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Roles of MicroRNAs in the Caenorhabditis elegans Nervous System

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Journal of Genetics and Genomics 2013年第9期40卷 445-452页

作者： Lingfeng Meng Liang Chen Zhaoyong Li zheng-xing wu Ge Shan School of Life Science and Technology Huazhong University of Science and Technology School of Life Sciences & CAS Key Laboratory of Brain Function and Disease University of Science and Technology of China

The first microRNA was discovered in Caenorhabditis elegans in 1993, and since then, thousands of microRNAs have been identified from almost all eukaryotic organisms examined. MicroRNAs function in many biological events such as cell fate determination, metabolism, apoptosis, and carcinogenesis. So far, more than 250 microRNAs have been identified in C. elegans; however, functions for most of these microRNAs are still unknown. A small number of C. elegans microRNAs are associated with known physiological roles such as developmental timing, cell differentiation, stress response, and longevity. In this review, we summarize known roles of micro- RNAs in neuronal differentiation and function of C. elegans, and discuss interesting perspectives for future studies.

关键词： C. elegans Nervous system MicroRNA Function Differentiation

Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans

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Protein & Cell 2010年第1期1卷 75-81页

作者： Ya-Ming Jiu Yang Yue Song Yang Lin Liu Jun-Wei Yu zheng-xing wu Tao Xu Key Laboratory of Molecular Biophysics Ministry of Educationand Institute of Biophysics and BiochemistryHuazhong University of Science and TechnologyWuhan 430074China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Animals integrate various environmental stimuli within the nervous system to generate proper behavioral ***,the underlying neural circuits and molecular mechanisms are largely *** insulinlike signaling pathway is known to regulate dauer formation,fat metabolism,and longevity in Caenorhabditis elegans(***).Here,we show that this highly conserved signaling pathway also functions in the integrative response to an olfactory diacetyl and a gustatory Cu^(2+) *** of wild-type N2 Bristol displayed a strong avoidance to the Cu^(2+) barrier in the migration pathway to the attractive *** of daf-2(insulin receptor),daf-18(PTEN lipid phosphatase),pdk-1(phosphoinositide-dependent kinase),akt-1/-2(Akt/PKB kinase)and sgk-1(serum-and glucocorticoidinducible kinase)show severe defects in the elusion from the Cu^(2+) .Mutations in DAF-16,a forkhead-type transcriptional factor,suppress the integrative defects of daf-2 and akt-1/-2 *** further report that neither cGMP nor TGFβpathways,two other dauer formation regulators,likely plays a role in the integrative *** results suggest that the insulin-like signaling pathway constitutes an essential component for sensory integration and decision-making behavior plasticity.

关键词： C.elegans insulin signaling pathway sensory integration decision making behavior

High-Velocity H_(2)O Masers Associated Massive Star Formation Regions

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Chinese Physics Letters 2001年第12期18卷 1663-1665页

作者： XU Ye JIANG Dong-Rong zheng xing-wu GU Min-Feng YU Zhi-Yao PEI Chun-Chuan Shanghai Astronomical Observatory National Astronomical ObservatoriesChinese Academy of SciencesShanghai 200030 Department of Astronomy Nanjing UniversityNanjing 210093 Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008

We report on the results of ^(12)CO (1-0) emission associated with H2O masers and massive star formation regions to identify high-velocity H2O masers. Several masers have a large blueshift, even up to 120km·s^(-1), with respect to the CO peak, but no large redshifted maser appears. This result suggests that high-velocity H_(2)O masers can most probably occur in high mass star-forming regions and quite a number of masers stem from the amplifications of a background source, which may enable those undetectable weak masers to come to an observable level.

关键词： massive probably source

Effects of estrogen on collagen gel contraction by human retinal glial cells

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Chinese Medical Journal 2012年第22期125卷 4098-4103页

作者： QIU Qing-hua CHEN Zhi-Yi YIN Li-li zheng Zhi wu xing-wei Shanghai Jiao Tong Univ Dept Ophthalmol Peoples Hosp 1 Shanghai 200080 Peoples R China Shanghai Heping Eye Hosp Shanghai 200437 Peoples R China

Background There are definite gender differences in patients with macular holes. Menopausal women over 50 years are most affected. We aimed to observe the effect of estrogen on collagen gel contraction by cultured human retinal glial cells. It is speculated that estrogen could strengthen the tensile stress of the macula by maintaining the correct morphology and contraction. Methods Estrogen was used to determine its effects on collagen gel contraction, and its function was measured using morphological changes in cells. Human retinal glial cells were cultured in collagen solution. The cells were then exposed to collagen gels and the degree of contraction of the gel was determined. Results Estrogen at differing concentrations had no effect on the growth of human retinal glial cells. However, after exposed to collagen gel block, less contraction was noted in the estrogen-treated group than in the control group. Conclusions Estrogen can inhibit collagen gel contraction by glial cells. These results suggest a mechanism for macular hole formation, which is observed in menopausal females.

