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Optoelectronics Letters 2024年第11期 676-680页

作者： DENG Zhichao mei Jianchun WANG Jin YE qing TIAN Jianguo Key Laboratory of Weak-Light Nonlinear Photonics Ministry of Education School of Physics and TEDA Applied Physics Nankai University

The complex refractive index dispersion(CRID) of absorbing materials is very important in many fields, especially in printing industry and medical research. However, due to their strong absorbing, CRID determination i...

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Covering corneal stromal lenticule for macular hole in pathological myopia

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1675-1680页

作者： Zi-Yan Tang Gang Qiao Xiao-Juan Zhang Li-Jun Xie Qiang-Xing Zou Chun-mei He Long Zhao Hua-qing Yang Yu Quan Kui Cao Hui Jiang Yu-Kun He Wanjiang Eye Hospital of Mianyang Mianyang 621000Sichuan ProvinceChina

AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological ***:This was a prospective non-randomized series case *** eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this *** cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)F_(8) gas *** cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were ***:All cases were successfully performed the surgery and the postoperative follow-up was *** surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence *** reattachment of retina was achieved in all 6 eyes(100%,6/6)with *** was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(F=10.46,P<0.01).No serious complications occurred in all ***:The new surgery technique(covering CSL)has high reattached rate of RD and high healing rate of MH in pathological myopia in the preliminary *** it can effectively improve the visual function of *** new technique offers meaningful new ideas for treating refractory MH in pathological myopia.

关键词： corneal stromal lenticule macular hole pathological myopia

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医院电子档案的收集归档与保护

医学信息 2010年第8期23卷 2511-2512页

作者：徐梅王子正周梅青山东省滨州市人民医院

随着信息技术和档案事业的飞速发展,以新的形式出现的电子档案与传统纸质档案汇集成庞大的信息潮,提醒着医院档案人员必须对医院电子档案管理采取有效的合理的管理措施,做好电子档案的技术处理工作。因此如何收集、归档、保护好这些电... 详细信息

随着信息技术和档案事业的飞速发展,以新的形式出现的电子档案与传统纸质档案汇集成庞大的信息潮,提醒着医院档案人员必须对医院电子档案管理采取有效的合理的管理措施,做好电子档案的技术处理工作。因此如何收集、归档、保护好这些电子文件,成为当前医院档案人员面临的新课题。

关键词：电子档案收集归档保护

紫外接枝聚合聚乙二醇甲基丙烯酸甲酯制备抗污染聚砜超滤膜

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高等学校化学学报 2010年第12期31卷 2506-2510页

作者：于海军曹义鸣康国栋周美青刘健辉袁权中国科学院大连化学物理研究所大连116023 中国科学院研究生院北京100049

以二苯甲酮(BP)为紫外引发剂,将聚乙二醇甲基丙烯酸甲酯(PEGMA)接枝在聚砜超滤膜表面以提高膜的抗污染性能.在二苯甲酮存在的条件下,波长较长(λ>300nm)的紫外光(UV)辐射下发生提氢反应,可以有效防止聚砜分子主链的剪切,保持改性膜的分... 详细信息

以二苯甲酮(BP)为紫外引发剂,将聚乙二醇甲基丙烯酸甲酯(PEGMA)接枝在聚砜超滤膜表面以提高膜的抗污染性能.在二苯甲酮存在的条件下,波长较长(λ>300nm)的紫外光(UV)辐射下发生提氢反应,可以有效防止聚砜分子主链的剪切,保持改性膜的分离性能.考察了PEGMA浓度、UV辐射时间和BP浓度对改性超滤膜接枝度、亲水性和抗污染性能的影响.用表面全反射红外光谱(ATR/FTIR)表征改性前后膜表面化学组成的变化.表面改性膜的纯水通量略有降低而牛血清白蛋白(BSA)截留率有所提高.随着接枝度的提高,PEGMA接枝改性膜的抗污染性能增加.

关键词：超滤膜二苯甲酮紫外辐射抗污染

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农家养猪日粮预混料配方试验

四川畜牧兽医 2000年第8期27卷 20-20,22页

作者：周梅卿张红易军四川省畜牧科学研究院四川成都610066

根据四川省农家养猪日粮的营养盈缺状况 ,设计了两个以补添营养要素和促长剂为主的复合预混料配方。选用 44头杜洛克×川白Ⅰ系二杂阉猪分成 4组 ,作了 1 2 0天农家日粮添加 1 %的预混料饲喂肉猪试验。全期试验结果表明 ,试验组比对照... 详细信息

根据四川省农家养猪日粮的营养盈缺状况 ,设计了两个以补添营养要素和促长剂为主的复合预混料配方。选用 44头杜洛克×川白Ⅰ系二杂阉猪分成 4组 ,作了 1 2 0天农家日粮添加 1 %的预混料饲喂肉猪试验。全期试验结果表明 ,试验组比对照组日采食量平均提高 2 7 9%和 30 2 % ,日增重提高 74 4 %和 6 0 6 % ,每千克增重提高饲料转化率2 6 3%和 2 6 8% ,节省饲料费 2 4 0 %和 2 4 4 % 。

