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Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

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Military Medical Research 2024年第1期11卷 115-147页

作者： Yuan-Peng Zhang Xin-Yun Zhang Yu-Ting Cheng Bing Li Xin-zhi Teng Jiang Zhang Saikit Lam Ta Zhou Zong-rui Ma Jia-Bao Sheng Victor CWTam Shara WYLee Hong Ge Jing Cai Department of Medical Informatics Nantong UniversityNantong 226001JiangsuChina Department of Health Technology and Informatics the Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518000GuangdongChina Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450008China

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’***,the interpretation of medical images can be highly subjective and dependent on the expertise of ***,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical *** contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical *** have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized ***,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical *** this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with *** focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical ***,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of ***,we offer possible solutions to current challenges in radiomics research.

关键词： Artificial intelligence Radiomics Feature extraction Feature selection Modeling Interpretability Multimodalities Head and neck cancer

FcRL3基因启动子-169A/G多态性与Graves病的关联研究

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免疫学杂志 2008年第4期24卷 448-451页

作者：郑瑞芝李蓉张素华汪志红汪茂荣梁松重庆医科大学附属第一医院内分泌科重庆400016

目的了解重庆地区汉族人群FcRL3基因启动子-169A/G的基因型分布;探讨该基因多态性与Graves病(GD)的相关性;探讨其基因型与甲状腺自身抗体、发病年龄、家族史和眼征的关系。方法采用PCR-DNA直接测序技术对128例GD患者,120例正常人FcRL3... 详细信息

目的了解重庆地区汉族人群FcRL3基因启动子-169A/G的基因型分布;探讨该基因多态性与Graves病(GD)的相关性;探讨其基因型与甲状腺自身抗体、发病年龄、家族史和眼征的关系。方法采用PCR-DNA直接测序技术对128例GD患者,120例正常人FcRL3基因启动子-169A/G位点进行多态性研究,同时进行甲状腺功能和自身抗体的检测。结果GD组患者GG基因型和G等位基因频率明显高于对照组(分别为31.3%vs21.7%,P<0.05;54.7%vs43.3%,P<0.05)。甲状腺疾病家族史在GG、AG、AA三种基因型之间相比,其差异有统计学意义(P<0.05),甲状腺自身抗体、发病年龄和眼征在3种基因型之间相比,其差异均无统计学意义。结论FcRL3基因启动子-169GG基因型和G等位基因可能为重庆地区汉族人GD患者的易感基因,该位点多态性可能与甲状腺疾病家族史有关,而与自身抗体的产生、发病年龄和眼征无明显相关性。

关键词： Graves病 FcRL3 TSH受体抗体单核苷酸多态性

原发性甲状旁腺功能亢进39例诊断及治疗分析

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中华实用诊断与治疗杂志 2015年第5期29卷 458-459页

作者：王晨赵志刚郑瑞芝郑州大学人民医院河南省人民医院内分泌科郑州450003

目的探讨原发性甲状旁腺功能亢进症（primary hyperparathyroidism,PHPT）的诊断与治疗方法。方法回顾性分析39例PHPT患者临床资料。结果（1）39例中骨型10例,肾型2例,肾骨型3例,高钙型16例,无症状型8例;（2）初诊时患者血钙[（3.47±0... 详细信息

目的探讨原发性甲状旁腺功能亢进症（primary hyperparathyroidism,PHPT）的诊断与治疗方法。方法回顾性分析39例PHPT患者临床资料。结果（1）39例中骨型10例,肾型2例,肾骨型3例,高钙型16例,无症状型8例;（2）初诊时患者血钙[（3.47±0.67）mmol/L]、血甲状旁腺激素（parathyroid hormonr,PTH）[（820.62±622.09）ng/L]及血碱性磷酸酶[（311.02±323.38）u/L]水平显著增高,血磷[（0.96±0.29）mmol/L]为正常值下限;（3）术前彩超、CT及MRI、99mTC-MIBI核素显像分别诊断14、5、24例;（4）12例合并高钙危象者,术前经＂水疗法＂和鲑鱼降钙素治疗4~8d,血钙水平[（3.22±0.43）mmol/L]较治疗前[（4.07±0.50）mmol/L]明显降低（P〈0.05）;（5）术后7d,血钙[（2.05±0.24）mmol/L]、PTH[（66.81±114.57）ng/L]水平与术前[（3.49±0.69）mmol/L、（1 275.45±1046.42）ng/L]比较差异有统计学意义（P〈0.05）。结论高血钙及高PTH是PHPT的特征性指标,99mTC-MIBI检查有助于定位诊断;手术是治疗PHPT的有效方法,＂水疗法＂及鲑鱼降钙素治疗有助于血钙的稳定。

