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Miniaturized power detection module operating in millimeter wave band

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Journal of Electronic Science and Technology 2024年第2期22卷 69-76页

作者： xiang zhou zhi-Yong Zhong School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real *** is highly prospective in military and scientific *** this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold *** module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is also applied to improve the measurement *** a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is *** designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 *** endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites.

关键词： Diode Miniaturization Power detection Temperature compensation

Wide local excision could be considered as the initial treatment of primary anorectal malignant melanoma

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Chinese Medical Journal 2010年第5期123卷 585-588页

作者： zhou Hai-tao zhou zhi-xiang ZHANG Hai-zeng BI Jian-jun ZHAO Ping Department of Abdominal Surgery Cancer Hospital (Institute) Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100021 China

Background Anorectal malignant melanoma was a rare disease with extremely poor prognosis. The aim of this study was to explore the clinical characteristic, diagnosis and treatment strategies of anorectal malignant melanoma. Methods The data of 57 patients with anorectal malignant melanoma was collected and retrospectively analyzed. Results Rectal bleeding and anal mass were found to be common symptoms of anorectal malignant melanoma. The preoperative diagnosis rate of anorectal malignant melanoma was 48.6%. The overall 3-year and 5-year survival rate was 38.0% and 21.3% respectively. The 3-year survival rates of stage I and II patients were 63.0% and 16.7% respectively （P=0.000）, and the 5-year survival rates were 33.3% and 11.1% （P=0.001）, which both had significant statistic differences. The 3-year survival rate of patients undergone abdmoninoperineal resection and patients undergone wide local excision were 36.7% and 53.0% respectively （P=0.280）, while the 5-year survival rate were 24.1% and 23.1% （P=0.642）, which both had no significant statistic differences. Conclusions This study identified no survival advantage to abdominoperineal resection in treatment of anorectal malignant melanoma, and we propose that wide local excision could be considered as the initial treatment of choice.

关键词： anal rectal melanoma prognosis

A Novel Synthesis Route of [1 ,2,5]Oxadiazolo [3,4-e] [ 1,2,3,4]tetrazine-4,6-Di-N-oxide

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含能材料 2013年第1期21卷 131-132页

作者： WANG Bo-zhou LI xiang-zhi LI Hui HUO Huan zhou Yan-shui FAN Xue-zhong LI Ji-zhen Xi'an Modern Chemistry Research Institute Xi'an 710065 China

1 Introduction An energetic material,[1,2,5] oxadiazolo [3,4-e][1,2,3,4] tetrazine-4,6-di-N-oxide (FTDO),whose density (tested) was 1.85 g · cm-3[2],enthalpy of formation was 1010 kcal· kg-1[3],calculated detonation velocity pressure was 9802 m · s-1,and detonation pressure was 44.78 GPa,was firstly synthesized and reported by Russian scientists in 1995[1].The five-step synthetic route of FTDO,which was synthesized from 3,4-diaminofurazan (DAF) via the reactions of oxidation,amino protection,condensation,hydrolysis and cyclization with a total yield of 14.63％,had been reported [1].

关键词：含能材料材料学研究理论

Clinicopathological characteristics and prognostic factors for the recurrence of abdominal desmoid tumors: a retrospective study of 113 patients from two Chinese hospitals

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Chinese Medical Journal 2021年第12期134卷 1505-1507页

作者： Si-Cheng zhou Wei Pei Zhen Sun zhi-xiang zhou Xi-Shan Wang Jian-Wei Liang Qiang Feng Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Beijing HospitalBeijing 100730China

To the Editor:Desmoid tumors(DTs)show local aggressiveness to surrounding structures and exhibit a propensity to recur,leading to a high local recurrence rate and significant functional impairments and morbidity.[1]It has been shown that DTs located in the abdominal wall and abdominal cavity are relatively minimally invasive and have a relatively low recurrence rate,[2]which indicated abdominal desmoid tumors(ADTs)may have different biological make-ups and *** study was aimed to delineate the clinicopathological features and determine the prognostic factors for recurrence-free survival(RFS)in ADTs after macroscopic complete surgical resection.

关键词： abdominal tumors patients

LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer

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Biomedical and Environmental Sciences 2020年第11期33卷 849-856页

作者： ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan zhou Ling TANG Min Zhong SJ O`Brien LAN Jiao zhou xiang Yang WANG Yong Li TANG Juan zhou zhi xiang DU Hai Jun LIN Hui State Key Laboratory for Infectious Disease Prevention and Control National Institute of Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China People's Hospital of Guangxi Zhuang Autonomous Region Nanning 530021GuangxiChina Cancer center Wuzhou Red Cross HospitalWuzhou 543002GuangxiChina Guy Harvey Oceanographic Center Halmos College of Natural Sciences and OceanographyNova Southeastern UniversityFlorida 33004USA College of Life Science and Bioengineering Beijing University of TechnologyBeijing 100124China

Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with *** prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth *** responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth *** clinicians performed the follow-up and tracking of *** We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical ***-nine patients with NPC were enrolled in this clinical *** LMP2-DCs vaccine was well tolerated in all of the *** responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with *** follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in *** In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with *** CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing.

