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Physical exercise suppresses hepatocellular carcinoma progression by alleviating hypoxia and attenuating cancer stemness through the Akt/GSK-3β/β-catenin pathway

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Journal of Integrative Medicine 2023年第2期21卷 184-193页

作者： Chu-lan Xiao Zhi-peng zhong Can Lü Bing-jie Guo Jiao-jiao Chen Tong Zhao Zi-fei Yin Bai Li Department of Rehabilitation Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Traditional Chinese Medicine The 920th Hospital of Joint Logistics Support ForceKunming 650000Yunnan ProvinceChina Second Team Graduate SchoolNaval Medical UniversityShanghai 200433China College of Integrated Traditional Chinese and Western Medicine Nanjing University of Traditional Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Military Traditional Chinese Medicine Faculty of Traditional Chinese MedicineNaval Medical UniversityShanghai 200433China

Objective:Physical exercise,a common non-drug intervention,is an important strategy in cancer treatment,including hepatocellular carcinoma(HCC).However,the mechanism remains largely *** to the importance of hypoxia and cancer stemness in the development of HCC,the present study investigated whether the anti-HCC effect of physical exercise is related to its suppression on hypoxia and cancer ***:A physical exercise intervention of swimming(30 min/d,5 d/week,for 4 weeks)was administered to BALB/c nude mice bearing subcutaneous human HCC *** anti-HCC effect of swimming was assessed in vivo by tumor weight monitoring,hematoxylin and eosin(HE)staining,and immunohistochemistry(IHC)detection of proliferating cell nuclear antigen(PCNA)and *** expression of stemness transcription factors,including Nanog homeobox(NANOG),octamer-binding transcription factor 4(OCT-4),v-Myc avian myelocytomatosis viral oncogene homolog(C-MYC)and hypoxia-inducible factor-1a(HIF-1a),was detected using real-time reverse transcription polymerase chain reaction.A hypoxia probe was used to explore the intratumoral hypoxia *** blot was used to detect the expression of HIF-1a and proteins related to protein kinase B(Akt)/glycogen synthase kinase-3β(GSK-3β)/β-catenin signaling *** IHC analysis of platelet endothelial cell adhesion molecule-1(CD31),and the immunofluorescence co-location of CD31 and desmin were used to analyze tumor blood ***-7721 cells were treated with nude mice *** inhibition effect on cancer stemness in vitro was detected using suspension sphere experiments and the expression of stemness transcription *** hypoxia status was inferred by measuring the protein and mRNA levels of ***,the expression of proteins related to Akt/GSK-3β/β-catenin signaling pathway was ***:Swimming significantly reduced the body weight and tumor weight in nude mice bearing HCC *** staining and IHC results show

关键词： Physical exercise Swimming Hepatocellular carcinoma Liver cancer Blood perfusion Hypoxia Cancer stemness Akt/GSK-3β/β-catenin

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4个羊草品种(系)耐盐性评价

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黑龙江畜牧兽医 2024年第9期 77-84页

作者：王建丽牟林林庄煦张冬梅尤佳钟鹏邸桂俐韩微波陈金利黑龙江省农业科学院草业研究所哈尔滨150086 黑龙江省农业科学院畜牧兽医分院黑龙江齐齐哈尔161005 黑龙江省农业科学院经济作物研究所哈尔滨150086 北大荒集团黑龙江绿色草原牧场有限公司黑龙江大庆163254

为了探究不同羊草品种(系)耐盐性,试验以JM007、JM009、吉生1号和东北羊草为材料,分析不同浓度(200,400,600 mmol/L) NaCl胁迫对其萌发期萌发指标和幼苗期生理指标的影响,以纯化水/Hoagland营养液为对照(CK),并利用主成分分析法、相关... 详细信息

