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Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation

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Chinese Journal of Natural Medicines 2022年第6期20卷 443-457页

作者： DUAN Fei-Peng LI yi-Sheng HU Tian-Yong PAN Xin-Quan MA Fang FENG Yue QIU Shu-Qi zheng yi-qing Institute of Otolaryngology Institute of Hearing and Speech of Sun Yat-sen UniversitySun Yat-sen Me-morial HospitalSun Yat-sen UniversityGuangzhou 510520China Department of Otolaryngology Longgang E.N.T hospital&Shenzhen Key Laboratory of E.N.TInstitute of E.N.TShenzhen 518172China

Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic ***,regulating the balance of intestinal flora may be useful for preventing and treating allergic ***,the underlying mechanism is *** nobile(Shihu)exhibits anti-inflammatory and immune ***,in this study,we investigated the mechanism via which Shihu may improve allergic *** models of allergic rhinitis with intestinal flora dysbiosis(Model-D,antibiotics induce intestinal flora dysbiosis with ovalbumin-induced allergy)and normal intestinal flora with allergic rhinitis(Model-N,ovalbumin-induced allergy)were *** effect of Shihu on intestinal flora and inflammation caused during allergic rhinitis were *** symptoms,infiltration of hematoxylin and eosin in the lungs and nose,and the release of various factors[interleukin(IL)-2,IL-4,IFN-y,IL-6,IL-10,and IL-17]in the lungs were *** results indicate that intestinal flora dysbiosis exacerbated lung and nose inflammation in allergic ***,treatment with the Shihu extract effectively reversed these ***,the Shihu extract inhibited the PI3K/AXT/mTOR pathway and increased the level of Forkhead box protein in the ***,the Shihu extract reversed intestinal flora dysbiosis at the phylum and genus levels and improved regulator T cell ***,in the Model-D group,the Shihu extract inhibited the decrease in the diversity and abundance of the intestinal *** was performed to determine which intestinal flora was positively correlated with Treg differentiation using Spearman5 s correlation *** conclusion,we showed that Shihu extract restored the balance in intestinal flora and ameliorated inflammation in the lungs of allergic rhinitis mice and predicted a therapeutic new approach using Traditional Chinese Medicine to improve allergic rhinitis.

关键词： Dendrobium nobile(Shihu) Allergic rhinitis Intestinal flora Regulator T cell Inflammation

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上海市民休闲行为研究

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旅游科学 2006年第2期20卷 60-64页

作者：郑怡清朱立新上海师范大学旅游学院上海200234

笔者采用问卷与访谈的调研方式,对上海市民日常休闲行为进行调查。比较了市民在工作日与双休日中休闲活动的分布情况,对不同年龄、职业、性别的上海市民的休闲偏好、休闲时间、休闲花费和休闲态度进行了较详细的分析,并列举出6种阻碍上... 详细信息

笔者采用问卷与访谈的调研方式,对上海市民日常休闲行为进行调查。比较了市民在工作日与双休日中休闲活动的分布情况,对不同年龄、职业、性别的上海市民的休闲偏好、休闲时间、休闲花费和休闲态度进行了较详细的分析,并列举出6种阻碍上海市民休闲的因素,从而揭示出上海市民休闲活动的现状。

关键词：上海休闲行为休闲阻碍经济效益文化现象

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Modification of closed tympanoplasty in middle ear cholesteatoma

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Chinese Medical Journal 2010年第4期123卷 447-451页

作者： ZHANG Zhi-gang LIU Xiang CHEN Sui-jun CHEN Bin zheng yi-qing Department of Otorhinolaryngology Head and Neck Surgery Second Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510120 China