关键词：甲状旁腺功能亢进诊断临床分析

Effectiveness and Safety of Qishen Yiqi Dripping Pill in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention:3-Year Results from a Multicentre Cohort Study

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Chinese Journal of Integrative Medicine 2024年第10期30卷 877-885页

作者： BAI rui-na GU Feng CHE Qian-zi ZHANG Xuan CAI Ya-jie XI rui-xi ZHAO Yang GUO Ming DONG Guo-ju GAO Zhu-ye FU Chang-geng WANG Pei-li DU Jian-peng ZHANG Da-wu DUAN Wen-hui LI Li-zhi YANG Qiao-ning SHI Da-zhuo Department of Cardiovascular Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China National Clinical Research Center for Chinese Medicine Cardiology Beijing100091China Department of Evidence-Based Medicine Basic Research Laboratory Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing100700China Department of Traditional Chinese Medicine Beijing Shangdi HospitalBeijing100193China National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Traditional Chinese MedicineBeijing100091China

Objectives:To evaluate the effectiveness and safety of Qishen Yiqi Dripping Pill(QSYQ)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods:This multicentre prospective cohort study was conducted at 40 centers in *** with ACS after PCI entered either the QSYQ or Western medicine(WM)groups naturally based on whether they had received QSYQ before *** group received QSYQ(0.52 g,3 times a day for 12 months)in addition to *** primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent *** secondary endpoint included rehospitalization due to ACS,heart failure,stroke,and other thrombotic *** of life was assessed by the Seattle Angina Questionnaire(SAQ).Results:A total of 936 patients completed follow-up of the primary endpoint from February 2012 to December ***,487 patients received QSYQ and *** a median follow-up of 566 days(inter quartile range,IQR,517–602),the primary endpoint occurred in 46(9.45%)and 65(14.48%)patients in QSYQ and WM groups respectively[adjusted hazard ratio(HR)0.60,95%confidence interval(CI)0.41–0.90;P=0.013].The secondary endpoint occurred in 61(12.53%)and 74(16.48%)patients in QSYQ and WM groups,respectively(adjusted HR 0.76,95%CI 0.53–1.09;P=0.136).In sensitivity analysis,the results still demonstrated that WM combined with QSYQ reduced the risk of the primary endpoint(HR 0.67,95%CI 0.46–0.98;P=0.039).Moreover,QSYQ improved the disease perception domain of the SAQ(P<0.05).Conclusions:In patients with ACS after PCI,QSYQ combined with WM reduced the incidence of the primary *** findings provide a promising option for managing ACS after PCI and suggest the potential treatment for reducing the risk of primary endpoint included cardiac death,non-fatal myocardial infarction,and urgent revascularization through intermittent administration of QSYQ.(Registration *** CTR-OOC-14005552).

关键词： Qishen Yiqi Dripping Pill acute coronary syndrome percutaneous coronary intervention primary and secondary endpoint

Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

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Oncology and Translational Medicine 2024年第1期10卷 22-29页

作者： Yang Yang zhi-Gang Liu Yan-Qi Yang zhi-Gang Zhang Xiao-Li Wang Yu-Long Li rui-Fang Sun School of Public Health Shaanxi University of Chinese MedicineXianyangChina Department of Thoracic Surgery Shaanxi Provincial Cancer HospitalXi'an Jiaotong UniversityXi'anChina Department of Pathology School of Basic Medical SciencesHealth Science CenterXi'an Jiaotong UniversityXi'anChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxiChina Department of Gastroenterology Shaanxi Provincial People's HospitalXi'anChina.

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various ***,a systematic pan-cancer analysis of TNFAIP6 is *** we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon ***:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor ***2 was used to evaluate the effect of TNFAIP6 on clinical cancer *** was used to assess TNFAIP6 *** correlation between TNFAIP6 and cancer immune infiltrates was explored using *** CancerSEA database was used to perform functional analysis of *** was used to identify TNFAIP6-related gene enrichment *** was performed to detect TNFAIP6 protein expression in the colon *** addition,the Comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with ***:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer ***6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial ***6 and similar genes may also be involved in the PID_VEGF_VEGFR_*** revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer *** known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the Comparative Toxicogenomics *** results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.

