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Analytical method for the mechanical response of buried pipeline under the action of strike-slip faulting

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Underground Space 2022年第2期7卷 268-277页

作者： zhiping hu Xiang Ren Qiyao Wang Rui Wang Rui Pan School of Civil Engineering Chang’an UniversityXi’an 710061China Institute of Underground Structure and Engineering Chang’an UniversityXi’an 710061China

Buried pipelines are commonly damaged when laid across strike-slip faults,always leading to some level of destruction with fault *** moment of the neutral axis of a pipe section was obtained by integration,and the equations for the bending moment and the bending strain on a pipeline’s section were presented here,based on a trilinear stress–strain *** calculation method for the lateral soil pressure and pipeline’s bending strain near the fault-crossing point was *** soil pressure was regarded as being related to lateral pipeline movement and,for accurate calculation,this part of the pipeline was divided into finite element *** iterative process for solving for pipe bending strain was derived,and the algorithm and program for calculating bending strain and the potential damage position of the pipeline’s sections was compiled based on Matlab *** with finite element method(FEM)results and the current standard method,in the situation of a pipeline being in tension under the action of a strike-slip fault(intersection angle<90),the result of the proposed method is in good agreement with FEM *** shows that the proposed analytical method possessed a good reference value for the strain response analysis of tensile steel pipelines under strike-slip faulting.

关键词： Strike-slip fault Buried pipeline Analytical method Mechanical response

The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells

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Neural Regeneration Research 2014年第4期9卷 402-406页

作者： Ting Zou Xiangqi Tang Zhiling huang Niangui Xu zhiping hu Department of Neurology Second Xiangya HospitalCentral South University

In this study, we established cell models for Parkinson＇s disease using rotenone. An RNA interfer- ence vector targeting Parkin-associated endothelin receptor-like receptor （Pad-R） was transfected into the model cells. The results of reverse-transcription polymerase chain reaction and western blot analysis showed that Pael-R expression was decreased after RNA interference compared with the control group （no treatment） and the model group （rotenone treatment）, while the rate of apoptosis and survival of dopaminergic cells did not differ significantly between groups, as detected by flow cytometry and an MTT assay. These experimental findings indicate that the Pael-R gene has no role in the changes in rotenone-induced Parkinson＇s disease model cells.

关键词： nerve regeneration neurodegeneration Parkinson's disease rotenone Pael-R RNA interference apoptosis mitochondria neural regeneration

Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway

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Neural Regeneration Research 2012年第28期7卷 2189-2198页

作者： Heping Yang Dapeng Wu Xiaojie Zhang Xiang Wang Yi Peng zhiping hu Department of Neurology Shangrao No.5 People's Hospitalthe Second Affiliated Hospital of Nanchang UniversityShangrao 334000Jiangxi ProvinceChina Department of Neurology Ruikang Hospital Affiliated to Guangxi Traditional Chinese Medical UniversityNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Neurology Xiangya Second HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry Xiangya Second HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

Telencephalin is a neural glycoprotein that reduces apoptosis induced by amyloid beta protein in the human neural tumor cell line PAJU. In this study, we examined the role of the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway in this process. Western blot analysis demonstrated that telencephalin, phosphorylated ezrin/radixin/moesin and phosphatidylinositol-3-kinase/protein kinase B were not expressed in PAJU cells transfected with empty plasmid, while they were expressed in PAJU cells transfected with a telencephalin expression plasmid. After treatment with 1.0 nM amyloid beta protein 42, expression of telencephalin and phosphorylated phosphatidylinositol-3-kinase/protein kinase B in the transfected cells gradually diminished, while levels of phosphorylated ezrin/radixin/moesin increased. In addition, the high levels of telencephalin, phosphorylated ezrin/radixin/moesin and phosphatidylinositol-3-kinase/protein kinase B expression in PAJU cells transfected with a telencephalin expression plasmid could be suppressed by the phosphatidylinositol-3-kinase inhibitor LY294002. These findings indicate that telencephalin activates the ezrin/radixin/moesin family/phosphatidylinositol-3-kinase/protein kinase B pathway and protects PAJU cells from amyloid beta protein-induced apoptosis.

关键词： telencephalin/intercellular adhesion molecule 5 amyloid beta protein ezrin/radixin/moesin familyproteins/phosphatidylinositol-3-kinase/protein kinase B signal transduction neural regeneration

不同热处理工艺对冷轧复相钢组织性能影响的研究

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轧钢 2024年第3期41卷 48-52页

作者：蒋睿婷胡智评林春青郭金宇徐鑫黄镇宇海洋装备用金属材料及其应用国家重点实验室辽宁鞍山114009 鞍钢集团钢铁研究院辽宁鞍山114009 鞍钢股份冷轧厂辽宁鞍山114021

随着汽车工业的发展,先进高强钢的应用越来越广泛。设计了一种低碳含Cr-Mo-Nb-Ti系冷轧复相钢,采用两相区加热—缓冷—过时效热处理工艺,通过光学显微镜(OM)、扫描电镜(SEM)、透射电子显微镜(TEM)、拉伸试验等检测手段,对不同热处理工... 详细信息

