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Determinants of lexical access in pure-anomic recovery:a longitudinal study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第5期10卷 341-347页

作者： Xiao zhou Hui liang ming-wei XU Ben-yan LUO Neuropsychology Laboratory the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Many studies involving lexical access in picture-naming tasks have been undertaken at a point in time,mainly focusing on age of acquisition(AoA).To identify the real determinates of lexical access in recovery and their traces in the brain,we carried out a longitudinal study on a Chinese pure anomic patient using multiple logistic regression *** found that AoA played an important role in early recovery but not in total recovery,whereas familiarity was significant in the whole *** a new dynamic point of view,our results indicate that AoA and familiarity are the main determinants of lexical access in anomia *** suggest that the changing effects of AoA during recovery may be related to the pathologic process;AoA and familiarity should be taken into account in constructing materials to assess and treat anomic patients.

关键词： Object naming Age of acquisition Anomia Therapy

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高强度望远镜载车平台结构优化设计与分析

机械研究与应用 2024年第1期37卷 115-118,133页

作者：周明亮张奔雷卢保伟中国科学院长春光学精密机械与物理研究所吉林长春130033

望远镜是天文观测的重要工具,其口径越大则分辨能力越高,分辨能力的大小又决定了人类可观测到的宇宙空间的大小。相较于传统的地基大口径望远镜,车载望远镜对天气和环境有着更强的适应能力,观测更高效。车载这种动态形式对望远镜的整体... 详细信息

望远镜是天文观测的重要工具,其口径越大则分辨能力越高,分辨能力的大小又决定了人类可观测到的宇宙空间的大小。相较于传统的地基大口径望远镜,车载望远镜对天气和环境有着更强的适应能力,观测更高效。车载这种动态形式对望远镜的整体质量和尺寸有着严格的要求,随着望远镜口径的增大,望远镜质量也会呈几何倍数增长,这对载车平台的结构也提出了更高的要求。该文以大型光学望远镜的载车平台为研究对象,通过将不同的设计方案进行有限元分析对比,从而得到较好的载车平台结构,以满足望远镜口径增大对载车的要求。

关键词：望远镜载车平台结构设计有限元分析

Synthesis and Characterization of Fluorine-containing Poly(ether ether ketone)s

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Chemical Research in Chinese Universities 2010年第4期26卷 672-674页

作者： ZHANG Pei ZHAO Yun TANG Xin-liang zhou ming-ji JIAO Qing-ze School of Chemical Engineering and Environment Beijing Institute of Technology Beijing 100081 P. R. China

Poly（ether ether ketone）s（PEEK） are a class of high performance engineering thermoplastics known for their excellent thermal, mechanical, and electrical properties. This class of advanced materials has currently received considerable attention for potential application in aerospace, electronics, automobile and other high technology fields. However, it is difficult for PEEK to be processed because of their high melting temperature and poor solubility.

关键词： Fluorine-containing polymer Solubility Dielectric constant

Aqueous Knoevenagel Condensation Catalyzed by Aminopropyl-functionalized MCM-41

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Chinese Chemical Letters 2006年第10期17卷 1293-1296页

作者： Guo Hua GAO Jin Bao GAO Wen Juan zhou liang LU ming Yuan HE Shanghai Key Laboratory of Green Chemistry and Chemical Process Department of Chemistry East China Normal University Shanghai 200062

An efficient, environmentally friendly procedure is developed for the condensation of aldchydcs/kctoncs and activated methylene compounds by using an aminopropyl-functionalized MCM-41 catalyst in aqueous solution. Different aldchydcs/kctoncs and activated methylene compounds gave the corresponding alkcncs in 78-97% isolated yields in mild reaction conditions. In comparison with organic solution, the aqueous solution gives higher yields in the same reaction conditions. Further more, the aminopropyl-functionalizcd MCM-41 in aqueous system can be reused for 8 flints without significant decrease of activity.

关键词： Knoevenagel condensation aqueous-phase reaction aminopropyl-functionalized MCM41.

