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In silico and in vitro genotoxicity evaluation of descarboxyl levofloxacin,an impurity in levofloxacin

中国药理学与毒理学杂志 2013年第3期 470-471页

作者： zhu qing-fen WEI Xi QU Jian-song LI Jun WANG Wei-jian Shandong Institute for Food and Drug Control

OBJECTIVE To evaluate the genotoxicity of Descarboxyl Levofloxacin by In silico and In vitro *** Assessment of genotoxicity using Derek for Windows We used DEREK for Windows(DfW,Lhasa Ltd.,Leeds,UK) version 11.0 for toxicity *** structures are entered into the program in *** *** program applies structure-activity relationships 〔(Q) SARs〕and other expert knowledge rules to derive a reasoned prediction about the potential toxicity of the query *** reverse mutation assay(Ames test) The Salmonella histidine point mutation assay proposed by Maron and Ameswas *** *** histidine autotrophic strains(TA97,TA98,TA100 and TA102) used in this test were obtained from Shandong center for disease *** saline(NS) was used as a vehicle control.2-Aminofluorene(2-AF,10 μg /plate),1,8-dihydroxyanthraquinone(50 μg /plate),Sodium azide(NaN3,1.5 μg /plate),and Dexon(50 μg /plate) were used as positive *** levofloxacin was assayed at concentrations of 31.25,62.5,125,250,and 500 μg /***,0.1 ml of test substance(or control solution),0.1 ml of bacterial culture 〔(1-2) × 1012 L-1 〕and 0.5 ml of S9 mix(NS for treatment without activation) were mixed and poured onto the agar plates after addition of 1.8 ml of top agar(0.6% agar Difco,0.5% NaCl,50 μmol·L-1 L-histidine,50 μmol·L-1 biotin,45℃) at 45℃.Plates were inverted and incubated for 48h at 37℃ in the *** colonies were counted and the background lawn was inspected for signs of toxicity or compound *** assay was performed two times in triple and included negative and positive *** al aberrations in Chinese ham ster lung cells Chinese Hamster Lung(CHL) cells were obtained from Shandong center for disease *** cells were grown in DMEM medium supplemented with 10% heat-inactivated calf serum at 37℃ in an atmosphere containing 5% of *** test for Chromosomal aberrations in CHL cells was con

关键词： genotoxicity impurity descarboxyl levofloxacin SARs CHL chromosomal aberration

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Fault Estimation for a Class of Markov Jump Piecewise-Affine Systems: Current Feedback Based Iterative Learning Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 418-429页

作者： Yanzheng zhu Nuo Xu fen Wu Xinkai Chen Donghua Zhou IEEE College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleigh NC 27695 USA Department of Electronic and Information Systems Shibaura Institute of TechnologySaitama 337-8570Japan

In this paper, the issues of stochastic stability analysis and fault estimation are investigated for a class of continuoustime Markov jump piecewise-affine(PWA) systems against actuator and sensor faults. Firstly, a novel mode-dependent PWA iterative learning observer with current feedback is designed to estimate the system states and faults, simultaneously, which contains both the previous iteration information and the current feedback mechanism. The auxiliary feedback channel optimizes the response speed of the observer, therefore the estimation error would converge to zero rapidly. Then, sufficient conditions for stochastic stability with guaranteed performance are demonstrated for the estimation error system, and the equivalence relations between the system information and the estimated information can be established via iterative accumulating ***, two illustrative examples containing a class of tunnel diode circuit systems are presented to fully demonstrate the effectiveness and superiority of the proposed iterative learning observer with current feedback.

关键词： Current feedback fault estimation iterative learning observer Markov jump piecewise-affine system

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Clinical prediction of insufficient vaults after implantable collamer lens implantation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1300-1306页

作者： Jun zhu Dan Cheng Xue-Ying zhu fen-fen Li Ye Yang Yu-feng Ye National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)***:The participants underwent ICL surgery and were divided into the low(<250μm)and normal(250-1000μm)vault groups based on the postoperative vault at *** preoperative biometric parameters and clinical outcomes were compared between the two *** relationship between the 3-month vault values and preoperative ocular parameters were evaluated by Generalized estimating ***:Sixteen(23 eyes)and 36 patients(63 eyes)were in the low and normal vault groups,*** implantation procedures were uneventful with no cataract formation in the early postoperative *** sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after *** 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in ***:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these *** the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.

关键词： insufficient vault implantable collamer lens ciliary body posterior chamber

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Escape probability for isotropic emitters near Kerr black hole with astrometric

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Communications in Theoretical Physics 2024年第5期76卷 128-133页

作者： Yu-Xuan Han qing-Hua zhu qing-Guo Huang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China Department of Physics Chongqing UniversityChongqing 401331China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced Study UCASHangzhou 310024China

The paper investigates the escape probability for isotropic emitters near a Kerr black *** propose a new approach to obtain the escape probability in a general manner,going beyond previous case-by-case *** approach is based on studies of the black hole shadow with astrometric observable and can be applied to emitters with an arbitrary 4-velocities and locations,even to the emitters outside of the equatorial *** also consider representative examples illustrating how escape probabilities vary with distance,velocity,and inclination ***,this new approach provides an effective method for studying escape probabilities near Kerr black holes.