关键词：预混料日粮农家养猪配方

某车辆段职业性噪声聋检出情况的两个诊断标准一致性比较

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工业卫生与职业病 2017年第2期43卷 123-127页

作者：荣欣熊冰清周梅昆明铁路局疾病预防控制中心云南昆明650011 昆明医科大学云南昆明650500

目的比较GBZ 49-2007《职业性噪声聋诊断标准》和GBZ 49-2014《职业性噪声聋的诊断》在实际运用中的优缺点。方法收集昆明铁路局车辆段2015年噪声从业人员职业健康检查中的208例听力检测结果。通过职业健康检查表和病史询问、耳部检查... 详细信息

目的比较GBZ 49-2007《职业性噪声聋诊断标准》和GBZ 49-2014《职业性噪声聋的诊断》在实际运用中的优缺点。方法收集昆明铁路局车辆段2015年噪声从业人员职业健康检查中的208例听力检测结果。通过职业健康检查表和病史询问、耳部检查和纯音气导听阈测试收集受检者基本信息及听力损失情况。分别采用GBZ 49-2007和GBZ 49-2014进行职业性噪声聋的诊断及诊断分级,运用Kappa分析和符合率对两个标准的评价结果进行一致性检验。结果采用GBZ 49-2007对208例听力检测结果进行评价,高频听力损失检出率为12.02%;其中:观察对象13人检出率为6.25%;轻度噪声聋2人,中度噪声聋9人,重度噪声聋1人,职业性噪声聋诊断率为5.77%。采用GBZ 49-2014对208例听力检测结果进行评价,高频损失率为13.94%。诊断:轻度噪声聋6人,中度噪声聋9人,重度噪声聋1人,职业性噪声聋诊断率为7.69%。比较两个标准的听力损失情况,Kappa值为0.867符合率为95.67%。对208例听力检测结果的评价进行一致性检验,Kappa值为0.850,符合率为96.63%。对GBZ 49-2014中诊断听力异常的16例诊断病例用GBZ 49-2007评价,符合率为75%。结论这两个标准对听力检测结果的评价是一致的。GBZ 49-2014取消了"观察对象",但通过将4 000Hz听阈值纳入到诊断分级中,进行加权计算,其中一部分人能够诊断为轻度噪声聋。这一修订国标2014在诊断上更为科学合理,并保护劳动者的权益。但由于2014版标准中取消了"观察对象",对于部分出现高频听损且达到原标准"观察对象"的劳动者,尚需采取一定补救措施。

关键词：职业性噪声聋诊断标准分析比较

Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： Ya-Ling Zhu Lei-Lei Meng Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang Yun-Shu Tang Min Xue mei-Zi Zhu Jin Peng Xue-Jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng qing-qing Dai Fan Huang Hao-Shu Fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain ***,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP ***,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory *** total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD *** on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating *** study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac Integrative analysis Enhancer

Effect of dietary with Zhibai dihuang pills and gonadotropinreleasing-hormone-analogue on girls with precocious and rapidly progressive puberty

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World Journal of Clinical Cases 2024年第24期12卷 5534-5541页

作者： Xue-mei Wang Wei Li Liu-qing Yang Rui Luo Chen-Chen Zhang Department of Pediatrics Ma’anshan Maternal and Child Health HospitalMa’anshan 243011Anhui ProvinceChina

BACKGROUND At present,the clinical mechanisms underlying precocious puberty remain unclear,making effective intervention for children experiencing this condition and rapidly progressive puberty *** To explore the effects of Zhibai dihuang pills and gonadotropin-releasing hormone analogue(GnRHa)on growth and ovarian function in girls with precocious *** The clinical data of 84 adolescent girls with precocious puberty and rapidly progressive puberty from February 2017 to August 2023 were retrospectively *** were divided into a control group and an observation group,with 42 cases in each *** control group received diet intervention combined with GnRHa treatment,while the observation group received diet intervention combined with Zhibai dihuang pills+GnRHa *** such as clinical efficacy,growth indicators,ovarian function,and adverse reactions were compared between the two *** The observation group showed superior clinical efficacy compared to the control group(P0.05).Post-intervention,the observation group exhibited significantly lower rates in growth,height,and bone age,along with reduced levels of progesterone,testosterone,estradiol,prolactin,luteinizing hormone,and follicle-stimulating hormone compared to the control group(P0.05).CONCLUSION Combining Zhibai dihuang pills with GnRHa and dietary intervention effectively improves growth,enhances ovarian function,and minimizes adverse reactions in adolescent girls with precocious and rapidly progressive puberty.

