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Chinese Expert Consensus on the Diagnosis and Treatment of Adult Dermatomyositis (2.2.)

International Journal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Hua Cao Ai-Jun Chen Yong cui Dan-Qi Deng Xing-Hua Gao yan-Ling He Xiao-Jing Kang Hong-Zhong Jin Cheng-Xin Li Feng Li Heng-Jin Li Wen-Jun Liao Xiao-Ming Liu Qian-Jin {2. yan {2. Meng Pan Wei-Hua Pan Xiao-Ming Shu Qing Sun Ke-Yun Tang Juan Tao Yu Wang Ting Xiao Fu-Ren Zhang Han-Lin Zhang Dermatology Branch of the china International Exchange and Promotion Association for Medical and Health Care National Clinical Research Center for Dermatologic and Immunologic Diseases Department of Dermatology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Dermatology the Second Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650101China Department of Dermatology the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical UniversityBeijing 100020China Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous Region 830001China Department of Dermatology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Dermatology First Medical CenterPLA General HospitalBeijing 100853China Department of Dermatology Hainan Hospital of PLA General HospitalSanyaHainan 572013China Department of Dermatology Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518052China Hospital for Skin Diseases(institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Jiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Dermatology Shanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Rheumatology China-Japan Friendship HospitalBeijing 100029China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Union Hospital

Dermatomyositis,an idiopathic inflammatory myopathy,is characterized by distinctive skin manifestations,proximal muscle weakness,and multiple organ involvement and can be accompanied by *** provide a reference for dermatologists and clinicians in other relevant fields of clinical practice,experts from the Dermatology Branch of the china International Exchange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and expert advice.

关键词： dermatomyositis adult diagnosis treatment clinical protocols expert consensus

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中国春季复合极端低温多雨事件的年代际变化及成因分析

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气候变化研究进展 2024年第1期20卷 1-9页

作者：周晶孙燕齐雅静江苏省气象科学研究所南京210019 南京信息工程大学大气科学学院南京210044

利用1961—2.2.年中国553站逐日最低气温、降水资料和ERA5再分析资料,探讨了我国春季复合极端低温多雨事件的年代际变化特征及可能成因。结果表明,春季复合极端低温多雨事件整体呈现出南多北少的分布型,并且高频次中心在西南和华南地区... 详细信息

利用1961—2.2.年中国553站逐日最低气温、降水资料和ERA5再分析资料,探讨了我国春季复合极端低温多雨事件的年代际变化特征及可能成因。结果表明,春季复合极端低温多雨事件整体呈现出南多北少的分布型,并且高频次中心在西南和华南地区,年平均超过了5 d。全国绝大部分地区春季复合极端低温多雨事件近60年呈现减少趋势,在1990年代末期出现了由多转少的全国范围的年代际突变,并以我国东南部季风区的减少最为显著。进一步分析发现,我国北方至白令海峡地区的异常气旋性环流和我国东南侧西北太平洋上的异常反气旋性环流是引起年代际突变的两个关键环流系统。

关键词：复合极端低温多雨事件年代际异常环流背景

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Influence of post-grown treatments on cuinS_2.thin films prepared by sulphurization of Cu-In films

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Rare Metals 2008年第5期27卷 490-495页

作者： yan Youhua LIU Yingchun FANG Ling ZHAO Haihua LI Deren lu Zhichao {2. Shaoxiong Advanced Technology ＆ Materials Co. Ltd. China Iron ＆ Steel Research Institute Group Beijing 100081 China

Polycrystalline cuinS2.（CIS） films were prepared by sulphurization of Cu-In films. The surface morphology and phase composition of the as-grown film, the KCN-etched film, and the annealed KCN-etched film were investigated. During the sulphurization, the secondary CuxS phase segregated on the surface of the as-grown films. To improve the crystalline quality of cuinS2.films, a series of post-grown treatments, such as KCN-etching and vacuum annealing KCN-etched films, were performed on the as-grown films. Both as-grown and post-treated films were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and energy dispersive spectroscopy （EDS）. The results indicated that a CuxS secondary phase segregated on the surface of the as-grown film, which could be removed effectively by KCN etching. After the vacuum annealing treatment, the KCN-etched film had a sphalerite structure with （112. preferred orientation. Meanwhile, the crystalline quality of the CIS film was significantly improved, which provided a novel method to improve the performance of thin film solar cells.

