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Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents:a systematic review and meta-analysis

World Journal of Pediatrics 2024年第6期20卷 569-580页

作者： Eun Joo Lee Miyoung Choi Sang Bong Ahn Jeong-ju Yoo Seong Hee Kang Yuri Cho Do Seon Song Hong Koh Dae Won Jeon Hye Won Lee Department of Pediatrics Yonsei University College of MedicineSeoulKorea Clinical Evidence Research National Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea Department of Internal Medicine Nowon Eulji Medical CenterEulji University College of MedicineSeoulKorea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheonKorea Department of Internal Medicine Sangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangKorea Department of Internal Medicine College of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea Department of Internal Medicine Hanyang University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver disease(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MEDLINE,Korean Medical Database(KMBASE),Embase,Global Health,and Cochrane Library databases were searched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the increasing rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.

关键词： Meta-analysis Nonalcoholic fatty liver disease Pediatric Prevalence

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Investigation on Damage Regularity of Mikania micrantha

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Plant Diseases and Pests 2024年第2期15卷 17-18,21页

作者： Shaojian MA Yanling LUO ju YANG Guangzhou Huadu District Forestry Management Center Guangzhou 510400China College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhou 510642China

[Objectives]The paper was to understand the occurrence and damage regularity of the invasive plant Mikania micrantha in Huadu District of Guangzhou.[Methods]The damage status of *** in different forest lands and its annual growth dynamics were investigated by field investigation.[Results]With the change of canopy density from low to high,the occurrence degree of *** changed from high to *** occurrence degree of *** in different forest land types was:abandoned orchard>wasteland>roadside greenbelt>waterside>forest edge>normally managed orchard.[Conclusions]*** enters the rapid growth period from March to May in spring,with the growth rate gradually slowing down after *** result provides a theoretical basis and practical guidance for the prevention and control of ***.

关键词： Mikania micrantha Regularity of outbreak Coverage survey Monitoring Prevention

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Analysis of Chemical Research Progress on Graphene

Expert Review of Chinese Chemical

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Expert Review of Chinese Chemical 2024年第1期2卷 34-35页

作者： Xiaoming Cheng Haiyang Bian Ye ju College of Chemistry and Chemical Engineering Northeast Petroleum University

Graphene materials have excellent optical and electrical properties,and in recent years,significant achievements have been made in the chemical improvement and preparation of *** article analyzes the progress in the chemical preparation,chemical modification,surface chemistry,and catalysis of graphene,in order to provide reference for relevant personnel.

关键词： graphene chemical research progress analysis

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Clinical characteristics of sudden hearing loss during pregnancy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 165-172页

作者： Xiao-Nan Wu Hong-Yang Wang Xiao-Long Zhang Guo-Hui Chen Jing Guan Yun Gao Da-Yong Wang Qiu-ju Wang Senior Department of Otolaryngology-Head&Neck Surgery The Sixth Medical Center of PLA General HospitalChinese PLA Medical SchoolBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina

Objective:The objective of this study was to explore the clinical characteristics and management of sudden hearing loss(HL)during pregnancy,thus better guiding the clinical ***:The clinical and follow-up data of 17 patients(17 ears)with sudden HL during pregnancy were analyzed retrospectively(the observe group).Twelve nonpregnant female patients(12 ears)with sudden HL of similar clinical characteristics were selected as the control *** prognosis of the two groups was *** the patients were followed up after delivery,and two of them were readmitted to the hospital 1–2 months after ***:The observe group had better improvement in hearing and a higher response rate compared to the control *** pure tone hearing and speech recognition rate of patients could still be improved after the readmitted treatment,and the hearing could partially recover spontaneously during *** laboratory indicators that affect the inflammatory response and coagulation pathway were significantly different between the two ***:The hearing condition of sudden HL during pregnancy is severe,and the prognosis of these patients is better than nonpregnant patients of similar clinical *** treatment is still effective,and some patients showed self-healing with time during *** inflammatory response and coagulation function may affect the hearing of patients through a metabolic pathway.

