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Chinese Journal of Integrative Medicine 2021年第10期27卷 767-773页

作者： MO Ji-hao XIE Han-kun zhou ye-mian Ng Sihan-benjamin LI Shao-xia WANG Lei Department of Medical Laboratory Luoyang Orthopedic Hospital of Henan ProvinceOrthopedic Institute of Henan ProvinceLuoyangHenan Province(471002)China Miller School of Medicine University of Miami(33136)MiamiFLUSA Institute of Technical Biology&Agriculture Engineering Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei(230031)China Eatobe Pte.Limited(573969) Singapore

Objective:To elucidate the active compounds and the molecular mechanism of Cyathula Off/c/na//s as a drug treatment for rheumatoid arthritis(RA).Methods:The target genes of active ingredients from Cyathula Officinalis were obtained from bioinformatics analysis tool for the molecular mechanism of traditional Chinese *** protein-protein interaction between the target genes were analyzed using STRING and *** transcriptome of RA patients compared to healthy people(GSE121894)were analyzed using R program package *** relative expression of the target genes was obtained from the RNA-seq *** molecular docking analyses were processed based on the molecular model of estrogen receptor 1(ESR1)binding with estradiol(PDB ID:1A52).The binding details were analyzed by ***:Inokosterone,ecdysterone,and cyaterone were the 3 active ingredients from Cyathula Officinalis that bind to target *** all the significantly changed genes from RA patients,ESR1,ADORA1,and ANXA1 were significantly increased in mRNA samples of RA ***:ESR1,the transcription factor that binds inokosterone in the molecular binding analysis,is the target protein of Cyathula Officinalis.

关键词： rheumatoid arthritis estrogen receptor 1 inokosterone Cyathula Officinalis Chinese medicine

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En zhou Yilin Li Xiaoming Lin Jiaye ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan zhou Hongdong Zhao ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

MDCFS: few-shot object detection with multilevel decoupled classifiers

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Optoelectronics Letters 2025年

作者： LI Chuanhui zhou mian FENG Zhikun SUI Zezhou GAO Zhan School of Computer Science and Engineering， Tianjin University of Technology

Few-shot object detection poses unique challenges as it requires effectively learning novel classes with limited labeled data. Current approaches often suffer from biases towards base classes during fine-tuning， leading to suboptimal performance on detecting novel classes. Additionally， in complex scenes， the confusion between foreground and background objects further affects the accuracy and robustness of the model. To address these issues， we propose the Multilevel Decoupling Classification Few-Shot Algorithm (MDCFS). we decouple the standard classifier into a parallel foreground classifier and a background classifier in the Few-Shot Object Detection (FSOD) setting. This decoupling enables the independent separation of positive samples from noisy negative samples， alleviating the foreground-background confusion problem commonly encountered in few-shot detectors. For Generalized Few-Shot Object Detection (G-FSOD)， where the few-shot dataset contains base classes， we further decouple the foreground classification head into a base class classification head and a novel class classification head. To ensure balance， we assign more weight to the novel class classification head， effectively addressing the bias towards base classes. Furthermore， we optimize the initial weights of the few-shot fine-tuning stage， significantly reducing training time and mitigating catastrophic forgetting in G-FSOD. Additionally， we incorporate metric learning into our model with minimal cost. Experimental results demonstrate the effectiveness of our approach. Compared to state-of-the-art few-shot object detection methods based on fine-tuning， MDCFS achieves performance improvements of up to 6.3% on the PASCAL VOC dataset and 1.5% on the COCO dataset.

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Multivariate synergy for heightening ionic HOF robustness and proton conductivity

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Science China Chemistry 2025年

作者： Xiang-Tian Bai Li-Hui Cao Xu-Yong Chen Jia-Yu Wang Zi-ye zhou Shaanxi Key Laboratory of Chemical Additives for Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology

Multicomponent crystalline materials construct more complex and diversified structures with different combinations and modes,which expands the material structure space and application *** this work,we have successfully synthesized two twocomponent ionic hydrogen-bonded organic frameworks （iHOF-32 and iHOF-33） and a three-component iHOF （iHOF-34）.Guanidine hydrochloride which is rich in N and H and has a short chain length strengthens the hydrogen bonding network of iHOF,thereby aiding in the efficient migration of *** rigid architecture of 1,1'-diamino-4,4'-bipyridine diiodide furnishes additional scaffolding for the iHOFs and enhances its robustness under harsh ***-34 accomplishes the combination of the ultra-high proton conductivity of iHOF-32 and the robustness of iHOF-33 by the synergistic interaction among the three components of *** addition,iHOF-34 was fabricated as a composite membrane with a peak proton conductivity of 1.55×10-1S cm-1,which is 3.8 times higher than that of recast Nafion,and has extensive potential in fuel *** self-assembly strategy of multicomponent HOFs opens up new avenues for constructing diverse structures while promising new opportunities for applications in the fields of proton conduction and energy storage.