关键词： estrogen human retinal glial cells three-dimensional culture

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia wu Mouxiong zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Loss Aware Feature Attention Mechanism for Class and Feature Imbalance Issue

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Computers, Materials & Continua 2025年第1期82卷 751-775页

作者： Yuewei wu Ruiling Fu Tongtong xing Fulian Yin College of Information and Communication Engineering Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

In the Internet era,recommendation systems play a crucial role in helping users find relevant information from large *** imbalance is known to severely affect data quality,and therefore reduce the performance of recommendation *** to the imbalance,machine learning algorithms tend to classify inputs into the positive(majority)class every time to achieve high prediction *** can be categorized such as by features and classes,but most studies consider only class *** this paper,we propose a recommendation system that can integrate multiple networks to adapt to a large number of imbalanced features and can deal with highly skewed and imbalanced datasets through a loss *** propose a loss aware feature attention mechanism(LAFAM)to solve the issue of feature *** network incorporates an attention mechanism and uses multiple sub-networks to classify and learn *** better results,the network can learn the weights of sub-networks and assign higher weights to important *** propose suppression loss to address class imbalance,which favors negative loss by penalizing positive loss,and pays more attention to sample points near the decision *** on two large-scale datasets verify that the performance of the proposed system is greatly improved compared to baseline methods.

关键词： Imbalanced data deep learning e-commerce recommendation loss function big data analysis

Field study of seasonal thermal comfort and adaptive behavior for occupants in residential buildings of Xi’an,China

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Journal of Central South University 2022年第7期29卷 2403-2414页

作者： WEI Na zheng wu-xing ZHANG Nan ZHAO Sheng-kai ZHAI Yong-chao YANG Liu State Key Laboratory of Green Building in Western China Xi'an University of Architecture and TechnologyXi’an 710055China College of Architecture Xi'an University of Architecture and TechnologyXi’an 710055China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China

The study aims to investigate the thermal comfort requirements in residential buildings and to establish an adaptive thermal comfort model in the cold zone of China.A year-long field study was conducted in residential buildings in Xi’an,China.A total of 2069 valid questionnaires,along with indoor environmental parameters were *** results indicated occupants’thermal comfort requirements varied with *** neutral temperatures were 17.9,26.1(highest),25.2,and 17.4℃(lowest),and preferred temperatures were 23.2,25.6(highest),24.8,and 22.4℃(lowest),respectively for spring,summer,autumn,and *** neutral temperature and preferred temperature in autumn are close to the neutral temperature in summer,while the neutral temperature and preferred temperature in spring are close to that in ***,the 80%and 90%acceptable temperature ranges,adaptive thermal comfort models,and thermal comfort zones for each season were ***’s adaptability is related to his/her thermal experience of the current season and the previous ***,compared with the traditional year-round adaptive thermal comfort model,seasonal models can better reflect seasonal variations of human *** study provides fundamental knowledge of the thermal comfort demand for people in this region.

关键词： thermal comfort seasonal variation adaptive thermal comfort model energy saving residential buildings

Mutations in β-G spectrin disrupt the DCVs excytosis in C. elegans

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生物物理学报 2009年第S1期25卷 210-211页

作者： Ya-Ming Jiu, Xian-Guang Lin, Jun-Wei Yu, zheng-xing wu College of Life Science and Technology, Huazhong University of Science and Technology, wuhan 430074, P.R.China

β spectrin is a major component of the membrane skeleton, a structure found at the plasma membrane of most animal cells. In C. elegans, the genome encodes only one

关键词： C.elegans β-G spectrin excytosis DCVs

时间同步误差对船体角形变测量的影响（英文）

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中国惯性技术学报 2017年第2期25卷 151-155页

作者：郑佳兴吴伟戴东凯国防科技大学光电科学与工程学院长沙410073

针对激光陀螺船体角形变测量,分析评估了两组激光陀螺组合体时间同步误差的影响,并提出了一种时间同步误差的在线估计算法。严格推导了考虑了时间同步误差的惯性姿态匹配方程,从方程可见,船体在波浪摇摆条件下时间同步误差将导致额外的K... 详细信息

针对激光陀螺船体角形变测量,分析评估了两组激光陀螺组合体时间同步误差的影响,并提出了一种时间同步误差的在线估计算法。严格推导了考虑了时间同步误差的惯性姿态匹配方程,从方程可见,船体在波浪摇摆条件下时间同步误差将导致额外的Kalman滤波观测量波动误差,直接影响船体角形变测量精度。另一方面,基于新推导的惯性姿态匹配方程,在滤波状态中增加时间延迟变量,通过Kalman滤波能够在线估计时间延迟大小。基于实测远望船体姿态和角变形数据进行了仿真,仿真测试表明大的时间延迟将导致大的船体角形变测量误差,同时验证了时间延迟在线估计方法的有效性。

关键词：船体角形变测量时间同步激光陀螺姿态匹配