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Glycosyltransferases and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第8期22卷 2483-2493页

作者： Yu-Tao zhan Hai-ying Su Wei An Department of Gastroenterology Beijing Tongren Hospital Capital Medical University Department of Obstetrics and Gynecology Shandong Jining First People’s Hospital Department of Cell Biology Municipal Laboratory for Liver Protection and Regulation of Regeneration Capital Medical University

Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.

关键词： Non-alcoholic fatty liver disease Pathogenesis Glycosyltransferases Glycosylation

Dose-dependent effects of procyanidin on nerve growth factor expression following cerebral ischemia/reperfusion injury in rats

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Neural Regeneration Research 2008年第4期3卷 390-393页

作者： Feng Li Hai Xie ying Gao Tongxia zhan Department of Health Weifang Renmin Hospital Weifang 261041 Shandong Province Chiina Department of Nuclear Medicine Weifang Medical College Weifang 261041 Shandong Province China

BACKGROUND： Recently, grape seed procyanidin （GSP） has been shown to be exhibit antioxidant effects, effectively reducing ischemia/reperfusion injury and inhibiting brain cell apoptosis. OBJECTIVE： To study the effects of GSP on nerve growth factor （NGF） expression and neurological function following cerebral ischemia/reperfusion injury in rats. DESIGN： Randomized controlled study based on SD rats. SETTING： Weifang Municipal People＇s Hospital. MATERIALS： Forty-eight healthy adult SD rats weighing 280-330 g and irrespective of gender were provided by the Experimental Animal Center of Shandong University. GSP derived from grape seed was a new high-effective antioxidant provided by Tianjin Jianfeng Natural Product Researching Company （batch number： 20060107）. Rabbit-anti-rat NGF monoclonal antibody was provided by Beijing Zhongshan Biotechnology Co., Ltd., and SABC immunohistochemical staining kit by Wuhan Boster Bioengineering Co., Ltd. METHODS： The present study was performed in the Functional Laboratory of Weifang Medical College from April 2006 to January 2007. Forty-eight SD rats were randomly divided into the sham operation group, ischemia/reperfusion group, high-dose GSP （40 mg/kg） group, or low-dose GSP （10 mg/kg） group （n = 12 per group）. Ischemia/reperfusion injury was established using the threading embolism method of the middle cerebral artery. Rats in the ischemia/reperfusion model group were given saline injection （2 mL/kg i.p.） once daily for seven days pre-ischemia/reperfusion, and once more at 15 minutes before reperfusion. Rats in the high-dose and low-dose GSP groups were injected with GSP （20 or 5 mg/mL i.p., respectively, 2 mL/kg） with the same regime as the ischemia/reperfusion model group. The surgical procedures in the sham operation group were as the same as those in the ischemia/reperfusion model group, but the thread was approximately 10 mm long, thus, the middle cerebral artery was not blocked. MAIN OUTCOME MEASURES： NGF expression in the is

关键词： procyanidin cerebral ischemia/reperfusion injury nerve growth factor

Enantioselective total syntheses of marine natural products(+)-cylindricines C,D,E and their diastereomers

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Organic Chemistry Frontiers 2022年第1期9卷 58-63页

作者： ying-Hong Huang zhan-Jiang Liu Pei-Qiang Huang Department of Chemistry Fujian Provincial Key Laboratory of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005P.R.China

A seven-step total synthesis of(+)-cylindricine D and epi-cylindricine D is *** efficiency relies on the highly diastereoselective reductive bis-functionalization of N,O-protected(S)-pyroglutaminol by our recently improved protocol to build the N-α-tert-alkylamine motif,and a telescoped one-step fourreaction protocol to build the fused bicyclic ring system.(+)-Cylindricine C and its 2-epimer were synthesized by essentially the same sequence in eight *** of the latter then delivered(+)-cylindricine E and its 2-epimer,respectively.