关键词： management pregnancy prognosis sudden hearing loss

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Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： Chen Yu Lin Hung ju Chen Yi Kit Chan Wei Ping Hsia Yu Len Huang Chia Jen Chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

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Tissue inhibitor of metalloproteinase-3 expression affects clinicopathological features and prognosis of aflatoxin B1-related hepatocellular carcinoma

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World Journal of Hepatology 2024年第8期16卷 1131-1144页

作者： Qiu-ju Liang Qin-Qin Long Feng-Qin Tian Qun-Ying Su Xiao-Ying Zhu Xi-Dai Long Clinicopathological Diagnosis and Research Center The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Tumor Pathology Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education InstitutesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND The dysregulation of tissue inhibitor of metalloproteinase-3(TIMP3)was positively correlated with the progression of hepatocellular carcinoma(HCC).However,it is not clear whether TIMP3 expression is associated with the clinico-pathological features and prognosis of aflatoxin B1(AFB1)-related HCC(AHCC).A retrospective study,including 182 patients with AHCC,was conducted to explore the link between TIMP3 expression in cancerous tissues and the clinico-pathological characteristics and prognosis of ***3 expression was detected by immunohistochemistry and its effects on the clinicopathological features and prognosis of AHCC were evaluated by Kaplan-Meier survival analysis and Cox regression survival *** ratio,hazard ratio(HR),median overall survival time(MST),median tumor recurrence-free survival time(MRT),and corresponding 95%confidential interval(CI)was calculated to RESULTS Kaplan-Meier survival analysis showed that compared with high TIMP3 expression,low TIMP3 expression in tumor tissues significantly decreased the MST(36.00 mo vs 18.00 mo)and MRT(32.00 mo vs 16 mo)of patients with *** Cox regression survival analysis further proved that decreased expression of TIMP3 increased the risk of death(HR=2.85,95%CI:2.04-4.00)and tumor recurrence(HR=2.26,95%CI:1.57-3.26).Furthermore,decreased expression of TIMP3 protein in tissues with AHCC was significantly correlated with tumor clinicopatho-logical features,such as tumor size,tumor grade and stage,tumor microvessel density,and tumor blood ***,TIMP3 protein expression was also negatively associated with amount of AFB1-DNA adducts in tumor *** These findings indicate that the dysregulation of TIMP3 expression is related to AHCC biological behaviors and affects tumor outcome,suggesting that TIMP3 may act as a prognostic biomarker for AHCC.

关键词： Tissue inhibitor of metalloproteinase-3 expression Aflatoxin B1 Hepatocellular carcinoma Clinicopathological feature Prognosis

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Global status and trends of metabolomics in diabetes: A literature visualization knowledge graph study

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World Journal of Diabetes 2024年第5期15卷 1021-1044页

作者： Hong Li Liu Li Qiu-Qing Huang Si-Yao Yang jun-ju Zou Fan Xiao Qin Xiang Xiu Liu Rong Yu College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of International Education Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Science and Technology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of Graduate Hunan University of Chinese MedicineHunan ChangshaHunan ProvinceChina

BACKGROUND Diabetes is a metabolic disease characterized by hyperglycemia,which has increased the global medical burden and is also the main cause of death in most *** To understand the knowledge structure of global development status,research focus,and future trend of the relationship between diabetes and metabolomics in the past 20 *** The articles about the relationship between diabetes and metabolomics in the Web of Science Core Collection were retrieved from 2002 to October 23,2023,and the relevant information was analyzed using CiteSpace6.2.2R(CiteSpace),VOSviewer6.1.18(VOSviewer),and Bibliometrix software under R *** A total of 3123 publications were included from 2002 to *** the past two decades,the number of publications and citations in this field has continued to *** United States,China,Germany,the United Kingdom,and other relevant funds,institutions,and authors have significantly contributed to this *** Reports and PLoS One are the journals with the most publications and the most *** keyword co-occurrence and cluster analysis,the closely related keywords are"insulin resistance","risk","obesity","oxidative stress","metabolomics","metabolites"and"biomarkers".Keyword clustering included cardiovascular disease,gut microbiota,metabonomics,diabetic nephropathy,molecular docking,gestational diabetes mellitus,oxidative stress,and insulin *** detection analysis of keyword depicted that"Gene","microbiota","validation","kidney disease","antioxidant activity","untargeted metabolomics","management",and"accumulation"are knowledge frontiers in recent *** The relationship between metabolomics and diabetes is receiving extensive *** nephropathy,diabetic cardiovascular disease,and kidney disease are key diseases for future research in this *** microbiota,molecular docking,and untargeted metabolomics are key research directions in the *** a

