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STCF conceptual design report (Volume 1): Physics & detector

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui university Hefei 230039China Beihang university Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china Normal university Wuhan 430079China Central South university Changsha 410083China china university of Geosciences Wuhan 430074China china university of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan university Shanghai 200433China Goethe university Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal university Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal university Shijiazhuang 050024China Hebei university Baoding 071002China Hefei university of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal university Xinxiang 453007China Henan university Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan university Huangshan 245000China Hubei university of Automotive Technology Shiyan 442002China Hunan Normal university Changsha 410081China Hunan university of Science and Technology Xiangtan 411201China Hunan university Changsha 410082China Indiana university BloomingtonIndiana 47405USA Inner Mongolia university Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin university Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2.to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2.·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

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National Science Review 2020年第6期7卷 998-1002页

作者： Yonggang zhou Binqing Fu Xiaohu Zheng Dongsheng wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang {2. Xiaoling Xu Haiming Wei Institute of Immunology and the CAS Key laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical Center University of Science and Technology of China Hefei National laboratory for physical Sciences at Microscale University of Science and Technology of China The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Institute of Immunology and the CAS Key laboratory of Innate Immunity and Chronic Disease School of Life Science and Medical Center University of Science and Technology ofChina

Pathogenic human coronavirus infections, such as severe acute respiratory syndrome Co V (SARS-Co V) and Middle East respiratory syndrome Co V(MERS-Co V), cause high morbidity and mortality [1,2.. Recently, a severe pn... 详细信息

关键词： ACUTE RESPIRATORY SYNDROME CLINICAL CHARACTERISTICS CORONAVIRUS DISEASE LYMPHOCYTE SUBSETS DISTRESS-SYNDROME EXPRESSION BIOLOGY DRIVES

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Theoretical dissection of superconductivity in two-dimensional honeycomb borophene oxide B_(2.O crystal with a high stability

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npj Computational Materials 2020年第1期6卷 892-898页

作者： Luo Yan Peng-Fei Liu Hengtao Li Yong Tang Junjie He Xingyong Huang Bao-tian wang Liujiang {2. Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054P.R.China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Key laboratory of Advanced Technology of Materials(Ministry of Education) School of Physical Science and TechnologySouthwest Jiaotong UniversityChengdu 610031China School of Material Sciences and Engineering Xiangtan UniversityXiangtanHunan 411105China Bremen Center for computational Materials Science University of BremenAm Falturm 1Bremen 28359Germany

Atomically thin borophene has recently been synthesized experimentally,significantly enriching the boron chemistry and broadening the family of two-dimensional(2.)***,oxides of 2. materials have been widely investigated for nextgeneration electronic *** on the first-principles calculations,we predict the existence of the superconductivity in honeycomb borophene oxide(B_(2.O),which possesses a high stability and could be potentially prepared by intrinsically incorporating oxygen into the recently synthesized borophene.

关键词： materials stability superconductivity

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

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Analysis of electromagnetic pulses generation from laser coupling with polymer targets: Effect of metal content in target

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Matter and Radiation at Extremes 2020年第1期5卷 1-7页

作者： Yadong Xia Feng Zhang Hongbo Cai Weimin zhou Chao tian Bo Zhang {2. Liu Tao Yi Yilin Xu Feng wang Tingshuai Li Shaoping Zhu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900People’s Republic of China Science and Technology on Plasma Physics laboratory Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900People’s Republic of China Institute of Applied Physics and Computational Mathematics Beijing100094People’s Republic of China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871People’s Republic of China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Graduate School China Academy of Engineering PhysicsP.O.Box 2101Beijing 100088People’s Republic of China

Powerful lasers interacting with solid targets can generate intense electromagnetic pulses(EMPs).In this study,EMPs produced by a pulsed laser(1 ps,100 J)shooting at CH targets doped with different titanium(Ti)contents at the XG-III laser facility are measured and *** results demonstrate that the intensity of EMPs first increases with Ti doping content from 1%to 7%and then *** electron spectra show that EMP emission is closely related to the hot electrons ejected from the target surface,which is confirmed by an analysis based on the target–holder–ground equivalent antenna *** conclusions of this study provide a new approach to achieve tunable EMP radiation by adjusting the metal content of solid targets,and will also help in understanding the mechanism ofEMPgeneration and ejection of hot electrons during laser coupling with targets.