随着汽车工业的发展,先进高强钢的应用越来越广泛。设计了一种低碳含Cr-Mo-Nb-Ti系冷轧复相钢,采用两相区加热—缓冷—过时效热处理工艺,通过光学显微镜(OM)、扫描电镜(SEM)、透射电子显微镜(TEM)、拉伸试验等检测手段,对不同热处理工艺下实验钢的组织与力学性能进行了研究。结果表明:不同热处理工艺下,实验钢组织为铁素体+贝氏体+马氏体;随退火温度的升高,铁素体再结晶程度较高,其内位错密度降低,过冷奥氏体增多,在过时效阶段生成更多的贝氏体;在较低过时效温度下,马氏体部分发生回火,生成回火马氏体。在退火温度800℃、过时效温度350℃工艺下,实验钢具有最理想的再结晶程度与贝氏体/马氏体回火状态,大角度晶界数量占比44.7%,实验钢屈服强度为613 MPa,抗拉强度为799 MPa,扩孔率为67%,拉伸断口呈现尺寸大而深的韧窝,成型性能良好。

关键词：复相钢热处理组织性能扩孔率断裂

Telencephalin protects Paju cells from beta-amyloid protein-induced apoptosis

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Neural Regeneration Research 2011年第29期6卷 2251-2255页

作者： Heping Yang Dapeng Wu Xiaojie Zhang Xiang Wang Yi Peng zhiping hu Department of Neurology Shangrao No.5 People＇s Hospital the Second Affiliated Hospital of Branch to Nanchang University Shangrao 334000 Jiangxi Province China Department of Neurology Xiangya Second Hospital Central South University Changsha 410011 Hunan Province China Department of Neurology Ruikang Hospital Affiliated to Guangxi Traditional Chinese Medical University Nanning 530011 Guangxi Zhuang Autonomous Region China Department of Psychiatry Xiangya Second Hospital Central South University Changsha 410011 Hunan Province China

Previous studies have confirmed that telencephalin （TLN） is a neural glycoprotein that protects axonal disruption induced by the beta-amyloid protein （Aβ42/35） in the neural crest-derived tumor cell line Paju. The present study investigated the effects of TLN on neuronal degeneration induced by Aβ42 in the differentiated Paju cell line. Results demonstrated that after cultivating cells in Aβ42 medium, the survival rate of Paju-TLN cells was significantly higher than that of Paju-neo cells, and that apoptotic rate was noticeably reduced. These results indicate that TLN reduces Paju cell apoptosis induced by Aβ42.

关键词： telencephalin/intercellular adhesion molecule-5 beta-amyloid protein neuroprotective effect apoptosis Alzheimer's disease neural regeneration

软硬互层围岩隧道二次衬砌开裂特征及原因分析

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现代隧道技术 2024年第4期61卷 266-274页

作者：邓锋张永辉孙志远胡志平肖吉勇王永亮陈光兴中铁四局集团有限公司第六工程分公司西安710082 长安大学建筑工程学院西安710061

软硬互层围岩隧道施工期间二次衬砌开裂屡见不鲜。以在建的G544线永丰隧道为依托,通过现场测试、力学试验和理论分析对隧道二次衬砌裂缝特征及开裂原因展开分析。研究结果表明:先行洞(右洞)二次衬砌裂缝数量较后行洞(左洞)多且呈非对称... 详细信息

软硬互层围岩隧道施工期间二次衬砌开裂屡见不鲜。以在建的G544线永丰隧道为依托,通过现场测试、力学试验和理论分析对隧道二次衬砌裂缝特征及开裂原因展开分析。研究结果表明:先行洞(右洞)二次衬砌裂缝数量较后行洞(左洞)多且呈非对称分布,主要聚集在右边墙及部分拱腰处,以环向裂缝为主;二次衬砌开裂主要是由于高地应力环境下隧道开挖使倾斜软硬岩层之间产生不协调变形,从而使支护结构承受较大围岩压力,导致具有设计缺陷的二次衬砌发生开裂;围岩强度的各向异性和地下水的分布不均,致使二次衬砌裂缝分布不均;左、右洞的开挖顺序不同使左、右洞的开裂程度不同。

关键词：隧道工程软硬互层围岩二次衬砌裂缝裂缝特征开裂原因

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汽车用钢的发展与低熵化先进高强钢设计

鞍钢技术 2024年第3期 1-8页

作者：刘仁东吴萌胡智评徐鑫林春青海洋装备用金属材料及其应用国家重点实验室辽宁鞍山114009 鞍钢集团钢铁研究院辽宁鞍山114009 鞍钢股份有限公司冷轧厂辽宁鞍山114021

介绍了汽车用钢的发展历史与推动汽车用钢发展的历史性事件,展望了未来汽车用钢在“双碳”背景下的发展方向。同时,介绍了汽车用先进高强钢的发展与分类,阐述汽车钢从软钢、低碳钢、高强钢到先进高强钢的发展过程,详细阐述第一代到第三... 详细信息

