检索结果-南通市图书馆

Herbal medicine Yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole

引用

Acta Pharmacologica Sinica 2007年第10期28卷 1685-1692页

作者： Lan FAN,Guo WANG,Lian-sheng WANG,Yao CHEN,Wei ZHANG,Yuan-fei huang,Rui-xue huang,Dong-li HU,DanWANG,Hong-hao ZHOU~2Pharmacogenetics Research Institute,Institute of Clinical Pharmacology,Central South University,Hu-nan 410078,China PharmacogeneticsResearchInstitute InstituteofClinicalPharmacologyCentralSouthUniversityHu-nan410078China

Aim:To explore the potential interactions between Yin zhi huang (YZH) andomeprazole,a substrate of CYP3A4 and ***:Eighteen healthyvolunteers,including 6 CYP2C19~*1/~*1,6 CYP2C19~*1/~*2 or ~*3 and 6 CYP2C19~*2/~*2 were enrolled in a 2-phase,randomized,crossover clinical *** each phase,the volunteers received either placebo or 10 mL YZH oral liquid,3 times daily for *** all the patients took a 20 mg omeprazole capsule *** sampleswere collected up to 12 h after omeprazole *** concentrationsof omeprazole and its metabolites were quantified by HPLC with UV ***:After 14 d of treatment of YZH,plasma omeprazole significantlydecreased and those of omeprazole sulfone and 5-hydroxyomeprazole signifi-cantly *** ratios of the area under the plasma concentration-timecurves from time 0 to infinity (AUC0-∞of omeprazole to 5-hydroxyomprazole andthose of omeprazole to omeprazole sulfone decreased by 64.80%±12.51% (P=0.001) and 63.31%±18.45% (P=0.004) in CYP2C 19~*1/~*1,57.98%±14.80% (P=0.002)and 54.87%±18.42% (P=0.003) in CYP2C19~*1/~*2 or ~*3,and 37.74%±16.07% (P=0.004) and 45.16%±15.54% (P=0.003) in CYP2C19~*2/~*2,*** of the AUC0-∞ratio of omeprazole to 5-hydroxyomprazole in CYP2C19~*1/~*1and CYP2C19~*1/~*2 or ~*3 was greater than those in CYP2C19~*2/~*2 (P=0.047and P=0.009).Conclusion:YZH induces both CYP3A4-catalyzed sulfoxidationand CYP2C 19-dependent hydroxylation of omeprazole leading to decreases inplasma omeprazole concentrations.

关键词： Yin zhi huang induction CYP3A4 CYP2C19 omeprazole

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Quantifying the Tension between Cosmological Models and JWST Red Candidate Massive Galaxies

引用

Research in Astronomy and Astrophysics 2024年第4期24卷 1-6页

作者： Jun-Chao Wang zhi-Qi huang Lu huang Jianqi Liu School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai519082China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

We develop a Python tool to estimate the tail distribution of the number of dark matter halos beyond a mass threshold and in a given volume in a *** code is based on the extended Press-Schechter model and is computationally efficient,typically taking a few seconds on a personal laptop for a given set of cosmological *** high efficiency of the code allows a quick estimation of the tension between cosmological models and the red candidate massive galaxies released by the James Webb Space Telescope,as well as scanning the theory space with the Markov Chain Monte Carlo *** an example application,we use the tool to study the cosmological implication of the candidate galaxies presented in Labbéet *** standard Λcold dark matter(ΛCDM)model is well consistent with the data if the star formation efficiency can reach~0.3 at high *** a low star formation efficiency ε~0.1,theΛCDM model is disfavored at~2σ-3σconfidence level.

关键词： (cosmology:)cosmological parameters Galaxy:abundances Galaxy:formation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cosmological Constraints on Neutrino Masses in Light of JWST Red and Massive Candidate Galaxies

引用

Research in Astronomy and Astrophysics 2024年第4期24卷 7-12页

作者： Jian-Qi Liu zhi-Qi huang Yan Su School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China

The overabundance of the red and massive candidate galaxies observed by the James Webb Space Telescope(JWST)implies efficient structure formation or large star formation efficiency at high redshift z~*** the scenario of a low or moderate star formation efficiency,because massive neutrinos tend to suppress the growth of structure of the universe,the JWST observation tightens the upper bound of the neutrino *** A cold dark matter cosmology and a star formation efficiency∈[0.05,0.3](flat prior),we perform joint analyses of Planck+JWST and Planck+BAO+JWST,and obtain improved constraints∑m_(ν)<0.196 eV and ∑m_(ν)+<0.111 eV at 95% confidence level,*** on the above assumptions,the inverted mass ordering,which implies ∑m_(ν)≥0.1 eV,is excluded by Planck+BAO+JWST at 92.7% confidence level.