关键词： solar energy cuinS2.thin film KCN etching annealing treatment sulphurization

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空腹血糖变异性与2.糖尿病患者脑卒中发病风险的前瞻性队列研究

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中华疾病控制杂志 2024年第7期28卷 777-783页

作者：顾淑君覃玉俞浩官昊宇崔岚沈冲陆艳程亭亭张宁周金意苏健常熟市疾病预防控制中心慢性非传染病防制科常熟215500 江苏省疾病预防控制中心慢性非传染病防制所南京210009 南京医科大学公共卫生学院流行病与卫生统计学系南京211166 苏州市疾病预防控制中心慢性非传染病防制科苏州215004 苏州高新区(虎丘区)疾病预防控制中心传防科苏州215011

目的探讨空腹血糖(fasting plasma glucose,FPG)长期变异性与2.糖尿病(type 2.diabetes mellitus,T2.M)患者脑卒中发病风险的关联。方法基于江苏省常熟市社区糖尿病患者队列人群,共62.7人纳入分析。≥3次FPG值计算FPG长期变异性指标,包... 详细信息

目的探讨空腹血糖(fasting plasma glucose,FPG)长期变异性与2.糖尿病(type 2.diabetes mellitus,T2.M)患者脑卒中发病风险的关联。方法基于江苏省常熟市社区糖尿病患者队列人群,共62.7人纳入分析。≥3次FPG值计算FPG长期变异性指标,包括FPG标准差(standard deviation,SD)、变异系数(coefficient of variation,CV)、平均真实变异(average real variability,ARV)和独立于均值的变异系数(variability independent of mean,VIM)。利用Cox比例风险回归模型探索FPG长期变异性与T2.M患者脑卒中发病风险的关联,并根据年龄、性别以及糖尿病用药史进行分层分析。结果队列人群平均随访7.2.年,共观察到脑卒中发病1080人,发病密度为2..81/1000人年。以FPG长期变异性指标三分位分组(T1~T3),调整相关因素后,Cox比例风险回归模型分析显示,与T1组相比,FPG-SD、FPG-CV、FPG-ARV和FPG-VIM的T2.T3组发生脑卒中的风险均增加,并呈上升趋势(P趋势2.1.16)、1.09(1.03~1.16)、1.08(1.02.1.16)和1.10(1.03~1.16);缺血性脑卒中的发病风险均增加,HR值(95%CI)分别为1.11(1.03~1.19),1.11(1.04~1.18),1.08(1.00~1.15),1.04(1.04~1.17);FPG-ARV每增加1个SD,出血性脑卒中的发病风险增加,HR值(95%CI)为1.2.(1.03~1.53)。分层分析显示,在年龄≥65岁患者(FPG-CV除外)、女性和单用降糖药的T2.M患者中,FPG-SD、FPG-CV、FPG-ARV和FPG-VIM每增加1个SD,其脑卒中发病风险均增加(均P2.M患者脑卒中发病风险呈正相关,应降低FPG长期变异性。

关键词：空腹血糖变异性 2.糖尿病脑卒中队列研究

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一体化活性污泥法降解氮和磷的研究

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水处理技术 2004年第1期30卷 39-43页

作者：石明岩张海龙吕锡武吴华明哈尔滨工业大学应用化学系黑龙江哈尔滨150001 哈尔滨绍和供水有限公司黑龙江哈尔滨150080 东南大学环境工程系江苏南京210096 南京市市政设计研究院江苏南京210008

考察了不同阶段运行时间的设置、水力停留时间、溶解氧浓度和污泥龄条件下,一体化活性污泥法除磷脱氮的规律。结果表明,将系统控制在适宜的条件下,出水NH3-N可达到污水综合排放一级标准。提出了后续研究中改善除磷效果的措施。

关键词：一体化活性污泥法降解脱氮除磷水力停留时间容解氧浓废污泥龄

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船舶碳捕集、利用与封存技术综述

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交通运输工程学报 2024年第2期24卷 1-19页

作者：卢明剑董胜节严新平李珂李晓东周晓武汉理工大学水路交通控制全国重点实验室湖北武汉430063 武汉理工大学智能交通系统研究中心湖北武汉又430063 武汉理工大学国家水运安全工程技术研究中心湖北武汉430063 武汉理工大学交通与物流工程学院湖北武汉430063 中国远洋海运集团有限公司院士工作站上海每200120 东湖实验室湖北武汉420202 中国船舶集团有限公司第七一一研究所上海201108 中海环境科技(上海)股份有限公司上海200135

追踪了国内外围绕船舶碳捕集、利用与封存(CCUS)技术开展的研究,梳理了重点内容和主要研究成果;从CCUS不同技术路径的优缺点出发,分析了目前CCUS技术在船舶上的应用可行性;针对发展迅猛的液化天然气船舶,提出了开展CCUS的技术路线;总结... 详细信息