为了探究不同羊草品种(系)耐盐性,试验以JM007、JM009、吉生1号和东北羊草为材料,分析不同浓度(200,400,600 mmol/L) NaCl胁迫对其萌发期萌发指标和幼苗期生理指标的影响,以纯化水/Hoagland营养液为对照(CK),并利用主成分分析法、相关性分析、隶属函数法等方法对各单项指标的耐盐系数进行分析,综合评价羊草品种(系)耐盐性。结果表明:羊草萌发期和幼苗期的各项指标均受到不同浓度NaCl胁迫的影响,但不同指标对NaCl胁迫的敏感度存在差异。随着NaCl浓度升高,羊草种子的相对发芽率、相对发芽势、相对发芽指数、相对种子活力、相对胚芽长和相对胚根长均呈逐渐下降趋势,此外NaCl胁迫对羊草胚芽长的抑制作用大于胚根长。与CK相比,不同浓度NaCl胁迫下4种羊草幼苗MDA、Pro含量均显著增加(PJM007>吉生1号>东北羊草,幼苗期为JM007>吉生1号> JM009>东北羊草。说明JM009羊草种子在萌发期耐盐能力较强,JM007羊草则在幼苗期耐盐能力较强。

关键词：羊草耐盐性萌发期幼苗期综合评价

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Research on Gait Trajectory Planning of Wall-Climbing Robot Based on Improved PSO Algorithm

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Journal of Bionic Engineering 2024年第4期21卷 1747-1760页

作者： Jian Li Xianlin Shi peng Liang Yanjun Li Yilin Lv Mingyue zhong Zezhong Han School of Mechanical and Automotive Engineering Guangxi University of Science and TechnologyLiuzhou545006China

In order to reduce the labor intensity of high-altitude workers and realize the cleaning and maintenance of high-rise building exteriors,this paper proposes a design for a 4-DOF bipedal wall-climbing bionic robot inspired by the inchworm’s *** robot utilizes vacuum adsorption for vertical wall attachment and legged movement for *** enhance the robot’s movement efficiency and reduce wear on the adsorption device,a gait mimicking an inchworm’s movement is planned,and foot trajectory planning is performed using a quintic polynomial *** velocity constraints,foot trajectory optimization is achieved using an improved Particle Swarm Optimization(PSO)algorithm,determining the quintic polynomial function with the best fitness through ***,through comparative experiments,the climbing time of the robot closely matches the simulation results,validating the trajectory planning method’s accuracy.

关键词： Bionic robot Wall-climbing robot PSO Gait planning Trajectory planning

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Growth and physiological responses of four kiwifruit genotypes to salt stress and resistance evaluation

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Journal of Integrative Agriculture 2019年第1期18卷 83-95页

作者： zhong Yun-peng QI Xiu-juan CHEN Jin-yong LI Zhi BAI Dan-feng WEI Cui-guo FANG Jin-bao Key Laboratory for Fruit Tree Growth Development and Quality ControlZhengzhou Fruit Research InstituteChinese Academy of Agricultural Sciences

In this study,four genotypes(Acva-1,Acva-2,Acva-3 and ZM-2) of Actinidia germplasm resources were grown in different NaCl concentrations(0,0.4,0.8 and 1.2 g L–1).The growth,physiological and biochemical indicators were measured,and a graded scale was developed as the salt damage index(SDI) according to different damage symptoms in *** results showed SDI increased gradually,and average number and length of new shoot decreased *** antioxidant enzymes(superoxide dismutase,peroxidase and catalase) and two osmotic adjustment substances(soluble sugar and proline) showed different changes in old and new leaves of four *** values exhibited a decreased trend in the whole except in the new leaves of *** contents increased and root activity decreased with the increasing salt *** component analysis was used to assess the salt tolerance,and the results showed Acva-3,from Actinidia valvata Dunn.,had the strongest tolerance to salt,and could be a potential resistant resource to the salt-tolerance dedicated rootstock breeding of kiwifruit.

关键词： kiwifruit salt stress principal component analysis resistance evaluation

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A parallel approach to direct resolution of albuterol

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Chinese Science Bulletin 2010年第25期55卷 2814-2816页

作者： zhong QingLin peng XiaoHua WU TongFei FU FangMin CUI Xin ZHU Jin DENG JinGen National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China

A library consisting of a series of O,O'-diaryzoyl-L-(-)-tartaric acids (2) was designed and synthesized. The substituent on the aromatic ring of 2 significantly affects the diastereomeric excess and efficiency of the resolution of racemic albuterol (1). Excel-lent resolving reagent 2a was selected for the resolution of rac-1 via the parallel approach. However,a family of three resolving reagents failed to improve the resolution efficiency of rac-1.