关键词： LMP2-DCs Nasopharyngeal carcinoma Immunotherapy

A New Method for Ultra-sensitive P24 Antigen Assay Based on Near-infrared Fluorescent Microsphere Immunochromatography

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Biomedical and Environmental Sciences 2020年第3期33卷 174-182页

作者： WANG Qi HOU Mei Ling LIU Li Peng MA Jing ZHANG Xiao Guang zhou zhi xiang CAO Yu Xi Beijing University of Technology College of Life Science and BioengineeringBeijing 100124China Beijing Runbio Biotechnology Development Co. LtdBeijing 100106China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective To develop a rapid,highly sensitive quantitative method for detecting P24 antigen based on near-infrared fluorescent microsphere *** First,we prepared a lateral flow assay test strip,and labeled the detection antibody using a fluorescent ***,we optimized the antibody labeling ***,we optimized the detection ***,we created a working ***,we conducted a methodological assessment of the established fluorescent microsphere immunochromatography ***-six clinical samples were tested,and we compared the established fluorescent microsphere immunochromatography with the quantitative ELISA *** According to the working curve,the detection limit of the method is 3.4 pg/mL,and the detection range is 3.4 pg/mL to 10 ng/*** average intra-assay recovery was 99.6%,and the Coefficient of Variation(CV)was 5.4%–8.6%;the average inter-assay recovery was 97.3%,and the CV was 8.5%–11%.The detection rate of fluorescent microsphere immunochromatography was higher than ELISA method,and had a good correlation with *** The P24 antigen quantitative detection method based on near-infrared fluorescent microsphere immunochromatography has the advantages of rapid detection,high sensitivity,and wide detection range;thus,it is suitable for early clinical diagnosis and continuous monitoring of AIDS.

关键词： Fluorescent microsphere immunochromatography HIV P24 antigen POCT

Surgical management for carcinoma of the gallbladder： a single-institution experience in 25 years

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Chinese Medical Journal 2008年第19期121卷 1900-1905页

作者： LIANG Jian-wei DONG Shu-xiao zhou zhi-xiang TIAN Yan-tao ZHAO Dong-bing WANG Cheng-feng ZHAO Ping Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China

Background Gallbladder carcinoma is rare and associated with dismal outcomes. Radical surgery is the only curative treatment, and options for adjuvant therapy remain limited. This study aimed to determine the factors influencing outcome of treatment in patients with gallbladder carcinoma, and to identify the patients who might benefit from radical surgery and adjuvant therapy. Methods Medical records and follow-up histories of 150 patients with gallbladder carcinoma who had undergone surgery between April 1980 and December 2005 were retrospectively reviewed. The factors predictive for the survival of the patients were identified using multivariate analysis. Results Surgery for gallbladder cancer was associated with an overall 5-year survival rate of 26.2%. After curative resection （40% of the patients）, the 5-year survival rate was 60.3%. The patients who underwent R0 resection had a significantly longer median survival （97.3 months） than those who had R1/R2 resection （8.3 months） or only laparotomy （3.7 months）（P 〈0.0001）. Univariate analysis showed that resectability, American Joint Committee on Cancer staging, tumor grade, adjuvant therapy, jaundice at presentation, depth of tumor invasion, lymph node involvement, distant metastasis, and carcinoembryonic antigen level were statistically significant predictors for survival. Multivariate analysis revealed American Joint Committee on Cancer staging and resectability were independent prognostic factors for survival. The patients who underwent noncurative resection might benefit from adjuvant therapy （median survival, 12.4 months vs 7.2 months, P=-0.006）. Conclusions Favorable survival rate can be achieved after curative resection, even for selected patients with advanced disease. Adjuvant therapy may improve the survival of patients with gallbladder carcinoma.

关键词： gallbladder carcinoma radical resection prognostic factor adjuvant therapy

Learnware:small models do big

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Science China(Information Sciences) 2024年第1期67卷 39-50页

作者： zhi-Hua zhou zhi-Hao TAN National Key Laboratory for Novel Software Technology Nanjing University

There are complaints about current machine learning techniques such as the requirement of a huge amount of training data and proficient training skills,the difficulty of continual learning,the risk of catastrophic forgetting,and the leaking of data privacy/*** research efforts have been focusing on one of those concerned issues separately,paying less attention to the fact that most issues are entangled in *** prevailing big model paradigm,which has achieved impressive results in natural language processing and computer vision applications,has not yet addressed those issues,whereas becoming a serious source of carbon *** article offers an overview of the learnware paradigm,which attempts to enable users not to need to build machine learning models from scratch,with the hope of reusing small models to do things even beyond their original purposes,where the key ingredient is the specification which enables a trained model to be adequately identified to reuse according to the requirement of future users who know nothing about the model in advance.

关键词： artificial intelligence machine learning learnware

Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway,and induces senescence in hepatocellular carcinoma

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Oncology Research 2024年第1期32卷 213-226页

作者： XUEGANG YANG XIANHONG xiang GUOHUI XU SHI zhou TIANzhi AN zhi HUANG Department of Interventional Radiology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaRadiation Oncology Key Laboratory of Sichuan ProvinceChengdu610041China Department of Interventional Radiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China Department of Interventional Radiology Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China School of Basic Medical Science Guizhou Medical UniversityGuiyang550002China

Hepatocellular carcinoma(HCC),a common malignancy worldwide,still lacks effective clinical *** study aimed to investigate the oncogenes that affect the progression of HCC and their possible *** our study,we initially confirmed a higher level of PRDX2 in the bile of HCC patients compared to those with choledocholithiasis by 2-DE,LC-MS,and ***,we demonstrated the high expression of peroxiredoxin 2(PRDX2)in HCC based on the TCGA database and clinical sample ***,PRDX2 overexpression enhanced the viability of HCC *** PRDX2 silencing induced senescence of HCC *** vivo,knockdown of PRDX2 significantly reduced the weight of xenograft ***2 also was found to activate the Wnt/β-catenin pathway by inducingβ-catenin nuclear ***,we proved that silencing PRDX2 could inhibit proliferation and Wnt/β-catenin pathway while promoting senescence in HCC cells.

关键词： Peroxiredoxin 2 Hepatocellular carcinoma Wnt/β-catenin pathway Senescence Proliferation