Taibai North Road 229Xi'an 710069China

The rare ginsenoside Compound K （C-K） is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside C-K, including chemical and biological methods. Among these, the conversion of PPD-type ginsenosides by enzymatic hydrolysis is a trend due to its high efficiency and mild conditions. For effectively extracting from the other panaxadiol saponins, the conversion process for ginsenoside C-K was investigated using snailases in this study. The univariate experimental design and response surface methodology were used to determine the optimal hydrolysis conditions for the conversion of ginsenoside Rbl into ginsenoside C-K by snailases. The optimum conditions were as follows： pH 5,12, temperature 51 ℃, ratio of snailase/substrate 0.21, and reaction time 48 h. On the basis of these parameters, the addition of 1.0 mmol· L- 1 ferric ion was found to significantly improve the enzymolysis ofsnailases for the first time. With the above conditions, the maximum conversion rate reached 89.7%, suggesting that the process can obviously increase the yield of ginsenoside C-K. The bioassay tests indicated that the ginsenoside C-K showed anti-tumor activity in a series of tumor cell lines. Based on these results, we can conclude that the process of rare ginsenoside C- K production by enzymolysis with snailase is feasible, efficient, and suitable for the industrial production and application.

关键词： Ginsenoside Rb1 Ginsenoside Compound K Snailase Enzymolysis

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自走式烟叶采摘机采摘机构的设计与试验

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农机化研究 2024年第3期46卷 120-127页

作者：马四杰朱晨辉张超超冉云亮李保谦王万章河南农业大学机电工程学院郑州450002 河南农先锋科技股份有限公司郑州450002

烟叶采摘机一直受到烟叶破损率高问题的掣肘,从而影响烟农的经济效益,如何降低烟叶的破损率是目前烟叶采摘车的发展方向。为此,结合以前的烟叶采摘车,设计一种烟叶采摘机构,旨在降低烟叶的破损率,提高烟农的经济效益。所设计的采摘机构... 详细信息

烟叶采摘机一直受到烟叶破损率高问题的掣肘,从而影响烟农的经济效益,如何降低烟叶的破损率是目前烟叶采摘车的发展方向。为此,结合以前的烟叶采摘车,设计一种烟叶采摘机构,旨在降低烟叶的破损率,提高烟农的经济效益。所设计的采摘机构由采摘刀、传送辊、隔叶板及导流板等组成,采摘刀和传送辊均由橡胶材料制成,传送辊由橡胶辊和光轴组成,隔叶板和导流板均由钢板制作而成。通过对采摘刀和传送辊进行力学分析,得到了烟株不被采摘刀蹭倒和烟叶在传送辊不打滑的临界条件,为降低烟叶的破损率提供了理论依据。三因素(采摘刀的转速、采摘车的行驶速度、烟株的株距)正交旋转试验表明:采摘刀的转速为240~260r/min、采摘车的行驶速度为1.38~1.42km/h、株距为570~590mm时,烟叶的破损率符合大纲要求。试验结果表明:影响烟叶破损率因素的主次顺序为采摘刀的转速>采摘车的行驶速度>烟株的株距,在烟株的株距为579mm、采摘刀的转速为246r/min、烟叶采摘车的行驶速度为1.4km/h时,烟叶的破损率为9.36%,达到了预期要求。

关键词：烟叶采摘车烟叶采摘机构采摘刀传送辊破损率烟叶

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白酒酿造副产物黄水中产酯酵母菌株分离鉴定及产酯条件优化

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现代农业科技 2024年第12期 154-159,166页

作者：申旻陈雅楠刘瑶刘晨朱晨辉薛文娇陕西省太白酒业有限责任公司陕西宝鸡722300 陕西省微生物研究所陕西西安710043 西北大学陕西西安710069

利用三丁酸甘油酯法,从太白酒酿造副产物黄水中分离筛选出产酯能力相对较高的酵母菌株,并对最高酶活菌株进行16S rDNA鉴定,结果确定其为异威克汉逊酵母(Wickerhamomyces anomalus)。根据单因素试验结果,结合Box-Behnken Design-响应面... 详细信息