追踪了国内外围绕船舶碳捕集、利用与封存(CCUS)技术开展的研究,梳理了重点内容和主要研究成果;从CCUS不同技术路径的优缺点出发,分析了目前CCUS技术在船舶上的应用可行性;针对发展迅猛的液化天然气船舶,提出了开展CCUS的技术路线;总结了目前船舶CCUS技术存在的问题,针对性地提出了建议,并探讨了船舶CCUS关键技术的发展方向。研究结果表明:船舶CCUS技术可以在短期内显著减排,且适用于营运和新造在内的绝大多数含碳燃料船舶;国外正在积极部署船舶CCUS技术实船验证研究,但国内的研究多处于概念设计与仿真研究阶段;由于改造简单,技术成熟度高且成本低,燃烧后捕集法中的化学吸收法目前最适用于船舶碳捕集,但要解决能耗高和系统尺寸大等问题,需加快探索性能更优良的先进化学溶剂及更具革命性的捕集方法;液态存储是目前最成熟的存储方式,但还需要提升其安全性与经济性;亟需加快构建以大型CO_(2.运输船为主的储运方式,推进港口与海洋平台CO_(2.转驳、接收的基础设施建设;CO_(2.在海洋油气田驱油驱气、淡化海水及能源催化重整等领域应用前景广阔,但船舶CO_(2.利用技术亟待规模化、产业化和相关产业技术协同发展;将液态CO_(2.或干冰进行海洋封存是未来的发展趋势,但亟需完善相关标准和法律法规,推动封存配套装备和技术开发;需要探索出一整套标准化、系统化的碳排放管理模式,推动CCUS技术配套发展,构建完整、绿色、经济、高效的船舶CCUS产业链。

关键词：船舶工程碳捕集碳封存碳排放航运业碳减排

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The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2.2.

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei {2. Ai-Ping {2. Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang yan-Qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin Shen Jin Li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2.2. update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in china,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2.HER2.-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2.2. CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of china,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

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Three-photon absorption in a push-pull type chromophore containing tricyanofuran acceptor

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Chinese Chemical Letters 2012年第7期23卷 757-760页

作者： yan Ji Ying Qian Zhi Qiang zhou Wei {2. Yi Ping cui School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Advanced Photonics Center Southeast UniversityNanjing 210096China

Three-photon absorption（3PA） of a push-pull chromophore,2.（3-cyano-（3-（4-（dimethylamino）styryl）-5,5-dimethylcyclohex- 2.enylidene）methyl）-5,5-dimethylfuran-2.ylidene） malononitrile（CFM） including TCF group was measured by the nonlinear transmission method using a femto-second Ti：Sapphire oscillator-amplifier laser *** three-photon absorption cross-sections at 1300 ran were 36.8×10^-79 cm^6 s^2.in the solution of DMF and 12.3×10^-79 cm^6 s^2.in the solution of CH_2.l_2.*** large values were got by experiments in this paper,which is a new exploration for these kinds of *** molecule has the potential application foreground of 3PA areas and optical power limiting.

关键词： Three-photon absorption Optical power limiting Nonlinear transmission method Push-pull chromophore TCF

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A Preliminary Study on Natural Matrix Materials for Controlled Release Nitrogen Fertilizers

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Pedosphere 2004年第1期14卷 45-52页

作者： DUChang-Wen zhouJian-Min WANGHuo-yan LIShou-Tian DepartmentofSoilScienceandPlantNutrition InstituteofSoilScienceChineseAcademyofSciencesNanjing210008（China）

A controlled release N fertilizer was developed by the carrier method using natural polysaccharides (PS)and urea. The results showed that mixing of PS and urea led to significant control of urea release. When a cross-linker (boric acid or glutaraldehyde) was added, a better control effect was observed. During a 30 min leaching time the nitrogen release rate from the controlled release fertilizer was nearly constant, which was significantly different from normal urea. One of the controlled release mechanisms was related to space resistance from a large molecular structure. Infrared (IR) analysis indicated that interaction of PS with urea was through a hydrogen bond or a covalent bond. These bonds created an α-helix or high molecular network fertilizer carrier system, which was another reason for a controlled nutrient release. Pot experiment showed that nitrogen use efficiency could increase significantly with a carrier fertilizer.

关键词： carrier controlled release fertilizer nitrogen fertilizer polysaccharides

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Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

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Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-yang yan Hong Lv Jing-Cheng yang Chao You Zi-Ang Li Ding Ma Yi Xiao Jia Hu Wen-Tao yang Yi-zhou Jiang Jun Xu Zhi-Ming Shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TNBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TNBC cohort(N=42.),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2.mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TNBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank P<0.001).Our prediction framework and neural network models were externally validated on the TNBC cases from TCGA(N=143)and appeared robust to the changes in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

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