关键词： Zhibai dihuang pills Gonadotropin-releasing hormone analogue Dietary intervention Precocious puberty Rapidly progressive puberty Ovarian function

基于TGF-β/Smad信号通路探究HSF1基因对CAL-27细胞放疗抵抗作用机制

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中国实验诊断学 2022年第11期26卷 1695-1701页

作者：周庆梅蔡永美侯宪鹏济南市妇幼保健院口腔科山东济南250001 济南市妇幼保健院儿童保健科山东济南250001 山东第一医科大学附属省立医院肿瘤治疗中心放疗科山东济南250021

目的基于TGF-β/Smad信号通路探究HSF1基因对CAL-27细胞放疗抵抗作用机制。方法用人口腔鳞癌细胞CAL-27建立放疗抵抗模型,随机分为抵抗组(放射抵抗CAL-27细胞)、NC组(放射抵抗CAL-27细胞转染空载体)、HSF1组(放射抵抗CAL-27细胞转染HSF1... 详细信息

目的基于TGF-β/Smad信号通路探究HSF1基因对CAL-27细胞放疗抵抗作用机制。方法用人口腔鳞癌细胞CAL-27建立放疗抵抗模型,随机分为抵抗组(放射抵抗CAL-27细胞)、NC组(放射抵抗CAL-27细胞转染空载体)、HSF1组(放射抵抗CAL-27细胞转染HSF1shRNA干扰慢病毒载体)。18只SD裸鼠分为口腔癌抵抗组(注射放射抵抗CAL-27细胞)、沉默HSF1组(注射HSF1shRNA干扰慢病毒载体放射抵抗CAL-27细胞),每组各9只。RT-PCR与Western blot检测HSF1、TGF-β、Smad2、Smad3、Smad7基因及蛋白水平。流式细胞仪检测各组口腔癌细胞凋亡情况。双荧光素酶报告基因分析HSF1与TGF-β/Smad2/Smad3靶向关系,游标卡尺测量瘤体并计算瘤体体积。结果放疗前,CAL-27口腔癌细胞形态无变化。放疗后,放疗抵抗口腔癌细胞株排列更加紊乱且细胞数目明显增加。抵抗组CAL-27口腔癌细胞中HSF1、TGF-β、Smad2、Smad3、Smad7基因与蛋白表达水平与NC组比较无显著差异(P>0.05)。与NC组相比,HSF1组CAL-27口腔癌细胞中HSF1、TGF-β、Smad2、Smad3基因与蛋白表达水平降低,Smad7基因与蛋白表达水平升高(P<0.05),HSF1与TGF-β、Smad2及Smad3表达水平呈现正相关性(P<0.05),与Smad7表达水平呈现负相关性(P<0.05)。抵抗组CAL-27口腔癌细胞凋亡率与NC组比较无显著差异(t=0.891,P=0.394),NC组细胞凋亡率低于HSF1组,组间比较差异显著(t=24.110,P<0.001)。双荧光素酶报告基因实验发现,与pcDNA3.1相比,转染pcDNA3.1-HSF1后野生型TGF-β/Smad2/Smad3活性升高。口腔癌抵抗组裸鼠瘤体体积明显高于沉默HSF1组(t=7.379,P<0.001)。结论沉默HSF1表达可促进口腔癌放疗抵抗细胞凋亡,降低裸鼠瘤体体积,其作用机制可能与调控TGF-β/Smad有关,可提高口腔癌放疗敏感性。

关键词：沉默HSF1 TGF-β/Smad信号通路口腔癌细胞放疗抗性

Ancient DNA unravels species identification from Laosicheng site,Hunan Province,China,and provides insights into maternal genetic history of East Asian leopards

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Zoological Research 2024年第1期45卷 226-229页

作者： Ming Zhang Cai-Hui Wang Yu-Xin Zheng Qi-Gao Jiangzuo Ye-Mao Hou Peng Cao qing-Yan Dai Ruo-Wei Yang Feng Liu Xiao-Tian Feng Lin-Heng Mo Qiao-mei Fu China-Central Asia"the Belt and Road"Joint Laboratory on Human and Environment Research Key Laboratory of Cultural Heritage Research and ConservationSchool of Culture HeritageNorthwest UniversityXi’anShaanxi 710127China Shanghai Qi Zhi Institute Shanghai 200232China College of Life Sciences Northwest UniversityXi’anShaanxi 710127China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyCenter for Excellence in Life and PaleoenvironmentChinese Academy of SciencesBeijing 100044China Cultural Relics and Archaeology Institute of Hunan ChangshaHunan 410083China University of the Chinese Academy of Sciences Beijing 100049China

DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle qing Dynasty(approximately 300 years ago).This site has yielded a substantial number of animal bones,11960 of which have been identified to the species level,serving as direct evidence of ancient animal populations(Hunan Provincial Institute of Cultural Relics and Archaeology,2018).

关键词： Hunan Ancient insight