关键词： Kerr black hole photon escape probability isotropic emitters

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乳钙咀嚼片细菌回复突变试验研究

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食品与药品 2024年第4期26卷 338-342页

作者：李志坤刘瑞李秀慧祝清芬赵艳霞李水仙董建欣山东省食品药品检验研究院国家药品监督管理局仿制药研究与评价重点实验室山东济南250101

目的对乳钙咀嚼片进行细菌回复突变试验,评价其是否有潜在的致突变性,并探索乳钙咀嚼片中组氨酸含量对自发回复突变菌落数的影响。方法采用鼠伤寒沙门菌突变型TA97a、TA98、TA100、TA102进行试验,用肝匀浆作为体外代谢活化系统(+/–s... 详细信息

目的对乳钙咀嚼片进行细菌回复突变试验,评价其是否有潜在的致突变性,并探索乳钙咀嚼片中组氨酸含量对自发回复突变菌落数的影响。方法采用鼠伤寒沙门菌突变型TA97a、TA98、TA100、TA102进行试验,用肝匀浆作为体外代谢活化系统(+/–s9),同时设空白对照组、溶剂对照组和阳性对照组。乳钙咀嚼片设50,10,2,0.4,0.08 mg/ml 5个剂量,按平板掺入法进行试验。另设1000,500,250,125,62.5,31.25μg/ml 6个剂量的组氨酸对照组。结果游离组氨酸在一定剂量范围内时,4种菌株自发回变菌落数随组氨酸剂量升高而增加,组氨酸剂量继续增高,回复突变菌落数降低。乳钙咀嚼片各剂量组在加与不加S9条件下各菌株回变菌落数均未超过溶剂对照组菌落数的2倍,未观察到剂量反应关系,Ames试验结果阴性。结论在本试验剂量范围内,乳钙咀嚼片Ames试验结果为阴性,提示该受试物无致突变性,同时排除了组氨酸成分对乳钙咀嚼片Ames试验结果的影响。

关键词：乳钙咀嚼片细菌回复突变试验组氨酸假阳性

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强度参数的不确定性对土石坝坝坡失稳概率的影响

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岩土工程学报 2008年第11期30卷 1594-1599页

作者：陈群唐岷朱分清四川大学水利水电学院山区河流开发与保护国家重点实验室四川成都610065 中国中铁二院工程集团有限责任公司四川成都610031

目前对土石坝坝坡的稳定性,主要是在坝料特性的确定参数基础上,采用极限平衡方法求出的坝坡抗滑稳定安全系数来评价。但实际的坝料特性参数往往是具有一定变化范围的变量,因此,安全系数大的坝坡不一定就比安全系数小的坝坡的失稳概率小... 详细信息

目前对土石坝坝坡的稳定性,主要是在坝料特性的确定参数基础上,采用极限平衡方法求出的坝坡抗滑稳定安全系数来评价。但实际的坝料特性参数往往是具有一定变化范围的变量,因此,安全系数大的坝坡不一定就比安全系数小的坝坡的失稳概率小。在分析研究12座均质土坝坝料强度参数统计特性的基础上,采用蒙特卡罗法对坝坡最危险滑裂面进行失稳概率分析,研究土石坝坝料强度参数的均值、变异性和相关性对坝坡失稳概率的影响。结果表明:强度参数的不确定性对坝坡的失稳概率有较大的影响,失稳概率随强度参数的均值的增大而减小,随变异系数的增大而增大。两个强度参数的相关性对坝坡的失稳概率也有显著的影响。由此可知,土石坝坝坡稳定性评价中,在确定性分析的同时,若能够考虑强度参数的不确定性,给出坝坡失稳概率,有利于更科学合理地评价土石坝的安全。

关键词：土石坝强度参数不确定性失稳概率

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An Image Fingerprint and Attention Mechanism Based Load Estimation Algorithm for Electric Power System

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 577-591页

作者： qing zhu Linlin Gu Huijie Lin Electricity Technology Branch Nari Technology Co.Ltd.Nanjing211106China NARI-TECH Nanjing Control Systems Co. Ltd.Nanjing211106China

With the rapid development of electric power systems,load estimation plays an important role in system operation and ***,load estimation techniques contain traditional,time series,regression analysis-based,and machine learning-based *** the machine learning-based method can lead to better performance,in this paper,a deep learning-based load estimation algorithm using image fingerprint and attention mechanism is ***,an image fingerprint construction is proposed for training *** the data preprocessing,the training data matrix is constructed by the cyclic shift and cubic spline ***,the linear mapping and the gray-color transformation method are proposed to form the color image ***,a convolutional neural network(CNN)combined with an attentionmechanism is proposed for training performance *** last,an experiment is carried out to evaluate the estimation *** with the support vector machine method,CNN method and long short-term memory method,the proposed algorithm has the best load estimation performance.

