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Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 114-120页

作者： Ming-zhu HUANG jian-zhong SHENTU jun-chun CHEN jian LIU Hui-li ZHOU Research Center of Clinical Pharmaceutical Science the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of risperidone (RIS) in human serum using paroxetine as an internal standard (IS). An Alltima-C18 column (2.1 mm×100 mm, 3 μm) and a mobile phase consisting of 0.1% formic acid-acetonitrile (40:60, v/v) were used for separation. The analysis was performed by selected reaction monitoring (SRM) method, and the peak area of the m/z 411.3→191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25～50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%～9.09% and 1.56%～4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%～84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent.

关键词： Risperidone High performance liquid chromatography-mass spectrometry (HPLC-MS) Pharmacokinetics

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一种基于骨架提取的FPC制造缺陷检测算法

机电产品开发与创新 2024年第5期37卷 10-13页

作者：陈宏辉姜研钟俊健申飘广东松山职业技术学院广东韶关512126

本文以国内某款手机FPC的金手指为研究对象,针对在制造过程中经常出现短路和开路缺陷,提出的一种基于骨架提取的缺陷检测算法。该算法以骨架提取为基础,结合骨架点的8邻域分析、区域生长法、图像差分法来实现对FPC制造缺陷中的短路、开... 详细信息

本文以国内某款手机FPC的金手指为研究对象,针对在制造过程中经常出现短路和开路缺陷,提出的一种基于骨架提取的缺陷检测算法。该算法以骨架提取为基础,结合骨架点的8邻域分析、区域生长法、图像差分法来实现对FPC制造缺陷中的短路、开路类型的缺陷检测,经试验该方法取得了良好的检测效果。

关键词： FPC 区域生长法图像差分法缺陷检测

Key issues on magnetic reconnection at Mercury

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Earth and Planetary Physics 2024年第5期8卷 673-685页

作者： jun zhong Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences

Magnetic reconnection processes and their impact on planetary magnetospheric dynamics exhibit significant differences due to differences in upstream solar wind conditions and internal planetary environments. Current understanding of reconnection phenomena at Mercury is rooted in the MESSENGER mission. However, direct detection of reconnection remains rare. Here, we aim to assess the limitations of MESSENGER in detecting reconnection in Mercury's space and to discuss key issues of reconnection that will be addressed by BepiColombo, including the dynamics of magnetic flux ropes, particle acceleration, density asymmetric reconnection,IMF-driven near-tail structures, and potential modes of magnetospheric convection.

关键词： magnetic reconnection Mercury MESSENGER BepiColombo

Recent progress in self-propelled particles

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Journal of Hydrodynamics 2024年第1期36卷 61-77页

作者： Zhen-yu Ouyang jian-zhong Lin Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo315201China Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou310027China

Self-propelled particles are commonly found in a large number of planktonic organisms such as bacteria,fungi,and algae in nature,and researchers have taken a long interest in exploring their swimming mechanisms for more than a *** in the past 20 years,with the development of computational fluid dynamics and flow display technology,as well as the need for the design of synthetic self-propelled particles and micro-swimming devices,self-propelled particles have become the forefront and hotspot of current research in the field of fluid *** paper first introduces the swimming characteristics of common self-propelled particles,leading to a classic“squirmer”type self-propelled particle *** this basis,a systematic introduction and summary of the theoretical and numerical simulation research of“squirmer”will be ***,the main challenges and opportunities faced by the current research will be summarized.

关键词： Self-propelled particles multiphase flow hydrodynamic interaction

A new interacting capillary bundle model on the multiphase flow in micropores of tight rocks

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Petroleum Science 2024年第2期21卷 1099-1112页

作者： Wen-Quan Deng Tian-Bo Liang Wen-zhong Wang Hao Liu jun-Lin Wu Fu-jian Zhou National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Surfactants are widely used in the fracturing fluid to enhance the imbibition and thus the oil recovery rate. However, current numerical models cannot capture the physics behind capillary imbibition during the wettability alteration by surfactants. Although the interacting capillary bundle(ICB) model shows potential in characterizing imbibition rates in different pores during wettability alteration, the existing ICB models neglect the influence of wettability and viscosity ratio on the imbibition behavior, making it difficult to accurately describe the oil-water imbibition behavior within the porous media. In this work,a new ICB mathematical model is established by introducing pressure balance without assuming the position of the leading front to comprehensively describe the imbibition behavior in a porous medium under different conditions, including gas-liquid spontaneous imbibition and oil-water *** the pore size distribution of a tight rock is known, this new model can predict the changes of water saturation during the displacement process in the tight rock, and also determine the imbibition rate in pores of different sizes. The water saturation profiles obtained from the new model are validated against the waterflooding simulation results from the CMG, while the imbibition rates calculated by the model are validated against the experimental observations of gas-liquid spontaneous imbibition. The good match above indicates the newly proposed model can show the water saturation profile at a macroscopic scale while capture the underlying physics of the multiphase flow in a porous medium at a microscopic scale. Simulation results obtained from this model indicate that both wettability and viscosity ratio can affect the sequence of fluid imbibition into pores of different sizes during the multiphase flow, where less-viscous wetting fluid is preferentially imbibed into larger pores while more-viscous wetting fluid tends to be imbibed into smaller pores. Fur

