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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin fang limin Wang Haoqin li Jiaxin Zhang Yang Ding Pan Pan li Bo Peng hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Probabilistic Robust linear Parameter-varying Control of a Small Helicopter Using Iterative Scenario Approach

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IEEE/CAA Journal of Automatica Sinica 2015年第1期2卷 85-93页

作者： zhou fang hua Tian Ping li the School of Aeronautics and Astronautics Zhejiang University the Department of Control Science and Engineering Zhejiang University

In this paper, we present an iterative scenario approach (ISA) to design robust controllers for complex linear parameter-varying (LPV) systems with uncertainties. The robust controller synthesis problem is transformed to a scenario design problem, with the scenarios generated by identically extracting random samples on both uncertainty parameters and scheduling parameters. An iterative scheme based on the maximum volume ellipsoid cutting-plane method is used to solve the problem. Heuristic logic based on relevance ratio ranking is used to prune the redundant constraints, and thus, to improve the numerical stability of the algorithm. And further, a batching technique is presented to remarkably enhance the computational efficiency. The proposed method is applied to design an output-feedback controller for a small helicopter. Multiple uncertain physical parameters are considered, and simulation studies show that the closed-loop performance is quite good in both aspects of model tracking and dynamic decoupling. For robust LPV control problems, the proposed method is more computationally efficient than the popular stochastic ellipsoid methods. © 2014 Chinese Association of Automation.

关键词： Aircraft control Algorithms Computation theory Computational efficiency Controllers Design Helicopters Optimization Problem solving Robust control Scheduling Stochastic systems Uncertainty analysis

Novel method for hybrid multiple attribute decision making based on TODIM method

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Journal of Systems Engineering and Electronics 2015年第5期26卷 1023-1031页

作者： fang Wang hua li School of Economics and Management Xidian University

The TODIM(an acronym in Portuguese for interactive and multiple attribute decision making) method is a valuable tool to solve the multiple attribute decision making(MADM) problems considering the behavior of the decision maker(DM), while it cannot be used to handle the problem with unknown weight information on attributes. In this paper, a novel method based on the classical TODIM method is proposed to solve the hybrid MADM problems with unknown weight information on attributes,in which attribute values are represented in four different formats:crisp numbers, interval numbers, triangular fuzzy numbers and trapezoidal fuzzy numbers. Firstly, the positive-ideal alternative and negative-ideal alternative are determined, and the gain and loss matrices are constructed by calculating the gain and loss of each alternative relatived to the ideal alternatives concerning each attribute based on different distance calculation formulas, which may avoid the information missing or information distortion in the process of unifying multiform attribute values into a certain representation form. Secondly, an optimization model based on the maximizing deviation(MD) method, by which the attribute weights can be determined, is established for the TODIM method. Further, the calculation steps to solve the hybrid MADM problems are given. Finally, two numerical examples are presented to illustrate the usefulness of the proposed method, and the results show that the DM’s psychological behavior, attribute weights and the transformed information would highly affect the ranking orders of alternatives.

关键词： hybrid multiple attribute decision making TODIM ranking

An improved adaptive differential evolution algorithm for single unmanned aerial vehicle multitasking

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Defence Technology（防务技术） 2021年第6期17卷 1967-1975页

作者： Jian-li su hua Wang School of Astronautics Beihang UniversityBeijing100191China

Single unmanned aerial vehicle(UAV)multitasking plays an important role in multiple UAVs cooperative control,which is as well as the most complicated and hardest *** paper establishes a threedimensional topographical map,and an improved adaptive differential evolution(IADE)algorithm is proposed for single UAV *** an optimized problem,the efficiency of using standard differential evolution to obtain the global optimal solution is very low to avoid this ***,the algorithm adopts the mutation factor and crossover factor into dynamic adaptive functions,which makes the crossover factor and variation factor can be adjusted with the number of population iteration and individual fitness value,letting the algorithm exploration and development more *** experimental results implicate that the IADE algorithm has better performance,higher convergence and efficiency to solve the multitasking problem compared with other algorithms.

关键词： Unmanned aerial vehicle Multitasking Adaptive differential evolution Mutation factor Crossover factor

Rare-earth and transition metal ion single-/co-doped double-perovskite tantalate phosphors: Validation of suitability for versatile applications

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Journal of Advanced Ceramics 2023年第5期12卷 954-971页

作者： Yongbin hua Jae su Yu li li Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-si 17104Republic of Korea School of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China