关键词： antenna coupling titanium

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Dehydro-Diels-Alder reaction and diamondization of bowl-shaped clusters C_(18)Te_(3)Br_(4)(Bu-O)_(6)

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Nano Research 2022年第5期15卷 4606-4612页

作者： Jinbo Zhang Manli Ma Rong zhou Hongqiang Chu Xue wang Shaojie wang Huhu tian Zhipeng Yan Mingtao Li Zhongyan Wu Bin Li Jiafeng Yan Lan Anh Thi Nguyen Rongxing Cao Guoqing Wu Xianghua Zeng Hao-Li Zhang Jaeyong Kim Lin wang Yongjun tian College of physical Science and Technology Yangzhou UniversityYangzhou 225002China Center for High Pressure Science(CHiPS) State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China State Key laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China Baotou Research Institute of Rare Earths Baotou 014000China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China Department of Physics and High Pressure Research CenterHanyang UniversitySeoul 04763Republic of Korea

Dehydro-Diels-Alder(DDA)reaction is a textbook reaction for preparing six-membered rings in solution but is scarcely seen in solid-state *** this work,using multiple characterization techniques,we demonstrate that the bowl-shaped clusters C_(18)Te_(3)Br_(4)(Bu-O)_(6) might experience a DDA reaction at room temperature and high pressure between 5.5 and 7.4 *** 17.0 GPa,it is found that the bonding conversion from the intramolecular sp^(2. to the intermolecular spa occurred,in the form of pressure-induced *** recovered samples from 2..0 and 36.1 GPa showed incomplete reversibility,while the decompression-induced graphitization of glassy carbon was observed during decompression from 46.5 *** electrochemical impedance spectroscopy results indicated that the transport properties changed from grain boundary dominant to grain dominant due to the DDA reaction and the grain boundary effect disappeared as the intermolecular sp3 bonding building-up and carrier transmission channel formation above 17.0 *** results in this study open a new route to construct the crystalline carbon materials with different transport properties.

关键词： polycyclic aromatic hydrocarbons dehydro-Diels-Alder reaction diamondization high-pressure

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Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2.RNA

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Journal of Molecular Cell Biology 2021年第10期13卷 748-759页

作者： Dongyao wang Dong wang Min Huang Xiaohu Zheng Yiqing Shen Binqing Fu Hong Zhao Xianxiang Chen Peng Peng Qi Zhu Yonggang {2. Jinghe Zhang Zhigang tian Wuxiang Guan Guiqiang wang Haiming Wei Division of Life Sciences and Medicine Department of HematologyThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001China Institute of Immunology and the CAS Key laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230001China Hefei National laboratory for physical Sciences at Microscale University of Science and Technology of ChinaHefei 230001China Department of laboratory Medicine Tongji HospitalTongji Medical CollegeHuaZhong University of Science and TechnologyWuhan 430030China Department of Infectious Diseases Peking University First HospitalBeijing 100034China Department of Tuberculosis Wuhan Pulmonary HospitalWuhan 430030China Center for Emerging Infectious Diseases Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Peking university International Hospital Beijing 100034China

Coronavirus disease 2.19(COVID-19),caused by severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.infection,has become a global public health *** patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2.RNA after discharge from *** such retest-positive(RTP)patients become infected again is not *** this study,30 RTP patients,2. convalescent patients,and 2. healthy controls were enrolled for the analysis of immunological characteristics of their peripheral blood mononuclear *** found that absolute numbers of CD4^(+)T cells,CD8^(+)T cells,and natural killer cells were not substantially decreased in RTP patients,but the expression of activation markers on these cells was significantly *** percentage of granzyme B-producing T cells was also lower in RTP patients than in convalescent *** transcriptome sequencing,we demonstrated that high expression of inhibitor of differentiation 1(ID1)and low expression of interferon-induced transmembrane protein 10(IFITM10)were associated with insufficient activation of immune cells and the occurrence of *** findings provide insight into the impaired immune function associated with COVID-19 and the pathogenesis of RTP,which may contribute to a better understanding of the mechanisms underlying RTP.

关键词： COVID-19 CD8f T cells NK cells RTP patients immune function

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Nickel Complexes with Non-innocent Ligands as Highly Active Electrocatalysts for Hydrogen Evolution

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Chinese Journal of Chemistry 2018年第12期36卷 1161-1164页

作者： Zhixin Chen Tao wang Tingting Sun Zhiyong Chen tian Sheng Yu-Hao Hong Zi-Ang Nan Jun Zhu Zhi-You {2. Haiping Xia Shi-Gang Sun Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory for Physical Chemistry of Solid SurfacesCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005China