介绍了汽车用钢的发展历史与推动汽车用钢发展的历史性事件,展望了未来汽车用钢在“双碳”背景下的发展方向。同时,介绍了汽车用先进高强钢的发展与分类,阐述汽车钢从软钢、低碳钢、高强钢到先进高强钢的发展过程,详细阐述第一代到第三代先进高强钢迭代升级过程中成本、合金、组态与性能等方面的设计思路。最后,提出创新性的低熵化设计理念,并介绍所设计的覆盖四类双相钢产品的低熵化产品,包含成分与工艺的设计思路。提出“组态异构”的低熵化设计,以用户切实的应用需求为导向,深入分析产品性能特征,结合钢铁材料的物理冶金机理与生产制造阶段装备及工艺特征,从设计端对产品进行减量化、单一化、归一化的梯度低熵化设计,实现产品低成本高性能生产制造思路。

关键词：汽车钢先进高强钢低熵化设计成分归一化跨强度级别

All-nanofiber self-powered PTFE/PA66 device for real-time breathing monitor by scalable solution blow spinning technology

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Nano Research 2022年第9期15卷 8458-8464页

作者： Pan Li Yibo Liu Han Zhang zhiping hu Luna Jia Dongkui Liu Lu Yu Bo Li Youwei Yao School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China

All-nanofiber self-powered device was fabricated using simple,low-cost,safe,and scalable solution blow spinning(SBS)technology for real-time respiratory monitor and timely identification of respiratory obstruction ***(PTFE)and polyamide-66(PA66)nanofibers were selected as triboelectric pairs,owing to strong ability to gain electrons of PTFE and supply electrons of ***(ethylene oxide)(PEO)was added to regulate spinning solution viscosity and prepare PTFE/PEO nanofibers,and the morphology and diameter distribution of nanofibers were *** nanofiber film was obtained after the decomposition of PEO in PTFE/PEO nanofiber and melt flow of PTFE pellets in a limited region,and possessed a tensile strength of 1.05 MPa and elongation at a break of 288.58%.Later,PTFE/PA66 all-nanofiber self-powered device was constructed containing PA66 nanofibers,and Au deposition film was used as electrodes by magnetron *** as-obtained device showed robust electrical performance with an open circuit voltage of~110 V at a loading force of 10 N,a short-circuit current of~5 uA at a loading force of 10 N and a frequency of 4 Hz,a maximum power density of 562 mW·m^(–2),and a current of 3.1 uA at a loading resistance of 30 MΩ.Based on the triboelectric mechanism,the device possessed stable response and effective sensibility for stimuli,was used to monitor human breathing conditions,prevent suffocation,and distinguish slow,normal,and fast breathing,with an output voltage of~0.08 V perceived in one normal respiratory circle.

关键词： polytetrafluoroethylene(PTFE) nanofibers triboelectric flexible electronics

Intercellular adhesion molecule-5 protects PAJU cells during in vitro ischemia following cerebral infarction

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Neural Regeneration Research 2010年第3期5卷 205-208页

作者： Weijun Zhou Heping Yang Xiang Wang Yi Peng Dapeng WU Xiaojie Zhang zhiping hu Department of Neurology Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China Department of Neurology Ruikang Hospital Affiliated to Guangxi Traditional Chinese Medical University Nanning 530011 Guangxi Zhuang Autonomous Region China Department of Psychiatry Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

BACKGROUND： Intercellular adhesion molecule-5 （ICAM-5） relieves the damage of beta-amyloid protein to PAJU cells, However, little is known about how ICAM-5 works as a neurotrophic factor, or whether ICAM-5 lessens neuronal damage under ischemic conditions following cerebral infarction. OBJECTIVE： To investigate the effects of ICAM-5 on PAJU cells growth in serum-free medium under ischemic conditions following cerebral infarction. DESIGN, TIME AND SETTING： The cytological in vitro study was performed at the Central Laboratory, Second Xiangya Hospital, Central South University, China, in June 2009. MATERIALS： human ICAM-5 gene transfected into PAJU-TLN cells was supplied by the Life Science College, Helsinki University, Finland. Empty vector transfected PAJU-NEO cells were established by the Gene Center, Second Xiangya Hospital, Central South University, China. METHODS： PAJU-TLN cells transfected with human ICAM-5 or empty vector were incubated in serum-free medium. MAIN OUTCOME MEASURES： Phase contrast microscopy was used to observe changes in PAJU cell morphology. 3-（4, 5-dimethylthiazolzyl）-2, 5-diphenyltetrazolium bromide was used to determine cell viability. Hoechst 33258 was used to stain cell nuclei. Flow cytometry was utilized to measure the apoptosis rate of both PAJU-TLN and PAJU-NEO cells. RESULTS： Both PAJU-TLN and PAJU-NEO cells were injured by cultivating in serum-free medium, but the survival rate of PAJU-TLN cells was significantly higher. CONCLUSION： ICAM-5 protects PAJU-TLN cells from serum deprivation-induced apoptosis, induces the outgrowth of PAJU cells, and diminishes their morphologic impairment.

关键词： intercellular adhesion molecule-5 cerebral infarction serum deprivation neuroprotective effect brain injury