利用三丁酸甘油酯法,从太白酒酿造副产物黄水中分离筛选出产酯能力相对较高的酵母菌株,并对最高酶活菌株进行16S rDNA鉴定,结果确定其为异威克汉逊酵母(Wickerhamomyces anomalus)。根据单因素试验结果,结合Box-Behnken Design-响应面试验优化该菌株的培养条件。结果表明,当初始乙醇体积分数为3%、发酵pH值为5.5、发酵时间为48 h、发酵温度为34℃时,该菌株能继续生长,且酯化能力明显增强,总酯含量从4.1330 g/L提高至9.9100 g/L,其中代表性组分乙酸乙酯的相对含量从41.7200 mg/100 mL提高到302.1200 mg/100 mL。

关键词：白酒黄水产酯酵母分离鉴定酯化能力条件优化

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夏季闲置大棚利用杏鲍菇菌渣栽培草菇技术

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食药用菌 2024年第2期32卷 140-143页

作者：贺伟强张旭峰高书悦朱晨辉陈思敏朱长俊徐艺伟嘉兴职业技术学院现代农业学院浙江嘉兴314036 嘉兴市秀洲区农业推广站浙江嘉兴314011 海宁市食品农产品检验检测中心浙江海宁314400 嘉兴学院生物与化学工程学院浙江嘉兴314036 嘉兴市金秋生态农业有限公司浙江嘉兴314015

利用夏秋季蔬菜大棚空闲期,以杏鲍菇菌渣90%、干稻草10%为原料栽培草菇,每667 m2大棚产草菇约700 kg,按照上海批发市场20元/kg收购价计,除去成本,净产值约9700元,既提高了蔬菜大棚棚歇期土地利用率,草菇种植后菌渣直接还田还可改良土壤... 详细信息

利用夏秋季蔬菜大棚空闲期,以杏鲍菇菌渣90%、干稻草10%为原料栽培草菇,每667 m2大棚产草菇约700 kg,按照上海批发市场20元/kg收购价计,除去成本,净产值约9700元,既提高了蔬菜大棚棚歇期土地利用率,草菇种植后菌渣直接还田还可改良土壤,减少化肥使用,是一种实现农业废弃物循环利用、经济和生态效益显著的绿色种植模式。从设施选择、季节安排、品种选择、培养料制作、铺料播种、覆膜、覆土、发菌管理、出菇管理、病虫害防控等方面详述该套技术。

关键词：草菇杏鲍菇菌渣稻草培养料

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Unraveling the Effect of Stacking Configurations on Charge Transfer in WS_(2) and Organic Semiconductor Heterojunctions

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Precision Chemistry 2023年第7期1卷 443-451页

作者： Shuchen Zhang Dewei Sun Jiaonan Sun Ke Ma Zitang Wei Jee Yung Park Aidan H.Coffey chenhui zhu Letian Dou Libai Huang Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIndiana 47907United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720United States Department of Chemistry Purdue UniversityWest LafayetteIndiana 47907United States

Photoinduced interfacial charge transfer plays a critical role in energy conversion involving van der Waals(vdW)heterostructures constructed of inorganic nanostructures and organic ***,the effect of molecular stacking configurations on charge transfer dynamics is less *** this study,we demonstrated the tunability of interfacial charge separation in a type-Ⅱ heterojunction between monolayer(ML)WS_(2) and an organic semiconducting molecule[2-(3″′,4′-dimethyl-[2,2′:5′,2′:5″,2″′-quaterthiophen]-5-yl)ethan-1-ammonium halide(4Tm)]by rational design of relative stacking *** assembly between ML-WS_(2) and the 4Tm molecule forms a face-to-face stacking when 4Tm molecules are in a selfaggregation *** contrast,a face-to-edge stacking is observed when 4Tm molecule is incorporated into a 2D organic-inorganic hybrid perovskite *** face-to-face stacking was proved to be more favorable for hole transfer from WS_(2) to 4Tm and led to interlayer excitons(IEs)*** absorption measurements show that the hole transfer occurs on a time scale of 150 *** the other hand,the face-to-edge stacking resulted in much slower hole transfer without formation of *** inefficient hole transfer occurs on a similar time scale as A exciton recombination in WS_(2),leading to the formation of negative *** investigations offer important fundamental insights into the charge transfer processes at organic−inorganic interfaces.