Background Classic mastoidectomy and modified mastoidectomy are traditional surgical procedures for middle ear cholesteatoma with goals of eradicating diseases, creating dry ears and preventing severe complications. However, the drawback of these procedures is the lack of hearing improvement. Therefore, our study aimed to investigate the effects and safety of a modification of closed tympanoplasty for middle ear cholesteatoma. Methods Eighty-three patients were recruited in this study based on the following two criteria： each patient had middle ear cholesteatoma in one ear; the affected ears had a functional eustachian tube and had neither intracranial nor extracranial complications. All the patients received a modification of closed tympanoplasty which included ossicular reconstruction with total ossicular replacement prosthesis （TORP） or partial ossicular replacement prosthesis （PORP） and membrane repair with conchal cartilage-perichondral complex. Results All the 83 cases had dry ears with membranes healed within 4-6 postoperative weeks. After 6 postoperative months, there were 3 cases with re-perforation at the tympanic membrane center and after 1.5 postoperative years, there were 5 cases with cholesteatoma recurrence （6.02%）. Function tests after one postoperative year exhibited an improvement of pure tone audiometry （PTA） in 27 cases that was more than 30 dB, in 33 cases between 20-29 dB, 14 cases with improvement between 10-19 dB, and in 9 cases there was no improvement. Conclusions The modified closed tympanoplasty procedure for middle ear cholesteatoma in the present study has all the advantages of both close-cavity and open-cavity procedures. It has low recurrence rate and good hearing improvement.

关键词： mastoidectomy tympanoplasty cholesteatoma cartilage middle ear

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Pediatric Middle Ear Congenital Cholesteatoma: A Case Report

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Journal of Otology 2008年第1期3卷 56-58页

作者： HUANG Qiu-hong, zheng yi-qing Department of Otolaryngology, 2nd Affliated Hospital of Sun Yat-sen Unilersity, Guang zhou, 510120, China Department of Otolaryngology 2nd Affliated Hospital of Sun Yat–sen Unilersity Guang zhou 510120 China

Congenital cholesteatoma（CC）is a rarely seen benign tumor of the temporal bone. There are five general sites of extradural occurrence: the middle ear, external auditory meatus, mastoid, squamous portion and the petrous apex of the temporal bone. CC grows slowly and presents no symptoms at the early stage. Delayed and mis-diagnosis are common with this condition. Case report A 10-year-old boy presented with a 3-month history of hearing loss on right side. There was no history of otorrhea, facial palsy, previous otological procedures or trauma. Otoscopy revealed a bulging posterosuperior quadrant in the otherwise intact right tympanic membrane （Fig.1）. Pure tone audiometry showed an average threshold of 51 dB for 500, 1000, 2000 and 4000Hz, with a 40 dB air-bone gap, suggesting a moderate conductive hearing loss（Fig.4）. CT scan of the temporal bone showed an isolated soft tissue density lesion in the middle ear（Fig.2）.

关键词： Case bone A Case Report Pediatric Middle Ear Congenital Cholesteatoma CC

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A anorectal fistula treatment with acellular extracellular matrix: A new technique

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World Journal of Gastroenterology 2008年第30期14卷 4791-4794页

作者： Wei-Liang Song Zhen-Jun Wang yi zheng Xin-qing Yang Ya-Ping Peng Department of General Surgery Chaoyang Hospital of Capital Medicine University Beijing 100020 China

AIM: To investigate a new technique of the anorectal fistula treatment with acellular extracellular matrix (AEM). METHODS: Thirty patients with anorectal fistula were treated with AEM. All fistula tracts and primary openings were identified using conventional fistula probe. All tracts were curetted with curet and irrigated with hydrogen peroxide and metronidazole. The AEM was pulled into the fistula tract from secondary to primary opening. The material was secured at the level of the primary opening. The excess AEM was trimmed at skin level at the secondary opening. RESULTS: All of the 30 patients had successful closure of their fistula after a 7-14 d follow-up. The healing rate of anal fistula in treatment group was 100%. The ache time, healing time and anal deformation of treatment group were obviously superior to traditional surgical methods. CONCLUSION: Using AEM anal fistula plug in treatment that causes the anorectal fistula is safe and successful in 100% of patients. It can reduce pain, shorten disease course and protect anal function.

