检索结果-南通市图书馆

Human adipose, placenta, and umbilical cord-derived mesenchymal stem cells ameliorate imiquimod-induced psoriatic mice via reducing T cells infiltration

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2021年第3期45卷 537-546页

作者： JIGANG LEI zhenyao xu SUKE LI MENG LI ZHIKAI WANG PING LI JING WANG YINGLU CHEN X IAOLE SONG CHENGJIE REN MEIPING SHEN CHENGXIANG DAI Cellular Biomedicine Group Shanghai200233China Translational Medicine Center Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200025China Shanghai Institute of Immunology Shanghai Jiaotong University School of MedicineShanghai200025China

Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3%around the world,involving increased keratinocyte ***,Th17 cells and IL-17 play critical roles in the pathogenesis of *** monoclonal antibodies against cytokines have been shown to have effectively immunosuppressive effects on human ***,there are still some patients that have no response to these *** patients have even serious side-effects which may affect their *** stem cells have the ability of immunosuppressive and anti-inflammatory effects,which may be an alternative therapy with more safety and efficacy for human ***,the underlying mechanisms by which the MSCs prevent or ameliorate psoriasis are still poorly ***,we first isolated and characterized human adipose,placenta,and umbilical cord-derived mesenchymal stem cells(haMSCs,hpMSCs,and huMSCs).After that,the animal model of imiquimod(IMQ)-induced psoriasis in C57BL/6 mice was *** investigated the impact of haMSCs,hpMSCs,and huMSCs on this model by H&E staining,immunohistochemistry staining,and quantitative real-time *** analysis showed that mice subcutaneously injected with these MSCs had a significantly decreased epidermal thickness,which was caused by obviously reduced hyper-proliferation of ***,our findings revealed that the infiltration of T cells to psoriatic lesions in IMQ-induced psoriasis mice was markedly downregulated by intradermal administration of haMSCs,hpMSCs,and huMSCs,***,the production of IL-17 from Th17 cells was reduced,which inhibits the proliferation of keratinocytes in lesioned skin of IMQ-induced psoriasis *** data suggest that haMSCs,hpMSCs,and huMSCs can inhibit the effects of proinflammatory Th17 cells on the development of psoriasis,which may be potential therapeutic candidates for skin inflammatory disease or other autoimmune

关键词： Mesenchymal stem cells Psoriasis T cells Skin inflammation Cell therapy

Protein phosphatase 6 (Pp6) is crucial for regulatory T cell function and stability in autoimmunity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2022年第2期9卷 562-575页

作者： Wei Cai Junxun Zhang Hong Zhou Xiangxiao Li Fangzhou Lou Yang Sun zhenyao xu Jing Bai Qianqian Yin Zhikai Wang Libo Sun Xiaojie Cai Sibei Tang Yue Wu Li Fan Hong Wang Honglin Wang Qun Li Department of Immunology and Microbiology Shanghai Institute of ImmunologyKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationInstitute of Translational MedicineShanghai General HospitalShanghai Jiao Tong University School of Medicine(SJTU-SM)Shanghai 200025PR China The Department of Cardiovascular Medicine State Key Laboratory of Medical GenomicsShanghai Key Laboratory of HypertensionRuijin HospitalShanghai Institute of HypertensionShanghai Jiao Tong University School of MedicineShanghai 200025PR China

Regulatory T(T_(reg))cells constitute a dynamic population that is critical in autoimmunity.T_(reg) cell therapies for autoimmune diseases are mainly focused on enhancing their suppressive ***,recent studies demonstrated that certain inflammatory conditions induce T_(reg) cell instability with diminished FoxP3 expression and convert them into pathogenic effector ***,the identification of novel targets crucial to both T_(reg) cell function and plasticity is of vital importance to the development of therapeutic approaches in *** this study,we found that conditional Pp6 knockout(cKO)in T_(reg) cells led to spontaneous autoinflammation,immune cell activation,and diminished levels of FoxP3 in CD4^(+)T cells in *** of Pp6 in T_(reg) cells exacerbated two classical mouse models of T_(reg)-related ***,Pp6 deficiency increased CpG motif methylation of the FoxP3 locus by dephosphorylating Dnmt1 and enhancing Akt phosphorylation at Ser473/Thr308,leading to impaired FoxP3 expression in T_(reg) *** summary,our study proposes Pp6 as a critical positive regulator of FoxP3 that acts by decreasing DNA methylation of the FoxP3 gene enhancer and inhibiting Akt signaling,thus maintaining T_(reg) cell stability and preventing autoimmune diseases.