关键词： (cosmology:)cosmological parameters galaxies:abundances galaxies:formation neutrinos

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

引用

Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-zhi huang Xiao-Xiao Liu Lan-Wei Li Guang-Ming huang Zhao-Xia huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Growth of Ag/g-C_(3)N_(4) nanocomposites on nickel foam to enhance photocatalytic degradation of formaldehyde under visible light

引用

Journal of Environmental Sciences 2024年第3期137卷 432-442页

作者： Ze Wang zhi huang Jiang Yu Xiao Shao Weidong Peng Jie Yu Yinying Jiang Department of Environmental Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Institute of New Energy and Low Carbon Technology Sichuan UniversityChengdu 610065China School of Agriculture and Environment University of Western AustraliaPerth 6907Western AustraliaAustralia Yibin Institute of Industrial Technology Sichuan UniversityYibin 644000China

Formaldehyde is a pollutant that significantly affects the indoor air ***,conventional remediation approaches can be challenging to deal with low-concentration formaldehyde in an indoor *** this study,Photocatalysts of Ag/graphitic carbon nitride(g-C_(3)N_(4))/Ni with 3D reticulated coral structure were prepared by thermal polymerization and liquid phase photo-deposition,using nickel foam(NF)as the *** demonstrated that when the Ag concentration was 3%,and the relative humidity was 60%,the Ni/Ag/g-C_(3)N_(4)showed the maximum degradation rate of formaldehyde at 90.19%under visible light irradiation,and the formaldehyde concentration after degradation was lower than the Hygienic standard stated by the Chinese *** porous structure of Ni/Ag/g-C_(3)N_(4)and the formation of Schottky junctions promoted the Adsorption efficiency and degradation of formaldehyde,while the nickel foam carrier effectively promoted the desorption of degradation ***,the degradation rate was only reduced by3.4%after 16 recycles,the three-dimensional porous structure extended the lifetime of the *** study provides a new strategy for the degradation of indoor formaldehyde at low concentrations.

关键词： Graphitic carbon nitride(g-C_(3)N_(4)) Nickel foam(NF) Ag Formaldehyde Photocatalysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent progress in co-detection of single-cell transcripts and proteins

引用

Nano Research 2024年第1期17卷 132-150页

作者： Shanqing huang Qian Fan Yidi Wang zhi huang Weixiong Shi Yanli Gong Ting Yang Jie Wang Lingling Wu Chaoyong Yang Discipline of Intelligent Instrument and Equipment College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of General Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361101China Research Center for Analytical Sciences Department of ChemistryCollege of SciencesNortheastern UniversityShenyang 110819China

Cellular heterogeneity is a universal property of living systems,and the interrogation of single cells facilitates in-depth understanding of distinct cellular states and functions in various biological ***-analysis of transcripts and proteins from the same single cells opens the way to decipher complex RNA regulatory frameworks and phenotypes,facilitating the understanding of cellular fate and function regulations,discovery of novel cell types,and construction of a high-resolution cell ***,we review the state-of-art advances in the development of methodologies for co-analysis of single-cell transcripts and ***,imaging-based methods are summarized with particular emphasis on optical and mass spectrometry ***,sequencing-based approaches for high-throughput and sensitive co-analysis of single-cell transcripts and proteins are described,including droplet-,microwell-,and split-pool-based ***,combined methods with more flexibility and universality are *** methods commonly employ different strategies or reactions to convert transcripts and proteins of single cells into distinct signals simultaneously,which can be detected by different instruments or ***,some perspectives on the future challenges and development trends in this field are presented.

关键词： single cell optical imaging mass spectrometry imaging single-cell RNA sequencing(scRNA-seq) co-detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway,and induces senescence in hepatocellular carcinoma

引用

Oncology Research 2024年第1期32卷 213-226页

作者： XUEGANG YANG XIANHONG XIANG GUOHUI XU SHI ZHOU TIANzhi AN zhi huang Department of Interventional Radiology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaRadiation Oncology Key Laboratory of Sichuan ProvinceChengdu610041China Department of Interventional Radiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China Department of Interventional Radiology Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China School of Basic Medical Science Guizhou Medical UniversityGuiyang550002China

Hepatocellular carcinoma(HCC),a common malignancy worldwide,still lacks effective clinical *** study aimed to investigate the oncogenes that affect the progression of HCC and their possible *** our study,we initially confirmed a higher level of PRDX2 in the bile of HCC patients compared to those with choledocholithiasis by 2-DE,LC-MS,and ***,we demonstrated the high expression of peroxiredoxin 2(PRDX2)in HCC based on the TCGA database and clinical sample ***,PRDX2 overexpression enhanced the viability of HCC *** PRDX2 silencing induced senescence of HCC *** vivo,knockdown of PRDX2 significantly reduced the weight of xenograft ***2 also was found to activate the Wnt/β-catenin pathway by inducingβ-catenin nuclear ***,we proved that silencing PRDX2 could inhibit proliferation and Wnt/β-catenin pathway while promoting senescence in HCC cells.