基于脂质组学的整合素αvβ6对结肠癌细胞的促癌机制研究

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中国现代普通外科进展 2024年第9期27卷 678-683页

作者：梁本甲付仰彬于金涛王军牛军周明良山东第一医科大学附属省立医院胃肠外科山东济南250021 淄博市张店区人民医院普外科山东淄博255020 山东大学齐鲁医院肝胆外科山东济南250012

目的:探讨整合素αvβ6对结肠癌细胞的脂质代谢的影响;确定用于诊断结肠癌的潜在代谢生物标志物。方法:利用基于液相色谱-质谱(LC-MS)的脂质组学分析研究αvβ6对结肠癌细胞系SW480代谢变化的影响。偏最小二乘判别分析模型在αvβ6过表... 详细信息

目的:探讨整合素αvβ6对结肠癌细胞的脂质代谢的影响;确定用于诊断结肠癌的潜在代谢生物标志物。方法:利用基于液相色谱-质谱(LC-MS)的脂质组学分析研究αvβ6对结肠癌细胞系SW480代谢变化的影响。偏最小二乘判别分析模型在αvβ6过表达或低表达的SW480中显示出不同的脂质特征。结果:在αvβ6过表达后,SW480细胞中共有252种脂质呈现出显著的差异,其中138种脂质出现上调、114种脂质出现下调。同时发现,甲基磷胆碱(MePC)、磷脂酰胆碱(PC)、磷酰乙醇胺(PE)和甘油三酯(TG)对αvβ6过表达的癌细胞具有良好的诊断潜力。结论:整合素αvβ6可能通过调节脂质代谢失调的途径,使癌细胞更具侵袭性和转移性。这些结果可能为αvβ6对结肠癌细胞作用的分子机制提供潜在的线索。

关键词：结肠肿瘤整合素 αvβ6 脂质组学脂质代谢

NUMERICAL SIMULATION OF SEA SURFACE DIRECTIONAL WAVE SPECTRA UNDER TYPHOON WIND FORCING

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Journal of Hydrodynamics 2008年第6期20卷 776-783页

作者： zhou liang-ming WANG Ai-fang GUO Pei-fang Physical Oceanography Laboratory Ocean University of China Qingdao 266100 China Engineering Reconnaissance and Design Institute Ocean University of China Qingdao 266071 China

Numercial simulation of sea surface directional wave spectra under typhoon wind forcing in the South China Sea （SCS） was carreid out using the WAVEWATCH-Ⅲ wave model. The simulation was run for 210 h until the Typhoon Damrey （2005） approached Vietnam. The simulated data were compared with buoy observations, which were obtained in the northwest sea area of Hainan Island. The results show that the significant wave height, wave direction, wave length and frequency spetra agree well with buoy observations. The spatial characteristics of the signifciant wave height, mean wave period, mean wave length, wave age and directional spectra depend on the relative position from the typhoon center. Also, the misalignment between local wind and wave directions were investigated.

关键词： typhoon directional spectra significant wave height South China Sea (SCS)

The pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black hole

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 55-75页

作者： Li-ming Cao Jia-Ning Chen liang-Bi Wu Libo Xie Yu-Sen zhou School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Peng Huanwu Center for Fundamental Theory Hefei 230026China Interdisciplinary Center for Theoretical Study and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

In this study,we investigate the pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black ***,we use the hyperboloidal framework to cast the quasinormal mode(QNM)problem into an eigenvalue problem associated with a non-selfadjoint operator,and then the spectrum and pseudospectrum are ***,the invariant subspace method is exploited to improve the computational efficiency for *** investigation into the spectrum(in)stability entails two main *** the one hand,we calculate the spectra of the quantum corrected black hole,then by the means of the migration ratio,the impact of the quantum correction effect on the Schwarzschild black hole has been *** results indicate that the so-called“migration ratio instability”will occur for small black holes with small angular momentum number *** the eikonal limit,the migration ratios remain the same for each *** the other hand,we study the spectrum(in)stability of the quantum corrected black hole by directly adding some particular perturbations into the effective potential,where perturbations are located at the event horizon and null infinity,*** are two interesting observations under the same perturbation energy ***,perturbations at infinity are more capable of generating spectrum instability than those at the event ***,we find that the peak distribution can lead to the instability of QNM spectrum more efficiently than the average distribution.