关键词： latter steps essentially

Thermodynamics of Third Order Lovelock Anti-de Sitter Black Holes Revisited

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Communications in Theoretical Physics 2011年第3期55卷 449-456页

作者： ZOU De-Cheng YUE Rui-Hong YANG zhan-ying Department of Physics Northwest University Xi＇an 710069 China Faculty of Science Ningbo University Ningbo 315211 China

We compute the mass and temperature of third order Lovelock black holes with negative Gauss-Bonnet coefficient a2 〈 0 in anti-de Sitter space and perform the stability analysis of topological black holes. When k = -1, the third order Lovelock black holes are thermodynamically stable for the whole range r＋. When k = 1, we found that the black hole has an intermediate unstable phase for D = 7. In eight dimensional spacetimes, however, a new phase of thermodynamically unstable small black holes appears if the coefficient a is under a critical value. For D ≥ 9, black holes have similar the distributions of thermodynamically stable regions to the case where the coefficient ＆ is under a critical value for D = 8. It is worth to mention that all the thermodynamic and conserved quantities of the black holes with fiat horizon do not depend on the Loveloek coefficients and are the same as those of black holes in general gravity.

关键词： third order Lovelock gravity AdS space thermodynamics

Image Semantic Segmentation Approach for Studying Human Behavior on Image Data

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Wuhan University Journal of Natural Sciences 2024年第2期29卷 145-153页

作者： zheng zhan CHEN Da HUANG Yanrong School of Communication Wuhan Textile UniversityWuhan 430073HubeiChina Walnut Street(Shanghai)Information Technology Co. Ltd.Shanghai 200051China College of Economics&Management Zhejiang University of Water Resources and Electric PowerHangzhou 310018ZhejiangChina Research Center for Digital Economy and Sustainable Development of Water Resources Hangzhou 310018ZhejiangChina

Image semantic segmentation is an essential technique for studying human behavior through image *** paper proposes an image semantic segmentation method for human behavior ***,an end-to-end convolutional neural network architecture is proposed,which consists of a depth-separable jump-connected fully convolutional network and a conditional random field network;then jump-connected convolution is used to classify each pixel in the image,and an image semantic segmentation method based on convolu-tional neural network is proposed;and then a conditional random field network is used to improve the effect of image segmentation of hu-man behavior and a linear modeling and nonlinear modeling method based on the semantic segmentation of conditional random field im-age is ***,using the proposed image segmentation network,the input entrepreneurial image data is semantically segmented to obtain the contour features of the person;and the segmentation of the images in the medical *** experimental results show that the image semantic segmentation method is *** is a new way to use image data to study human behavior and can be extended to other research areas.

关键词： human behavior research image semantic segmentation hop-connected full convolution network conditional random field network deep learning

Rational construction of hollow nanoboxes for long cycle life alkali metal ion batteries

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Journal of Materials Science & Technology 2022年第7期102卷 46-55页

作者： zheng zhang ying Huang Xiang Li Zhiming Zhou MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions School of Natural and Applied SciencesNorthwestern Polytechnical UniversityXi’an 710072China CAS Key Laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research InstituteChinese Academy of Sciences100 Haike RoadShanghai 201210China

Hollow nanostructures are extremely attractive in energy storage and show broad application *** the preparation method is accompanied by a complicated *** this article,the CoZn-based hol-low nanoboxes with electrochemical synergy are prepared in a simple *** structure can effectively shorten the transmission distance of ions and electrons,and alleviate the volume expansion during the *** particular,bimetallic oxides are rich in oxygen vacancies,providing more active sites for electro-chemical *** addition,the stepwise oxidation-reduction reaction can also improve the volume change of the electrode *** to the kinetic analysis and density functional theory(DFT)calculation,it is confirmed that the synergistic effect of the bimetallic oxide can accelerate the reaction *** on these characteristics,the electrode exhibits stable cycle performance and long cycle life in alkali metal ion batteries,and can provide reversible capacities of 302.1(LIBs,2000 cycles),172.5(SIBs,10000 cycles)and 109.6(PIBs,5000 cycles)mA h g^(-1)at a current density of 1.0 A g^(-1),*** ad-dition,by assembling(LiCoO_(2)//CoZn-O_(2))and(Na_(3)V_(2)(PO_(4))_(3)//CoZn-O_(2))full-cells,the practical application value is *** sharing of this work introduces a simple way to synthesize hollow nanoboxes,and shows excellent electrochemical performance,which can also be expanded in other areas.