关键词： Diabetes Metabolomics Bibliometric CiteSpace VOSviewer

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Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression

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World Journal of Psychiatry 2024年第2期14卷 276-286页

作者： Xin-Lin Huang ju Gao Yong-Ming Wang Feng Zhu Jing Qin Qian-Nan Yao Xiao-Bin Zhang Hong-Yan Sun Imaging and Nuclear Medicine Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina School of Biology&Basic Medical Sciences Medical College of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Radiology Shanghai Anting HospitalShanghai 20000China Department of Radiology The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND Major depression disorder(MDD)constitutes a significant mental health *** surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of *** studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is *** researchers even mistakenly regard the signals generated by the WM as noise *** fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal *** alterations in WM signals and their relationship with disease severity in adolescents with MDD remain *** To explore potential abnormalities in WM functional signals in adolescents with *** This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide *** addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image *** DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC *** component analysis(ICA)was also used to evaluate the WM functional ***’s correlation was performed to assess the relationship between statistical test results and clinical *** Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel corre

关键词： White matter Regional homogeneity The fractional amplitude of low-frequency fluctuations Independent component analysis Adolescents Major depression disorders

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中国本土特色农村社会研究:主要取向、反思与创新

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西北师大学报（社会科学版） 2024年第4期61卷 15-24页

作者：林聚任山东大学哲学与社会发展学院山东济南250100

改革开放以来,中国农村社会研究取得了较大进展,并已形成了具有本土特色的一些研究问题和基本取向。系统梳理国内关于农村社会研究的主要进展,可以概括出三个具有代表性的研究取向,即学术取向、现实问题取向和政策取向,这三个主要研究... 详细信息

改革开放以来,中国农村社会研究取得了较大进展,并已形成了具有本土特色的一些研究问题和基本取向。系统梳理国内关于农村社会研究的主要进展,可以概括出三个具有代表性的研究取向,即学术取向、现实问题取向和政策取向,这三个主要研究取向在基本目标、价值倾向、研究者的角色定位和主要特征等方面存在明显差异。这些研究取向也存在着需要进行反思的问题,包括偏重于本土性问题、过于经验化、碎片化。为克服存在的这些问题,就需要注重发掘和利用自身的话语资源提高学科自信,实现理论上的创新发展;注重经验研究积累与理论创新的有机结合,超越经验描述的局限性;加强理论与实践相结合,促进本土特色的农村社会研究新发展。

关键词：农村社会研究本土特色研究取向创新发展

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“歌剧学”学科内涵与定位若干问题之我见

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中国音乐学 2024年第1期 93-96页

作者：居其宏郑州西亚斯学院

“歌剧学”逻辑地包含了歌剧文学创作、音乐创作、表导演艺术、舞台美术、剧目制作与演出、歌剧艺术教育、歌剧国别史及地区史、歌剧风格演变史、歌剧美学与哲学、歌剧艺术的社会文化阐释、歌剧与其他舞台艺术的比较研究等范畴;在这些... 详细信息

“歌剧学”逻辑地包含了歌剧文学创作、音乐创作、表导演艺术、舞台美术、剧目制作与演出、歌剧艺术教育、歌剧国别史及地区史、歌剧风格演变史、歌剧美学与哲学、歌剧艺术的社会文化阐释、歌剧与其他舞台艺术的比较研究等范畴;在这些范畴之上,以“歌剧学”三字统括之,并与“艺术学”“音乐学”“戏剧学”等学科称谓并列,置身于一级学科“艺术学理论”之下,新辟二级学科“歌剧学”,不啻是一个名正言顺的可行之选。

关键词：歌剧学学科内涵学科定位

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