关键词：沙丁胺醇并行方式直接解选择试剂 Excel RAC 脂肪酸酒石酸

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CrossLinkNet: An Explainable and Trustworthy AI Framework for Whole-Slide Images Segmentation

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Computers, Materials & Continua 2024年第6期79卷 4703-4724页

作者： peng Xiao Qi zhong Jingxue Chen Dongyuan Wu Zhen Qin Erqiang Zhou Network and Data Security Key Laboratory of Sichuan Province University of Electronic Science and Technology of ChinaChengdu610054China Faculty of Data Science City University of MacaoMacao999078China

In the intelligent medical diagnosis area,Artificial Intelligence(AI)’s trustworthiness,reliability,and interpretability are critical,especially in cancer *** neural networks,while excellent at processing natural images,often lack interpretability and adaptability when processing high-resolution digital pathological *** limitation is particularly evident in pathological diagnosis,which is the gold standard of cancer diagnosis and relies on a pathologist’s careful examination and analysis of digital pathological slides to identify the features and progression of the ***,the integration of interpretable AI into smart medical diagnosis is not only an inevitable technological trend but also a key to improving diagnostic accuracy and *** this paper,we introduce an innovative Multi-Scale Multi-Branch Feature Encoder(MSBE)and present the design of the CrossLinkNet *** MSBE enhances the network’s capability for feature extraction by allowing the adjustment of hyperparameters to configure the number of branches and *** CrossLinkNet Framework,serving as a versatile image segmentation network architecture,employs cross-layer encoder-decoder connections for multi-level feature fusion,thereby enhancing feature integration and segmentation *** quantitative and qualitative experiments on two datasets demonstrate that CrossLinkNet,equipped with the MSBE encoder,not only achieves accurate segmentation results but is also adaptable to various tumor segmentation tasks and scenarios by replacing different feature ***,CrossLinkNet emphasizes the interpretability of the AI model,a crucial aspect for medical professionals,providing an in-depth understanding of the model’s decisions and thereby enhancing trust and reliability in AI-assisted diagnostics.

关键词： Explainable AI security trustworthy CrossLinkNet whole slide images

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Nonphytate Phosphorus Requirement and Efficacy of a Genetically Engineered Yeast Phytase for Yellow Broilers at 22- to 42-d-Old Age

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Agricultural Sciences in China 2011年第2期10卷 304-311页

作者： JIANG Zong-yong ZHOU Gui-lian LIN Ying-cai JIANG Shou-qun LI De-zhong XI peng-bin ZHANG Han-xing Key Laboratory of Animal Nutrition and Feed Science（South China） Ministry of Agriculture/Institute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China

An experiment was conducted to investigate the requirement of nonphytate phosphorus（nPP） and efficacy of a genetically engineered yeast phytase（PHY A） for Lingnan yellow broilers from 22-to 42-d-old age.A total of 1 320 1-d-old male chicks were randomly divided into 11 dietary treatment groups,which consisted of 4 replicate floor pens with 30 birds per *** control group（treatment 1） was fed with basal diet of nPP 0.08% without dicalcium phosphate or phytase *** levels of nPP were 0.16,0.24,0.32,0.40,0.48,and 0.56%,respectively,for treatments 2 to 7,through addition of dicalcium phosphate（chemistry grade） to the basal *** of treatments 8 to 11 were supplemented with PHY A at 200,400 and 600 U kg-1,a commercial phytase product（PHY B） at 400 U kg-1 level,*** birds in 0.32-0.56% nPP groups gained more than those of the other groups（P0.05）.The nPP supplementation significantly improved feed intake（P0.05）.The feed gain ratio was significantly decreased by 0.40% nPP diet compared to the control birds（P0.05）.The level of 0.48% nPP was required for optimum tibia *** additions of PHY A at 400 and 600 U kg-1 level and PHY B all significantly improved ADG（P0.05）,ADFI（P0.05）,and dry defatted tibia weight（P0.05）.Similarly,the percentage of tibia ash was increased by 600 U kg-1 PHY A supplementation（P0.05）.The requirement of nPP for maximal ADG and highest percentage tibia ash both was 0.40%.The phosphorus equivalency value of PHY A was estimated as 685 U kg-1 for male yellow broilers of 22-to 42-d-old age.

