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Expression and contribution of microphthalmia-associated transcription factor to the melanin deposition in Liancheng white ducks

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Journal of Integrative Agriculture 2020年第3期19卷 800-809页

作者： XIN qing-wu MIAO Zhong-wei LIU Zhao-yuan LI Li zhang Lin-li ZHU Zhi-ming zhang zhenghong zheng Nen-zhu WANG zheng-chao Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural SciencesFuzhou 350013P.R.China Provincial Key Laboratory for Developmental Biology and Neurosciences/Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education College of Life SciencesFujian Normal UniversityFuzhou 350007P.R.China

The present study investigates the expression of microphthalmia-associated transcription factor(MITF) and its contribution to the melanin deposition in Liancheng white *** PCR was used to clone the MITF gene sequence from the skin tissue of female Liancheng white *** spectrophotometry was used to detect the melanin *** mRNA expression and melanin deposition in different tissues and organs were detected and their correlation was *** MITF gene(GenBank number: MG516570) was 1 323 bp in length,contains a complete CDS region(34-1 323 bp) and codes 429 amino acids with 100% homology to the MITF of Anas platyrhynchos and over 95% homology to those of Gallus gallus and Coturnix *** evolution analysis reveals a close relationship of Liancheng white ducks with ***,and also to lesser extents with Anser cygnoides,silky fowl and ***,as well as Sus scrofa,Ovis aries and other ***-time quantitative PCR(qPCR) analysis demonstrated that MITF was expressed in skin,gizzard,liver,kidney and muscle,and of these tissues,its expression was the highest in the skin tissue(skin>gizzard>liver>kidney>muscle).Ultraviolet spectrophotometry showed that melanin deposition was positively correlated with the MITF expression level in these five tissues and organs(P<0.05).Together,these results demonstrated a tissue-specific pattern of MITF expression and a positive correlation between MITF expression and melanin deposition,indicating that MITF expression may contribute to the melanin deposition in Liancheng white ducks.

关键词： microphthalmia-associated transcription factor genetic evolution analysis melanin deposition Liancheng white ducks

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Repair of posterior ventricular septal rupture by right atrial approach

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Journal of Geriatric Cardiology 2023年第12期20卷 886-889页

作者： Shan-qing BAO Teng-Long WANG yuan-hong LI Cheng-Xin zhang Department of Cardiovascular Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina

Ventricular septal rupture(VSR)is a serious complication that may occur after myocardial infarction(MI).[1]If left untreated,it will lead to high morbidity and *** several surgical interventions have been developed,mortality and complications associated with surgical management are still high,especially in terms of transventricular approaches.[2]

关键词： rupture mortality ventricular

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TMEM16F may be a new therapeutic target for Alzheimer's disease

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Neural Regeneration Research 2023年第3期18卷 643-651页

作者： Zhi-Qiang Cui Xiao-ying Hu Tuo Yang Jing-Wei Guan ying Gu Hui-yuan Li Hui-Yu zhang qing-Huan Xiao Xiao-hong Sun Department of Neurology The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Ion Channel Pharmacology School of PharmacyChina Medical UniversityShenyangLiaoning ProvinceChina

TMEM16F is involved in many physiological processes such as blood coagulation,cell membrane fusion and bone *** of TMEM16F has been studied in various central nervous system *** TMEM16F level has been also found to participate in microglial phagocytosis and ***-mediated neuroinflammation is a key factor in promoting the progression of Alzheimer’s ***,few studies have examined the effects of TMEM16F on neuroinflammation in Alzheimer’s *** this study,we established TMEM16F-knockdown AD model in vitro and in vivo to investigate the underlying regulatory mechanism about TMEM16F-mediated neuroinflammation in *** performed a Morris water maze test to evaluate the spatial memory ability of animals and detected markers for the microglia M1/M2 phenotype and NLRP3 *** results showed that TMEM16F was elevated in 9-month-old APP/PS1 *** TMEM16F knockdown in mice,spatial memory ability was improved,microglia polarization to the M2 phenotype was promoted,NLRP3 inflammasome activation was inhibited,cell apoptosis and Aβplaque deposition in brain tissue were reduced,and brain injury was *** used amyloid-beta(Aβ_(25-35))to stimulate human microglia to construct microglia models of Alzheimer’s *** levels of TMEM16F,inducible nitric oxide synthase(iNOS),proinflammatory cytokines and NLRP3 inflammasome-associated biomarkers were higher in Aβ_(25-35) treated group compared with that in the control ***16F knockdown enhanced the expression of the M2 phenotype biomarkers Arg1 and Socs3,reduced the release of proinflammatory factors interleukin-1,interleukin-6 and tumor necrosis factor-α,and inhibited NLRP3 inflammasome activation through reducing downstream proinflammatory factors interleukin-1βand *** inhibitory effect of TMEM16F knockdown on M1 microglia was partially reversed by the NLRP3 agonist *** findings suggest that TMEM16F participates i