关键词： Akt DNA methyltransferase 1(Dnmt1) FoxP3 Protein phosphatase 6(Pp6)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于代理模型的电机多学科优化关键技术综述

电工技术学报 2022年第20期37卷 5117-5143页

作者：谢冰川张岳徐振耀张凤阁刘文慧沈阳工业大学电气工程学院沈阳110870 山东大学电气工程学院济南250110 沈阳玉衡科技有限公司沈阳110122

随着电机应用领域的不断拓宽,电机多学科优化技术已经成为电机优化技术的重要研究方向。该文概述了目前电机优化技术领域中囊括的多学科模型,分析了代理模型的优势;阐述了高精度电机代理模型的构造流程,提出了不同代理模型在电机多学科... 详细信息

随着电机应用领域的不断拓宽,电机多学科优化技术已经成为电机优化技术的重要研究方向。该文概述了目前电机优化技术领域中囊括的多学科模型,分析了代理模型的优势;阐述了高精度电机代理模型的构造流程,提出了不同代理模型在电机多学科优化中的选取原则;探讨了电机不同子学科之间协调策略、耦合形式、耦合参数的最新研究进展情况,比较了不同协调策略在电机多学科优化中的优劣并提出了改进方向;分析了几种优化算法在电机多学科优化中的使用情况;最后讨论了基于代理模型的电机多学科优化技术面临的问题,展望了未来的发展方向。

关键词：电机代理模型电机多学科优化技术电机多场耦合优化技术电机优化算法

同方期刊数据库

Novel Mechanisms Underlying Skin-Derived Mesenchymal Stem Cell Trafficking and Immunomodulation

在线全文

学校读者我要写书评

暂无评论

Novel Mechanisms Underlying Skin-Derived Mesenchymal Stem Ce...

基于GeoHash和B+树的环卫车调度算法

第二届全国发育生物学大会

作者： Fang Ke Lingyun Zhang Zhaoyuan Liu Jinlin Liu Sha Yan zhenyao xu Jing Bai Hong Wang Yufang Shi Bing Su Honglin Wang Shanghai Institute of Immunology Institute of Medical SciencesShanghai Jiao Tong University School of Medicine The Key Laboratory of Stem Cell Biology Institute of Health SciencesShanghai Institute for Biological SciencesChinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine Child Health Institute of New Jersey Robert Wood Johnson Medical SchoolUniversity of Medicine and Dentistry of New Jersey89 French StreetNew BrunswickNJ 08901USA Department of Immunobiology Yale University School of Medicine Shanghai Key Laboratory for Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of Medicine

Mesenchymal stem cells(MSCs)have demonstrated promising therapeutic potential for a variety of diseases including autoimmune disorders.A fundamental requirement for MSC-mediated in vivo immunosuppression is their effective *** the mechanism underlying MSC trafficking remains *** we report that skin-derived MSCs(S-MSCs)secrete high levels of interleukin-6(IL-6)in inflammatory *** of the U6 or its signaling transducer gpl30blocks voltage-gated calcium(Ca)channels(VGCC)critically required for cell contraction involved in the sequential adhesion and de-adhesion events during S-MSC *** of il6 gene leads to a severe defect in S-MSC’s trafficking and immunosuppressive function in ***,this unexpected requirement of autocrine IL-6 for activating Cachannels uncovers a previously unrecognized link between the IL-6 signaling and the *** as the largest lymphoid organ,provides an easily accessible and ideal source for the isolation of *** discovered that S-MSCs after intraperitoneal injection were capable of migrating to the inflamed spleen,and selectively inhibited the polarization of pathogenic T helper type 17(Thl7)-cells in autoimmune disease.A novel factor released by S-MSCs was identified to be critical in the inhibition of Th17 ***,our data reveal mechanistic insights for the trafficking and immunomodulatory activities of S-MSCs in autoimmunity.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

现代计算机 2022年第17期28卷 61-64页

作者：许镇尧余伟豪南华大学计算机学院衡阳421200

随着社会的快速发展,垃圾存量急剧上升,环卫车容易出现混装混运、调度困难等问题。为了解决相关问题,论文基于GeoHash编码和B+树设计了一种新型的环卫车调度算法。该算法能适用于传统的垃圾清运模式下的环卫车调度和垃圾分类下的垃圾清... 详细信息