关键词： nonphytate phosphorus growth tibia ash genetically engineered yeast phytase phosphorus equivalency value yellow broilers

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研究生社会实践标准化模式研究--以河南中医药大学为例

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中国标准化 2024年第6期 219-222页

作者：秦中朋张可欣张艳丽刁青蕊河南中医药大学

研究生社会实践是高校人才培养的重要环节,也是大学生了解国情、增长才干、奉献社会的重要途径。本研究以河南中医药大学为例,阐述社会实践标准化模式的意义,如有利于规范研究生社会实践活动开展、促进研究生创新能力培养和全面发展等,... 详细信息

研究生社会实践是高校人才培养的重要环节,也是大学生了解国情、增长才干、奉献社会的重要途径。本研究以河南中医药大学为例,阐述社会实践标准化模式的意义,如有利于规范研究生社会实践活动开展、促进研究生创新能力培养和全面发展等,并通过对研究生社会实践存在的问题进行分析,提出了建立研究生社会实践标准化模式的策略,期望对新时代加强研究生思想政治教育有所助益。

关键词：研究生社会实践标准化模式

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Measurement of the Absolute Photoionization Cross Section for the 5P_(3/2) State of ^(87)Rb in a Vapor Cell Magneto-optic Trap

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Chinese Physics Letters 2012年第1期29卷 86-89页

作者： HUANG Wei RUAN Ya-Ping JIA Feng-Dong zhong Yin-peng LIU Long-Wei DAI Xing-Can XUE Ping XU Xiang-Yuan zhong Zhi-Ping State Key Laboratory for Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084 College of Physical Sciences Graduate University of the Chinese Academy of SciencesPO Box 4588Beijing 100049 Department of Physics Capital Normal UniversityBeijing 100037

We report the measurement of the absolute photoionization cross section for the 5P_(3/2 )state of ^(87) Rb at wavelength of 473 nm,which results in the photoelectron energies of 33 meV above the ionization threshold,using cold atoms confined in a vapor-loaded magneto-optical *** 87Rb 5P_(3/2 )photoionization cross section at 473nm is determined to be σ_(PI) =10.5 ± 2.2 *** the spatial distribution of the trapped atoms,the average intensity I_(PI) of the ionization laser seen by an atom in the MOT instead of ionizing laser intensity I_(PI) is used in our calculations for the photoionization cross *** excited state fraction is also accurately estimated using the latest experimental result.

关键词： ionization state loaded

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Image transmission in an OFDM VLC system using symbol scrambling and chaotic Walsh-Hadamard precoding

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Optoelectronics Letters 2019年第4期15卷 284-287页

作者： WANG zhong-peng YE Zhuo-ying WANG Xiu-min ZHAI Zhi-nian School of Information and Electronic Engineering Zhejiang University of Science and Technology Hangzhou 310023 China Xiamen City University Xiamen 361008 China College of Information Engineering China Jiliang University Hangzhou 310038 China

An image secure transmission scheme combining symbol scrambling and chaotic Wahsh-Hardmard precoding is proposed in orthogonal frequency division multiplexing(OFDM)-based visible light communication(VLC) *** the proposed scheme, a two-dimensional(2 D) logistic-sine-coupling map(LSCM) is employed to generate two chaotic sequences. One is used to scramble the 16 quadrature amplitude modulation(QAM) symbols, and the other is used to scramble the rows of standard Walsh-Hadamard transform(WHT). The simulation results show that the proposed scheme can not only reduce the peak-average-power ratio(PAPR) but also achieve the image secure transmission over OFDM-based VLC systems.

关键词： OFDM VLC LSCM QAM

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