关键词： Load estimation deep learning attention mechanism image fingerprint construction

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Text Reasoning Chain Extraction for Multi-Hop Question Answering

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Tsinghua Science and Technology 2024年第4期29卷 959-970页

作者： Pengming Wang Zijiang zhu qing Chen Weihuang Dai School of Data Science and Artificial Intelligence Wenzhou University of TechnologyWenzhou 325035China School of Computer Science and also with Institute of Intelligent Information ProcessingSouth China Business CollegeGuangdong University of Foreign StudiesGuangzhou 510545China School of Psychology Jiangxi Normal UniversityNanchang 330022China also with School of Science East China Jiaotong UniversityNanchang 330013China Institute of Intelligent Information Processing South China Business CollegeGuangdong University of Foreign StudiesGuangzhou 510545China

With the advent of the information age, it will be more troublesome to search for a lot of relevant knowledge to find the information you need. Text reasoning is a very basic and important part of multi-hop question and answer tasks. This paper aims to study the integrity, uniformity, and speed of computational intelligence inference data capabilities. That is why multi-hop reasoning came into being, but it is still in its infancy, that is, it is far from enough to conduct multi-hop question and answer questions, such as search breadth, process complexity, response speed, comprehensiveness of information, etc. This paper makes a text comparison between traditional information retrieval and computational intelligence through corpus relevancy and other computing methods. The study finds that in the face of multi-hop question and answer reasoning, the reasoning data that traditional retrieval methods lagged behind in intelligence are about 35% worse. It shows that computational intelligence would be more complete, unified, and faster than traditional retrieval methods. This paper also introduces the relevant points of text reasoning and describes the process of the multi-hop question answering system, as well as the subsequent discussions and expectations.

关键词： intelligent computing multi-hop quiz text reasoning document retrieval text complex network

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A unified Minorization-Maximization approach for estimation of general mixture models

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 343-362页

作者： HUANG Xi-fen LIU Deng-ge ZHOU Yun-peng zhu Fei School of Mathematics Yunnan Normal UniversityKunming 650092China Department of Statistics and Actuarial Science The University of Hong KongHong KongChina

The mixed distribution model is often used to extract information from heteroge-neous data and perform modeling *** the density function of mixed distribution is complicated or the variable dimension is high,it usually brings challenges to the parameter es-timation of the mixed distribution *** application of MM algorithm can avoid complex expectation calculations,and can also solve the problem of high-dimensional optimization by decomposing the objective *** this paper,MM algorithm is applied to the parameter estimation problem of mixed distribution *** method of assembly and decomposition is used to construct the substitute function with separable parameters,which avoids the problems of complex expectation calculations and the inversion of high-dimensional matrices.

关键词： MM algorithm mixed distribution model parameter estimation assembly decomposition tech-nology parameter separation

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Effect of comprehensive nursing on the quality of life and swallowing function in individuals diagnosed with ischemic stroke

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World Journal of Clinical Cases 2024年第8期12卷 1406-1415页

作者： Heng-fen Hu Yu-Fei Sang Yan-qing Xiao Medical School Hunan Vocational and Technical College of Environmental BiologyHengyang 421005Hunan ProvinceChina Medical Team The Unit 95246 Of Chinese People’s Liberation ArmyNanning 530007Guangxi Zhuang Autonomous RegionChin Department of Gynecology and Obstetrics Hengyang Maternal and Child Health HospitalHengyang 421001Hunan ProvinceChina

BACKGROUND Ischemic stroke(IS)is a widely recognized disease characterized by high preva-lence,mortality,morbidity,disability,and recurrence *** ranks prominently in terms of mortality,constituting 60%-80%of stroke *** To explore the impact of comprehensive nursing care on the quality of life and swallowing function in individuals diagnosed with *** This study comprised 172 patients with IS admitted to our hospital between February 2018 to March *** participants were divided into two groups,namely the control group(n=80)receiving routine care and the research group(n=92)receiving comprehensive *** assessment scales,including the standard swallowing function assessment scale(SSA),National Institutes of Health Stroke scale(NIHSS),European stroke scale(ESS),self-rating anxiety scale(SAS),self-rating depression scale(SDS),Barthel index(BI),and the motor func-tion assessment scale(MAS),were employed to evaluate the improvement in swallowing function,neurological deficits,clinical outcomes,anxiety,depression,daily living activities,and motor function before and after ***,the study compared the occurrence of adverse reactions during the nursing period,life quality before and after the intervention,rehabilitation compliance,and nursing satisfaction between the two *** After the nursing intervention,the research group exhibited significantly improved SSA and NIHSS scores compared to the control group(P<0.05).Moreover,both groups demonstrated significant reductions in SAS and SDS scores(P<0.05),with the research group showing more obvious advantages(P<0.05).Compared to the control group,the research group displayed significantly better ESS,BI,and MAS scores(P<0.05),coupled with a lower incidence of adverse reactions(P<0.05).Additionally,the research group demonstrated markedly higher levels of life quality,rehabilitation compliance,and nursing satisfaction compared to the control group(P<0.05).CONCLUSION Comprehensive nu

关键词： Comprehensive nursing Stroke Swallowing function Quality of life Patient satisfaction

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