关键词： Alzheimer’s disease Aβplaque inflammatory cytokines M1 phenotype M2 phenotype microglia polarization neuroinflammation NLRP3 inflammasome siRNA TMEM16F

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Dynamic Properties of Two-Dimensional Polydisperse Granular Gases

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Communications in Theoretical Physics 2007年第2X期48卷 343-347页

作者： LI Rui zhang Duan-Ming HUANG Ming-Tao SU Xiang-ying CHEN Zhi-yuan ZHU hong-ying zhang Lin Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We propose a two-dimensional model of polydisperse granular mixtures with a power-law size distribution in the presence of stochastic driving. A fractal dimension D is introduced as a measurement of the inhomogeneity of the size distribution of particles. We define the global and partial granular temperatures of the multi-component mixture. By direct simulation Monte Carlo, we investigate how the inhomogeneity of the size distribution influences the dynamic properties of the mixture, focusing on the granular temperature, dissipated energy, velocity distribution, spatial clusterization, and collision time. We get the following results： a single granular temperature does not characterize a multi-component mixture and each species attains its own ＂granular temperature＂; The velocity deviation from Gaussian distribution becomes more and more pronounced and the partial density of the assembly is more inhomogeneous with the increasing value of the fractal dimension D; The global granular temperature decreases and average dissipated energy per particle increases as the value olD augments.

关键词： fractal fractal dimension polydisperse mixture

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Reduction of Carbon-bearing Pellets of Oolitic Hematite in a Shaft Furnace

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Journal of Iron and Steel Research International 2016年第3期23卷 210-219页

作者： Wei WU Jian-jun GAO Jia-qing ZENG yuan-hong QI Jian-chang WANG Xi-dong zhang Metallurgical Technology Research Department Central Iron and Steel Research Institute State Key Laboratory for Advanced Iron and Steel Processes and Products Central Iron and Steel Research Institute WU Xi Zhao Shun Stainless Steel Middle Plate Co. Ltd.

When carbon-bearing pellets of oolitic hematite are treated in a shaft furnace,some problems are typically encountered：the metallization ratio of the metal pellets is low;the carbon-bearing pellets bond with each other at high temperatures;and the separation of phosphorus from iron is *** solve these problems,experiments were conducted on oolitic hematite reduction in a resistance furnace and semi-industrial test shaft *** results showed that the metallization rate reached 90% or greater under the conditions of a reduction temperature of 1 150℃,an atmosphere of simulated flue gas,and a reduction time between 1.5and *** problem of high-temperature bonding among pellets can be solved by increasing the strength of the pellets,coating their surface with a surface transfer agent and maintaining an even temperature inside the shaft *** basicity of the ore blend exerted no obvious effect on the magnetic concentrate and phosphorus *** phosphorus content in the magnetic concentrate can be further reduced by improving the grinding capacity of the ball mills used in the *** the basis of the experimental results related to oolitic hematite reduction with carbon-bearing pellets in a shaft furnace,the experimental requirements were satisfied with an average 88.27%total Fe content and 0.581% P content in the pellets.

关键词： oolitic hematite carbon-bearing pellet metallization rate high temperature bonding resistance furnace shaft furnace phosphorus separation

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A Novel Method of Recycling CO_2 for Slag Splashing in Converter

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Journal of Iron and Steel Research International 2010年第12期17卷 11-16页

作者： ZHAO hong-xin yuan zhang-fu WANG Wen jing PAN Yi-fang LI Shu-qing State Key I.aboratory of Multiphase and Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China College of Engineering Peking University Beijing 100871 China Graduate University Chinese Academy of Sciences Beijing 100049 China Tianjin Iron and Steel Group Co Ltd Tianjin 300301 China

Converter off-gas, an important energy resource for steel industries, is one of the weak points in the recov ery and utilization of secondary energy resources. To improve the level of recycling converter off-gas in steel plants, a novel approach to the recycle of CO2 separated from converter off-gas or other off-gas for the green slag splashing technique was developed, and the CO2 equilibrium conversion ratio of the green CO2 slag splashing under different technological conditions was calculated by the program of enthalpy （H）, entropy （S）, and heat capacity （C）, i.e. HSC software. Furthermore, the experiments of CO2 injected into molten converter slag were carried out, and the influencing factors of the green slag splashing technique using CO2 were analyzed. The experimental results showed that the carbon content for smooth slag splashing using COs was about 4.0%.

关键词： converter slag converter off-gas slag splashing CO2

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Emission Mitigation of CO_2 in Steel Industry: Current Status and Future Scenarios

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Journal of Iron and Steel Research International 2006年第6期13卷 38-42,52页

作者： HU Chang-qing CHEN Li-yun zhang Chun-xia QI yuan-hong YIN Rui-yu School of Metallurgy and Energy Hebei Polytechnic University Tangshan 063009 Hebei China State KeyLaboratory of Advanced Steel Process and Products Central Iron and Steel Research Institute Beijing 100081 China

The sustainable development against global warming is a challenge faced by societies at global level. For steel industry; the pressure of reducing CO2 emission is likely to last many years. During the past decades, the CO2 emission per ton steel has been reduced mainly due to the improvement of energy efficiency. Entering the 21st century, the steel manufacturing route must have three functions, namely, production of high performance steel products, conversion of energy, and treatment of waste. In the near future, it is expected that existing BF-BOF and EAF routes will be improved, in order to produce high performance steels, increase the use of scrap, and integrate steel industry with other industries for mitigating CO2 emission. In the long term, using carbon-free energy, reducing agents, and storing CO2 securely or converting CO2 into a harmless substance can be presumed for tremendous reduction in CO2 emission.