关键词： Peroxiredoxin 2 Hepatocellular carcinoma Wnt/β-catenin pathway Senescence Proliferation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of differentially expressed mRNAs as novel predictive biomarkers for gastric cancer diagnosis and prognosis

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1947-1964页

作者： Jian-Wei Zhou Yi-Bing Zhang zhi-Yang huang Yu-Ping Yuan Jie Jin Department of Gastroenterology Wenzhou Central HospitalDingli Clinical College of Wenzhou Medical UniversityThe Second Affiliated Hospital of Shanghai UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate *** significant progress in GC diagnosis and treatment,the prognosis for affected patients still remains *** To identify important candidate genes related to the development of GC and iden-tify potential pathogenic mechanisms through comprehensive bioinformatics *** The Gene Expression Omnibus database was used to obtain the GSE183136 dataset,which includes a total of 135 GC *** limma package in R software was employed to identify differentially expressed genes(DEGs).Thereafter,enrichment analyses of Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways were performed for the gene modules using the clusterProfile package in R *** protein-protein interaction(PPI)networks of target genes were constructed using STRING and visualized by Cytoscape *** common hub genes that emerged in the cohort of DEGs that was retrieved from the GEPIA database were then screened using a Venn *** expression levels of these overlapping genes in stomach adenocarcinoma samples and non-tumor samples and their association with prognosis in GC patients were also obtained from the GEPIA database and Kaplan-Meier ***,real-time quantitative polymerase chain reaction(RT-qPCR)and western blotting were performed to determine the mRNA and protein levels of glutamic-pyruvic transaminase(GPT)in GC and normal immortalized cell *** addition,cell viability,cell cycle distribution,migration and invasion were evaluated by cell counting kit-8,flow cytometry and transwell ***,we also conducted a retrospective analysis on 70 GC patients diagnosed and surgically treated in Wenzhou Central Hospital,Dingli Clinical College of Wenzhou Medical University,The Second Affiliated Hospital of Shanghai University between January 2017 to December *** tumor and adjacent normal samples were collected from the patients to determine the

关键词： Gastric cancer Differentially expressed genes Bioinformatics Hub genes Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneous Bulk-and Surface-initiated Living Polymerization Studied with a Heterogeneous Stochastic Reaction Model

引用

Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： Jia-Shu Ma zhi-Ning huang Jia-Hao Li Bang-Ping Jiang Yan-Da Liao Shi-Chen Ji Xing-Can Shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model Heterogeneous polymerization Simultaneous polymerization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insight into structural degradation of NCMs under extreme fast charging process

引用

Rare Metals 2024年第1期43卷 41-50页

作者： Yu Tang Xing-Yu Wang Jin-Can Ren Bo-Wen Chen zhi-Yong huang Wei Wang Ya-Lan huang Bing-Hao Zhang Si Lan Zhang-Long He Qi Liu Hao He Department of Physics City University of Hong KongHong Kong 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China College of Materials Science and Engineering Changsha University of Science&TechnologyChangsha 410114China

Lithium-ion batteries(LIBs)with extreme fast charging(XFC)capability are considered an effective way to alleviate range anxiety for electric vehicle(EV)*** to the high ionic and electronic conductivity of LiNi_(x)Co_(y)Mn_zO_(2)(x+y+z=1,NCM)cathodes,the inevitable Li plating of graphite in NCM|graphite cell is usually identified as a key bottleneck for XFC ***,the capacity decay mechanism of cathode materials under XFC has not been fully *** this work,three typical NCM cathode materials with different Ni fractions were chosen and their electrochemical performances under XFC associated with structural evolution were investigated.A faster capacity decay of NCMs under XFC conditions is observed,especially for Ni-rich ***-situ X-ray diffraction(XRD)reveals that the multiple caxis parameters appear at the high-voltage regions in Nirich NCMs,which is probably triggered by the larger obstruction of Li(de)***,NCMs with moderate Ni fraction also present a similar trend under XFC *** phenomenon is more detrimental to the structural and morphological stability,resulting in a faster capacity decay than that under low current *** work provides new insight into the degradation mechanism of NCMs under XFC conditions,which can promote the development of NCM cathode materials with XFC capability.

关键词： Lithium-ion batteries Ni fraction Extreme fast charging Structural evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：