Rational design of a molecular catalyst for a hydrogen evolution reaction (HER) with both high rates and low overpotential remains a challenge. Here we report a series of Ni‐based catalysts incorporating non‐innocent ligands and aimed at reduction of the overpotential by reserving electrons in the ligand, which could decouple the correlation between metal center reduction and metal hydride formation. The third‐order rate constant of our catalysts can be increased by 2.orders of magnitude without increase of overpotential by altering the substituents in the imide since the electronic effect of substituents can change the kinetics of metal hydride formation dramatically. Furthermore, constructing a proton shuttle in the ligand further improves the activity. The catalyst with both of these features can catalyze HER at a turnover frequency of 2.72.s-1 with low concentrations of acid and an extremely high third‐order rate constant of 2.7×106 M-2./sup>·s-1 at a low overpotential.

关键词： hydrogen evolution molecular electrocatalysis non‐innocent ligand electrochemistry homogeneous catalysis N ligands

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Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-α-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2019年第3期20卷 273-281页

作者： Su-fang GU Li-ying wang Ying-jie tian Zhu-xian {2. Jian-bin TANG Xiang-rui LIU Hai-ping JIANG You-qing SHEN Key laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Hangzhou Ubao Healthcare Technology Co. Ltd.Hangzhou 310012China Department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310006China

Hesperetin,an abundant bioactive component of citrus fruits,is poorly water-soluble,resulting in low oral *** developed new formulations to improve the water solubility,antioxidant activity,and oral absorption of *** nano-based formulations were developed,namely hesperetin-TPGS(D-α-tocopheryl polyethylene glycol 1000 succinate)micelles and hesperetin-phosphatidylcholine(PC)*** two formulations were prepared by a simple technique called solvent dispersion,using US Food and Drug Administration(FDA)-approved excipients for *** scanning calorimetry(DSC)and dynamic light scattering(DLS)were used to characterize the formulations’physical *** analysis,cellular antioxidant activity assay,and a pharmacokinetic study were performed to evaluate the biological properties of these two *** final weight ratios of both hesperetin to TPGS and hesperetin to PC were 1:12.based on their water solubility,which increased to 2..5-and 2..7-fold,*** hesperetin-TPGS micelles had a small particle size of 2..19 nm,whereas the hesperetin-PC complexes exhibited a larger particle size of 2.9.15 *** addition,the cellular antioxidant activity assay indicated that both hesperetin-TPGS micelles and hesperetin-PC complexes increased the antioxidant activity of hesperetin to 4.2.and 3.9-fold,***,the in vivo oral absorption study on rats indicated that the micelles and complexes significantly increased the peak plasma concentration(Cmax)from 2.64μg/mL to 2..67 and 33.09μg/mL and also increased the area under the concentration–time curve of hesperetin after oral administration to 16.2.and 18.0-fold,*** micelles and complexes increased the solubility and remarkably improved the in vitro antioxidant activity and in vivo oral absorption of hesperetin,indicating these formulations’potential applications in drugs and healthcare products.

关键词： Hesperetin D-α-Tocopheryl polyethylene glycol 1000 succinate(TPGS) Phosphatidylcholine Antioxidant activity Oral absorption

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基于希尔伯特变换的结构光照明快速三维彩色显微成像方法

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物理学报 2020年第12期69卷 330-340页

作者：千佳党诗沛周兴但旦汪召军赵天宇梁言生姚保利雷铭中国科学院西安光学精密机械研究所瞬态光学与光子技术国家重点实验室西安710119 中国科学院大学光电学院北京100049 西安交通大学理学院西安710049

结构光照明显微是一种宽场显微技术,可以实现超分辨成像和三维光切片成像.基于HSV(色相、饱和度、明度)彩色空间的结构光照明全彩色三维光切片成像技术可以复原样品表面的真彩色信息,但每一层光切片都需要采集3幅固定相移差的原始图像,... 详细信息

结构光照明显微是一种宽场显微技术,可以实现超分辨成像和三维光切片成像.基于HSV(色相、饱和度、明度)彩色空间的结构光照明全彩色三维光切片成像技术可以复原样品表面的真彩色信息,但每一层光切片都需要采集3幅固定相移差的原始图像,这对于需要多视场拼接的大尺寸样品而言,图像采集数据量大、图像重构时间长的缺点就凸显出来.鉴于此,本文提出一种基于希尔伯特变换的结构光照明快速三维彩色显微成像方法,只需在样品的每一层采集2.原始图像便可以重构出该层的全彩色光切片图像,因此图像采集量减少了1/3,图像重构时间节约了约2.%,有效提高了彩色三维成像的效率和速度.

关键词：三维成像结构光照明彩色显微

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