关键词： quasinormal modes pseudospectrum hyperboloidal coordinate

Engineering a high-barrier d-f single-molecule magnet centered with hexagonal bipyramidal Dy(Ⅲ)unit

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Science China Chemistry 2024年第10期67卷 3291-3298页

作者： Wei Deng Chan-Ying Yao Yan-Cong Chen Ying-Qian zhou Shan-Nan Du Jun-liang Liu ming-liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen UniversityGuangzhou 510006China

In the pursuit of high-performance single-molecule magnets(SMMs),incorporating intramolecular magnetic coupling emerges as a pivotal *** these,d-f SMMs have garnered significant attention due to their remarkable versatility,which lies in their ability to tune coordination environments and facilely substitute metal ***,achieving performance-centric d-f SMMs through the synergistic interplay between highly anisotropic f ions and d-f magnetic interactions remains a formidable *** mononuclear hexagonal bipyramidal(D_(6h))Dy^(Ⅲ)SMMs have been successfully isolated,the exploration of d-f SMMs featuring D_(6h)-lanthanide metal centers remains uncharted *** this study,we employed planar bipodal ligands in conjunction with“staple-like”axial phenoxide ligands to synthesize the first hexagonal bipyramidal d-f ***,this compound exhibits alternating-current magnetic susceptibilities peaking up to 68 K with an energy barrier surpassing 1,200 K,thus establishing a new benchmark within the heterometallic d-f SMM landscape inclusive of complexes with diamagnetic d metals and paramagnetic f ***,the ferromagnetic interaction at the d-f sites engenders oscillating relaxation times contingent on the magnetic field—a characteristic distinct from mononuclear *** findings shed light on a deliberate design approach for d-f SMMs,emphasizing the cooperative utilization of high-barrier lanthanide modules alongside d ions through magnetic *** synergy significantly enhances and diversifies the magnetic dynamics of these intriguing molecular systems.

关键词： single-molecule magnets magnetic coupling crystal engineering hexagonal bipyramid energy barrier

Hepatic　arterial　infusion　chemotherapy　and　embolization　in　the　treatment　of　primary　hepatic　carcinoma

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World Journal of Gastroenterology 1997年第2期3卷 47-50页

作者： ZHENG Chuan Sheng, FENG Gan Sheng, zhou Ru ming, liang Bo, liang Hui Min, ZHEN Jun, YU Jian ming and LIU Hui

AIM To study the effects of hepatic arterial infusion chemotherapy (HAI) or embolization (HAE) in the treatment of primary hepatic carcinoma (PHC) and the factors influencing the effects. METHODS Follow up information in 188 patients (166 males and 22 females) with PHC treated with HAI ( n =82) or HAE ( n =106) were analyzed retrospectively. RESULTS The overall therapeutic effects were as follows: symptomatic relief in 59 6%; tumor shrinkage in 55%, blood AFP decrease in 37 8% and the overall survival rates of 1/2, 1, 2 and 3 years after treatment being 75 4%, 46%, 23 5% and 14 7%, respectively. The mean survival time was 12 2 months and the longest survival period was 50 months after treatment. In the HAI group the 1/2, 1, 2 and 3 years survival rates were 61 0%, 25 4%, 4 5% and 0%, respectively, the mean survival time being 7 7 months; in the HAE group the survival rates were 86 8%, 61 7%, 37 8% and 26 1%, respectively, the mean survival time being 15 7 months. Eighteen patients received secondary surgery. Seven factors influencing the therapeutic effects were analyzed. CONCLUSION Those cases of PHC with or without mild liver cirrhosis, stages Ⅰ and Ⅱ, single tumor, tumor size less than 10cm in diameter, no cancerous thrombus within the portal vein or hepatic arterio venous fistula, and HAE treatment time more than 3 times had better therapeutic effects than the contrast cases. To overcome these influencing factors and to adopt the comprehensive therapy would improve the effects of HAI or HAE in the treatment of PHC.

关键词： liver neoplasms/therapy chemoembolization, therapeutic