关键词： Charge transfer two-dimensional materials organic semiconductors heterojunction stacking configuration interlayer exciton

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烟草打顶抑芽收集装置的设计

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农业装备与车辆工程 2024年第5期62卷 23-27页

作者：刘园牛莉莉吴疆刘流程玉渊李连豪朱晨辉黄会男河南省烟草公司南阳市公司河南南阳473009 河南农业大学河南郑州450002

烟草种植业是我国农业产业的重要组成部分,烟草产量与烟叶质量、烟草打顶抑芽的及时性和完成度密切相关。目前我国很多地方仍使用人工打顶抑芽,作业繁琐、效率低、成本高。为解决这一问题,通过查阅文献和调研,设计了一款烟草打顶抑芽收... 详细信息

烟草种植业是我国农业产业的重要组成部分,烟草产量与烟叶质量、烟草打顶抑芽的及时性和完成度密切相关。目前我国很多地方仍使用人工打顶抑芽,作业繁琐、效率低、成本高。为解决这一问题,通过查阅文献和调研,设计了一款烟草打顶抑芽收集装置。该装置由打顶装置、抑芽剂喷施装置、悬挂系统组成。经过SolidWorks建模并分析,并于河南南阳的试验基地进行了试验,试验结果为打顶准确率98%,抑芽剂喷施准确率94.5%,顶芽收集率94.1%,烟株损失率小于5%。该装置能够更好地解决人工打顶抑芽效率低的问题,可以高效率、低损伤率去除烟草顶芽,为打顶抑芽装置的设计提供参考。

关键词：烟草打顶机抑芽 SolidWorks建模

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多功能烟草田间管理一体机底盘优化设计

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农业装备与车辆工程 2024年第4期62卷 26-29页

作者：刘园程玉渊牛莉莉马宇吴疆李连豪朱晨辉黄会男河南省烟草公司南阳市公司河南南阳473009 河南农业大学河南郑州450002

针对现有烟草田间管理机械体积大、质量大、移动不灵活等问题,设计了一种自走式烟草田间管理一体机底盘,通过对车架、转向机构及底盘液压动力系统的优化设计以及车架应力分析,结果表明,优化后的底盘降低了车体质量,使传动更平稳、响应... 详细信息

针对现有烟草田间管理机械体积大、质量大、移动不灵活等问题,设计了一种自走式烟草田间管理一体机底盘,通过对车架、转向机构及底盘液压动力系统的优化设计以及车架应力分析,结果表明,优化后的底盘降低了车体质量,使传动更平稳、响应更迅速、安装更便捷、移动更灵活、布置更紧凑,为烟草打顶抑芽机械底盘的设计提供参考。

关键词：烟草田间管理机底盘液压系统转向机构

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A Study on the Sound Insulation Effect of Resilient Interlayer of a Floating Floor

A Study on the Sound Insulation Effect of Resilient Interlay...

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2015 3rd International Conference on Machinery,Materials and Information Technology Applications(ICMMITA 2015)

作者： Xianfeng Huang chenhui zhu Meng Yao Shi Quan Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Guangxi University College of Civil Engineering and Architecture Guangxi University

Due to favorable sound isolation to the impact sound transmission, People are prone to adopt floating floor as insulation structure. Of the researches on impact sound insulation through a floating floor, the theoretical study is much less than the experiment analysis. For the purpose to determine sound insulation and the dominate sound transmission path through a floating floor, the Statistical Energy Analysis（SEA） is employed to set up a theoretical model for predicting sound transmission across two floor plates connected by a resilient interlayer, and there are two main paths: the stud path and the cavity path. It reveals that the resilient interlayer plays a key role in impact sound insulation of a floating floor, and there exists a good agreement between predicted and measured sound pressure level（SPL） in the rooms below the floors.

关键词： Floating floor Resilient interlayer Impact sound Sound insulation

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