关键词： Imbibition Multiphase flow Tight rock Interacting capillary bundle model Wettability

Cooperative enhancement of mechanical and tribological properties through tailoring TiN transition interface in boron nitride nanosheets reinforced copper composites

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Rare Metals 2024年第10期43卷 5202-5215页

作者： zhong-Hua Li Liang Liu Xin You jian-Hong Yi Rui Bao Ming-Yi Zhu Song Lu jun-jun Pai Faculty of Materials Science and Engineering Kunming University of Science and Technology Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and Technology

Strengthening interface bonding between boron nitride nanosheets(BNNS) and copper matrix is an essential prerequisite for exploiting a new generation of copper matrix composites(CMCs) with high strength and wear resistance. Herein, BNNS/Cu composites were fabricated by the powder metallurgy route, matrix-alloying(adding 1.0 wt% Ti) strategy was adopted to improve the interfacial wettability and strengthen interface adhesion. A typical "sandwich"-like multiply interface structure involving TiN transition layers, BNNS and Cu matrix had been well constructed through the rational heat treatment(900℃for 120 min). Additionally, nano-sized TiB whisker was in situ formed in the vicinity of the interface, it had linked the BNNS-Cu-TiN multiply interface, which played a role of "threading the needle" and significantly strengthened the multi-interfaces bonding. This specific interface structure was finely characterized, and the formation mechanism of solid-state interfacial reaction feature was proposed. The results demonstrated that the ultimate tensile strength(UTS) of BNNS/Cu-(Ti)-900℃ increased from 248 to 530 MPa(increased by 114%), and the coefficient of friction(COF) decreased from 0.51 to 0.28 than pure Cu. This work highlights the importance of interface configuration design, which contributes to the development of CMCs with prominent comprehensive properties.

关键词： Boron nitride nanosheets Copper matrix composites Interface structure Mechanical and frictional properties

Tuning Surface Molecular Design of Porous Carbon for Blue Energy Harvesting

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Research 2024年第1期2023卷 651-662页

作者： jian Yu zhong-Lin Wang Tianwei Ma Department of Civil and Environmental Engineering University of Hawaii at MānoaHonoluluHI 96822USA Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China College of Engineering Texas A&M University-Corpus ChristiCorpus ChristiTX 78412USA

Capacitive mixing is a promising blue energy technology due to its membrane-free electricity generation and long electrode life ***,because of limited performance,existing systems do not lend themselves to practical *** it is a crucial factor directly influencing electrode behavior,surface chemistry has largely been overlooked in capacitive ***,we show that manipulating surface functionalization alone can tune the responses of electrodes to produce a high voltage rise without altering the pore structure of the *** findings reveal that the spontaneous electrode potential of a surface-modified carbon electrode shifts negatively proportional to the surface charge due to the surface groups,which explains why and how manipulating the surface chemistry can improve the power generation capacity.

关键词： electrode Porous mixing

Recent advancements in hydrometallurgical recycling technologies of spent lithium-ion battery cathode materials

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Rare Metals 2024年第3期43卷 879-899页

作者： Juan Wu Li Xiao Li Shen jian-jun Ran Hui zhong Yi-Rong Zhu Han Chen College of Materials and Advanced Manufacturing Hunan University of TechnologyZhuzhou412007China School of Resources Processing and Bioengineering Central South UniversityChangsha410083China Guangdong jiana Energy Technology Company Qingyuan513000China

The rapidly increasing production of lithium-ion batteries(LIBs)and their limited service time increases the number of spent LIBs,eventually causing serious environmental issues and resource *** the perspectives of clean production and the development of the LIB industry,the effective recovery and recycling of spent LIBs require urgent *** study provides an overview of the current hydrometallurgical processes employed in the recycling of spent cathode materials,focusing on the leaching of valuable metals and their *** particular,this research reviews the various leaching systems(inorganic acid,organic acid,and ammonia)and the separation of valuable metals,and then,recommendations for subsequent study are offered in an attempt to contribute to the development of highly efficient methods for recycling spent cathode *** addition,a range of existing technologies,such as solvent extraction,chemical precipitation,electrochemical deposition,and regeneration,for the postprocessing of leaching solutions are ***,the promising technologies,existing challenges and suggestions with respect to the development of effective and environmentally friendly recycling methods for handling spent cathode materials are identified.

关键词： Spent lithium-ion batteries(LIBs) Cathode material Hydrometallurgy Leaching Recycling

Adjuvant therapy for hepatocellular carcinoma:Dilemmas at the start of a new era

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World Journal of Gastroenterology 2024年第8期30卷 806-810页

作者： jian-Hong zhong Department of Hepatobiliary Surgery Guangxi Medical University Cancer HospitalNanning 530021Guangxi Zhuang Autonomous RegionChina

Approximately 50%-70%of patients with hepatocellular carcinoma experience recurrence within five years after curative hepatic resection or *** a result,many patients receive adjuvant therapy after curative resection or ablation in order to prolong recurrence-free *** therapy recommended by national guidelines can differ,and guidelines do not specify when to initiate adjuvant therapy or how long to continue *** and other unanswered questions around adjuvant therapies make it difficult to optimize them and determine which may be more appropriate for a given type of *** questions need to be addressed by clinicians and researchers.

关键词： Adjuvant therapy Hepatocellular carcinoma Tumor recurrence Unanswered questions