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang zhou Ru ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Saturated super-twisting sliding mode missile guidance

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Chinese Journal of Aeronautics 2022年第10期35卷 292-300页

作者： mian GONG Di zhou Xinguang ZOU School of Astronautics Harbin Institute of TechnologyHarbin 150001China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China

This paper concentrates on developing a missile terminal guidance law against a highly maneuvering target whose maneuvering acceleration is very close to that of the missile or even exceeds the missile normal acceleration in a finite period of time.A new saturated super-twisting algorithm is proposed and applied to the design of missile guidance *** proposed algorithm has the advantages of simple structure,easy parameter tuning rules and a full utilization of the limit control *** designed saturated super-twisting sliding mode guidance law is then employed in a missile guidance *** and its superior performance against strong maneuvering targets is demonstrated.

关键词： Highly maneuvering target Input saturation Missile guidance control Robust control Sliding mode control Super-twisting algorithm

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开发保护饮食非遗赋能乡村振兴促进共同富裕

江苏商论 2025年第1期 7-10页

作者：叶方舟浙江农业商贸职业学院浙江绍兴312088

共同富裕是中华民族千百年来的共同理想。在消除绝对贫困后,如何在广大农村地区坚持高质量发展,减少相对贫困,实现乡村振兴就是社会主义共同富裕的必经之路。而饮食非遗延续自数千年来的传统农业生活,根植于乡土文化土壤中,也同乡村振... 详细信息

共同富裕是中华民族千百年来的共同理想。在消除绝对贫困后,如何在广大农村地区坚持高质量发展,减少相对贫困,实现乡村振兴就是社会主义共同富裕的必经之路。而饮食非遗延续自数千年来的传统农业生活,根植于乡土文化土壤中,也同乡村振兴一样遇到经济条件差,传统断层等问题。绍兴市从饮食非遗的活态开发保护中,走出了一条社会经济文化价值并存,促振兴致共富的创新之路。

关键词：饮食非遗乡村振兴共同富裕非遗开发保护

How the radial gap affects the runner’s hydrodynamic damping characteristic of a pump-turbine:A physical experiment on a rotating disc

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Journal of Hydrodynamics 2023年第4期35卷 736-745页

作者： Yong-shun Zeng Xin Qi mian-mian Bai Ling-jiu zhou Zhi-feng Yao College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China BAPTEEC LTD Beijing100176China Shanxi Province Institute of Water Resources and Electric Power Investigation and Design Xi’an710001China Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System Beijing100083China

Clarifying how radial gap affects the vibration characteristic of a disc-like structure is of importance in engineering applications,such as in evaluating the operational stability of a runner of a pump *** the present investigation,the runner is simplified as a disc,and a physical experiment is designed on it with variable radial gaps to measure the vibration characteristics,especially by considering *** frequency peaks for the diametrical mode are generated due to the rotation,and those with lower and higher frequencies are defined as positive and negative modes,*** frequency difference between positive and negative modes increases linearly with the increasing rotating speed,and a linear function is captured to describe the relationship between natural frequency and rotating *** the radial gap,its increase causes a slight increase in the natural frequencies but results in a significant reduction in the hydrodynamic damping *** in the smaller radial gap conditions,such as when the relative radial gap increases from 0.67%to 3.3%,the reduction in hydrodynamic damping ratio reaches 31.52%.From the perspective of suppressing the resonance amplitude,reducing the radial gap of a runner is recommended due to the mechanism of increasing hydrodynamic damping.

关键词： Rotating disc radial gap rotating speed natural frequency hydrodynamic damping

Inverse-square-root-acceleration method for predicting the failure time of landslides

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Science China(Technological Sciences) 2021年第5期64卷 1127-1136页

作者： zhou XiaoPing ye Teng School of Civil Engineering Chongqing UniversityChongqing 400045China

Predicting the failure time of unstable slopes is one of the most pivotal issues. In this paper, the inverse square root acceleration(INSRA) method was proposed to estimate the time-of-failure(TOF) of landslides. Four collapsed slopes were presented in the three open-pit mines, two of them were probed by ground-based radar, and two of them were obtained from previous scientific papers. The inverse velocity(INV) method and INSRA method were adopted to analyze these four landslides and one slope which had great deformation but did not reach failure. Compared with the traditional INV method, the INSRA method can promote the forecasting effectiveness and has the advantage of higher accuracy.

关键词： failure time of landslide inverse square root of acceleration traditional inverse velocity method