关键词： Hollow nanoboxes Bimetallic oxides DFT calculation Alkali metal ion batteries

Enhancing short-term ethanol-type fermentation of waste activated sludge by adding saccharomycetes and the implications for bioenergy and resource recovery

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Journal of Environmental Sciences 2022年第3期34卷 179-189页

作者： Linke zheng ying Xu Hui Geng Xiaohu Dai State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China East China Architecture Design&Research Institute Shanghai 200002China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Ethanol-type sludge fermentation has recently attracted much attention because it can enhance direct interspecies electron transfer and thus improve the anaerobic digestion of waste activated sludge(WAS). In this paper, the enhancement of short-term ethanol-type fermentation of WAS via adding Saccharomyces was investigated. The experimental results show that the maximum ethanol production of 1030.8 ± 20.6 mg/L was achieved, with the optimum fermentation conditions of a p H of 5.1, temperature of 26.0 ℃ and time of 8.0 hr. Although the content of volatile fatty acid(VFA) increased within 10 hr, it is one order of magnitude lower than the content of ethanol, indicating that the VFA generation did not affect the efficient production of ethanol. The analyses of changes in the microbial community during the fermentation process demonstrate that the greatest Saccharomyces activity occurred in the first 8 hr and it can play an important role in ethanol production even at a very low relative abundance. Meanwhile, most typical acid-producing bacteria were inhibited, but the hydrogenotrophic methanogens(i.e., Methanobacterium) were enriched to a certain extent. Further statistical analyses reveal that the Rhodobacter, Thermomonas, Terrimonas and Saccharomyces are responsible for ethanol production during the fermentation. However, these findings not only provide a reference for the development of enhancing ethanol-type fermentation of sludge, but also are expected to provide a new way of thinking for the efficient bioenergy and resource recovery from sludge.

关键词： Anaerobic digestion Sewage sludge Methane production Ethanol production Biodegradability

Kink-like breathers in Bose–Einstein condensates with helicoidal spin–orbit coupling

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Frontiers of physics 2022年第3期17卷 155-163页

作者： Yixin Yang Peng Gao Li-Chen Zhao zhan-ying Yang School of Physics Northwest UniversityXi'an 710127China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi'an 710127China Peng Huanwu Center for Fundamental Theory Xi'an 710127China

We report a kind of kink-like breathers in one-dimensional Bose–Einstein condensates (BECs) with helicoidal spin–orbit coupling (SOC), on whose two sides the background densities manifest obvious difference (called kink amplitude). The kink amplitude and shape of breather can be adjusted by the strength and period of helicoidal SOC, and its atomic number in two components exchanges periodically with time. The SOC has similar influence on the kink amplitude and the exchanged atomic number, especially when the background wave number is fixed. It indicates that the oscillating intensity of breather can be controlled by adjusting initial kink amplitude. Our work showcases the great potential of realizing novel types of breathers through SOC, and deepens our understanding on the formation mechanisms of breathers in BECs.

关键词： Bose–Einstein condensates spin–orbit coupling breather

Recent advances in statistical methodologies in evaluating program for high-dimensional data

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Applied Mathematics(A Journal of Chinese Universities) 2022年第1期37卷 131-146页

作者： zhan Ming-feng CAI Zong-wu FANG ying LIN Ming Wang Yanan Institute for Studies in Economics and Fujian Key Laboratory of Statistical Sciences Xiamen UniversityXiamen 361005China Department of Economics University of KansasLawrenceKS 66045USA Department of Statistics and Data Science Xiamen UniversityXiamen 361005China

The era of big data brings opportunities and challenges to developing new statistical methods and models to evaluate social programs or economic policies or interventions. This paper provides a comprehensive review on some recent advances in statistical methodologies and models to evaluate programs with high-dimensional data. In particular, four kinds of methods for making valid statistical inferences for treatment effects in high dimensions are addressed. The first one is the so-called doubly robust type estimation, which models the outcome regression and propensity score functions simultaneously. The second one is the covariate balance method to construct the treatment effect estimators. The third one is the sufficient dimension reduction approach for causal inferences. The last one is the machine learning procedure directly or indirectly to make statistical inferences to treatment effect. In such a way, some of these methods and models are closely related to the de-biased Lasso type methods for the regression model with high dimensions in the statistical literature. Finally, some future research topics are also discussed.

关键词： causal inference covariate balance de-biased Lasso dimension reduction doubly robust high dimensions machine learning treatment effect