关键词： Cancer IHC Mutation Survival TNFAIP6

2例17α-羟化酶/17,20碳链裂解酶缺陷症患者临床及遗传学分析

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上海交通大学学报（医学版） 2015年第3期35卷 375-379页

作者：虎子颖赵志刚汪艳芳袁慧娟张会峰郑瑞芝郑州大学人民医院(河南省人民医院)内分泌科郑州450003

目的分析2例17α-羟化酶/17,20碳链裂解酶缺陷症患者的临床特点和分子遗传学特征。方法收集2007年9月—2008年7月在河南省人民医院内分泌科治疗的2例患者临床、基础激素测定和影像学检查资料,对患者进行CYP17A1基因检测。结果 2例患者... 详细信息

目的分析2例17α-羟化酶/17,20碳链裂解酶缺陷症患者的临床特点和分子遗传学特征。方法收集2007年9月—2008年7月在河南省人民医院内分泌科治疗的2例患者临床、基础激素测定和影像学检查资料,对患者进行CYP17A1基因检测。结果 2例患者血压高于正常值,血钾低于正常值,第二性征发育不良。激素测定示血皮质醇水平低于正常,促肾上腺皮质激素反馈性增高;肾素活性受抑制;睾酮、雌二醇低于正常值,而促性腺激素增高。CT示双侧肾上腺增生。CYP17A1基因检测显示,2例患者基因第6外显子上发现c.1 045del和c.1 047C>A,329位密码子发生了TAC-AA纯合突变,引起Tyr329Lys错义突变及以后密码子的移码突变,并提前产生一个终止密码子(418TGA)。结论高血压伴低血钾患者同时存在性发育不良,应考虑17α-羟化酶缺陷症的可能,CYP17A1基因突变导致的P450c17蛋白的结构改变是17α-羟化酶缺陷症的分子基础。

关键词： 17α-羟化酶/17 20碳链裂解酶缺陷症 CYP17A1基因突变

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法律推理中的辩证推理与实践推理刍议

菏泽师专学报 2004年第1期26卷 83-85页

作者：谢旭郑志锐谢罡辽宁大学法学院辽宁沈阳110036 北京城市学院北京100761

共识认为 ,在法律推理时仅仅依靠形式法律推理是不够的。但不同的法学家对如何弥补“不够”并不一致。本文针对辩证推理与实践推理两个理论的要义进行比较 ,以期找到在中国法律制度下的法律推理的理论模式。

关键词：法律推理辩证推理实践推理

Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

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World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： Hui Hua Qian-Qian Zhao Miriam Nkesichi Kalagbor Guo-zhi Yu Man Liu zheng-rui Bian Bei-Bei Zhang Qian Yu Yin-Hai Xu Ren-Xian Tang Kui-Yang zheng Chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment *** adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been *** To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing *** A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC *** sacrifice,the liver and the serum were collected from each *** hepatobiliary injuries,hepatic inflammation and fibrosis were *** targets of let-7a-5p and downstream molecule NF-κB were detected using Western *** rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 *** reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary ***,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic *** Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

Separation of halogens and recovery of heavy metals from secondary copper smelting dust

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2686-2701页

作者： zhi-lou LIU zhi-kang CHEN Fu-ze SUN zhi-heng ZHANG Kang YAN Shui-ping ZHONG Hui LIU rui-xiang WANG Jia-yuan LI zhi-feng XU School of Metallurgy Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Chemistry and Environmental Science Xiangnan UniversityChenzhou 423000China Ganzhou Engineering Technology Research Centre of Green Metallurgy and Process Intensification Ganzhou 341000China Key Laboratory of Ionic Rare Earth Resources and Environment Ministry of Natural ResourcesGanzhou 341000China

The separation of halogens and recovery of heavy metals from secondary copper smelting(SCS)dust using a sulfating roasting−water leaching process were *** thermodynamic analysis results confirm the feasibility of the phase transformation to metal sulfates and to gaseous HF and *** the sulfating roasting conditions of the roasting temperature of 250℃ and the sulfuric acid excess coefficient of 1.8,over 74 wt.%of F and 98 wt.%of Cl were volatilized into flue *** 98.6 wt.%of Zn and 96.5 wt.%of Cu in the roasting product were dissolved into the leaching solution after the water leaching process,while the leaching efficiencies of Pb and Sn were only 0.12%and 0.22%,*** mechanism studies indicate the pivotal effect of roasting temperature on the sulphation reactions from various metal species to metal sulfates and the salting out reactions from various metal halides to gaseous hydrogen halides.

关键词： secondary copper smelting dust sulfating roasting water leaching halogen volatilization heavy metal separation