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Relationship between cellular radio-sensitivity and naked DNA damage in mammalian cells exposed to heavy ions

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Nuclear Science and Techniques 2009年第6期20卷 349-353页

作者： LI Wenjian zhou guangming WANG Zhuanzi LI Qiang DANG Bingrong WANG Jufang Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

The relationship between deoxyribonucleic acid (DNA) damage and the cell death induced by 12C ions irradiation was examined in four kinds of cells, Melanoma B16, cervical squamous carcinoma HeLa, Chinese hamster V79 and hepatoma SMMC-7721. Cell survival was determined by a colonogenic assay, and the sensitivity was described by D50 (the dose of radiation necessary to reduce the survival to 50%). For all cell lines, D50 ranged from 0.74 Gy to 3.85 Gy, among them B16 was the most radiosensitive to 12C ions, and V79 and HeLa cells had almost the same radio-sensitivity, SMMC-7721 was the last. The induction of deproteinized DNA double-strand breaks induced by 12C ions were measured by pulsed-field gel electrophoresis (PFGE), and the initial yield of the deproteinized DNA dsbs per unit dose was expressed as the DNA double break level (L). A linear dose-response curve was seen for initial DNA dsbs for all cell lines (slopes range from 0.40-0.98 (DSBs/100Mbp/Gy)). V79 was the steepest, B16 was the last. There was an inverse relationship between the initial DNA dsb and D50 if the B16 cell line was not considered, but there was no relativity even excludes the B16 cell line. The present results indicate that there is no relationship between cellular sensitivity and initial DNA dsb, even exclude the effects of chromatin structure.

关键词：哺乳动物细胞 DNA损伤放射敏感性重离子 DNA双链断裂脉冲场凝胶电泳无线蜂窝

Space Life Science of China in 2013

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空间科学学报 2014年第5期34卷 747-756页

作者： LEI Runhong zhou guangming MA Hong ZHUANG Fengyuan DENG Yulin School of Life Science Beijing Institute of Technology Department of Space Radiobiology Key Laboratory of Heavy Ion Radiation Biology and MedicineInstitute of Modern Physics Chinese Academy of Sciences

In the past two years, space life science research in China is characterized by a wide area of basic researches for providing foundation for the future China Space Station. The effect of microgravity and radiation was further studied from physiology phenomena to the level of bio-molecule mechanisms. Chinese space life science is maturing in a new era of comprehensive ***, we review and summarize researches on space life sciences which were contributed by Chinese scientists.

关键词： Space life sciences Simulated microgravity Ionizing radiation

Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and tumor tissues

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Radiation Medicine and Protection 2020年第1期1卷 35-40页

作者： guangming zhou State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow University199 Renai RoadSuzhou215123China

Different from conventional radiotherapy(CONV-RT),FLASH radiotherapy(FLASH-RT)delivers a single high dose at a mean dose rate40 Gy/s in milliseconds to achieve similar tumor control to CONV-RT while sparing normal tissues from detrimental *** provides an intriguing perspective in improving clinical outcomes for tumor patients as well as a novel way to enhance the differential responses between normal and tumor ***,its mechanisms remain largely *** this paper,we review the currently available publications on FLASH-RT and parse the probable mechanisms of three major aspects including the production of reactive oxygen species,DNA damage response,and *** specifically designed to disclose the intrinsic difference between normal and malignant cells in response to FLASH-RT and CONV-RT are necessary to prove these hypotheses.

关键词： FLASH ROS Radiation quality Immune response

The clinical prospect of FLASH radiotherapy

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Radiation Medicine and Protection 2023年第4期4卷 190-196页

作者： Jiyuan Liu guangming zhou Hailong Pei State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSuzhou Medical College of Soochow UniversitySuzhou 215123China

FLASH radiotherapy(FLASH-RT)is a new strategy for tumor treatment with an ultra-high dose rate of more than 40 Gy/*** with conventional radiotherapy(CONV-RT),FLASH-RT has no different inhibitory effects on tumors but less damage to normal tissues,which is called the“spare”***“spare”effect triggers our exploration of the great prospect of subverting conventional radiotherapy and its intricate *** homeostasis,the immune microenvironment,or DNA integrity may potentially represent the primary breakthrough direction in understanding the ***,it is imperative to advance timely clinical translation *** trials of FLASH-RT have progressed to Phase II in both the United States and Switzerland,with current findings suggesting that FLASH-RT achieves comparable efficacy to CONV-RT while mitigating side effects in select cancer cell *** summarizing the existing FLASH experiments,this paper emphasizes the significance of clinical transformation and the challenges that will be faced and proposes possible solutions.

