Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway,and induces senescence in hepatocellular carcinoma

作     者：XUEGANG YANG XIANHONG XIANG GUOHUI XU SHI ZHOU TIANZHI AN ZHI HUANG 

作者机构：Department of Interventional RadiologySichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaRadiation Oncology Key Laboratory of Sichuan ProvinceChengdu610041China Department of Interventional RadiologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China Department of Interventional RadiologyAffiliated Hospital of Guizhou Medical UniversityGuiyang550004China School of Basic Medical ScienceGuizhou Medical UniversityGuiyang550002China 

出 版 物：《Oncology Research》 (肿瘤学研究（英文）)

年 卷 期：2024年第32卷第1期

页      面：213-226页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Nature Science Foundation of China(Nos.81960118,81860115,81760116 and 82060116) Guizhou Science and Technology Project:Qiankehe Foundation(No.(2020)1Y300) Natural Science Foundation of Sichuan(No.2022NSFSC0837) Science and Technology Project of Chengdu(No.2022-YF05-01811-SN) Science and Technology Project of Guizhou Province(No.YQK(2023)032) Guizhou Medical University Doctoral Start-Up Fund(No.gyfybsky-2021-27) Guizhou Medical University Doctoral Start-Up Fund(No.gyfybsky-2021-26) Guizhou Science and Technology Department(No.(2019)1259) Guizhou Science and Technology Department Guizhou Science and Technology Platform Talents(No.(2017)5718) Science and Technology Fund of Guizhou Provincial Health Commission(No.gzwki2021-382) The Affiliated Hospital of Guizhou Medical University Excellent Reserve Talent in 2023(No.gyfyxkrc-2023-06) 

主　　题：Peroxiredoxin 2 Hepatocellular carcinoma Wnt/β-catenin pathway Senescence Proliferation 

摘      要：Hepatocellular carcinoma(HCC),a common malignancy worldwide,still lacks effective clinical *** study aimed to investigate the oncogenes that affect the progression of HCC and their possible *** our study,we initially confirmed a higher level of PRDX2 in the bile of HCC patients compared to those with choledocholithiasis by 2-DE,LC-MS,and ***,we demonstrated the high expression of peroxiredoxin 2(PRDX2)in HCC based on the TCGA database and clinical sample ***,PRDX2 overexpression enhanced the viability of HCC *** PRDX2 silencing induced senescence of HCC *** vivo,knockdown of PRDX2 significantly reduced the weight of xenograft ***2 also was found to activate the Wnt/β-catenin pathway by inducingβ-catenin nuclear ***,we proved that silencing PRDX2 could inhibit proliferation and Wnt/β-catenin pathway while promoting senescence in HCC cells.