关键词： global warming CO2 emission steel industry emission mitigation

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Molecular insights of nanozymes from design to catalytic mechanism

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Science China Chemistry 2023年第5期66卷 1318-1335页

作者： yuan Xu Zhixin Zhou Nankai Deng Kangchun Fu Caixia Zhu qing hong Yanfei Shen Songqin Liu yuanjian zhang Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical ResearchSchool of Chemistry and Chemical EngineeringMedical SchoolSoutheast UniversityNanjing 21l189China

Emerging as cost-effective potential alternatives to natural enzymes,nanozymes have attracted increasing interest in broad *** exploit the in-depth potential of nanozymes,rational structural engineering and explicit catalytic mechanisms at the molecular scale are ***,impressive progress has been made in mimicking the characteristics of natural enzymes by constructing metal active sites,binding pockets,scaffolds,and delicate allosteric *** in-depth studies have been conducted with advances in structural characterization and theoretical calculations,unveiling the“black box”of nanozymecatalytic *** review introduces the state-of-art synthesis strategies by learning from the natural enzyme counterparts and summarizes the general overview of the nanozyme mechanism with a particular emphasis on the adsorbed intermediates and descriptors that predict the nanozyme *** emerging activity assessment methodology that illustrates the relationship between electrochemical oxygen reduction and enzymatic oxygen reduction is discussed with up-to-date *** opportunities and challenges are presented in the end to spark more profound work and attract more researchers from various backgrounds to the flourishing field of nanozymes.

关键词： nanozyme mechanism descriptor free-ROS bound-ROS

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Europe ***:Pholcus(Araneae,Pholcidae)from Yanshan-Taihang Mountains confirms uneven distribution of spiders in Eurasia

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Zoological Research 2022年第4期43卷 532-534页

作者： ying Lu Chang Chu Xiao-qing zhang Shu-Qiang Li Zhi-yuan Yao College of Life Science Shenyang Normal UniversityShenyangLiaoning 110034China Institute of Zoology Chinese Academy of SciencesBeijing 100101China Liaoning Key Laboratory of Evolution and Biodiversity ShenyangLiaoning 110034China Liaoning Key Laboratory for Biological Evolution and Agricultural Ecology ShenyangLiaoning 110034China

DEAR EDITOR,Morphological and molecular data were used to study 35 species of the Pholcus phungiformes species group from the Yanshan-Taihang Mountains in *** uneven distribution pattern of spiders in Eurasia is discussed,with a focus on Europe and *** covers approximately 10.18 million km2 in western Eurasia,while China covers about 9.6 million km2 in the *** to their relative positions to each other and similar land areas,spider species richness in Europe and China is comparable(Li,2020).

关键词： China distribution Mountains

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0D-2D Schottky heterostructure coupling of FeS nanosheets and Co_(9)S_(8)nanoparticles for long-term industrial-level water oxidation

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Nano Research 2023年第4期16卷 5929-5937页

作者： Hai-Jun Liu Ning Yu Xiao-qing yuan Hui-ying Zhao Xin-Yu zhang Yong-Ming Chai Bin Dong State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China

The effective electron and interface/structural coupling for heterostructure electrocatalyst is the key to regulating the intrinsic activity and stability for oxygen evolution reaction(OER).Herein,a facile strategy is developed to fabricate well-dispersed zerodimensional(0D)metallic Co_(9)S_(8)nanoparticles on two-dimensional(2D)FeS nanosheets,forming FeS-Co_(9)S_(8)Schottky heterostructures with abundant heterointerfaces as OER *** strong electronic coupling between FeS and Co_(9)S_(8)expedites electrons flow from Fe atoms in FeS nanosheets to Co atoms in tetrahedron sites(CoTd),thereby leading to the structural integrity of the heterostructure and the constant exposure of active *** Raman spectroscopy also indicates the Co sites in the FeS-Co_(9)S_(8)Schottky heterostructure are OER active ***,FeS-Co_(9)S_(8)heterostructure supported by iron foam(FeS-Co_(9)S_(8)/IF)shows the remarkable activity and durability,achieving an industrial-level 500 mA·cm^(−2)current density at an overpotential of only 332 mV and maintaining for 100 *** work demonstrates that constructing Schottky heterostructure interface with strong coupling effect may be a good strategy for excellent catalytic performances.

关键词： Schottky heterostructure strong electronic coupling electron rearrangement operando Raman oxygen evolution reaction

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