关键词： Radiotherapy FLASH-RT Oxygen depletion Immune microenvironment Clinical translation

Quadrature Element Vibration Analysis of Arbitrarily Shaped Membranes

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Transactions of Nanjing University of Aeronautics and Astronautics 2022年第1期39卷 1-11页

作者： WANG Xinwei CAI Deng’an zhou guangming State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

The aim of the present study is to develop an efficient weak form quadrature element for free vibration analysis of arbitrarily shaped *** arbitrarily shaped membrane is firstly mapped into a regular domain using blending functions,and the displacement in the element is assumed as the trigonometric *** formulations are worked out for nodes of any type and a varying number of *** verifications,results are compared with exact solutions and data obtained by other numerical *** is demonstrated that highly accurate frequencies can be obtained with a small number of nodes by present method.

关键词： arbitrarily shaped membrane free vibration quadrature element blending function

Oxygen-driven cuproptosis synergizes with radiotherapy to potentiate tumor immunotherapy

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Aggregate 2024年第3期5卷 219-231页

作者： Pei Pei Yuhong Wang Wenhao Shen Qing He Xiangming Han Chonghai Zhang Yuyuan Xie guangming zhou Ye Zhao Lin Hu Kai Yang Teaching and Research Section of Nuclear Medicine School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhouJiangsuChina Department of Pathology The First Afﬁliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Oncology Taizhou People’s Hospital Afﬁliated to Nanjing Medical UniversityNanjingJiangsuChina

The immunological implications of cuproptosis,a form of cell death highly sensitive to oxygen presence,remain largely unexplored in the context of tumor ***,we initially investigate the positive correlation between cuproptosis and tumor immunotherapy through bioinformatics ***,an oxygen generator loaded with copper ions(Cu/APH-M)has been constructed,which serves as an effective carrier of copper ions and crucially enhances the oxygenation of the tumor ***,Cu/APH-M-mediated dual strengthening of cuproptosis and radiotherapy could not only trigger a powerful antitumor immunity related to immunogenic cell death by RNA-sequencing analysis,but also effec-tively inhibit the growth of both distal and in situ low rectal tumors after combined immunotherapy,creating a robust immune memory *** work reveals the ben-eﬁcial effects of enhanced cuproptosis in radio-immunotherapy and elucidates its underlying mechanisms,which provides a novel approach for the synergistic inte-gration of cuproptosis with immunotherapy and radiotherapy,broadening the scope of cuproptosis-mediated tumor therapy.

关键词： cuproptosis immune response oxygen generator radio-immunotherapy RNA-seq analysis

3 - 93 Anti-radiation Effects of GANRA-Iike Medicine

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IMP & HIRFL Annual Report 2010年第1期 197-198页

作者： Zhu Mingyue Wang Jufang zhou guangming

Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents

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Bioactive Materials 2022年第3期7卷 157-167页

作者： Hao Huang Guotao Yuan Ying Xu Yuan Gao Qiulian Mao Yin Zhang Lu Bai Weijie Li Anqing Wu Wentao Hu Yue Pan guangming zhou State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou510120PR China Department of Nutrition and Food Hygiene Soochow University of Public HealthSuzhou215123China

The integration of photothermal therapy(PTT)with gene therapy(GT)in a single nanoscale platform demonstrates great potential in cancer *** iron oxide nanoagents(PIONs)are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal ***,the therapeutic efficacy of PIONs-mediated GT has not been *** long noncoding RNA(lncRNA)CRYBG3(LNC CRYBG3),a lncRNA induced by heavy ion irradiation in lung cancer cells,has been reported to directly bind to globular actin(G-actin)and cause degradation of cytoskeleton and blocking of cytokinesis,thus indicating its potential for use in GT by simulating the effect of heavy ion irradiation and functioning as an antitumor *** the present study,we investigated the possibility of combining PIONs-mediated PTT and LNC CRYBG3-mediated GT to destroy non-small cell lung cancer(NSCLC)cells both in vitro and in *** combination therapy showed a high cancer cell killing efficacy,and the cure rate was better than that achieved using PTT or GT ***,as a type of magnetic nanoagent,PIONs can be used for magnetic resonance imaging(MRI)and photoacoustic imaging(PAI)both in vitro and in *** findings indicate that the new combination therapy has high potential for cancer treatment.

关键词： Gene therapy(GT) Porous iron oxide nanoagents(PIONs) Photothermal therapy(PTT) Long noncoding RNA CRYBG3

Multiple functions of BCCIP roles in maintaining genomic instability

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Multiple functions of BCCIP roles in maintaining genomic ins...