关键词： Acellular extracellular matrix Anorectal fistula

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基于Hilbert变换的全波场分离逆时偏移成像

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地球物理学报 2016年第11期59卷 4200-4211页

作者：王一博郑忆康薛清峰常旭 Tong W.Fei yi Luo 中国科学院地质与地球物理研究所 EXPEC ARC Saudi AramcoDhahran 31311Saudi Arabia

逆时偏移方法利用双程波算子模拟波场的正向和反向传播,通常采用互相关成像条件获得偏移剖面,是一种高精度的成像方法.但是传统的互相关成像条件会在偏移结果中产生低频噪声;此外,如果偏移速度中存在剧烈速度变化还可能进一步产生偏移假... 详细信息

逆时偏移方法利用双程波算子模拟波场的正向和反向传播,通常采用互相关成像条件获得偏移剖面,是一种高精度的成像方法.但是传统的互相关成像条件会在偏移结果中产生低频噪声;此外,如果偏移速度中存在剧烈速度变化还可能进一步产生偏移假象.为了提高逆时偏移的成像质量,可在成像过程中先对震源波场和检波点波场分别进行波场分离,然后选择合适的波场成分进行互相关成像.本文基于Hilbert变换,推导了可在偏移过程中进行上下行和左右行波场分离的高效波场分离公式以及相应的成像条件,结合Sigsbee 2B合成数据,给出了不同波场成分的互相关成像结果.数值算例结果表明,采用本文提出的高效波场分离算法以及合理的波场成分互相关成像条件可以获得高信噪比的成像结果.

关键词：逆时偏移互相关成像条件波场分离 Hilbert变换

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高密度脂蛋白保护烫伤大鼠多脏器功能

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基础医学与临床 2011年第3期31卷 252-258页

作者：郑健生郑庆亦解放军第175医院厦门大学附属东南医院烧伤整形科福建漳州363000

目的了解高密度脂蛋白(HDL)对严重烫伤大鼠脏器功能的保护作用及其机制。方法将Wistar大鼠随机分为对照组(15只)、烫伤组(60只)和HDL组(60只)。后2组均造成30%TBSAⅢ度烫伤,伤后常规补液,其中HDL组伤后立即经尾静脉注入HDL(80 mg/kg)。... 详细信息

目的了解高密度脂蛋白(HDL)对严重烫伤大鼠脏器功能的保护作用及其机制。方法将Wistar大鼠随机分为对照组(15只)、烫伤组(60只)和HDL组(60只)。后2组均造成30%TBSAⅢ度烫伤,伤后常规补液,其中HDL组伤后立即经尾静脉注入HDL(80 mg/kg)。检测各组血清ICAM-1、TNF-α、oxLDL、CK、ALT、AST、BUN和Cr的含量和PCO2、PO2;观察大鼠伤后各时相点的心、肺、肝及肾组织病理学变化。结果烫伤组大鼠伤后各时相点ICAM-1、TNF-α、oxLDL、CK、ALT、AST、BUN、Cr及PCO2均显著高于对照组(P<0.05),PO2显著降低(P<0.05);烫伤组大鼠心、肺、肝及肾组织病理学变化明显,HDL组上述指标变化显著低于烫伤组。结论 HDL对严重烫伤大鼠脏器功能具有保护作用,可能与通过抑制ICAM-1、TNF-α的表达、减轻体内的炎性反应有关。

关键词： HDL 保护烫伤脏器功能

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Obstructive Sleep Apnea-Hypopnea Ssyndrome and Hearing in Children

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Journal of Otology 2008年第2期3卷 116-120页

作者： HE Xiao-zheng1, XU Yao-dong2, CAI Qian2, zheng yi-qing2 1 Department of Otorhinolargygology, Renmin Hospital of Jiangmen 2 Department of Otorhinolargygology, The 2nd Affiliated Hospital, Sun Yat-sen University, GuangZhou, China Department of Otorhinolargygology Renmin Hospital of Jiangmen Department of Otorhinolargygology The 2nd Affiliated Hospital Sun Yat–sen University GuangZhou China