Novel rare-earth (RE;e.g., europium (Eu^(3+)), samarium (Sm^(3+)), and praseodymium (Pr^(3+))) and transition metal (TM^(4+);e.g., manganese (Mn^(4+))) ion single-/co-doped double-perovskite Ca2InTaO6 (CITO) phosphors were prepared and investigated with respect to their crystal structure and photoluminescence (PL) properties. Among them, the CITO:Eu^(3+) phosphors were found to exhibit an ultra-high internal PL quantum yield (89.1%) and good thermal stability (78.7% at 423 K relative to the initial value at 303 K). As such, the corresponding packaged white light-emitting diode (LED) was able to display a remarkable color rendering index (CRI;= 91.51@10 mA). Besides, the potential in applications of anti-counterfeiting fields and a novel LED structure based on flexible phosphor-converted films was also studied. Moreover, due to their different thermal quenching, trivalent lanthanide (Ln^(3+))/Mn^(4+) co-doped CITO phosphors were designed for optical thermometry based on the luminescence intensity ratio (liR) between different 4f transitions of various Ln^(3+) ions and ^(2)Eg → ^(4)A_(2g) (Mn^(4+)) transition. Particularly, the liR between the ^(4)G_(5/2) → ^(6)H_(9/2) and ^(2)Eg → ^(4)A_(2g) peaks of the CITO activated with 5 mol% Sm^(3+) and 0.3 mol% Mn^(4+) exhibited the most excellent relative sensitivity (Sr;= 3.80 %·K^(−1)) with beneficial temperature uncertainty of 0.0648 K. Overall, these results are of significance to offer valuable databases for constructing multifunctional high-performance optical platforms using single-/co-doped double-perovskite tantalates.

关键词： phosphors quantum yields(QYs) light-emitting diodes(LEDs) thermometry anti-counterfeiting

Generalized Competition Index of Primitive Digraphs

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Acta Mathematicae Applicatae Sinica 2017年第2期33卷 475-484页

作者： li-hua YOU fang CHEN Jian SHEN Bo zhou School of Mathematical Sciences South China Normal University Department of Mathematics Texas State University

For any positive integers k and m, the k-step m-competition graph C^（D） of a digraph D has the same set of vertices as D and there is an edge between vertices x and y if and only if there are distinct m vertices vi, v2, .., Vm in D such that there are directed walks of length k from x to vi and from y to vi for all 1 ≤ i≤ m. The m-competition index of a primitive digraph D is the smallest positive integer k such that Ckm（D） is a complete graph. In this paper, we obtained some sharp upper bounds for the m-competition indices of various classes of primitive digraphs.

关键词： competition index m-competition index scrambling index primitive digraph

Study of a ceramic burner for shaftless stoves

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 149-153页

作者： fang-qin Dai su-yi huang Shao-hua li Ke liu School of Energy ＆ Power Engineering Huazhong University of Science and Technology Wuhan 430074 China Thermal Engineering Research Institute Wuhan Research Institute of Metallurgical Construction Wuhan 430081 China

A multi-burner-port annular flameless ceramic burner （MAFCB） of the shaftless stove for blast furnaces was designed. The characteristics of pressure drop, homogeneousness of the flows at burner ports, and distribution of the flows in the chambers and joint were studied by cold model experiments. This type of ceramic burner was successfully applied in 6# blast furnace at liuzhou Iron ＆ Steel Co. Ltd. （liSC） and this practice proved that it could be used in the hot blast stove and other stoves with a higher efficiency and a higher steadiness of hot blast temperature at 1200℃. With the combustion of blast furnace gas alone, the thermal efficiency was up to 78.95%, saving energy remarkably.

关键词： ceramic burner blast furnace cold model experiments ironmaking

Photosynthesis and biochemical responses to elevated O_3 in Plantago major and Sonchus oleraceus growing in a lowland habitat of northern China

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Journal of Environmental Sciences 2017年第3期29卷 113-121页

作者： benying su Meihua zhou Hong Xu Xiujie Zhang Yonggeng li hua su Bao Xiang State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

A field experiment was carried out to compare the responses to ozone （03） in two common herbaceous plant species, Plantago major L. and Sonchus oleraceus L., by building open-top growth chambers in situ to simulate 03 stress （＋03, 85 ± 5 ppb, 9 hr/day for 30 days） in a lowland habitat in Inner Mongolia, Northern China. Responses to 03 of gas exchange, chlorophyll a fluorescence, leaf pigment content, andoxidant capability, soluble protein content, membrane lipid peroxidation and dark respiration （Rd） were analyzed. Results showed that elevated 03 exposure significantly reduced the light-saturated net photosyn- thesis （PNsat）, stomata] conductance （gs） and transpiration rate （E） in both species. Although non-significant interactive effect between species and 0s on PNsat was analyzed, the reduction in PNsat in S. oleraceus might be due primarily to the higher fraction of close PSII reaction centers and impaired activities of plant mesophyll cells as evidences by decreased maximum efficiency of PSII photochemistry after dark adapted state （Fv/Fm） and unchanged intercellular CO2 concentration （Ci）. Besides, biochemical analysis showed that S. oleraceus had lower antioxidant ability compared to P. major. As a result, S. oleraceus was damaged to the larger extent in terms of lipid peroxidation and visible O3 injury, indicating that S. oleraceus was more sensitive to O3 than P. major. Our results indicated that wild herbaceous plant species growing in a lowland habitat in sandy grassland were sensitive to O3 stress and S. oleraceus can be considered as one of the bio-indicators for high O3 concentration in semi-arid -rassland of northern China.

关键词： Biochemical analysisHerbaceous speciesGas exchangeOzoneSemi-arid grassland