随着社会的快速发展,垃圾存量急剧上升,环卫车容易出现混装混运、调度困难等问题。为了解决相关问题,论文基于GeoHash编码和B+树设计了一种新型的环卫车调度算法。该算法能适用于传统的垃圾清运模式下的环卫车调度和垃圾分类下的垃圾清运模式的环卫车调度,通过利用GeoHash编码对环卫车的位置进行编码,随即使用B+树对垃圾存量、路径等相关数据进行筛选,选择合适的环卫车进行调度。该算法能对环卫车搜寻精度进行设置且能对环卫车位置信息进行保护。

关键词：环卫车调度 GeoHash编码 B+树

在线全文

学校读者我要写书评

暂无评论

布沼坝露天矿采剥工艺优化实践与提高

露天采矿技术 2017年第9期32卷 43-48页

作者：王堂娃徐振尧王刚波云南省小龙潭矿务局云南开远661699

云南省小龙潭矿务局五期扩建后布沼坝露天矿采剥需新增生产能力,根据生产系统实际情况进行采剥工艺系统优化成为必然。布沼坝露天矿通过采剥工艺系统废、改、建的实践,实现生产工艺与技术优胜劣汰,使采剥工艺优化取得了丰硕成果,从根本... 详细信息

云南省小龙潭矿务局五期扩建后布沼坝露天矿采剥需新增生产能力,根据生产系统实际情况进行采剥工艺系统优化成为必然。布沼坝露天矿通过采剥工艺系统废、改、建的实践,实现生产工艺与技术优胜劣汰,使采剥工艺优化取得了丰硕成果,从根本上转变矿业发展建设的方式。

关键词：露天矿采剥工艺优化实践提高

二氧化碳致裂器爆破技术在布沼坝露天矿的应用

在线全文

学校读者我要写书评

暂无评论

露天采矿技术 2017年第10期32卷 40-42页

作者：王刚波彭继杨徐振尧云南省小龙潭矿务局云南开远661699

传统化学爆破技术对露天煤矿最大程度提高块煤率作用有限,布沼坝露天矿进行二氧化碳致裂器物理爆破实验,块煤率加大,煤的经济效益提升,且显著减小了爆破飞煤和飞尘对生产安全和环境的影响。该技术不仅为煤矿绿色安全高效提供技术支持,... 详细信息

传统化学爆破技术对露天煤矿最大程度提高块煤率作用有限,布沼坝露天矿进行二氧化碳致裂器物理爆破实验,块煤率加大,煤的经济效益提升,且显著减小了爆破飞煤和飞尘对生产安全和环境的影响。该技术不仅为煤矿绿色安全高效提供技术支持,而且为露天煤矿爆破产品的更新提供了一种新思路。

关键词：二氧化碳爆破致裂器块煤率物理爆破

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

基于MEA-BP的NTC热敏电阻温度传感器非线性补偿研究

在线全文

学校读者我要写书评

暂无评论

计算机与数字工程 2023年第11期51卷 2752-2757页

作者：徐振耀陈德智路达刘金国沈阳工业大学电气工程学院沈阳110870 中国科学院沈阳自动化研究所沈阳110016 中国科学院机器人与智能制造创新研究院沈阳110169

热敏电阻作为温度传感器其阻温特性表现为非线性,在工程实际温度测量中存在一定的非线性误差,精度较低。论文使用NTC热敏电阻温度传感器作为研究对象,针对其存在的非线性问题,通过MEA(思维进化算法)优化BP神经网络模型从而实现对NTC热... 详细信息

热敏电阻作为温度传感器其阻温特性表现为非线性,在工程实际温度测量中存在一定的非线性误差,精度较低。论文使用NTC热敏电阻温度传感器作为研究对象,针对其存在的非线性问题,通过MEA(思维进化算法)优化BP神经网络模型从而实现对NTC热敏电阻温度传感器的非线性补偿,论文简要阐述了有关温度传感器补偿的相关方法与研究成果,分析了热敏电阻的阻温特性、工作原理,介绍了MEA-BP的模型构建,补偿原理与方法,利用5种评估标准对比传统RBF与BP神经网络模型。结果表明该补偿模型在各个评价指标上均优于传统RBF与BP神经网络,具有补偿精度更好、稳定性更强等优势,在测控、军工、航空等众多领域有一定实用价值。

关键词： NTC热敏电阻思维进化算法非线性补偿 MEA-BP