Objective To explore the relationship between hypoxemia and hearing in children with obstructive sleep apnea-hypopnea syndrome. Methods Auditory brainstem responses (ABRs) were recorded in 68 ears and distortion product otoacoustic emissions (DPOAEs) in 60 ears in children with OSAHS and type "A" tym-panograms, and in 30 ears in normal children. Results ABR latencies of waves I, III and V, and I-III, III-V and I-V intervals were not statistically different between OSAHS and normal children. Wave I latency was delayed in children with OSAHS compared to normal children3 (P < 0.05). DPOAE amplitudes in children with mild OSAHS were lower than normal children at 8 kHz (P < 0.05). DPOAEs were lower at 6 kHz and 8 kHz in children with moderate/severe OSAHS than normal children (P < 0.05). Conclusion Cochlear function was affected when AHI was at or greater than 10/hour. ABR and DPOAE can be used to detect early changes in auditory function in children with OSAHS.

关键词： obstructive sleep apnea-hypopnea syndrome children auditory brainstem response otoacoustic emissions

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Diagnosis and management of first branchial fistula: a study of 12 cases

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Journal of Otology 2008年第1期3卷 51-55页

作者： OU Yong-kang, XU Yao-dong, LIU Xiang, HUANG Xiao-ming, PENG Jie-ren, zheng yi-qing Department of Otorhinolaryngology&Head-Neck Surgery, The 2nd Affiliated Hospital of Sun Yat-sen University Department of Otorhinolaryngology&Head–Neck Surgery The 2nd Affiliated Hospital of Sun Yat–sen University

Objectives To report authors’ experiences in the diagnosis and treatments of congenital first branchial fistula (congenital auriculocervical fistula). Materials and Methods Twelve cases of congenital first branchial fistula were reviewed. Of these, 8 underwent fistulectomy with facial nerve dissection and partial parotidectomy and 4 underwent simple fistulectomy. Results The inner openings (upper opening) of fistulae lay in the following sites: inferioposterior wall at the junction of cartilaginous and bony segments of the auricular canal and inferior wall of cartilaginous auricular canal. The outer openings(lower opening) lay along the anterior border of upper sternocleidomastoid muscle, at the mastoid tip and posterior to the mandibular angle. Complete fistulae resection was achieved in all but one case. Eleven cases were followed for 5 year with no recurrence. Recurrence occurred in 1 case 6 months after the primary surgery and revision surgery was performed. Conclusions Pre-operative radiography for the location and course of the fistula is crucial for successful fistula resection, especially in cases with past infections. Facial nerve dissection should be done routinely for deeply located fistulae.

关键词： Congenital Malformation First Branchia Auriculocervical Fistula Diagnosis Surgery

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工作要求对煤矿工人不安全行为的影响:情绪衰竭和行事风格的作用

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中国临床心理学杂志 2022年第3期30卷 573-577,553页

作者：张登浩王毅辰郑庆颐董妍中国人民大学心理学系北京100872

目的:探讨煤矿工人工作要求对其不安全行为的影响,并研究情绪衰竭和行事风格在不安全行为产生过程中发挥的作用。方法:在对煤矿企业进行调研走访,了解生产一线实际情况的基础上,结合已有成熟量表,编制了煤矿企业井下作业不安全行为问卷... 详细信息

目的:探讨煤矿工人工作要求对其不安全行为的影响,并研究情绪衰竭和行事风格在不安全行为产生过程中发挥的作用。方法:在对煤矿企业进行调研走访,了解生产一线实际情况的基础上,结合已有成熟量表,编制了煤矿企业井下作业不安全行为问卷,收集了294名一线煤矿工人的数据。结果:(1)煤矿工人工作要求对其不安全行为的产生有显著正向影响;(2)情绪衰竭在工作要求对不安全行为的影响过程中发挥完全中介作用;(3)行事风格调节了中介过程的后半路径,行事风格得分较低者的情绪衰竭水平对其不安全行为的正向预测作用更显著。结论:情绪衰竭在工作要求与不安全行为之间起完全中介作用,行事风格调节了工作要求对不安全行为的间接效应。

关键词：工作要求不安全行为情绪衰竭行事风格

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